LU Jianguo , ZHAO Xiangmei , GAN Shaoyin , CHEN Xiaofang , ZHU Deqi , YAN Ershuai , LI Xiaojie
  • The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453100, Henan, P. R. China;
LU Jianguo, Email: doctorlujianguo@163.com
Single-pore thoracoscopic lung surgery; liposome bupivacaine; bupivacaine hydrochloride; intercostal nerve block
10.7507/1007-4848.202403051
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Objective  To compare the analgesic effect, duration and incidence of adverse reactions of liposome bupivacaine and bupivacaine hydrochloride after intercostal nerve block in single-pore thoracoscopic lung surgery. Methods  A total of 228 patients in our hospital who needed to undergo thoracoscopic lung surgery were selected and divided into two groups by random number table method: a group B with bupivacaine hydrochloride (n=128) and a group LB with liposome bupivacaine (n=110). Intraoperative intercostal nerve block was performed under endoscopy, and the time of first use of analgesic drugs after surgery, cumulative use of opioids 72 h after surgery, incidence of postoperative nausea and vomiting, length of stay and other indicators were evaluated and recorded. Results  Visual analogue scale (VAS) scores at 4 h, 8 h, 12 h, 24 h, 48 h and 72 h in the LB group were significantly lower than those in the group B (P<0.05). The total number of activities within 48 h after surgery in the group B was significantly lower than that in the LB group (P<0.05), and the postoperative hospitalization days in the LB group was shorter than that in the group B, but the difference was not statistically significant.There was no statistical difference between the two groups in postoperative adverse reactions Conclusion  Intercostal nerve block with liposome bupivacaine during single-pore thoracoscopic lung surgery can significantly reduce postoperative pain, improve quality of life, and promote recovery. It is worthy of clinical promotion.