Progress and Prospect of Liver Transplantation Standard for Hepatocellular Carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 LIChuan ,  WENTian-fu

Department of Liver Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China;

Corresponding author：

WENTian-fu, Email: ccwentianfu@sohu.com

Keywords：

Hepatocellular carcinoma; Liver transplantation; Standard

DOI：

10.7507/1007-9424.20140100

Video：

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Objective To understand the progress and problems of liver transplantation standard for hepatocellular carcinoma. Methods The related articles regarding transplant criteria of hepatocellular carcinoma were reviewed and analyzed. Results Since Milan criteria were proposed by Mazzaferro in 1996, a number of criteria were porposed by many transplant centers. These criteria expanded Milan criteria. Compared with Milan criteria, these criteria expanded tumor size and (or) tumor number, or combined with some biological variables, or combined with some immunological variables. However, there are still some issues should be clarified. Conclusion Despite there are many transplant criteria of hepatocellular carcinoma, but a number of issues should be further investigated.

Citation： LIChuan, WENTian-fu. Progress and Prospect of Liver Transplantation Standard for Hepatocellular Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(4): 410-413. doi: 10.7507/1007-9424.20140100 Copy

1.	Starzl TE, Marchioro TL, Vonkaulla KN, et al. Homotransplantation of the Liver in Humans[J]. Surg Gynecol Obstet, 1963, 117:659-676.
2.	Bismuth H, Chiche L, Adam R, et al. Liver resection versus transplantation for hepatocellular carcinoma in cirrhotic patients[J]. Ann Surg, 1993, 218(2):145-151.
3.	Ringe B, Pichlmayr R, Wittekind C, et al. Surgical treatment of hepatocellular carcinoma:experience with liver resection and transplantation in 198 patients[J]. World J Surg, 1991, 15(2):270-285.
4.	Selby R, Kadry Z, Carr B, et al. Liver transplantation for hepatocellular carcinoma[J]. World J Surg, 1995, 19(1):53-58.
5.	Mazzaferro V, Regalia E, Doci R, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis[J]. N Engl J Med, 1996, 334(11):693-699.
6.	Sharma P, Balan V, Hernandez JL, et al. Liver transplantation for hepatocellular carcinoma:the MELD impact[J]. Liver Transpl, 2004, 10(1):36-41.
7.	Lee YH, Hsu CY, Hsia CY, et al. A prognostic model for patients with hepatocellular carcinoma within the Milan criteria undergoing non-transplant therapies, based on 1106 patients[J]. Aliment Pharmacol Ther, 2012, 36(6):551-559.
8.	Duvoux C, Roudot-Thoraval F, Decaens T, et al. Liver transpl-antation for hepatocellular carcinoma:a model including alpha-feto-protein improves the performance of Milan criteria[J]. Gastroenterology, 2012, 143(4):986-994.
9.	Mazzaferro V, Bhoori S, Sposito C, et al. Milan criteria in liver transplantation for hepatocellular carcinoma:an evidence-based analysis of 15 years of experience[J]. Liver Transpl, 2011, 17 Suppl 2:S44-S57.
10.	Heinzow HS, Brockmann JG, Kohler M, et al. Liver transplantation versus supraselective transarterial chemoembolization in palliative patients with hepatocellular carcinoma exceeding the Milan Criteria-is it time for a more individual approach?[J]. Ann Transplant, 2013, 18:515-524.
11.	Ahn KS, Kang KJ, Kim HT, et al. Living-donor liver transplant with an interposition graft of the inferior vena cava for hepatocellular carcinoma:beyond the Milan criteria and within the UCSF criteria[J]. Exp Clin Transplant, 2013, 11(3):283-286.
12.	Yao FY, Ferrell L, Bass NM, et al. Liver transplantation for hepatocellular carcinoma:expansion of the tumor size limits does not adversely impact survival[J]. Hepatology, 2001, 33(6):1394-1403.
13.	Fan J, Yang GS, Fu ZR, et al. Liver transplantation outcomes in 1078 hepatocellular carcinoma patients:a multi-center experience in Shanghai, China[J]. J Cancer Res Clin Oncol, 2009, 135(10):1403-1412.
14.	Silva M, Moya A, Berenguer M, et al. Expanded criteria for liver transplantation in patients with cirrhosis and hepatocellular carcinoma[J]. Liver Transpl, 2008, 14(10):1449-1460.
15.	Jonas S, Mittler J, Pascher A, et al. Living donor liver transplantation of the right lobe for hepatocellular carcinoma in cirrhosis in a European center[J]. Liver Transpl, 2007, 13(6):896-903.
16.	Sugawara Y, Tamura S, Makuuchi M. Living donor liver transp-lantation for hepatocellular carcinoma:Tokyo University series[J]. Dig Dis, 2007, 25(4):310-312.
17.	Lee SG, Hwang S, Moon DB, et al. Expanded indication criteria of living donor liver transplantation for hepatocellular carcinoma at one large-volume center[J]. Liver Transpl, 2008, 14(7):935-945.
18.	Li J, Yan LN, Yang J, et al. Indicators of prognosis after liver transplantation in Chinese hepatocellular carcinoma patients[J]. World J Gastroenterol, 2009, 15(33):4170-4176.
19.	Mazzaferro V, Llovet JM, Miceli R, et al. Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria:a retrospective, exploratory analysis[J]. Lancet Oncol, 2009, 10(1):35-43.
20.	Gugenheim J, Bredt LC, Iannelli A, et al. Recurrence after liver transplantation for hepatocellular carcinoma according to up-to-seven criteria[J]. Hepatogastroenterology, 2013, 60(124):799-806.
21.	de Ataide EC, Garcia M, Mattosinho TJ, et al. Predicting survival after liver transplantation using up-to-seven criteria in patients with hepatocellular carcinoma[J]. Transplant Proc, 2012, 44(8):2438-2440.
22.	Toso C, Trotter J, Wei A, et al. Total tumor volume predicts risk of recurrence following liver transplantation in patients with hepatocellular carcinoma[J]. Liver Transpl, 2008, 14(8):1107-1115.
23.	Zheng SS, Xu X, Wu J, et al. Liver transplantation for hepatocellular carcinoma:Hangzhou experiences[J]. Transplantation, 2008, 85(12):1726-1732.
24.	DuBay D, Sandroussi C, Sandhu L, et al. Liver transplantation for advanced hepatocellular carcinoma using poor tumor differentiation on biopsy as an exclusion criterion[J]. Ann Surg, 2011, 253(1):166-172.
25.	Ito T, Takada Y, Ueda M, et al. Expansion of selection criteria for patients with hepatocellular carcinoma in living donor liver transplantation[J]. Liver Transpl, 2007, 13(12):1637-1644.
26.	Otto G, Schuchmann M, Hoppe-Lotichius M, et al. How to dec-ide about liver transplantation in patients with hepatocellular carci-noma:size and number of lesions or response to TACE?[J]. J Hepatol, 2013, 59(2):279-284.
27.	Li C, Wen TF, Yan LN, et al. Scoring selection criteria including total tumour volume and pretransplant percentage of lymphocytes to predict recurrence of hepatocellular carcinoma after liver transplantation[J]. PLoS One, 2013, 8(8):e72235.
28.	Nagai S, Abouljoud MS, Kazimi M, et al. Peritransplant Lymp-hopenia Is a Novel Prognostic Factor in Recurrence of Hepatocellular Carcinoma After Liver Transplantation[J]. Transplantation, 2014, 97(6):694-701.
29.	Welker MW, Bechstein WO, Zeuzem S, et al. Recurrent hepatocellular carcinoma after liver transplantation-an emerging clinical challenge[J]. Transpl Int, 2013, 26(2):109-118.
30.	Sun YF, Xu Y, Yang XR, et al. Circulating stem cell-like epithe-lial cell adhesion molecule-positive tumor cells indicate poor prognosis of hepatocellular carcinoma after curative resection[J]. Hepatology, 2013, 57(4):1458-1468.
31.	Wimmer CD, Angele MK, Schwarz B, et al. Impact of cyclos-porine versus tacrolimus on the incidence of de novo malignancy following liver transplantation:a single center experience with 609 patients[J]. Transpl Int, 2013, 26(10):999-1006.

1. Starzl TE, Marchioro TL, Vonkaulla KN, et al. Homotransplantation of the Liver in Humans[J]. Surg Gynecol Obstet, 1963, 117:659-676.
2. Bismuth H, Chiche L, Adam R, et al. Liver resection versus transplantation for hepatocellular carcinoma in cirrhotic patients[J]. Ann Surg, 1993, 218(2):145-151.
3. Ringe B, Pichlmayr R, Wittekind C, et al. Surgical treatment of hepatocellular carcinoma:experience with liver resection and transplantation in 198 patients[J]. World J Surg, 1991, 15(2):270-285.
4. Selby R, Kadry Z, Carr B, et al. Liver transplantation for hepatocellular carcinoma[J]. World J Surg, 1995, 19(1):53-58.
5. Mazzaferro V, Regalia E, Doci R, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis[J]. N Engl J Med, 1996, 334(11):693-699.
6. Sharma P, Balan V, Hernandez JL, et al. Liver transplantation for hepatocellular carcinoma:the MELD impact[J]. Liver Transpl, 2004, 10(1):36-41.
7. Lee YH, Hsu CY, Hsia CY, et al. A prognostic model for patients with hepatocellular carcinoma within the Milan criteria undergoing non-transplant therapies, based on 1106 patients[J]. Aliment Pharmacol Ther, 2012, 36(6):551-559.
8. Duvoux C, Roudot-Thoraval F, Decaens T, et al. Liver transpl-antation for hepatocellular carcinoma:a model including alpha-feto-protein improves the performance of Milan criteria[J]. Gastroenterology, 2012, 143(4):986-994.
9. Mazzaferro V, Bhoori S, Sposito C, et al. Milan criteria in liver transplantation for hepatocellular carcinoma:an evidence-based analysis of 15 years of experience[J]. Liver Transpl, 2011, 17 Suppl 2:S44-S57.
10. Heinzow HS, Brockmann JG, Kohler M, et al. Liver transplantation versus supraselective transarterial chemoembolization in palliative patients with hepatocellular carcinoma exceeding the Milan Criteria-is it time for a more individual approach?[J]. Ann Transplant, 2013, 18:515-524.
11. Ahn KS, Kang KJ, Kim HT, et al. Living-donor liver transplant with an interposition graft of the inferior vena cava for hepatocellular carcinoma:beyond the Milan criteria and within the UCSF criteria[J]. Exp Clin Transplant, 2013, 11(3):283-286.
12. Yao FY, Ferrell L, Bass NM, et al. Liver transplantation for hepatocellular carcinoma:expansion of the tumor size limits does not adversely impact survival[J]. Hepatology, 2001, 33(6):1394-1403.
13. Fan J, Yang GS, Fu ZR, et al. Liver transplantation outcomes in 1078 hepatocellular carcinoma patients:a multi-center experience in Shanghai, China[J]. J Cancer Res Clin Oncol, 2009, 135(10):1403-1412.
14. Silva M, Moya A, Berenguer M, et al. Expanded criteria for liver transplantation in patients with cirrhosis and hepatocellular carcinoma[J]. Liver Transpl, 2008, 14(10):1449-1460.
15. Jonas S, Mittler J, Pascher A, et al. Living donor liver transplantation of the right lobe for hepatocellular carcinoma in cirrhosis in a European center[J]. Liver Transpl, 2007, 13(6):896-903.
16. Sugawara Y, Tamura S, Makuuchi M. Living donor liver transp-lantation for hepatocellular carcinoma:Tokyo University series[J]. Dig Dis, 2007, 25(4):310-312.
17. Lee SG, Hwang S, Moon DB, et al. Expanded indication criteria of living donor liver transplantation for hepatocellular carcinoma at one large-volume center[J]. Liver Transpl, 2008, 14(7):935-945.
18. Li J, Yan LN, Yang J, et al. Indicators of prognosis after liver transplantation in Chinese hepatocellular carcinoma patients[J]. World J Gastroenterol, 2009, 15(33):4170-4176.
19. Mazzaferro V, Llovet JM, Miceli R, et al. Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria:a retrospective, exploratory analysis[J]. Lancet Oncol, 2009, 10(1):35-43.
20. Gugenheim J, Bredt LC, Iannelli A, et al. Recurrence after liver transplantation for hepatocellular carcinoma according to up-to-seven criteria[J]. Hepatogastroenterology, 2013, 60(124):799-806.
21. de Ataide EC, Garcia M, Mattosinho TJ, et al. Predicting survival after liver transplantation using up-to-seven criteria in patients with hepatocellular carcinoma[J]. Transplant Proc, 2012, 44(8):2438-2440.
22. Toso C, Trotter J, Wei A, et al. Total tumor volume predicts risk of recurrence following liver transplantation in patients with hepatocellular carcinoma[J]. Liver Transpl, 2008, 14(8):1107-1115.
23. Zheng SS, Xu X, Wu J, et al. Liver transplantation for hepatocellular carcinoma:Hangzhou experiences[J]. Transplantation, 2008, 85(12):1726-1732.
24. DuBay D, Sandroussi C, Sandhu L, et al. Liver transplantation for advanced hepatocellular carcinoma using poor tumor differentiation on biopsy as an exclusion criterion[J]. Ann Surg, 2011, 253(1):166-172.
25. Ito T, Takada Y, Ueda M, et al. Expansion of selection criteria for patients with hepatocellular carcinoma in living donor liver transplantation[J]. Liver Transpl, 2007, 13(12):1637-1644.
26. Otto G, Schuchmann M, Hoppe-Lotichius M, et al. How to dec-ide about liver transplantation in patients with hepatocellular carci-noma:size and number of lesions or response to TACE?[J]. J Hepatol, 2013, 59(2):279-284.
27. Li C, Wen TF, Yan LN, et al. Scoring selection criteria including total tumour volume and pretransplant percentage of lymphocytes to predict recurrence of hepatocellular carcinoma after liver transplantation[J]. PLoS One, 2013, 8(8):e72235.
28. Nagai S, Abouljoud MS, Kazimi M, et al. Peritransplant Lymp-hopenia Is a Novel Prognostic Factor in Recurrence of Hepatocellular Carcinoma After Liver Transplantation[J]. Transplantation, 2014, 97(6):694-701.
29. Welker MW, Bechstein WO, Zeuzem S, et al. Recurrent hepatocellular carcinoma after liver transplantation-an emerging clinical challenge[J]. Transpl Int, 2013, 26(2):109-118.
30. Sun YF, Xu Y, Yang XR, et al. Circulating stem cell-like epithe-lial cell adhesion molecule-positive tumor cells indicate poor prognosis of hepatocellular carcinoma after curative resection[J]. Hepatology, 2013, 57(4):1458-1468.
31. Wimmer CD, Angele MK, Schwarz B, et al. Impact of cyclos-porine versus tacrolimus on the incidence of de novo malignancy following liver transplantation:a single center experience with 609 patients[J]. Transpl Int, 2013, 26(10):999-1006.

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