Analysis of Association Between The Polymorphisms of DNA Repair Gene XRCC1 and Susceptibility to Colorectal Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 沈宏 ,  赵冬雨 , 张宁

武警后勤学院附属医院普通外科（天津 300162）;

Corresponding author：

赵冬雨, Email: 185082583@qq.com

Keywords：

结直肠癌; 修复基因; XRCC1; Arg194Trp; 基因多态性; 易感性

DOI：

10.7507/1007-9424.20140114

Video：

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Abstract Full text Figures/Tables Video References Cited by

目的探讨DNA损伤修复基因XRCC1 Arg194Trp位点多态性与结直肠癌易感性的关系。方法选取120例结直肠癌患者与120例正常对照者进行对比研究。取外周血提取DNA，采用限制性片段长度多态性聚合酶链反应（PCR-RFLP）技术对XRCC1 Arg194Trp基因多态性进行检测分析，比较不同基因型与结直肠癌易感性的关系。结果 2组观察对象在年龄、性别、吸烟、饮酒、饮食特点等常见暴露因素方面的差异均无统计学意义（P＞0.05），变异基因型Arg/Trp＋Trp/Trp出现频率在2组观察对象中分别为30.00%和24.17%，差异无统计学意义（P＞0.05）。结论 XRCC1 Arg194Trp位点多态性与结直肠癌的易感性并无显著相关性。

Citation： 沈宏, 赵冬雨, 张宁. Analysis of Association Between The Polymorphisms of DNA Repair Gene XRCC1 and Susceptibility to Colorectal Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(4): 476-478. doi: 10.7507/1007-9424.20140114 Copy

1.	Colditz GA, McGowan LD, James AS, et al. Screening for colorectal cancer:using data to set prevention priorities[J]. Cancer Causes Control, 2014, 25(1):93-98.
2.	Lieberman D. Screening for colorectal cancer in individuals at average risk:current methods and emerging issues[J]. JAMA Intern Med, 2014, 174(1):10-11.
3.	万德森.结直肠癌流行病学与预防[J].中国中西医结合外科杂志, 2011, 17(1):3-8.
4.	王永兵, 何苗, 程宏文. BRCA1、XRCC1基因多态性与乳腺癌易感性研究进展[J].中国医药导报, 2012, 9(33):30-31.
5.	黄姗, 易斌, 杨星海, 等.结直肠癌患者的DNA修复基因XRCC1单核苷酸多态研究[J].中华实验外科杂志, 2010, 27(8):1057-1059.
6.	叶慈慈, 黄智铭, 周春燕, 等. APE1D148E、PARP1 V762A、XRCC1 R399Q的多态性与结直肠癌的易患性[J].世界华人消化杂志, 2010, 18(12):1275-1279.
7.	宋洁云, 刘芳宏, 马军, 等.酚/氯仿法和盐析法提取人类外周血基因组DNA方法的比较[J].中国实验诊断学, 2013, 17(5):802-805.
8.	Chen K, Cai J, Liu XY, et al. Nested case-control study on the risk factors of colorectal cancer[J]. World J Gastroenterol, 2003, 9(1):99-103.
9.	赵波, 钟华戈, 吴卫, 等.结直肠癌危险因素的流行病学研究进展[J].结直肠肛门外科, 2013, 19(3):199-202.
10.	Ruffinengo O, Tanno F, Covernton J, et al. Colorectal cancer:epidemiologic characteristics in a hospital center of Rosario, Arge-ntina[J]. Acta Gastroenterol Latinoam, 2010, 40(2):98-104.
11.	李莉, 黄河浪.结直肠癌发生危险因素的流行病学研究进展[J].结直肠肛门外科, 2010, 16(6):397-401.
12.	Gsur A, Bernhart K, Baierl A, et al. No association of XRCC1 polymorphisms Arg194Trp and Arg399Gln with colorectal cancer risk[J]. Cancer Epidemiol, 2011, 35(5):e38-e41.
13.	Lee JM, Lee YC, Yang SY, et al. Genetic polymorphisms ofXRCC1 and risk of the esophageal cancer[J]. Int J Cancer, 2001, 95(4):240-246.
14.	Huang YS, Li LG, Yu L, et al. XRCC1 Arg399Gln, Arg194Trp and Arg280His polymorphisms in breast cancer risk:a meta-analysis[J]. Mutagenesis, 2009, 24(4):331-339.
15.	宋春英, 谭文, 林东昕.中国人DNA修复基因XRCC1单核苷酸多态及其与食管癌风险的关系[J].癌症, 2001, 20(1):28-31.
16.	Yin G, Morita M, Ohnaka K, et al. Genetic polymorphisms of XRCC1, alcohol consumption, and the risk of colorectal cancer in Japan[J]. J Epidemiol, 2012, 22(1):64-71.
17.	Skjelbred CF, Saebø M, Wallin H, et al. Polymorphisms of the XRCC1, XRCC3 and XPD genes and risk of colorectal adenoma and carcinoma, in a Norwegian cohort:a case control study[J]. BMC Cancer, 2006, 6:67.

1. Colditz GA, McGowan LD, James AS, et al. Screening for colorectal cancer:using data to set prevention priorities[J]. Cancer Causes Control, 2014, 25(1):93-98.
2. Lieberman D. Screening for colorectal cancer in individuals at average risk:current methods and emerging issues[J]. JAMA Intern Med, 2014, 174(1):10-11.
3. 万德森.结直肠癌流行病学与预防[J].中国中西医结合外科杂志, 2011, 17(1):3-8.
4. 王永兵, 何苗, 程宏文. BRCA1、XRCC1基因多态性与乳腺癌易感性研究进展[J].中国医药导报, 2012, 9(33):30-31.
5. 黄姗, 易斌, 杨星海, 等.结直肠癌患者的DNA修复基因XRCC1单核苷酸多态研究[J].中华实验外科杂志, 2010, 27(8):1057-1059.
6. 叶慈慈, 黄智铭, 周春燕, 等. APE1D148E、PARP1 V762A、XRCC1 R399Q的多态性与结直肠癌的易患性[J].世界华人消化杂志, 2010, 18(12):1275-1279.
7. 宋洁云, 刘芳宏, 马军, 等.酚/氯仿法和盐析法提取人类外周血基因组DNA方法的比较[J].中国实验诊断学, 2013, 17(5):802-805.
8. Chen K, Cai J, Liu XY, et al. Nested case-control study on the risk factors of colorectal cancer[J]. World J Gastroenterol, 2003, 9(1):99-103.
9. 赵波, 钟华戈, 吴卫, 等.结直肠癌危险因素的流行病学研究进展[J].结直肠肛门外科, 2013, 19(3):199-202.
10. Ruffinengo O, Tanno F, Covernton J, et al. Colorectal cancer:epidemiologic characteristics in a hospital center of Rosario, Arge-ntina[J]. Acta Gastroenterol Latinoam, 2010, 40(2):98-104.
11. 李莉, 黄河浪.结直肠癌发生危险因素的流行病学研究进展[J].结直肠肛门外科, 2010, 16(6):397-401.
12. Gsur A, Bernhart K, Baierl A, et al. No association of XRCC1 polymorphisms Arg194Trp and Arg399Gln with colorectal cancer risk[J]. Cancer Epidemiol, 2011, 35(5):e38-e41.
13. Lee JM, Lee YC, Yang SY, et al. Genetic polymorphisms ofXRCC1 and risk of the esophageal cancer[J]. Int J Cancer, 2001, 95(4):240-246.
14. Huang YS, Li LG, Yu L, et al. XRCC1 Arg399Gln, Arg194Trp and Arg280His polymorphisms in breast cancer risk:a meta-analysis[J]. Mutagenesis, 2009, 24(4):331-339.
15. 宋春英, 谭文, 林东昕.中国人DNA修复基因XRCC1单核苷酸多态及其与食管癌风险的关系[J].癌症, 2001, 20(1):28-31.
16. Yin G, Morita M, Ohnaka K, et al. Genetic polymorphisms of XRCC1, alcohol consumption, and the risk of colorectal cancer in Japan[J]. J Epidemiol, 2012, 22(1):64-71.
17. Skjelbred CF, Saebø M, Wallin H, et al. Polymorphisms of the XRCC1, XRCC3 and XPD genes and risk of colorectal adenoma and carcinoma, in a Norwegian cohort:a case control study[J]. BMC Cancer, 2006, 6:67.

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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Analysis of Association Between The Polymorphisms of DNA Repair Gene XRCC1 and Susceptibility to Colorectal Cancer

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