Dolichocolon with Colorectal Cancer: Report of 17 Cases and Review of The Literatures_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 周强 ^1,2 , 柴琛 ¹ ,  杨磊 ¹ , 李德榜 ¹

1. ;
2. ;

Corresponding author：

杨磊, Email: yl41023@126.com

Keywords：

结肠冗长症; 结直肠癌; 慢传输型便秘; 结肠黑变病

DOI：

10.7507/1007-9424.20140117

Video：

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目的总结结肠冗长症合并结直肠癌的临床病理特征，并文献复习结肠冗长症与结直肠癌的关系。方法回顾性分析兰州大学第一医院普外一科2011年1月至2012年12月期间收治的17例结肠冗长症合并结直肠癌患者的临床资料。结果 184例结直肠癌患者中合并结肠冗长症17例（9.24%），合并家族性息肉病恶变2例（1.09%），合并遗传性非息肉病性结直肠癌1例（0.54%），合并炎症性肠病1例（0.54%）。合并结肠冗长症的比例较高（P＜0.05）。其中术前经结肠气钡灌肠检查诊断为结肠冗长症5例，术中诊断为结肠冗长症12例。所有患者均行手术治疗，切除结肠13～80 cm，平均33.8 cm。术后发生肺部感染、切口液化1例，腹水1例，肠瘘1例，骶前感染1例。术后17例患者均获随访，随访时间6～12个月，中位数为10个月。随访期间，1例患者于术后1年出现卵巢转移。结论结肠冗长症合并顽固性便秘可能是结直肠癌发病的高危因素。

Citation： 周强, 柴琛, 杨磊, 李德榜. Dolichocolon with Colorectal Cancer: Report of 17 Cases and Review of The Literatures. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(4): 485-487. doi: 10.7507/1007-9424.20140117 Copy

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2.	Jemal A, Bray F, Center MM, et al. Global cancer statistics[J]. CA Cancer J Clin, 2011, 61(2):69-90.
3.	郝捷, 赵平, 陈万青. 2011中国肿瘤登记年报[M].北京:军事医学出版社, 2012:57-58.
4.	杨维良, 张新晨, 张好刚, 等.成人结肠冗长症的诊断与外科治疗82例报告[J].中华普通外科杂志, 2007, 22(12):905-908.
5.	Bharucha AE, Phillips SF. Slow transit constipation[J]. Gastroenterol Clin North Am, 2001, 30(1):77-95.
6.	丁义江, 哈楠林, 丁曙晴, 等.结肠慢传输型便秘与突触素和P物质及血管活性肠肽的临床研究[J].中华胃肠外科杂志, 2004, 7(6):485-487.
7.	Tomita R, Igarashi S, Fujisaki S, et al. The effects of neurotensin in the colon of patients with slow transit constipation[J]. Hepatogastroenterology, 2007, 54(78):1662-1666.
8.	童卫东.结肠慢传输型便秘的病因和诊断[J].医学新知杂志, 2007, 17(1):1-2.
9.	谭丽, 谭至柔, 黄雪, 等.不同类型一氧化氮合酶在慢传输型便秘大鼠结肠中的表达[J].胃肠病学和肝病学杂志, 2011, 20(1):64-66.
10.	Lonkar P, Dedon PC. Reactive species and DNA damage in chronic inflammation:reconciling chemical mechanisms and biological fates[J]. Int J Cancer, 2011, 128(9):1999-2009.
11.	Gochman E, Mahajna J, Shenzer P, et al. The expression of iNOS and nitrotyrosine in colitis and colon cancer in humans[J]. Acta Histochem, 2012, 114(8):827-835.
12.	Zhu Y, Michelle Luo T, Jobin C, et al. Gut microbiota and probiotics in colon tumorigenesis[J]. Cancer Lett, 2011, 309(2):119-127.
13.	Sobhani I, Tap J, Roudot-Thoraval F, et al. Microbial dysbiosis in colorectal cancer (CRC) patients[J]. PLoS One, 2011, 6(1):e16393.
14.	Shen XJ, Rawls JF, Randall T, et al. Molecular characterization of mucosal adherent bacteria and associations with colorectal adenomas[J]. Gut Microbes, 2010, 1(3):138-147.
15.	Speare GS. Melanosis coli:experimental observations of its production and elimination in 23 cases[J]. Am J Surg, 1951, 82(5):631-637.
16.	Virchow R. Die pathologischen piganente[J]. Virchows Arch Patbol Anat, 1847, 1(2):379-486.
17.	Tikkanen L, Matsushima T, Natori S. Mutagenicity of anthraquinones in the Salmonella preincubation test[J]. Mutat Res, 1983, 116(3-4):297-304.
18.	Westendorf J, Marquardt H, Poginsky B, et al. Genotoxi-city of naturally occurring hydroxyanthraquinones[J]. Murat Res, 1990, 240(1):1-12.
19.	子树明, 崔龙, 杨明.结肠黑变病与结肠直肠息肉、结肠直肠癌的关系[J].外科理论与实践, 2010, 15(2):188-190.

1. 郑树, 蔡善荣.中国大肠癌的病因学及人群防治研究[J].中华肿瘤杂志, 2004, 26(1):1-3.
2. Jemal A, Bray F, Center MM, et al. Global cancer statistics[J]. CA Cancer J Clin, 2011, 61(2):69-90.
3. 郝捷, 赵平, 陈万青. 2011中国肿瘤登记年报[M].北京:军事医学出版社, 2012:57-58.
4. 杨维良, 张新晨, 张好刚, 等.成人结肠冗长症的诊断与外科治疗82例报告[J].中华普通外科杂志, 2007, 22(12):905-908.
5. Bharucha AE, Phillips SF. Slow transit constipation[J]. Gastroenterol Clin North Am, 2001, 30(1):77-95.
6. 丁义江, 哈楠林, 丁曙晴, 等.结肠慢传输型便秘与突触素和P物质及血管活性肠肽的临床研究[J].中华胃肠外科杂志, 2004, 7(6):485-487.
7. Tomita R, Igarashi S, Fujisaki S, et al. The effects of neurotensin in the colon of patients with slow transit constipation[J]. Hepatogastroenterology, 2007, 54(78):1662-1666.
8. 童卫东.结肠慢传输型便秘的病因和诊断[J].医学新知杂志, 2007, 17(1):1-2.
9. 谭丽, 谭至柔, 黄雪, 等.不同类型一氧化氮合酶在慢传输型便秘大鼠结肠中的表达[J].胃肠病学和肝病学杂志, 2011, 20(1):64-66.
10. Lonkar P, Dedon PC. Reactive species and DNA damage in chronic inflammation:reconciling chemical mechanisms and biological fates[J]. Int J Cancer, 2011, 128(9):1999-2009.
11. Gochman E, Mahajna J, Shenzer P, et al. The expression of iNOS and nitrotyrosine in colitis and colon cancer in humans[J]. Acta Histochem, 2012, 114(8):827-835.
12. Zhu Y, Michelle Luo T, Jobin C, et al. Gut microbiota and probiotics in colon tumorigenesis[J]. Cancer Lett, 2011, 309(2):119-127.
13. Sobhani I, Tap J, Roudot-Thoraval F, et al. Microbial dysbiosis in colorectal cancer (CRC) patients[J]. PLoS One, 2011, 6(1):e16393.
14. Shen XJ, Rawls JF, Randall T, et al. Molecular characterization of mucosal adherent bacteria and associations with colorectal adenomas[J]. Gut Microbes, 2010, 1(3):138-147.
15. Speare GS. Melanosis coli:experimental observations of its production and elimination in 23 cases[J]. Am J Surg, 1951, 82(5):631-637.
16. Virchow R. Die pathologischen piganente[J]. Virchows Arch Patbol Anat, 1847, 1(2):379-486.
17. Tikkanen L, Matsushima T, Natori S. Mutagenicity of anthraquinones in the Salmonella preincubation test[J]. Mutat Res, 1983, 116(3-4):297-304.
18. Westendorf J, Marquardt H, Poginsky B, et al. Genotoxi-city of naturally occurring hydroxyanthraquinones[J]. Murat Res, 1990, 240(1):1-12.
19. 子树明, 崔龙, 杨明.结肠黑变病与结肠直肠息肉、结肠直肠癌的关系[J].外科理论与实践, 2010, 15(2):188-190.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Dolichocolon with Colorectal Cancer: Report of 17 Cases and Review of The Literatures

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