Application Advances of Carbon Nanoparticles in Thyroid Carcinoma Surgery_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 CHUNLin , HUANGMan ,  SUXin-liang , WUKai-nan

Department of Endocrinology and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China;

Corresponding author：

SUXin-liang, Email: suxinliang@21cn.com

Keywords：

Carbon nanoparticle; Lymphatic mapping; Thyroid carcinoma; Parathyroid gland

DOI：

10.7507/1007-9424.20140156

Video：

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Objective To explore the value of carbon nanoparticles on surgery for thyroid carcinoma. Method Literatures about application of carbon nanoparticles and lymphatic mapping in the thyroid carcinoma were reviewed. Results The carbon nanoparticle was a new lymph tracer with a clear lymphatic mapping and a longer time for dying, which could accurately reflect the status of cervical lymph nodes, trace the sentinel lymph node in the thyroid carcinoma. The parathyroid gland could not be stained black, it was easy to be identified and protected. Conclusions The carbon nanoparticle provides an effective help in treatment for thyroid carcinoma. The more extensive and more profound application of lymphatic mapping depends on more clinical study.

Citation： CHUNLin, HUANGMan, SUXin-liang, WUKai-nan. Application Advances of Carbon Nanoparticles in Thyroid Carcinoma Surgery. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(5): 646-649. doi: 10.7507/1007-9424.20140156 Copy

1.	姚京, 刘洋, 田文.分化型甲状腺癌再次手术技巧的探讨[J].中国普外基础与临床杂志, 2013, 20(9):981-986.
2.	Davidson HC, Park BJ, Johnson JT.Papillary thyroid cancer:controversies in the management of neck metastasis[J].Laryngoscope, 2008, 118(12):2161-2165.
3.	曾玉剑, 钱军, 程若川, 等.甲状腺癌术中淋巴示踪剂应用对于甲状旁腺保护作用的研究[J].重庆医学, 2012, 41(11):1076, 1088.
4.	Weinberg J, Greaney EM.Identification of regional lymph nodes by means of a vital staining dye during surgery of gastric cancer[J].Surg Gynecol Obstet, 1950, 90(5):561-567.
5.	Morl F.Importance of the sternal lymph vessels for metastases of cancer of the breast[J].Chirurg, 1952, 23(7):298-300.
6.	Reitsamer R, Peintinger F, Prokop E, et al.Sentinel lymph node biopsy alone without axillary lymph node dissection-follow up of sentinel lymph node negative breast cancer patients[J].Eur J Surg Oncol, 2003, 29(3):221-223.
7.	邱树升, 李良, 李新兵, 等.美蓝法定位前哨淋巴结活检在cN0分化型甲状腺癌治疗中的应用[J].中国肿瘤外科杂志, 2012, 4(4):242-244.
8.	苏力夫, 张生彬, 朱永蒙.纳米碳示踪前哨淋巴结在cN0甲状腺乳头状癌中的应用[J].中国现代医学杂志, 2013, 23(7):110-112.
9.	尹源, 汪晓东, 吕东昊, 等.淋巴示踪剂在结直肠癌外科的研究进展[J].中国普外基础与临床杂志, 2010, 17(3):306-308.
10.	徐鲲, 刘晓安, 王水, 等.乳腺癌前哨淋巴结活检染料选择的实验研究[J].南京医科大学学报:自然科学版, 2005, 25(3):201-203.
11.	Haigh PI, Giuliano AE.Sentinel lymph node dissection for thyroid malignancy[J].Recent Results Cancer Res, 2000, 157:201-205.
12.	Yang F, Jin C, Yang D, et al.Magnetic functionalised carbon nanotubes as drug vehicles for cancer lymph node metastasis treatment[J].Eur J Cancer, 2011, 47(12):1873-1882.
13.	蔡长茂, 李威.纳米炭在普外科恶性肿瘤诊治中的应用[J].中华实用诊断与治疗杂志, 2010, 24(9):833-834.
14.	Montgomery LL, Thorne AC, Van Zee KJ, et al.Isosulfan blue dye reactions during sentinel lymph node mapping for breast cancer[J].Anesth Analg, 2002, 95(2):385-388.
15.	Dionigi G, Bacuzzi A, Bertocchi V, et al.Prospectives and surgical usefulness of perioperative parathyroid hormone assay in thyroid surgery[J].Expert Rev Med Devices, 2008, 5(6):699-704.
16.	傅朝春, 徐安书, 张杰, 等.甲状腺手术中预防甲状旁腺损伤的体会[J].中国普外基础与临床杂志, 2013, 19(3):333-334.
17.	朱精强.分化型甲状腺癌颈淋巴结清扫的相关问题[J].中国普外基础与临床杂志, 2013, 19(8):809-813.
18.	闫利英, 李随勤, 张少强, 等.甲状腺全切及近全切术中甲状旁腺的原位保护[J].临床耳鼻咽喉科杂志, 2006, 20(21):980-982.
19.	黄韬.甲状腺术中损伤的预防和处理[J].中国实用外科杂志, 2008, 28(3):179-180.
20.	赵挺, 颜育祥, 许践刚, 等.975例甲状腺疾病患者手术预防甲状旁腺损伤体会[J].中国肿瘤, 2007, 16(6):467-468.
21.	Kihara M, Miyauchi A, Kontani K, et al.Recovery of parathyroid function after total thyroidectomy:long-term follow-up study[J].ANZ J Surg, 2005, 75(7):532-536.
22.	Derom AF, Wallaert PC, Janzing HM, et al.Intraoperative identification of parathyroid glands with methylene blue infusion[J].Am J Surg, 1993, 165(3):380-382.
23.	车红缨, 曾玉剑, 程中.纳米炭淋巴示踪剂在胃癌淋巴结清扫和病理检查中的价值[J].重庆医学, 2009, 38(20):2571-2572.
24.	杨晓晖, 王勇, 王平.纳米碳在腔镜甲状腺癌手术中的应用[J].腹腔镜外科杂志, 2013, 18(4):262-265.
25.	杨志芳, 岳瑞雪, 朱智, 等.纳米碳在cN0期甲状腺乳头状癌中央区淋巴结清扫手术中的应用[J].中国普外基础与临床杂志, 2013, 20(9):976-980.
26.	张筱骅, 郝儒田, 尤捷, 等.甲状腺淋巴管造影在鉴别甲状旁腺中的意义[J].温州医学院学报, 2010, 40(1):31, 35.
27.	朱精强, 汪洵理, 魏涛, 等.纳米碳甲状旁腺负显影辨认保护技术在甲状腺癌手术中的应用[J].中国普外基础与临床杂志, 2013, 20(9):992-994.
28.	Lo CY, Lam KY.Routine parathyroid autotransplantation during thyroidectomy[J].Surgery, 2001, 129(3):318-323.
29.	Krag DN, Weaver DL.Pathological and molecular assessment of sentinel lymph nodes in solid tumors[J].Semin Oncol, 2002, 29(3):274-279.
30.	高庆军, 王南鹏, 周彦, 等.甲状腺乳头状癌颈部淋巴结转移规律及影响因素分析[J].中国普外基础与临床杂志, 2013, 20(3):303-309.
31.	赏金标, 王可敬.甲状腺乳头状腺癌的前哨淋巴结研究[J].国际耳鼻咽喉头颈外科杂志, 2006, 30(1):33-34, 48.
32.	Cabanas RM.An approach for the treatment of penile carcinoma[J].Cancer, 1977, 39(2):456-466.
33.	Morton DL, Wen DR, Wong JH, et al.Technical details of intraoperative lymphatic mapping for early stage melanoma[J].Arch Surg, 1992, 127(4):392-399.
34.	Beslić N.The role of sentinel lymph node detection in management of patients with breast cancer[J].Med Arh, 2008, 62(4):240-241.
35.	Kelemen PR, Van Herle AJ, Giuliano AE.Sentinel lymphadenectomy in thyroid malignant neoplasms[J].Arch Surg, 1998, 133(3):288-292.
36.	Lee SK, Choi JH, Lim HI, et al.Sentinel lymph node biopsy in papillary thyroid cancer:comparison study of blue dye method and combined radioisotope and blue dye method in papillary thyroid cancer[J].Eur J Surg Oncol, 2009, 35(9):974-979.
37.	Liu CL, Yang TL, Chen BF.Sentinel lymph node mapping with emulsion of activated carbon particles in patients with pre-mastectomy diagnosis of intraductal carcinoma of the breast[J].J Chin Med Assoc, 2003, 66(7):406-410.
38.	Catarci M, Guadagni S, Zaraca F, et al.Prospective randomized evaluation of preoperative endoscopic vital staining using CH-40 for lymph node dissection in gastric cancer[J].Ann Surg Oncol, 1999, 5(7):580-584.
39.	王晓雷, 吴跃煌, 徐震纲, 等.纳米碳在鉴别甲状腺周围淋巴结和甲状旁腺中的作用[J].中华耳鼻咽喉头颈外科杂志, 2009, 44(2):136-140.
40.	江国斌, 方红燕, 蔡建明.纳米碳混悬液示踪前哨淋巴结在甲状腺乳头状癌中的应用[J].中国癌症杂志, 2010, 20(12):938-940.
41.	Fukui Y, Yamakawa T, Taniki T, et al.Sentinel lymph node biopsy in patients with papillary thyroid carcinoma[J].Cancer, 2001, 92(11):2868-2874.
42.	Hao RT, Chen J, Zhao LH, et al.Sentinel lymph node biopsy using carbon nanoparticles for Chinese patients with papillary thyroid microcarcinoma[J].Eur J Surg Oncol, 2012, 38(8):718-724.
43.	江国斌, 贾中明, 刘艳, 等.纳米炭定位前哨淋巴结在cN0甲状腺乳头状癌中的临床研究[J].临床合理用药, 2013, 4(9C):9-11.

1. 姚京, 刘洋, 田文.分化型甲状腺癌再次手术技巧的探讨[J].中国普外基础与临床杂志, 2013, 20(9):981-986.
2. Davidson HC, Park BJ, Johnson JT.Papillary thyroid cancer:controversies in the management of neck metastasis[J].Laryngoscope, 2008, 118(12):2161-2165.
3. 曾玉剑, 钱军, 程若川, 等.甲状腺癌术中淋巴示踪剂应用对于甲状旁腺保护作用的研究[J].重庆医学, 2012, 41(11):1076, 1088.
4. Weinberg J, Greaney EM.Identification of regional lymph nodes by means of a vital staining dye during surgery of gastric cancer[J].Surg Gynecol Obstet, 1950, 90(5):561-567.
5. Morl F.Importance of the sternal lymph vessels for metastases of cancer of the breast[J].Chirurg, 1952, 23(7):298-300.
6. Reitsamer R, Peintinger F, Prokop E, et al.Sentinel lymph node biopsy alone without axillary lymph node dissection-follow up of sentinel lymph node negative breast cancer patients[J].Eur J Surg Oncol, 2003, 29(3):221-223.
7. 邱树升, 李良, 李新兵, 等.美蓝法定位前哨淋巴结活检在cN0分化型甲状腺癌治疗中的应用[J].中国肿瘤外科杂志, 2012, 4(4):242-244.
8. 苏力夫, 张生彬, 朱永蒙.纳米碳示踪前哨淋巴结在cN0甲状腺乳头状癌中的应用[J].中国现代医学杂志, 2013, 23(7):110-112.
9. 尹源, 汪晓东, 吕东昊, 等.淋巴示踪剂在结直肠癌外科的研究进展[J].中国普外基础与临床杂志, 2010, 17(3):306-308.
10. 徐鲲, 刘晓安, 王水, 等.乳腺癌前哨淋巴结活检染料选择的实验研究[J].南京医科大学学报:自然科学版, 2005, 25(3):201-203.
11. Haigh PI, Giuliano AE.Sentinel lymph node dissection for thyroid malignancy[J].Recent Results Cancer Res, 2000, 157:201-205.
12. Yang F, Jin C, Yang D, et al.Magnetic functionalised carbon nanotubes as drug vehicles for cancer lymph node metastasis treatment[J].Eur J Cancer, 2011, 47(12):1873-1882.
13. 蔡长茂, 李威.纳米炭在普外科恶性肿瘤诊治中的应用[J].中华实用诊断与治疗杂志, 2010, 24(9):833-834.
14. Montgomery LL, Thorne AC, Van Zee KJ, et al.Isosulfan blue dye reactions during sentinel lymph node mapping for breast cancer[J].Anesth Analg, 2002, 95(2):385-388.
15. Dionigi G, Bacuzzi A, Bertocchi V, et al.Prospectives and surgical usefulness of perioperative parathyroid hormone assay in thyroid surgery[J].Expert Rev Med Devices, 2008, 5(6):699-704.
16. 傅朝春, 徐安书, 张杰, 等.甲状腺手术中预防甲状旁腺损伤的体会[J].中国普外基础与临床杂志, 2013, 19(3):333-334.
17. 朱精强.分化型甲状腺癌颈淋巴结清扫的相关问题[J].中国普外基础与临床杂志, 2013, 19(8):809-813.
18. 闫利英, 李随勤, 张少强, 等.甲状腺全切及近全切术中甲状旁腺的原位保护[J].临床耳鼻咽喉科杂志, 2006, 20(21):980-982.
19. 黄韬.甲状腺术中损伤的预防和处理[J].中国实用外科杂志, 2008, 28(3):179-180.
20. 赵挺, 颜育祥, 许践刚, 等.975例甲状腺疾病患者手术预防甲状旁腺损伤体会[J].中国肿瘤, 2007, 16(6):467-468.
21. Kihara M, Miyauchi A, Kontani K, et al.Recovery of parathyroid function after total thyroidectomy:long-term follow-up study[J].ANZ J Surg, 2005, 75(7):532-536.
22. Derom AF, Wallaert PC, Janzing HM, et al.Intraoperative identification of parathyroid glands with methylene blue infusion[J].Am J Surg, 1993, 165(3):380-382.
23. 车红缨, 曾玉剑, 程中.纳米炭淋巴示踪剂在胃癌淋巴结清扫和病理检查中的价值[J].重庆医学, 2009, 38(20):2571-2572.
24. 杨晓晖, 王勇, 王平.纳米碳在腔镜甲状腺癌手术中的应用[J].腹腔镜外科杂志, 2013, 18(4):262-265.
25. 杨志芳, 岳瑞雪, 朱智, 等.纳米碳在cN0期甲状腺乳头状癌中央区淋巴结清扫手术中的应用[J].中国普外基础与临床杂志, 2013, 20(9):976-980.
26. 张筱骅, 郝儒田, 尤捷, 等.甲状腺淋巴管造影在鉴别甲状旁腺中的意义[J].温州医学院学报, 2010, 40(1):31, 35.
27. 朱精强, 汪洵理, 魏涛, 等.纳米碳甲状旁腺负显影辨认保护技术在甲状腺癌手术中的应用[J].中国普外基础与临床杂志, 2013, 20(9):992-994.
28. Lo CY, Lam KY.Routine parathyroid autotransplantation during thyroidectomy[J].Surgery, 2001, 129(3):318-323.
29. Krag DN, Weaver DL.Pathological and molecular assessment of sentinel lymph nodes in solid tumors[J].Semin Oncol, 2002, 29(3):274-279.
30. 高庆军, 王南鹏, 周彦, 等.甲状腺乳头状癌颈部淋巴结转移规律及影响因素分析[J].中国普外基础与临床杂志, 2013, 20(3):303-309.
31. 赏金标, 王可敬.甲状腺乳头状腺癌的前哨淋巴结研究[J].国际耳鼻咽喉头颈外科杂志, 2006, 30(1):33-34, 48.
32. Cabanas RM.An approach for the treatment of penile carcinoma[J].Cancer, 1977, 39(2):456-466.
33. Morton DL, Wen DR, Wong JH, et al.Technical details of intraoperative lymphatic mapping for early stage melanoma[J].Arch Surg, 1992, 127(4):392-399.
34. Beslić N.The role of sentinel lymph node detection in management of patients with breast cancer[J].Med Arh, 2008, 62(4):240-241.
35. Kelemen PR, Van Herle AJ, Giuliano AE.Sentinel lymphadenectomy in thyroid malignant neoplasms[J].Arch Surg, 1998, 133(3):288-292.
36. Lee SK, Choi JH, Lim HI, et al.Sentinel lymph node biopsy in papillary thyroid cancer:comparison study of blue dye method and combined radioisotope and blue dye method in papillary thyroid cancer[J].Eur J Surg Oncol, 2009, 35(9):974-979.
37. Liu CL, Yang TL, Chen BF.Sentinel lymph node mapping with emulsion of activated carbon particles in patients with pre-mastectomy diagnosis of intraductal carcinoma of the breast[J].J Chin Med Assoc, 2003, 66(7):406-410.
38. Catarci M, Guadagni S, Zaraca F, et al.Prospective randomized evaluation of preoperative endoscopic vital staining using CH-40 for lymph node dissection in gastric cancer[J].Ann Surg Oncol, 1999, 5(7):580-584.
39. 王晓雷, 吴跃煌, 徐震纲, 等.纳米碳在鉴别甲状腺周围淋巴结和甲状旁腺中的作用[J].中华耳鼻咽喉头颈外科杂志, 2009, 44(2):136-140.
40. 江国斌, 方红燕, 蔡建明.纳米碳混悬液示踪前哨淋巴结在甲状腺乳头状癌中的应用[J].中国癌症杂志, 2010, 20(12):938-940.
41. Fukui Y, Yamakawa T, Taniki T, et al.Sentinel lymph node biopsy in patients with papillary thyroid carcinoma[J].Cancer, 2001, 92(11):2868-2874.
42. Hao RT, Chen J, Zhao LH, et al.Sentinel lymph node biopsy using carbon nanoparticles for Chinese patients with papillary thyroid microcarcinoma[J].Eur J Surg Oncol, 2012, 38(8):718-724.
43. 江国斌, 贾中明, 刘艳, 等.纳米炭定位前哨淋巴结在cN0甲状腺乳头状癌中的临床研究[J].临床合理用药, 2013, 4(9C):9-11.

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Application Advances of Carbon Nanoparticles in Thyroid Carcinoma Surgery

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