Advance in Study of MicroRNA in Invasion and Metastasis of Breast Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 LIDan ,  GUOLi-ying

Department of Breast Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumchi 830054, Xinjiang Uygur Autonomous Region, China;

Corresponding author：

GUOLi-ying, Email: ggs318@126.com

Keywords：

MicroRNA; Breast cancer; Metastasis; Invasion

DOI：

10.7507/1007-9424.20140158

Video：

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Objective To summarize the relationship of microRNA (miRNA) to metastasis and invasion of breast cancer. Method Domestic and international publications involving the relationship of miRNA to breast cancer were screened and reviewed. Results miRNA played a key role in the process of breast cancer metastasis. According to its function, it could be distinguished from cancer-promoting gene (such as miR-21, miR-10b, etc.) to suppressor gene (such as miR-31, let-7, etc.). Conclusion The more detailed experimental studies about the relationship of miRNA to metastasis and invasion of breast cancer need to be researched in order to provide a new method for the diagnosis and treatment of breast cancer metastasis and invasion.

Citation： LIDan, GUOLi-ying. Advance in Study of MicroRNA in Invasion and Metastasis of Breast Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(5): 654-657. doi: 10.7507/1007-9424.20140158 Copy

1.	Negrini M, Calin GA.Breast cancer metastasis:a microRNA story[J].Breast Cancer Res, 2008, 10:203-206.
2.	Kozomara A, Griffiths-Jones S.miRBase:integrating microRNA annotation and deep-sequencing data[J].Nucleic Acids Res, 2011, 39(Database issue):D152-D157.
3.	Krol J, Loedige I, Filipowicz W.The widespread regulation of microRNA biogenesis, function and decay[J].Nat Rev Genet, 2010, 11(9):597-610.
4.	Li J, Zhang Y, Zhang W, et al.Genetic heterogeneity of breast cancer metastasis may be related to miR-21 regulation of TIMP-3 in translation[J].Int J Surg Oncol, 2013, 2013:875078.
5.	Bartel DP.MicroRNAs:genomics, biogenesis, mechanism, and function[J].Cell, 2004, 116(2):281-297.
6.	Dalmay T.Mechanism of miRNA-mediated repression of mRNA translation[J].Essays Biochem, 2013, 54:29-38.
7.	Jiang Q, Wang Y, Hao Y, et al.miR2disease:a manually curated database for microRNA deregulation in human disease[J].Nucleic Acids Res, 2009, 37(Database issue):D98-D104.
8.	Stark A, Brennecke J, Bushati N, et al.Animal microRNAs confer robustness to gene expression and have a significant impact on 3' UTR evolution[J].Cell, 2005, 123(6):1133-1146.
9.	Chen X, Ba Y, Ma L, et al.Characterization of microRNAs in serum:a novel class of biomarkers for diagnosis of cancer and other diseases[J].Cell Res, 2008, 18(10):997-1006.
10.	Sablok G, Milev I, Minkov G, et al.IsomiRex:web-based identification of microRNAs, isomiR variations and differential expression using next-generation sequencing datasets[J].FEBS Lett, 2013, 587(16):2629-2634.
11.	Russo F, Di Bella S, Nigita G, et al.miRandola:extracellular circulating microRNAs database[J].PLoS One, 2012, 7(10):e47786.
12.	黄金, 吴正升, 张晴, 等.乳腺癌miRNAs表达谱的检测[J].临床与实验病理学杂志, 2010, 26(2):173-177.
13.	Song B, Wang C, Liu J, et al.MicroRNA-21 regulates breast cancer invasion partly by targeting tissue inhibitor of metalloproteinase 3 expression[J].J Exp Clin Cancer Res, 2010, 29:29-36.
14.	Jiang S, Zhang HW, Lu MH, et al.MicroRNA-155 functions as an oncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene[J].Cancer Res, 2010, 70(8):3119-3127.
15.	Blenkiron C, Goldstein LD, Thorne NP, et al.MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype[J].Genome Biol, 2007, 8(10):R214.
16.	Wang F, Zheng Z, Guo J, et al.Correlation and quantitation of microRNA aberrant expression in tissues and sera from patients with breast tumor[J].Gynecol Oncol, 2010, 119(3):586-593.
17.	Li H, Bian C, Liao L, et al.miR-17-5p promotes human breast cancer cell migration and invasion through suppression of HBP1[J].Breast Cancer Res Treat, 2011, 126(3):565-575.
18.	Paulson KE, Rieger-Christ K, McDevitt MA, et al.Alterations of the HBP1 transcriptional repressor are associated with invasive breast cancer[J].Cancer Res, 2007, 67(13):6136-6145.
19.	Rosenfeld N, Aharonov R, Meiri E, et al.MicroRNAs accurately identify cancer tissue origin[J].Nat Biotechnol, 2008, 26(4):462-469.
20.	Rather MI, Nagashri MN, Swamy SS, et al.Oncogenic micro-RNA-155 down-regulates tumor suppressor CDC73 and promotes oral squamous cell carcinoma cell proliferation:implications for cancer therapeutics[J].J Biol Chem, 2013, 288(1):608-618.
21.	Liang Z, Ahn J, Guo D, et al.MicroRNA-302 replacement therapy sensitizes breast cancer cells to ionizing radiation[J].Pharm Res, 2013, 30(4):1008-1016.
22.	Thomas M, Lange-Grünweller K, Weirauch U, et al.The protooncogene Pim-1 is a target of miR-33a[J].Oncogene, 2012, 31(7):918-928.
23.	Volinia S, Galasso M, Sana ME, et al.Breast cancer signatures for invasiveness and prognosis defined by deep sequencing of microRNA[J].Proc Natl Acad Sci USA, 2012, 109(8):3024-3029.
24.	Song B, Wang C, Liu J, et al.MicroRNA-21 regulates breast cancer invasion partly by targeting tissue inhibitor of metalloproteinase 3 expression[J].J Exp Clin Cancer Res, 2010, 29:29.
25.	Qi L, Bart J, Tan LP, et al.Expression of miR-21 and its targets (PTEN, PDCD4, TM1) in flat epithelial atypia of the breast in relation to ductal carcinoma in situ and invasive carcinoma[J].BMC Cancer, 2009, 9:163.
26.	Yan LX, Wu QN, Zhang Y, et al.Knockdown of miR-21 in human breast cancer cell lines inhibits proliferation, in vitro migration and in vivo tumor growth[J].Breast Cancer Res, 2011, 13(1):R2.
27.	Liu Z, Zhu J, Cao H, et al.miR-10b promotes cell invasion through RhoC-AKT signaling pathway by targeting HOXD10 in gastric cancer[J].Int J Oncol, 2012, 40(5):1553-1560.
28.	Ma L, Teruya-Feldstein J, Weinberg RA.Tumour invasion and metastasis initiated by microRNA-10b in breast cancer[J].Nature, 2007, 449(7163):682-688.
29.	Ma L, Reinhardt F, Pan E, et al.Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model[J].Nat Biotechnol, 2010, 28(4):341-347.
30.	Yan GR, Xu SH, Tan ZL, et al.Global identification of miR-373-regulated genes in breast cancer by quantitative proteomics[J].Proteomics, 2011, 11(5):912-920.
31.	Huang Q, Gumireddy K, Schrier M, et al.The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis[J].Nat Cell Biol, 2008, 10(2):202-210.
32.	Kong W, He L, Coppola M, et al.MicroRNA-155 regulates cell survival, growth, and chemosensitivity by targeting FOXO3a in breast cancer[J].J Biol Chem, 2010, 285(23):17869-17879.
33.	张学营, 甄林林, 韩学东, 等.全血中miR-155与乳腺癌的关系研究[J].中华内分泌外科杂志, 2012, 6(2):77-80.
34.	宋传贵, 吴雪英, 傅芳萌, 等.miR-155预测乳腺癌侵袭及预后的研究[J].中华外科杂志, 2012, 50(11):1011-1014.
35.	Van der Auwera I, Limame R, van Dam P, et al.Integrated miRNA and mRNA expression profiling of the inflammatory breast cancer subtype[J].Br J Cancer, 2010, 103(4):532-541.
36.	Wu ZS, Wu Q, Wang CQ, et al.MiR-339-5p inhibits breast cancer cell migration and invasion in vitro and may be a potential biomarker for breast cancer prognosis[J].BMC Cancer, 2010, 10:542.
37.	Yu Z, Willmarth NE, Zhou J, et al.microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling[J].Proc Natl Acad Sci U S A, 2010, 107(18):8231-8236.
38.	Hurst DR, Edmonds MD, Scott GK, et al.Breast cancer metastasis suppressor 1 up-regulates miR-146, which suppresses breast cancer metastasis[J].Cancer Res, 2009, 69(4):1279-1283.
39.	Valastyan S, Reinhardt F, Benaich N, et al.A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis[J].Cell, 2009, 137(6):1032-1046.
40.	Schmittgen TD.miR-31:a master regulator of metastasis[J].Future Oncol, 2010, 6(1):17-20.
41.	Johnson CD, Esquela-Kerscher A, Stefani G, et al.The let-7 microRNA represses cell proliferation pathways in human cells[J].Cancer Res, 2007, 67(16):7713-7722.
42.	朱益民, 刘志明, 白卫兵, 等.let-7a对人胃癌细胞周期的影响[J].中华实验外科杂志, 2010, 27(4):424.
43.	吕淑华, 牛昀, 于琦, 等.雄激素抑制雌激素受体阴性雄激素受体阳性乳腺癌细胞增殖相关微小RNA的筛选及其功能学研究[J].中华实验外科杂志, 2012, 29(8):1521-1524.

1. Negrini M, Calin GA.Breast cancer metastasis:a microRNA story[J].Breast Cancer Res, 2008, 10:203-206.
2. Kozomara A, Griffiths-Jones S.miRBase:integrating microRNA annotation and deep-sequencing data[J].Nucleic Acids Res, 2011, 39(Database issue):D152-D157.
3. Krol J, Loedige I, Filipowicz W.The widespread regulation of microRNA biogenesis, function and decay[J].Nat Rev Genet, 2010, 11(9):597-610.
4. Li J, Zhang Y, Zhang W, et al.Genetic heterogeneity of breast cancer metastasis may be related to miR-21 regulation of TIMP-3 in translation[J].Int J Surg Oncol, 2013, 2013:875078.
5. Bartel DP.MicroRNAs:genomics, biogenesis, mechanism, and function[J].Cell, 2004, 116(2):281-297.
6. Dalmay T.Mechanism of miRNA-mediated repression of mRNA translation[J].Essays Biochem, 2013, 54:29-38.
7. Jiang Q, Wang Y, Hao Y, et al.miR2disease:a manually curated database for microRNA deregulation in human disease[J].Nucleic Acids Res, 2009, 37(Database issue):D98-D104.
8. Stark A, Brennecke J, Bushati N, et al.Animal microRNAs confer robustness to gene expression and have a significant impact on 3' UTR evolution[J].Cell, 2005, 123(6):1133-1146.
9. Chen X, Ba Y, Ma L, et al.Characterization of microRNAs in serum:a novel class of biomarkers for diagnosis of cancer and other diseases[J].Cell Res, 2008, 18(10):997-1006.
10. Sablok G, Milev I, Minkov G, et al.IsomiRex:web-based identification of microRNAs, isomiR variations and differential expression using next-generation sequencing datasets[J].FEBS Lett, 2013, 587(16):2629-2634.
11. Russo F, Di Bella S, Nigita G, et al.miRandola:extracellular circulating microRNAs database[J].PLoS One, 2012, 7(10):e47786.
12. 黄金, 吴正升, 张晴, 等.乳腺癌miRNAs表达谱的检测[J].临床与实验病理学杂志, 2010, 26(2):173-177.
13. Song B, Wang C, Liu J, et al.MicroRNA-21 regulates breast cancer invasion partly by targeting tissue inhibitor of metalloproteinase 3 expression[J].J Exp Clin Cancer Res, 2010, 29:29-36.
14. Jiang S, Zhang HW, Lu MH, et al.MicroRNA-155 functions as an oncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene[J].Cancer Res, 2010, 70(8):3119-3127.
15. Blenkiron C, Goldstein LD, Thorne NP, et al.MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype[J].Genome Biol, 2007, 8(10):R214.
16. Wang F, Zheng Z, Guo J, et al.Correlation and quantitation of microRNA aberrant expression in tissues and sera from patients with breast tumor[J].Gynecol Oncol, 2010, 119(3):586-593.
17. Li H, Bian C, Liao L, et al.miR-17-5p promotes human breast cancer cell migration and invasion through suppression of HBP1[J].Breast Cancer Res Treat, 2011, 126(3):565-575.
18. Paulson KE, Rieger-Christ K, McDevitt MA, et al.Alterations of the HBP1 transcriptional repressor are associated with invasive breast cancer[J].Cancer Res, 2007, 67(13):6136-6145.
19. Rosenfeld N, Aharonov R, Meiri E, et al.MicroRNAs accurately identify cancer tissue origin[J].Nat Biotechnol, 2008, 26(4):462-469.
20. Rather MI, Nagashri MN, Swamy SS, et al.Oncogenic micro-RNA-155 down-regulates tumor suppressor CDC73 and promotes oral squamous cell carcinoma cell proliferation:implications for cancer therapeutics[J].J Biol Chem, 2013, 288(1):608-618.
21. Liang Z, Ahn J, Guo D, et al.MicroRNA-302 replacement therapy sensitizes breast cancer cells to ionizing radiation[J].Pharm Res, 2013, 30(4):1008-1016.
22. Thomas M, Lange-Grünweller K, Weirauch U, et al.The protooncogene Pim-1 is a target of miR-33a[J].Oncogene, 2012, 31(7):918-928.
23. Volinia S, Galasso M, Sana ME, et al.Breast cancer signatures for invasiveness and prognosis defined by deep sequencing of microRNA[J].Proc Natl Acad Sci USA, 2012, 109(8):3024-3029.
24. Song B, Wang C, Liu J, et al.MicroRNA-21 regulates breast cancer invasion partly by targeting tissue inhibitor of metalloproteinase 3 expression[J].J Exp Clin Cancer Res, 2010, 29:29.
25. Qi L, Bart J, Tan LP, et al.Expression of miR-21 and its targets (PTEN, PDCD4, TM1) in flat epithelial atypia of the breast in relation to ductal carcinoma in situ and invasive carcinoma[J].BMC Cancer, 2009, 9:163.
26. Yan LX, Wu QN, Zhang Y, et al.Knockdown of miR-21 in human breast cancer cell lines inhibits proliferation, in vitro migration and in vivo tumor growth[J].Breast Cancer Res, 2011, 13(1):R2.
27. Liu Z, Zhu J, Cao H, et al.miR-10b promotes cell invasion through RhoC-AKT signaling pathway by targeting HOXD10 in gastric cancer[J].Int J Oncol, 2012, 40(5):1553-1560.
28. Ma L, Teruya-Feldstein J, Weinberg RA.Tumour invasion and metastasis initiated by microRNA-10b in breast cancer[J].Nature, 2007, 449(7163):682-688.
29. Ma L, Reinhardt F, Pan E, et al.Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model[J].Nat Biotechnol, 2010, 28(4):341-347.
30. Yan GR, Xu SH, Tan ZL, et al.Global identification of miR-373-regulated genes in breast cancer by quantitative proteomics[J].Proteomics, 2011, 11(5):912-920.
31. Huang Q, Gumireddy K, Schrier M, et al.The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis[J].Nat Cell Biol, 2008, 10(2):202-210.
32. Kong W, He L, Coppola M, et al.MicroRNA-155 regulates cell survival, growth, and chemosensitivity by targeting FOXO3a in breast cancer[J].J Biol Chem, 2010, 285(23):17869-17879.
33. 张学营, 甄林林, 韩学东, 等.全血中miR-155与乳腺癌的关系研究[J].中华内分泌外科杂志, 2012, 6(2):77-80.
34. 宋传贵, 吴雪英, 傅芳萌, 等.miR-155预测乳腺癌侵袭及预后的研究[J].中华外科杂志, 2012, 50(11):1011-1014.
35. Van der Auwera I, Limame R, van Dam P, et al.Integrated miRNA and mRNA expression profiling of the inflammatory breast cancer subtype[J].Br J Cancer, 2010, 103(4):532-541.
36. Wu ZS, Wu Q, Wang CQ, et al.MiR-339-5p inhibits breast cancer cell migration and invasion in vitro and may be a potential biomarker for breast cancer prognosis[J].BMC Cancer, 2010, 10:542.
37. Yu Z, Willmarth NE, Zhou J, et al.microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling[J].Proc Natl Acad Sci U S A, 2010, 107(18):8231-8236.
38. Hurst DR, Edmonds MD, Scott GK, et al.Breast cancer metastasis suppressor 1 up-regulates miR-146, which suppresses breast cancer metastasis[J].Cancer Res, 2009, 69(4):1279-1283.
39. Valastyan S, Reinhardt F, Benaich N, et al.A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis[J].Cell, 2009, 137(6):1032-1046.
40. Schmittgen TD.miR-31:a master regulator of metastasis[J].Future Oncol, 2010, 6(1):17-20.
41. Johnson CD, Esquela-Kerscher A, Stefani G, et al.The let-7 microRNA represses cell proliferation pathways in human cells[J].Cancer Res, 2007, 67(16):7713-7722.
42. 朱益民, 刘志明, 白卫兵, 等.let-7a对人胃癌细胞周期的影响[J].中华实验外科杂志, 2010, 27(4):424.
43. 吕淑华, 牛昀, 于琦, 等.雄激素抑制雌激素受体阴性雄激素受体阳性乳腺癌细胞增殖相关微小RNA的筛选及其功能学研究[J].中华实验外科杂志, 2012, 29(8):1521-1524.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Advance in Study of MicroRNA in Invasion and Metastasis of Breast Cancer

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