Research Progress of Imatinib Preoperative Chemotherapy in Treatment of Advanced Gastrointestinal Stromal Tumor_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 CAOFeng ,  LIFei

Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China;

Corresponding author：

LIFei, Email: feili36@ccmu.edu.cn

Keywords：

Gastrointestinal stromal tumor; Preoperative chemotherapy; Imatinib

DOI：

10.7507/1007-9424.20140222

Video：

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Objective To discuss the role of imatinib preoperative chemotherapy in treatment of advanced gastrointestinal stromal tumor(GIST). Method The related literatures about imatinib preoperative chemotherapy for GIST were reviewed. Results Imatinib preoperative chemotherapy is an effective treatment for advanced GIST, which significantly improve the resection rate and prolong the overall survival time for patients with advanced GIST. Conclusions Preoperative imatinib treatment has good effect for metastatic or locally advanced GIST. It should be individualized by gene type of the GIST, which is deserved to be further studied.

Citation： CAOFeng, LIFei. Research Progress of Imatinib Preoperative Chemotherapy in Treatment of Advanced Gastrointestinal Stromal Tumor. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(7): 925-929. doi: 10.7507/1007-9424.20140222 Copy

1.	Perez EA, Livingstone AS, Franceschi D, et al. Current incidence and outcomes of gastrointestinal mesenchymal tumors including gastrointestinal stromal tumors[J]. J Am Coll Surg, 2006, 202(4):623-629.
2.	Hirota S, Isozaki K, Moriyama Y, et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors[J]. Science, 1998, 279(5350):577-580.
3.	Heinrich MC, Corless CL, Duensing A, et al. PDGFRA activating mutations ingastrointestinal stromal tumors[J]. Science, 2003, 299(5607):708-710.
4.	Hirota S, Ohashi A, Nishida T, et al. Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors[J]. Gastroenterology, 2003, 125(3): 660-667.
5.	DeMatteo RP, Ballman KV, Antonescu CR, et al. Long-term results of adjuvant imatinib mesylate in localized, high-risk, primary gastrointestinal stromal tumor:ACOSOG Z9000(Alliance) intergroup phase 2 trial[J]. Ann Surg, 2013, 258(3):422-429.
6.	Liu SL, Chen G, Zhao YP, et al. Optimized dose of imatinib for treatment of gastrointestinal stromal tumors:a meta-analysis[J]. J Dig Dis, 2013, 14(1):16-21.
7.	Rutkowski P, Gronchi A. Efficacy and economic value of adjuvant imatinib for gastrointestinal stromal tumors[J]. Oncologist, 2013, 18(6):689-696.
8.	张艳, 季峰.胃肠道间质瘤继发耐药机制及其处理对策研究进展[J].国际消化病杂志, 2013, 33(2):105-108.
9.	Kanda T, Ishikawa T, Hirota S, et al. Prospective observational study of imatinib therapy in Japanese patients with advanced gastrointestinal stromal tumors:long-term follow-up and second malignancy[J]. Jpn J Clin Oncol, 2012, 42(7):578-585.
10.	Linch M, Claus J, Benson C. Update on imatinib for gastrointestinal stromal tumors:duration of treatment[J]. Onco Targets Ther, 2013, 6:1011-1023.
11.	Kang G, Park YS, Jung ES, et al. Gastrointestinal stromal tumors in children and young adults:a clinicopathologic and molecular genetic study of 22 Korean cases[J]. APMIS, 2013, 121(10): 938-944.
12.	何丹, 伍晓汀.胃肠道间质瘤c-kit基因突变的研究进展[J].中国普外基础与临床杂志, 2013, 20(7):820-825.
13.	刘传, 王宁, 王雅杰.伊马替尼治疗胃肠道间质瘤的继发性耐药机制[J].国际肿瘤学杂志, 2010, 37(12):936-939.
14.	Eisenberg BL, Trent JC. Adjuvant and neoadjuvant imatinib therapy:current role in the management of gastrointestinal stromal tumors[J]. Int J Cancer, 2011, 129(11):2533-2542.
15.	Andtbacka RH, Ng CS, Scaife CL, et al. Surgical resection of gastrointestinal stromal tumors after treatment with imatinib[J]. Ann Surg Oncol, 2007, 14(1):14-24.
16.	DeMatteo RP, Maki RG, Singer S, et al. Results of tyrosine kinase inhibitor therapy followed by surgical resection for metastatic gastrointestinal stromal tumor[J]. Ann Surg, 2007, 245(3): 347-352.
17.	Rutkowski P, Gronchi A, Hohenberger P, et al. Neoadjuvant imatinib in locally advanced gastrointestinal stromal tumors (GIST): the EORTC STBSG experience[J]. Ann Surg Oncol, 2013, 20(9):2937-2943.
18.	Eisenberg BL, Harris J, Blanke CD, et al. PhaseⅡtrial of neoadjuvant/adjuvant imatinib mesylate(IM) for advanced primary and metastatic/recurrent operable gastrointestinal stroma tumor (GIST): early results of RTOG0132/ACRIN 6665[J]. J Surg Oncol, 2009, 99(1):42-47.
19.	Wang D, Zhang Q, Blanke CD, et al. Phase II trial of neoadjuvant/adjuvant imatinib mesylate for advanced primary and metastatic/ recurrent pperable gastrointestinal stromal tumors:long-term follow-up results of radiation therapy oncology group 0132[J]. Ann Surg Oncol, 2012, 19(4):1074-1080.
20.	Hohenberger P, Oladeji O, Licht T, et al. Neoadjuvant imatinib and organ preservation in locally advanced gastrointestinal stromal tumors (GIST)[J]. J Clin Oncol(Meeting Abstracts), 2009, 27: 10550.
21.	Blesius A, Cassier PA, Bertucci F, et al. Neoadjuvant imatinib in patients with locally advanced non metastatic GIST in the prospective BFR14 trial[J]. BMC Cancer, 2011, 11:72.
22.	McAuliffe JC, Hunt KK, Lazar AJF, et al. A randomized, phaseⅡstudy of preoperative plus postoperative imatinib in GIST:evidence of rapid radiographic response and temporal induction of tumor cell apoptosis[J]. Ann Surg Oncol, 2009, 16(4):910-919.
23.	Xia L, Zhang MM, Ji L, et al. Resection combined with imatinib therapy for liver metastases of gastrointestinal stromal tumors[J]. Surg Today, 2010, 40(10):936-942.
24.	Fiore M, Palassini E, Fumagalli E, et al. Preoperative imatinib mesylate for unresectable or locally advanced primary gastrointestinal stromal tumors(GIST)[J]. EJSO, 2009, 35(7):739-745.
25.	Demetri GD, von Mehren M, Blanke CD, et al. Efficacy and safety of im atinib mesylate in advanced gastrointestinal stromal tumors[J]. N Engl J Med, 2002, 347(7):472-480.
26.	王昱, 钟捷.胃肠道间质瘤分子靶向治疗的不良反应及对策[J].国际消化病杂志, 2010, 30(2):93-96, 105.
27.	DeLuca C, Shenouda-Awad N, Haskes C, et al. Imatinib mesylate (Gleevec) induced unilateral optic disc edema[J]. Optom Vis Sci, 2012, 89(10):e16-e22.
28.	Gulati AP, Saif MW. Retinal neovascularization and hemorrhage associated with the use of imatinib (Gleevec^®) in a patient being treated for gastrointestinal stromal tumor (GIST)[J]. Anticancer Res, 2012, 32(4):1375-1377.
29.	Saad Aldin E, Mourad F, Tfayli A. Gastric antral vascular ectasia in a patient with GIST after treatment with imatinib:case report and literature review[J]. Jpn J Clin Oncol, 2012, 42(5):447-450.
30.	National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/pdf/sarcoma.pdf.
31.	ESMO/European Sarcoma Network Working Group. Gastrointestinal stromal tumors:ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up[J]. Ann Oncol, 2012, 23(Suppl 7):vii49-vii55.
32.	中国CSCO胃肠间质瘤专家委员会.中国胃肠间质瘤诊断治疗专家共识(2011年版)[J].中华胃肠外科杂志, 2012, 15(3): 301-307.
33.	Heinrich MC, Corless CL, Demetri GD, et al. Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor[J]. J Clin oncol, 2003, 21(23):4342-4349.
34.	Heinrich MC, Owzar K, Corless CL, et al. Correlation of kinase geno type and clinical outcome in the north American intergroup phaseⅢtrial of imatinib mesylate for treatment of advanced gastrointestinal stromal tumor:CALGB150105 study by cancer and leukemia group B and southwest oncology group[J]. J Clin Oncol, 2008, 26(33):5360-5367.
35.	Li J, Gong JF, Li J, et al. Efficacy of imatinib dose escalation in Chinese gastrointestinal stromal tumor patients[J]. World J Gastroenterol, 2012, 21, 18(7):698-703.

1. Perez EA, Livingstone AS, Franceschi D, et al. Current incidence and outcomes of gastrointestinal mesenchymal tumors including gastrointestinal stromal tumors[J]. J Am Coll Surg, 2006, 202(4):623-629.
2. Hirota S, Isozaki K, Moriyama Y, et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors[J]. Science, 1998, 279(5350):577-580.
3. Heinrich MC, Corless CL, Duensing A, et al. PDGFRA activating mutations ingastrointestinal stromal tumors[J]. Science, 2003, 299(5607):708-710.
4. Hirota S, Ohashi A, Nishida T, et al. Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors[J]. Gastroenterology, 2003, 125(3): 660-667.
5. DeMatteo RP, Ballman KV, Antonescu CR, et al. Long-term results of adjuvant imatinib mesylate in localized, high-risk, primary gastrointestinal stromal tumor:ACOSOG Z9000(Alliance) intergroup phase 2 trial[J]. Ann Surg, 2013, 258(3):422-429.
6. Liu SL, Chen G, Zhao YP, et al. Optimized dose of imatinib for treatment of gastrointestinal stromal tumors:a meta-analysis[J]. J Dig Dis, 2013, 14(1):16-21.
7. Rutkowski P, Gronchi A. Efficacy and economic value of adjuvant imatinib for gastrointestinal stromal tumors[J]. Oncologist, 2013, 18(6):689-696.
8. 张艳, 季峰.胃肠道间质瘤继发耐药机制及其处理对策研究进展[J].国际消化病杂志, 2013, 33(2):105-108.
9. Kanda T, Ishikawa T, Hirota S, et al. Prospective observational study of imatinib therapy in Japanese patients with advanced gastrointestinal stromal tumors:long-term follow-up and second malignancy[J]. Jpn J Clin Oncol, 2012, 42(7):578-585.
10. Linch M, Claus J, Benson C. Update on imatinib for gastrointestinal stromal tumors:duration of treatment[J]. Onco Targets Ther, 2013, 6:1011-1023.
11. Kang G, Park YS, Jung ES, et al. Gastrointestinal stromal tumors in children and young adults:a clinicopathologic and molecular genetic study of 22 Korean cases[J]. APMIS, 2013, 121(10): 938-944.
12. 何丹, 伍晓汀.胃肠道间质瘤c-kit基因突变的研究进展[J].中国普外基础与临床杂志, 2013, 20(7):820-825.
13. 刘传, 王宁, 王雅杰.伊马替尼治疗胃肠道间质瘤的继发性耐药机制[J].国际肿瘤学杂志, 2010, 37(12):936-939.
14. Eisenberg BL, Trent JC. Adjuvant and neoadjuvant imatinib therapy:current role in the management of gastrointestinal stromal tumors[J]. Int J Cancer, 2011, 129(11):2533-2542.
15. Andtbacka RH, Ng CS, Scaife CL, et al. Surgical resection of gastrointestinal stromal tumors after treatment with imatinib[J]. Ann Surg Oncol, 2007, 14(1):14-24.
16. DeMatteo RP, Maki RG, Singer S, et al. Results of tyrosine kinase inhibitor therapy followed by surgical resection for metastatic gastrointestinal stromal tumor[J]. Ann Surg, 2007, 245(3): 347-352.
17. Rutkowski P, Gronchi A, Hohenberger P, et al. Neoadjuvant imatinib in locally advanced gastrointestinal stromal tumors (GIST): the EORTC STBSG experience[J]. Ann Surg Oncol, 2013, 20(9):2937-2943.
18. Eisenberg BL, Harris J, Blanke CD, et al. PhaseⅡtrial of neoadjuvant/adjuvant imatinib mesylate(IM) for advanced primary and metastatic/recurrent operable gastrointestinal stroma tumor (GIST): early results of RTOG0132/ACRIN 6665[J]. J Surg Oncol, 2009, 99(1):42-47.
19. Wang D, Zhang Q, Blanke CD, et al. Phase II trial of neoadjuvant/adjuvant imatinib mesylate for advanced primary and metastatic/ recurrent pperable gastrointestinal stromal tumors:long-term follow-up results of radiation therapy oncology group 0132[J]. Ann Surg Oncol, 2012, 19(4):1074-1080.
20. Hohenberger P, Oladeji O, Licht T, et al. Neoadjuvant imatinib and organ preservation in locally advanced gastrointestinal stromal tumors (GIST)[J]. J Clin Oncol(Meeting Abstracts), 2009, 27: 10550.
21. Blesius A, Cassier PA, Bertucci F, et al. Neoadjuvant imatinib in patients with locally advanced non metastatic GIST in the prospective BFR14 trial[J]. BMC Cancer, 2011, 11:72.
22. McAuliffe JC, Hunt KK, Lazar AJF, et al. A randomized, phaseⅡstudy of preoperative plus postoperative imatinib in GIST:evidence of rapid radiographic response and temporal induction of tumor cell apoptosis[J]. Ann Surg Oncol, 2009, 16(4):910-919.
23. Xia L, Zhang MM, Ji L, et al. Resection combined with imatinib therapy for liver metastases of gastrointestinal stromal tumors[J]. Surg Today, 2010, 40(10):936-942.
24. Fiore M, Palassini E, Fumagalli E, et al. Preoperative imatinib mesylate for unresectable or locally advanced primary gastrointestinal stromal tumors(GIST)[J]. EJSO, 2009, 35(7):739-745.
25. Demetri GD, von Mehren M, Blanke CD, et al. Efficacy and safety of im atinib mesylate in advanced gastrointestinal stromal tumors[J]. N Engl J Med, 2002, 347(7):472-480.
26. 王昱, 钟捷.胃肠道间质瘤分子靶向治疗的不良反应及对策[J].国际消化病杂志, 2010, 30(2):93-96, 105.
27. DeLuca C, Shenouda-Awad N, Haskes C, et al. Imatinib mesylate (Gleevec) induced unilateral optic disc edema[J]. Optom Vis Sci, 2012, 89(10):e16-e22.
28. Gulati AP, Saif MW. Retinal neovascularization and hemorrhage associated with the use of imatinib (Gleevec^®) in a patient being treated for gastrointestinal stromal tumor (GIST)[J]. Anticancer Res, 2012, 32(4):1375-1377.
29. Saad Aldin E, Mourad F, Tfayli A. Gastric antral vascular ectasia in a patient with GIST after treatment with imatinib:case report and literature review[J]. Jpn J Clin Oncol, 2012, 42(5):447-450.
30. National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/pdf/sarcoma.pdf.
31. ESMO/European Sarcoma Network Working Group. Gastrointestinal stromal tumors:ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up[J]. Ann Oncol, 2012, 23(Suppl 7):vii49-vii55.
32. 中国CSCO胃肠间质瘤专家委员会.中国胃肠间质瘤诊断治疗专家共识(2011年版)[J].中华胃肠外科杂志, 2012, 15(3): 301-307.
33. Heinrich MC, Corless CL, Demetri GD, et al. Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor[J]. J Clin oncol, 2003, 21(23):4342-4349.
34. Heinrich MC, Owzar K, Corless CL, et al. Correlation of kinase geno type and clinical outcome in the north American intergroup phaseⅢtrial of imatinib mesylate for treatment of advanced gastrointestinal stromal tumor:CALGB150105 study by cancer and leukemia group B and southwest oncology group[J]. J Clin Oncol, 2008, 26(33):5360-5367.
35. Li J, Gong JF, Li J, et al. Efficacy of imatinib dose escalation in Chinese gastrointestinal stromal tumor patients[J]. World J Gastroenterol, 2012, 21, 18(7):698-703.

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