Effect of High Platelet Count on Short-and Long-Term Outcomes for Patient with Colorectal Cancer Following Operation_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 YANGChuan-hua ^1,2 , ZHOUXiao-shuang ^1,2 , ZHAOQin ^1,2 , WEIMeng-huan ^1,2 , GANZhi-ming ^1,2 , WANGXiao-dong ¹ ,  LILi ¹

1. Center of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China;
2. West China Medical School/MCQ Group, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China;

Corresponding author：

LILi, Email: drlili116@126.com

Keywords：

Platelet count; Colorectal cancer; Prognosis

DOI：

10.7507/1007-9424.20140236

Video：

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Objective To study the short-and long-term outcomes of high platelet count in patients with colorectal cancer after surgery. Methods A total of 398 patients with colorectal cancer who complied with the requirements for this study and operated in professional group on colorectal surgery of Gastrointestinal Surgery Center of West China Hospital in Sichuan University from January 2009 to October 2009 were retrospectively included in this study. Based on the last preoperative platelet count, these patients were divided into normal platelet group(100×10⁹/L-300×10⁹/L)and high platelet group( > 300×10⁹/L). The short-and long-term outcomes were analyzed and compared between two groups. Results ①The gender, age, histological type, degree of differentiation, diameter of tumor, site of tumor, and operation method had no significant differences between two groups(P > 0.05), but the ratio ofⅢ, Ⅳstages of TNM in the high platelet group was significantly higher than that in the normal platelet group(P < 0.05).②The first exhaust time and defecation time of the normal platelet group was significantly shorter than those of the high platelet group(P < 0.05). The time of the first oral intake, the time of pull out the drainage, ureter, and nasogastric tube, the time of the first ambulation, and hospitalstay had no significant differences between two groups(P > 0.05).③The total complications rate and single complication rate had no significant differences between two groups(P > 0.05).④All the patients were followed-up with average following-up time 58 months, there were 7 patients with recurrence and 35 patients with death in all the followed-up patients, the recurrence rate and death rate in the high platelet group were significantly higher than those in the normal platelet group(3.5% versus 1.1%, P=0.013; 15.7% versus 6.0%, P=0.002). Conclusions There is a relationship of platelet count to colorectal malignant degree. The recovery time of gastrointestinal function is longer, and the local recurrence rate and the postoperative death rate are higher for the patients with high platelet count.

Citation： YANGChuan-hua, ZHOUXiao-shuang, ZHAOQin, WEIMeng-huan, GANZhi-ming, WANGXiao-dong, LILi. Effect of High Platelet Count on Short-and Long-Term Outcomes for Patient with Colorectal Cancer Following Operation. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(8): 980-984. doi: 10.7507/1007-9424.20140236 Copy

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3.	Zhang J, Ito R, Oue N, et al. Expression of thrombospondin-1 is correlated with microvessel density in gastric carcinoma[J]. Virchows Arch, 2003, 442(6): 563-568.
4.	Byrne GJ, Hayden KE, McDowell G, et al. Angiogenic characteristics of circulating and tumoural thrombospondin-1 in breast cancer[J]. Int J Oncol, 2007, 31(5): 1127-1132.
5.	Monreal M, Fernandez-Llamazares J, Piñol M, et al. Platelet count and survival in patients with colorectal cancer-a preliminary study[J]. Thromb Haemost, 1998, 79(5): 916-918.
6.	吕东昊, 汪晓东, 阳川华, 等.结直肠肿瘤多学科协作诊治模式的数据库初期建设现状[J].中国普外基础与临床杂志, 2007, 14(6): 713-715.
7.	Bilous M, Osamura RY, Rüschoff J, et al. HER-2 amplification is highly homogenous in gastric cancer[J]. Hum Pathol, 2010, 41(2): 304-305.
8.	Pinedo HM, Verheul HM, D'Amato RJ, et al. Involvement of platelets in tumour angiogenesis?[J]. Lancet, 1998, 352(9142): 1775-1777.
9.	Hippo Y, Yashiro M, Ishii M, et al. Differential gene expression profiles of scirrhous gastric cancer cells with high metastatic potential to peritoneum or lymph nodes[J]. Cancer Res, 2001, 61(3): 889-895.
10.	Wang YD, Wu P, Mao JD, et al. Relationship between vascular invasion and microvessel density and micrometastasis[J]. World J Gastroenterol, 2007, 13(46): 6269-6273.
11.	Lawler PR, Lawler J. Molecular basis for the regulation of angiogenesis by thrombospondin-1 and-2[J]. Cold Spring Harb Perspect Med, 2012, 2(5): a006627.
12.	刘元波, 赵相印.肿瘤所致凝血异常的研究进展[J].首都医科大学学报, 2000, 21(3): 270-272.
13.	陈静, 支宇, 常晓静, 等.血小板反应素-1在胃癌及转移淋巴结中的表达及其与血管生成相关性的研究[J].中国普外基础与临床杂志, 2013, 20(11): 1257-1262.
14.	Muhammadnejad S, Muhammadnejad A, Haddadi M, et al. Correlation of microvessel density with nuclear pleomorphism, mitotic count and vascular invasion in breast and prostate cancers at preclinical and clinical levels[J]. Asian Pac J Cancer Prev, 2013, 14(1): 63-68.
15.	Armstrong LC, Bornstein P. Thrombospondins 1 and 2 function as inhibitors of angiogenesis[J]. Matrix Biol, 2003, 22(1): 63-71.
16.	Dymicka-Piekarska V, Kemona H, Piotrowski Z, et al. Does colorectal cancer influence platelet activation?[J]. Przegl Lek, 2003, 60(11): 716-718.
17.	甘志明, 马琛, 李立, 等. TNM分期对直肠/肛管癌患者结肛吻合术后近期疗效的影响[J].西部医学, 2012, 24(9): 1705-1708.
18.	Cushman M. Epidemiology and risk factors for venous thrombosis[J]. Semin Hematol, 2007, 44(2): 62-69.
19.	Sierko E, Wojtukiewicz MZ. Inhibition of platelet function: does it offer a chance of better cancer progression control?[J]. Semin Thromb Hemost, 2007, 33(7): 712-721.
20.	Miyazaki T, Okada N, Ishibashi K, et al. Clinical significance of plasma level of vascular endothelial growth factor-C in patients with colorectal cancer[J]. Jpn J Clin Oncol, 2008, 38(12): 839-843.
21.	Kisucka J, Butterfield CE, Duda DG, et al. Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage[J]. Proc Natl Acad Sci USA, 2006, 103(4): 855-860.
22.	Brockmann MA, Giese A, Mueller K, et al. Preoperative thrombocytosis predicts poor survival in patients with glioblastoma[J]. Neuro Oncol, 2007, 9(3): 335-342.
23.	Salgado R, Vermeulen PB, Benoy I, et al. Platelet number and interleukin-6 correlate with VEGF but not with bFGF serum levels of advanced cancer patients[J]. Br J Cancer, 1999, 80(5/6): 892-897.
24.	Sasaki K, Kawai K, Tsuno NH, et al. Impact of preoperative thrombocytosis on the survival of patients with primary colorectal cancer[J]. World J Surg, 2012, 36(1): 192-200.
25.	Ferroni P, Spila A, D'Alessandro R, et al. Platelet activation and vascular endothelial growth factor 165 release in hepatocellular cancer[J]. Clin Chim Acta, 2011, 412(5/6): 450-454.

1. Nash GF, Turner LF, Scully MF, et al. Platelets and cancer[J]. Lancet Oncol, 2002, 3(7): 425-430.
2. Makrilia N, Lappa T, Xyla V, et al. The role of angiogenesis in solid tumours: an overview[J]. Eur J Intern Med, 2009, 20(7): 663-671.
3. Zhang J, Ito R, Oue N, et al. Expression of thrombospondin-1 is correlated with microvessel density in gastric carcinoma[J]. Virchows Arch, 2003, 442(6): 563-568.
4. Byrne GJ, Hayden KE, McDowell G, et al. Angiogenic characteristics of circulating and tumoural thrombospondin-1 in breast cancer[J]. Int J Oncol, 2007, 31(5): 1127-1132.
5. Monreal M, Fernandez-Llamazares J, Piñol M, et al. Platelet count and survival in patients with colorectal cancer-a preliminary study[J]. Thromb Haemost, 1998, 79(5): 916-918.
6. 吕东昊, 汪晓东, 阳川华, 等.结直肠肿瘤多学科协作诊治模式的数据库初期建设现状[J].中国普外基础与临床杂志, 2007, 14(6): 713-715.
7. Bilous M, Osamura RY, Rüschoff J, et al. HER-2 amplification is highly homogenous in gastric cancer[J]. Hum Pathol, 2010, 41(2): 304-305.
8. Pinedo HM, Verheul HM, D'Amato RJ, et al. Involvement of platelets in tumour angiogenesis?[J]. Lancet, 1998, 352(9142): 1775-1777.
9. Hippo Y, Yashiro M, Ishii M, et al. Differential gene expression profiles of scirrhous gastric cancer cells with high metastatic potential to peritoneum or lymph nodes[J]. Cancer Res, 2001, 61(3): 889-895.
10. Wang YD, Wu P, Mao JD, et al. Relationship between vascular invasion and microvessel density and micrometastasis[J]. World J Gastroenterol, 2007, 13(46): 6269-6273.
11. Lawler PR, Lawler J. Molecular basis for the regulation of angiogenesis by thrombospondin-1 and-2[J]. Cold Spring Harb Perspect Med, 2012, 2(5): a006627.
12. 刘元波, 赵相印.肿瘤所致凝血异常的研究进展[J].首都医科大学学报, 2000, 21(3): 270-272.
13. 陈静, 支宇, 常晓静, 等.血小板反应素-1在胃癌及转移淋巴结中的表达及其与血管生成相关性的研究[J].中国普外基础与临床杂志, 2013, 20(11): 1257-1262.
14. Muhammadnejad S, Muhammadnejad A, Haddadi M, et al. Correlation of microvessel density with nuclear pleomorphism, mitotic count and vascular invasion in breast and prostate cancers at preclinical and clinical levels[J]. Asian Pac J Cancer Prev, 2013, 14(1): 63-68.
15. Armstrong LC, Bornstein P. Thrombospondins 1 and 2 function as inhibitors of angiogenesis[J]. Matrix Biol, 2003, 22(1): 63-71.
16. Dymicka-Piekarska V, Kemona H, Piotrowski Z, et al. Does colorectal cancer influence platelet activation?[J]. Przegl Lek, 2003, 60(11): 716-718.
17. 甘志明, 马琛, 李立, 等. TNM分期对直肠/肛管癌患者结肛吻合术后近期疗效的影响[J].西部医学, 2012, 24(9): 1705-1708.
18. Cushman M. Epidemiology and risk factors for venous thrombosis[J]. Semin Hematol, 2007, 44(2): 62-69.
19. Sierko E, Wojtukiewicz MZ. Inhibition of platelet function: does it offer a chance of better cancer progression control?[J]. Semin Thromb Hemost, 2007, 33(7): 712-721.
20. Miyazaki T, Okada N, Ishibashi K, et al. Clinical significance of plasma level of vascular endothelial growth factor-C in patients with colorectal cancer[J]. Jpn J Clin Oncol, 2008, 38(12): 839-843.
21. Kisucka J, Butterfield CE, Duda DG, et al. Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage[J]. Proc Natl Acad Sci USA, 2006, 103(4): 855-860.
22. Brockmann MA, Giese A, Mueller K, et al. Preoperative thrombocytosis predicts poor survival in patients with glioblastoma[J]. Neuro Oncol, 2007, 9(3): 335-342.
23. Salgado R, Vermeulen PB, Benoy I, et al. Platelet number and interleukin-6 correlate with VEGF but not with bFGF serum levels of advanced cancer patients[J]. Br J Cancer, 1999, 80(5/6): 892-897.
24. Sasaki K, Kawai K, Tsuno NH, et al. Impact of preoperative thrombocytosis on the survival of patients with primary colorectal cancer[J]. World J Surg, 2012, 36(1): 192-200.
25. Ferroni P, Spila A, D'Alessandro R, et al. Platelet activation and vascular endothelial growth factor 165 release in hepatocellular cancer[J]. Clin Chim Acta, 2011, 412(5/6): 450-454.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Effect of High Platelet Count on Short-and Long-Term Outcomes for Patient with Colorectal Cancer Following Operation

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