New Progress of Unresectable Liver Metastasis from Colorectal Carcinoma with Transcatheter Arterial Chemoem-bolization Based Combination Therapies_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 ZHUFeng-feng , SIMa-hui ,  ZHAOJun

Department of Ⅴ Hepatic Surgery, Eastern Hepatobiliary Hospital, The Second Military Medical University, Shanghai 200438, China;

Corresponding author：

ZHAOJun, Email: 1239635303@qq.com

Keywords：

liver metastasis from colorectal carcinoma; Transcatheter arterial chemoembolization; Systemic chemotherapy; Molecular targeted therapy; Portal vein embolization; Radiofrequency ablation

DOI：

10.7507/1007-9424.20140327

Video：

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Objective To understand the latest progress of transcatheter arterial chemoembolization (TACE)-based combination therapies for unresectable liver metastasis from colorectal carcinoma, and to explore the safe and effective combination therapies in order to controlling the rapid progress of disease and improving the quality of life of patients. Methods The literatures about TACE-based combination therapies of liver metastasis from colorectal carcinoma and the latest advance in researches of this field at home and abroad were collected, and the application of combination therapies, the advantages and features of the combined treatments were reviewed. Results TACE was a safe and effective therapeutic modality in treating primary liver cancer or secondary liver cancer.Compared with a single treatment, TACE-based combination therapies had distinct advantages to patients with liver metastasis from colorectal carcinoma not only improved the quality of life but also prolonged the survival time.With the emerging of various kinds of new drugs and the rapid development of a variety of interventional treatments, it could bring long-term survival benifit for patients with liver metastasis from colorectal carcinoma. Conclusions Doctors should pay attention to the combined treatments of patients with liver metastasis from colorectal carcinoma, improve the knowledge of personalized medication about advanced tumors and actively promote more usage of combination therapies.

Citation： ZHUFeng-feng, SIMa-hui, ZHAOJun. New Progress of Unresectable Liver Metastasis from Colorectal Carcinoma with Transcatheter Arterial Chemoem-bolization Based Combination Therapies. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(11): 1360-1365. doi: 10.7507/1007-9424.20140327 Copy

1.	Jemal A, Bray F, Center MM, et al.Global cancer statistics[J].CA Cancer J Clin, 2011, 61(2):69-90.
2.	Mayo SC, Pawlik TM.Current management of colorectal hepatic metastasis[J].Expert Rev Gastroenterol Hepatol, 2009, 3(2):131-144.
3.	Viganò L, Russolillo N, Ferrero A, et al.Evolution of long-term outcome of liver resection for colorectal metastases:analysis of actual 5-year survival rates over two decades[J].Ann Surg Oncol, 2012, 19(6):2035-2044.
4.	Martin RC, Robbins K, Tomalty D, et al.Transarterial chemoembolization (TACE) using irinotecan-loaded beads for the treatment of unresectable metastases to the liver in patients with colorectal cancer:an interim report[J].World J Surg Oncol, 2009, 7:80.
5.	Yukisawa S, Ishii H, Kasuga A, et al.A transcatheter arterial chemotherapy using a novel lipophilic platinum derivative (miriplatin) for patients with small and multiple hepatocellular carcinomas[J].Eur J Gastroenterol Hepatol, 2012, 24(5):583-588.
6.	Ackerman NB.The blood supply of experimental liver metastases.Ⅳ.Changes in vascularity with increasing tumor growth[J].Surgery, 1974, 75(4):589-596.
7.	Power DG, Kemeny NE.The role of floxuridine in metastatic liver disease[J].Mol Cancer Ther, 2009, 8(5):1015-1025.
8.	Yatsuoka T, Nishimura Y, Sakamoto H, et al.A case of recurrent rectal cancer with paraaortic lymph node metastasis treated by FOLFIRI therapy leading to complete response[J].Gan To Kagaku Ryoho, 2011, 38(12):2057-2059.
9.	Kridel R, Cochet S, Roche B, et al.Successful closure of anal cancer-related fistulas with upfront intra-arterial chemotherapy:a report of 8 cases[J].Dis Colon Rectum, 2011, 54(5):566-569.
10.	Hirasawa T, Asahara S, Fujisaki S, et al.Transcatheter arterial chemoembolization (TACE) using degradable starch microspheres (DSM) for metastatic liver tumors in patients with gastric cancer[J].Nihon Shokakibyo Gakkai Zasshi, 2008, 105(3):367-372.
11.	Morise Z, Sugioka A, Kato R, et al.Transarterial chemoembolization with degradable starch microspheres, irinotecan, and mitomycin-C in patients with liver metastases[J].J Gastrointest Surg, 2006, 10(2):249-258.
12.	Kawai F, Otani S, Sano T, et al.A long-term survival case of colon cancer with multiple liver metastases treated with multidisciplinary therapy[J].Nihon Shokakibyo Gakkai Zasshi, 2010, 107(2):241-247.
13.	Wallace S, Goldstein HM.Intravascular occlusive therapy:use of interventional radiology in cancer patients[J].Postgrad Med, 1976, 59(2):141-146.
14.	Skitzki JJ, Chang AE.Hepatic artery chemotherapy for colorectal liver metastases:technical considerations and review of clinical trials[J].Surg Oncol, 2002, 11(3):123-135.
15.	中华医学会外科学分会胃肠外科学组, 中华医学会外科学分会结直肠肛门外科学组, 中国抗癌协会大肠癌专业委员会.结直肠癌肝转移诊断和综合治疗指南(V2013)[J].中国实用外科杂志, 2013, 33(8):635-644.
16.	Ammori JB, D'Angelica MI, Fong Y, et al.Hepatic artery infusional chemotherapy in patients with unresectable colorectal liver metastases and extrahepatic disease[J].J Surg Oncol, 2012, 106(8):953-958.
17.	Kingham TP, D'Angelica M, Kemeny NE.Role of intra-arterial hepatic chemotherapy in the treatment of colorectal cancer metastases[J].J Surg Oncol, 2010, 102(8):988-995.
18.	Del Prete M, Fiore F, Modica R, et al.Hepatic arterial embolization in patients with neuroendocrine tumors[J].J Exp Clin Cancer Res, 2014, 33:43.
19.	Konopke R, Roth J, Volk A, et al.Colorectal liver metastases:an update on palliative treatment options[J].J Gastrointestin Liver Dis, 2012, 21(1):83-91.
20.	Abdalla EK.Commentary:radiofrequency ablation for colorectal liver metastases:do not blame the biology when it is the technology[J].Am J Surg, 2009, 197(6):737-739.
21.	叶涛, 王耀辉, 夏景林, 等.肝动脉化疗栓塞治疗结直肠癌肝转移的疗效和预后影响因素[J].中华肿瘤杂志, 2012, 34(9):706-709.
22.	Kemeny NE, Melendez FD, Capanu M, et al.Conversion to resectability using hepatic artery infusion plus systemic chemotherapy for the treatment of unresectable liver metastases from colorectal carcinoma[J].J Clin Oncol, 2009, 27(21):3465-3471.
23.	Kemeny N, Huang Y, Cohen AM, et al.Hepatic arterial infusion of chemotherapy after resection of hepatic metastases from colorectal cancer[J].N Engl J Med, 1999, 341(27):2039-2048.
24.	Kulaylat MN, Gibbs JF.Regional treatment of colorectal liver metastasis[J].J Surg Oncol, 2010, 101(8):693-698.
25.	Zhu DX, Ren L, Wei Y, et al.Outcome of patients with colorectal liver metastasis:analysis of 1613 consecutive cases[J].Ann Surg Oncol, 2012, 19(9):2860-2868.
26.	Cassidy J, Clarke S, Díaz-Rubio E, et al.XELOX vs FOLFOX-4 as first-line therapy for metastatic colorectal cancer:NO16966 updated results[J].Br J Cancer, 2011, 105(1):58-64.
27.	Coimbra FJ, Pires TC, Costa Junior WL, et al.Advances in surgical treatment of colorectal liver metastases[J].Rev Assoc Med Bras, 2011, 57(2):220-227.
28.	Makuuchi M, Thai BL, Takayasu K, et al.Preoperative portal embolization to increase safety of major hepatectomy for hilar bile duct carcinoma:a preliminary report[J].Surgery, 1990, 107(5):521-527.
29.	Shirai Y, Wakai T, Ohtani T, et al.Colorectal carcinoma metastases to the liver.Does primary tumor location affect its lobar distribution?[J].Cancer, 1996, 77(11):2213-2216.
30.	刘辉, 李德泰.肝癌肝动脉化疗栓塞前后门脉供血的变化[J].湖南医科大学学报, 1998, 23(3):295-298.
31.	王晓强, 孙立军.经导管肝动脉化疗栓塞联合门静脉栓塞治疗中晚期肝癌临床价值的Meta分析[J].实用放射学杂志, 2012, 28(2):271-274, 279.
32.	Kokudo N, Tada K, Seki M, et al.Proliferative activity of intrahepatic colorectal metastases after preoperative hemihepatic portal vein embolization[J].Hepatology, 2001, 34(2):267-272.
33.	Schnitzbauer AA, Lang SA, Goessmann H, et al.Right portal vein ligation combined with in situ splitting induces rapid left lateral liver lobe hypertrophy enabling 2-staged extended right hepatic resection in small-for-size settings[J].Ann Surg, 2012, 255(3):405-414.
34.	de Santibañes E, Alvarez FA, Ardiles V.How to avoid postoperative liver failure:a novel method[J].World J Surg, 2012, 36(1):125-128.
35.	Kim HC, Chung JW, Lee W, et al.Recognizing extrahepatic collateral vessels that supply hepatocellular carcinoma to avoid complications of transcatheter arterial chemoembolization[J].Radiographics, 2005, 25(Suppl 1):S25-S39.
36.	Lunt SJ, Fyles A, Hill RP, et al.Interstitial fluid pressure in tumors:therapeutic barrier and biomarker of angiogenesis[J].Future Oncol, 2008, 4(6):793-802.
37.	Chibaudel B, Tournigand C, André T, et al.Therapeutic strategy in unresectable metastatic colorectal cancer[J].Ther Adv Med Oncol, 2012, 4(2):75-89.
38.	郭鹏, 陈卉, 卢红, 等.沙利度胺联合介入疗法治疗中晚期肝癌的临床研究[J].华西药学杂志, 2007, 22(3):359-359.
39.	郑志勇.肝动脉介入联合靶向治疗结肠癌肝转移临床研究[J].河北医学, 2013, 19(4):546-549.
40.	Chen MS, Li JQ, Zheng Y, et al.A prospective randomized trial comparing percutaneous local ablative therapy and partial hepatectomy for small hepatocellular carcinoma[J].Ann Surg, 2006, 243(3):321-328.
41.	Rivoire M, De Cian F, Meeus P, et al.Combination of neoadjuvant chemotherapy with cryotherapy and surgical resection for the treatment of unresectable liver metastases from colorectal carcinoma[J].Cancer, 2002, 95(11):2283-2292.
42.	高松学.肝动脉化疗栓塞术联合射频消融治疗肝癌的现状[J].中国介入影像与治疗学, 2010, 7(6):680-683.
43.	Kirikoshi H, Saito S, Yoneda M, et al.Outcome of transarterial chemoembolization monotherapy, and in combination with percutaneous ethanol injection, or radiofrequency ablation therapy for hepatocellular carcinoma[J].Hepatol Res, 2009, 39(6):553-562.
44.	Yi Y, Zhang Y, Wei Q, et al.Radiofrequency ablation or microwave ablation combined with transcatheter arterial chemoembolization intreatment of hepatocellular carcinoma by comparing with radiofrequency ablation alone[J].Chin J Cancer Res, 2014, 26(1):112-118.
45.	含笑, 吕维富.经肝动脉化疗栓塞联合射频消融治疗原发性肝癌远期疗效的荟萃分析[J].介入放射学杂志, 2013, 22(5):387-391.
46.	房星宇, 于淼, 杨倚天, 等.肝动脉化疗栓塞及射频消融治疗胰腺神经内分泌肿瘤肝转移的疗效和生存分析[J].介入放射学杂志, 2013, 22(5):377-380.
47.	代向党, 王赢, 程喆, 等.肝动脉化疗栓塞联合射频消融治疗中晚期肝癌的临床疗效分析[J].放射学实践, 2010, 25(7):799-802.
48.	钟以胜, 孙斐予, 曾明亮, 等.射频消融联合肝动脉栓塞化疗对无手术切除机会原发性肝癌的治疗价值[J].泰山医学院学报, 2013, 34(10):748-751.
49.	Meloni MF, Goldberg SN, Moser V, et al.Colonic perforation and abscess following radiofrequency ablation treatment of hepatoma[J].Eur J Ultrasound, 2002, 15(1/2):73-76.

1. Jemal A, Bray F, Center MM, et al.Global cancer statistics[J].CA Cancer J Clin, 2011, 61(2):69-90.
2. Mayo SC, Pawlik TM.Current management of colorectal hepatic metastasis[J].Expert Rev Gastroenterol Hepatol, 2009, 3(2):131-144.
3. Viganò L, Russolillo N, Ferrero A, et al.Evolution of long-term outcome of liver resection for colorectal metastases:analysis of actual 5-year survival rates over two decades[J].Ann Surg Oncol, 2012, 19(6):2035-2044.
4. Martin RC, Robbins K, Tomalty D, et al.Transarterial chemoembolization (TACE) using irinotecan-loaded beads for the treatment of unresectable metastases to the liver in patients with colorectal cancer:an interim report[J].World J Surg Oncol, 2009, 7:80.
5. Yukisawa S, Ishii H, Kasuga A, et al.A transcatheter arterial chemotherapy using a novel lipophilic platinum derivative (miriplatin) for patients with small and multiple hepatocellular carcinomas[J].Eur J Gastroenterol Hepatol, 2012, 24(5):583-588.
6. Ackerman NB.The blood supply of experimental liver metastases.Ⅳ.Changes in vascularity with increasing tumor growth[J].Surgery, 1974, 75(4):589-596.
7. Power DG, Kemeny NE.The role of floxuridine in metastatic liver disease[J].Mol Cancer Ther, 2009, 8(5):1015-1025.
8. Yatsuoka T, Nishimura Y, Sakamoto H, et al.A case of recurrent rectal cancer with paraaortic lymph node metastasis treated by FOLFIRI therapy leading to complete response[J].Gan To Kagaku Ryoho, 2011, 38(12):2057-2059.
9. Kridel R, Cochet S, Roche B, et al.Successful closure of anal cancer-related fistulas with upfront intra-arterial chemotherapy:a report of 8 cases[J].Dis Colon Rectum, 2011, 54(5):566-569.
10. Hirasawa T, Asahara S, Fujisaki S, et al.Transcatheter arterial chemoembolization (TACE) using degradable starch microspheres (DSM) for metastatic liver tumors in patients with gastric cancer[J].Nihon Shokakibyo Gakkai Zasshi, 2008, 105(3):367-372.
11. Morise Z, Sugioka A, Kato R, et al.Transarterial chemoembolization with degradable starch microspheres, irinotecan, and mitomycin-C in patients with liver metastases[J].J Gastrointest Surg, 2006, 10(2):249-258.
12. Kawai F, Otani S, Sano T, et al.A long-term survival case of colon cancer with multiple liver metastases treated with multidisciplinary therapy[J].Nihon Shokakibyo Gakkai Zasshi, 2010, 107(2):241-247.
13. Wallace S, Goldstein HM.Intravascular occlusive therapy:use of interventional radiology in cancer patients[J].Postgrad Med, 1976, 59(2):141-146.
14. Skitzki JJ, Chang AE.Hepatic artery chemotherapy for colorectal liver metastases:technical considerations and review of clinical trials[J].Surg Oncol, 2002, 11(3):123-135.
15. 中华医学会外科学分会胃肠外科学组, 中华医学会外科学分会结直肠肛门外科学组, 中国抗癌协会大肠癌专业委员会.结直肠癌肝转移诊断和综合治疗指南(V2013)[J].中国实用外科杂志, 2013, 33(8):635-644.
16. Ammori JB, D'Angelica MI, Fong Y, et al.Hepatic artery infusional chemotherapy in patients with unresectable colorectal liver metastases and extrahepatic disease[J].J Surg Oncol, 2012, 106(8):953-958.
17. Kingham TP, D'Angelica M, Kemeny NE.Role of intra-arterial hepatic chemotherapy in the treatment of colorectal cancer metastases[J].J Surg Oncol, 2010, 102(8):988-995.
18. Del Prete M, Fiore F, Modica R, et al.Hepatic arterial embolization in patients with neuroendocrine tumors[J].J Exp Clin Cancer Res, 2014, 33:43.
19. Konopke R, Roth J, Volk A, et al.Colorectal liver metastases:an update on palliative treatment options[J].J Gastrointestin Liver Dis, 2012, 21(1):83-91.
20. Abdalla EK.Commentary:radiofrequency ablation for colorectal liver metastases:do not blame the biology when it is the technology[J].Am J Surg, 2009, 197(6):737-739.
21. 叶涛, 王耀辉, 夏景林, 等.肝动脉化疗栓塞治疗结直肠癌肝转移的疗效和预后影响因素[J].中华肿瘤杂志, 2012, 34(9):706-709.
22. Kemeny NE, Melendez FD, Capanu M, et al.Conversion to resectability using hepatic artery infusion plus systemic chemotherapy for the treatment of unresectable liver metastases from colorectal carcinoma[J].J Clin Oncol, 2009, 27(21):3465-3471.
23. Kemeny N, Huang Y, Cohen AM, et al.Hepatic arterial infusion of chemotherapy after resection of hepatic metastases from colorectal cancer[J].N Engl J Med, 1999, 341(27):2039-2048.
24. Kulaylat MN, Gibbs JF.Regional treatment of colorectal liver metastasis[J].J Surg Oncol, 2010, 101(8):693-698.
25. Zhu DX, Ren L, Wei Y, et al.Outcome of patients with colorectal liver metastasis:analysis of 1613 consecutive cases[J].Ann Surg Oncol, 2012, 19(9):2860-2868.
26. Cassidy J, Clarke S, Díaz-Rubio E, et al.XELOX vs FOLFOX-4 as first-line therapy for metastatic colorectal cancer:NO16966 updated results[J].Br J Cancer, 2011, 105(1):58-64.
27. Coimbra FJ, Pires TC, Costa Junior WL, et al.Advances in surgical treatment of colorectal liver metastases[J].Rev Assoc Med Bras, 2011, 57(2):220-227.
28. Makuuchi M, Thai BL, Takayasu K, et al.Preoperative portal embolization to increase safety of major hepatectomy for hilar bile duct carcinoma:a preliminary report[J].Surgery, 1990, 107(5):521-527.
29. Shirai Y, Wakai T, Ohtani T, et al.Colorectal carcinoma metastases to the liver.Does primary tumor location affect its lobar distribution?[J].Cancer, 1996, 77(11):2213-2216.
30. 刘辉, 李德泰.肝癌肝动脉化疗栓塞前后门脉供血的变化[J].湖南医科大学学报, 1998, 23(3):295-298.
31. 王晓强, 孙立军.经导管肝动脉化疗栓塞联合门静脉栓塞治疗中晚期肝癌临床价值的Meta分析[J].实用放射学杂志, 2012, 28(2):271-274, 279.
32. Kokudo N, Tada K, Seki M, et al.Proliferative activity of intrahepatic colorectal metastases after preoperative hemihepatic portal vein embolization[J].Hepatology, 2001, 34(2):267-272.
33. Schnitzbauer AA, Lang SA, Goessmann H, et al.Right portal vein ligation combined with in situ splitting induces rapid left lateral liver lobe hypertrophy enabling 2-staged extended right hepatic resection in small-for-size settings[J].Ann Surg, 2012, 255(3):405-414.
34. de Santibañes E, Alvarez FA, Ardiles V.How to avoid postoperative liver failure:a novel method[J].World J Surg, 2012, 36(1):125-128.
35. Kim HC, Chung JW, Lee W, et al.Recognizing extrahepatic collateral vessels that supply hepatocellular carcinoma to avoid complications of transcatheter arterial chemoembolization[J].Radiographics, 2005, 25(Suppl 1):S25-S39.
36. Lunt SJ, Fyles A, Hill RP, et al.Interstitial fluid pressure in tumors:therapeutic barrier and biomarker of angiogenesis[J].Future Oncol, 2008, 4(6):793-802.
37. Chibaudel B, Tournigand C, André T, et al.Therapeutic strategy in unresectable metastatic colorectal cancer[J].Ther Adv Med Oncol, 2012, 4(2):75-89.
38. 郭鹏, 陈卉, 卢红, 等.沙利度胺联合介入疗法治疗中晚期肝癌的临床研究[J].华西药学杂志, 2007, 22(3):359-359.
39. 郑志勇.肝动脉介入联合靶向治疗结肠癌肝转移临床研究[J].河北医学, 2013, 19(4):546-549.
40. Chen MS, Li JQ, Zheng Y, et al.A prospective randomized trial comparing percutaneous local ablative therapy and partial hepatectomy for small hepatocellular carcinoma[J].Ann Surg, 2006, 243(3):321-328.
41. Rivoire M, De Cian F, Meeus P, et al.Combination of neoadjuvant chemotherapy with cryotherapy and surgical resection for the treatment of unresectable liver metastases from colorectal carcinoma[J].Cancer, 2002, 95(11):2283-2292.
42. 高松学.肝动脉化疗栓塞术联合射频消融治疗肝癌的现状[J].中国介入影像与治疗学, 2010, 7(6):680-683.
43. Kirikoshi H, Saito S, Yoneda M, et al.Outcome of transarterial chemoembolization monotherapy, and in combination with percutaneous ethanol injection, or radiofrequency ablation therapy for hepatocellular carcinoma[J].Hepatol Res, 2009, 39(6):553-562.
44. Yi Y, Zhang Y, Wei Q, et al.Radiofrequency ablation or microwave ablation combined with transcatheter arterial chemoembolization intreatment of hepatocellular carcinoma by comparing with radiofrequency ablation alone[J].Chin J Cancer Res, 2014, 26(1):112-118.
45. 含笑, 吕维富.经肝动脉化疗栓塞联合射频消融治疗原发性肝癌远期疗效的荟萃分析[J].介入放射学杂志, 2013, 22(5):387-391.
46. 房星宇, 于淼, 杨倚天, 等.肝动脉化疗栓塞及射频消融治疗胰腺神经内分泌肿瘤肝转移的疗效和生存分析[J].介入放射学杂志, 2013, 22(5):377-380.
47. 代向党, 王赢, 程喆, 等.肝动脉化疗栓塞联合射频消融治疗中晚期肝癌的临床疗效分析[J].放射学实践, 2010, 25(7):799-802.
48. 钟以胜, 孙斐予, 曾明亮, 等.射频消融联合肝动脉栓塞化疗对无手术切除机会原发性肝癌的治疗价值[J].泰山医学院学报, 2013, 34(10):748-751.
49. Meloni MF, Goldberg SN, Moser V, et al.Colonic perforation and abscess following radiofrequency ablation treatment of hepatoma[J].Eur J Ultrasound, 2002, 15(1/2):73-76.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

New Progress of Unresectable Liver Metastasis from Colorectal Carcinoma with Transcatheter Arterial Chemoem-bolization Based Combination Therapies

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