The Relationship Between Signal Intensity on Hepatobiliary Phase of Gd-EOB-DTPA-Enhanced MRI and The Degree of Differentiation of Hepatocelluar Carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 LIUXi-jiao ¹ , TANGHe-han ¹ , ZHANGXiao ² , LINLi-li ¹ , LIUYang-yang ¹ , HUANGZi-xing ¹ , CHENGuo-yong ¹ , CAILei ¹ ,  SONGBin ¹

1. Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China;
2. Department of CT/MRI, The People's Hospital of Leshan, Leshan 614000, Sichuan Province, China;

Corresponding author：

SONGBin, Email: ajr.songbin@vip.163.com

Keywords：

Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid; Magnetic resonance imaging; Hepatocelluar carcinoma; The degree of differentiation

DOI：

10.7507/1007-9424.20140377

Video：

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Objective To explore the relationship between the signal intensity on hepatobiliary phase of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI and the degree of differentiation of hepatocelluar carcinoma (HCC). Methods Forty-eight cases of HCC with Gd-EOB-DTPA-enhanced MRI images in our hospital were retrospectively included. The signal to noise ratio (SNR), contrast ratio (CR), enhancement ratio of signal to noise ratio (%Enhancement_SNR), enhancement ratio of the contrast ratio (%Enhancement_CR), enhancement ratio (ER), and relative enhancement ratio (RER) were calculated, respectively. Then comparisons of these signal values among different differentiations of HCC were performed. Results Among the 48 cases of HCC, there were 6 cases of well differentiated, 24 cases of moderately differentiated, and 18 cases of poorly differentiated. There were 37 cases of Child-Turcotte-Pugh (CTP)A classification and 11 cases of B classification, respectively. Neither in all cases nor in cases of CTP A classification, there was no statistically significant difference in SNR, CR, %Enhancement_SNR, %Enhancement_CR, ER, and RER among cases of different differentiation (P > 0.05). Conclusion The signal intensity on hepatobiliary phase images of Gd-EOB-DTPA-enhanced MRI has limited value in predicting the degree of differentiation of HCC.

Citation： LIUXi-jiao, TANGHe-han, ZHANGXiao, LINLi-li, LIUYang-yang, HUANGZi-xing, CHENGuo-yong, CAILei, SONGBin. The Relationship Between Signal Intensity on Hepatobiliary Phase of Gd-EOB-DTPA-Enhanced MRI and The Degree of Differentiation of Hepatocelluar Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(12): 1583-1586. doi: 10.7507/1007-9424.20140377 Copy

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11.	Ahn SS, Kim MJ, Lim JS, et al.Added value of gadoxetic acid-enhanced hepatobiliary phase MR imaging in the diagnosis of hepatocellular carcinoma[J].Radiology, 2010, 255(2):459-466.
12.	Golfieri R, Renzulli M, Lucidi V, et al.Contribution of the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI to dynamic MRI in the detection of hypovascular small (≤2 cm) HCC in cirrhosis[J].Eur Radiol, 2011, 21(6):1233-1242.
13.	Motosugi U, Ichikawa T, Sou H, et al.Distinguishing hypervas-cular pseudolesions of the liver from hypervascular hepatocellular carcinomas with gadoxetic acid-enhanced MR imaging[J]. Radiology, 2010, 256(1):151-158.
14.	Weinmann HJ, Ebert W, Misselwitz B, et al.Tissue-specific MR contrast agents[J].Eur J Radiol, 2003, 46(1):33-44.
15.	Van Beers BE, Pastor CM, Hussain HK.Primovist, eovist:what to expect?[J].J Hepatol, 2012, 57(2):421-429.
16.	Kogita S, Imai Y, Okada M, et al.Gd-EOB-DTPA-enhanced magnetic resonance images of hepatocellular carcinoma:correlation with histological grading and portal blood flow[J].Eur Radiol, 2010, 20(10):2405-2413.
17.	Kim HY, Choi JY, Kim CW, et al.Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging predicts the histological grade of hepatocellular carcinoma only in patients with Child-Pugh class A cirrhosis[J].Liver Transpl, 2012, 18(7):850-857.
18.	Frericks BB, Loddenkemper C, Huppertz A, et al.Qualitative and quantitative evaluation of hepatocellular carcinoma and cirrhotic liver enhancement using Gd-EOB-DTPA[J].AJR Am J Roentgenol, 2009, 193(4):1053-1060.
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1. Parkin DM, Bray F, Ferlay J, et al.Global cancer statistics, 2002[J].CA Cancer J Clin, 2005, 55(2):74-108.
2. Hussain SM, Zondervan PE, Ijzermans JN, et al.Benign versus malignant hepatic nodules:MR imaging findings with pathologic correlation[J].Radiographics, 2002, 22(5):1023-1036.
3. Gandhi SN, Brown MA, Wong JG, et al.MR contrast agents for liver imaging:what, when, how[J].Radiographics, 2006, 26(6):1621-1636.
4. Liu X, Zou L, Liu F, et al.Gadoxetic acid disodium-enhanced magnetic resonance imaging for the detection of hepatocellular carcinoma:a meta-analysis[J].PLoS One, 2013, 8(8):e70896.
5. Seale MK, Catalano OA, Saini S, et al.Hepatobiliary-specific MR contrast agents:role in imaging the liver and biliary tree[J].Radiographics, 2009, 29(6):1725-1748.
6. 刘曦娇, 唐鹤菡, 钟欢欢, 等.肝硬变相关结节Gd-EOB-DTPA增强磁共振成像初步研究[J].中国普外基础与临床杂志, 2013, 20(3):328-333.
7. Motosugi U, Ichikawa T, Sou H, et al.Liver parenchymal enhancement of hepatocyte-phase images in Gd-EOB-DTPA-enhanced MR imaging:which biological markers of the liver function affect the enhancement?[J].J Magn Reson Imaging, 2009, 30(5):1042-1046.
8. 罗宴吉, 蔡华崧, 汤地, 等.肝细胞特异性MR对比剂在肝脏功能评价中的初步研究[J/CD].中华消化病与影像杂志:电子版, 2013, 3(5):23-26.
9. Di Martino M, Marin D, Guerrisi A, et al.Intraindividual comp-arison of gadoxetate disodium-enhanced MR imaging and 64-section multidetector CT in the detection of hepatocellular carcinoma in patients with cirrhosis[J].Radiology, 2010, 256(3):806-816.
10. Huppertz A, Balzer T, Blakeborough A, et al.Improved detection of focal liver lesions at MR imaging:multicenter comparison of gadoxetic acid-enhanced MR images with intraoperative findings[J].Radiology, 2004, 230(1):266-275.
11. Ahn SS, Kim MJ, Lim JS, et al.Added value of gadoxetic acid-enhanced hepatobiliary phase MR imaging in the diagnosis of hepatocellular carcinoma[J].Radiology, 2010, 255(2):459-466.
12. Golfieri R, Renzulli M, Lucidi V, et al.Contribution of the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI to dynamic MRI in the detection of hypovascular small (≤2 cm) HCC in cirrhosis[J].Eur Radiol, 2011, 21(6):1233-1242.
13. Motosugi U, Ichikawa T, Sou H, et al.Distinguishing hypervas-cular pseudolesions of the liver from hypervascular hepatocellular carcinomas with gadoxetic acid-enhanced MR imaging[J]. Radiology, 2010, 256(1):151-158.
14. Weinmann HJ, Ebert W, Misselwitz B, et al.Tissue-specific MR contrast agents[J].Eur J Radiol, 2003, 46(1):33-44.
15. Van Beers BE, Pastor CM, Hussain HK.Primovist, eovist:what to expect?[J].J Hepatol, 2012, 57(2):421-429.
16. Kogita S, Imai Y, Okada M, et al.Gd-EOB-DTPA-enhanced magnetic resonance images of hepatocellular carcinoma:correlation with histological grading and portal blood flow[J].Eur Radiol, 2010, 20(10):2405-2413.
17. Kim HY, Choi JY, Kim CW, et al.Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging predicts the histological grade of hepatocellular carcinoma only in patients with Child-Pugh class A cirrhosis[J].Liver Transpl, 2012, 18(7):850-857.
18. Frericks BB, Loddenkemper C, Huppertz A, et al.Qualitative and quantitative evaluation of hepatocellular carcinoma and cirrhotic liver enhancement using Gd-EOB-DTPA[J].AJR Am J Roentgenol, 2009, 193(4):1053-1060.
19. Kobayashi S, Matsui O, Gabata T, et al.Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging findings of borderline lesions at high risk for progression to hypervascular classic hepatocellular carcinoma[J].J Comput Assist Tomogr, 2011, 35(2):181-186.

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The Relationship Between Signal Intensity on Hepatobiliary Phase of Gd-EOB-DTPA-Enhanced MRI and The Degree of Differentiation of Hepatocelluar Carcinoma

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