Effect of B Ultrasound-Guided Percutaneous Catheter Drainage Combined with Veno-Venous Hemofiltration at Different Time Points and Multi-Site in Treatment of Hyperlipidemic Severe Acute Pancreatitis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 LUOYong-fu ^1,2 , ZENGZhi-yao ² ,  WNGXiang-ying ² , ZHANGXing-wen ² , LUYi-zhan ³

1. Departmengt of General Surgery, The Central Hospital of Yongzhou City, Yongzhou 425000, Hunan Province, China;
2. Departmengt of Hepatobiliary Surgery of Hunan People's Hospital, Changsha 410005, Hunan Province, China;
3. Departmengt of General Surgery, Xiangxi Autonomous Prefecture People's Hospital of Hunan Province, Xiangxi Jishou 416000, Hunan Province, China;

Corresponding author：

WNGXiang-ying, Email: luoyongfu0746@163.com

Keywords：

Ultrasound Guided; Percutaneous catheter drainage; Veno-venous hemofiltration; Hyperlipidemic severe acute pancreatitis

DOI：

10.7507/1007-9424.20150009

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To investigate the therapeutic effect of B ultrasound-guided percutaneous catheter drainage combined with veno-venous hemofiltration at different time points and multi-site in treatment of hyperlipidemic severe acute pancreatitis (HL-SAP). Methods The clinical data of 34 patients with HL-SAP initially underwent B ultrasound-guided percutaneous catheter drainage combined with veno-venous hemofiltration at different time points and multi-site from January 2010 to June 2014 were retrospectively analyzed. According to the different of the onset to treatment time, 34 cases were divided into the≤24 h group and > 24 h group. The serum platelet activating factor (PAF) and triglyceride (TG) at the time of admission and after admission 1, 3, 5, 7, and 10 days were detected, and the hospitalization time, mortality, and the rate of conversion to open surgery were observed. Results The levels of PAF and TG in the both groups tended to gradually decrease with different degrees, were significantly lower than that the before treatment (P < 0.05), and the decline of PAF and TG in≤24 h group were more significant than > 24 h group. The hospitalization time, mortality, and the rate of conversion to open surgery in the≤24 h group were significantly lower than those of the > 24 h group (P < 0.05). Conclusion The early using of B ultrasound-guided percutaneous catheter drainage combined with veno-venous hemofiltration at different time points and multi-site would have a beneficial impact on the management of HL-SAP and complications.

Citation： LUOYong-fu, ZENGZhi-yao, WNGXiang-ying, ZHANGXing-wen, LUYi-zhan. Effect of B Ultrasound-Guided Percutaneous Catheter Drainage Combined with Veno-Venous Hemofiltration at Different Time Points and Multi-Site in Treatment of Hyperlipidemic Severe Acute Pancreatitis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2015, 22(1): 33-36. doi: 10.7507/1007-9424.20150009 Copy

1.	Huang YX, Jia L, Jiang SM, et al. Incidence and clinical features of hyperlipidemic acute pancreatitis from Guangdong, China:a retrospective multicenter study. Pancreas, 2014, 43(4):548-552.
2.	Xin MJ, Chen H, Luo B, et al. Severe acute pancreatitis in the elderly:etiology and clinical characteristics. World Jgastroenterol, 2008, 14(16):2517-2521.
3.	Heinrich S, Schäfer M, Rousson V, et al. Evidencebased treatment of acute pancreatitis:a look at established paradigms. Ann Surg, 2006, 243(2):154-168.
4.	Dervenis C, Smailis D, Hatzitheoklitos E. Bacterial translocation and its prevention in acute pancreatitis. J Hepatobiliary Pancreat Surg, 2003, 10(6):415-418.
5.	Carnovale A, Rabitti PG, Manes G, et al. Mortality in acute pancreatitis:is it an early or a late event?. JOP, 2005, 6(5):438-444.
6.	Stefanutti C, Labbadia G, Morozzi C. Severe hypertriglyceridemia-related acute pancreatitis. Ther Apher Dial, 2013, 17(2):130-137.
7.	Beger HG, Rau BM. Severe acute pancreatitis:Clinical course and management. World J Gastroenterol, 2007, 13(38):5043-5051.
8.	陈修涛, 邹德平, 何铁英, 等. B超引导下经皮穿刺置管引流治疗重症急性胰腺炎局部并发症.中国普通外科杂志, 2012, 21(3):257-261.
9.	卢进利, 严锋, 戴小平, 等.超声引导下经皮穿刺置管引流在重症急性胰腺炎治疗价值的探讨:附57例报告.中国普通外科杂志, 2012, 21(3):364-366.
10.	金炜东, 蔡逊, 胡逸林, 等.高脂血症性重症急性胰腺炎的临床特征分析.中国普通外科杂志, 2009, 18(3):209-211.
11.	Li MQ, Shi ZX, Xu JY, et al. Hemodiafiltration combined with resin-mediated absorption as a therapy for hyperlipidemic acute pancreatitis. Cell Biochem Biophys, 2014, 69(3):699-702.
12.	Yan MX, Li YQ, Meng M, et al. Long-term high-fat diet induces pancreatic injuries via pancreatic microcirculatory disturbances and oxidative stress in rats with hyperlipidemia. Biochem Biophys Res Commun, 2006, 347(1):192-199.
13.	Ramos G, Kazimi N, Nghiem DX, et al. Platelet activating factor receptor binding plays a critical role in jet fuel-induced immune suppression. Toxicol Appl Pharmacol, 2004, 195(3):331-338.
14.	Chen C, Xia SH, Chen H, et al, Therapy for acute pancreatitis with platelet-activating factor receptor antagonists. World J Gastroenterol, 2008, 14(30):4735-4738.
15.	Jiang K, Chen XZ, Xia Q, et al. Cost-effectiveness analysis of early veno-venous hemofiltration for severe acute pancreatitis in China. World J Gastroenterol, 2008, 14(12):1872-1877.

1. Huang YX, Jia L, Jiang SM, et al. Incidence and clinical features of hyperlipidemic acute pancreatitis from Guangdong, China:a retrospective multicenter study. Pancreas, 2014, 43(4):548-552.
2. Xin MJ, Chen H, Luo B, et al. Severe acute pancreatitis in the elderly:etiology and clinical characteristics. World Jgastroenterol, 2008, 14(16):2517-2521.
3. Heinrich S, Schäfer M, Rousson V, et al. Evidencebased treatment of acute pancreatitis:a look at established paradigms. Ann Surg, 2006, 243(2):154-168.
4. Dervenis C, Smailis D, Hatzitheoklitos E. Bacterial translocation and its prevention in acute pancreatitis. J Hepatobiliary Pancreat Surg, 2003, 10(6):415-418.
5. Carnovale A, Rabitti PG, Manes G, et al. Mortality in acute pancreatitis:is it an early or a late event?. JOP, 2005, 6(5):438-444.
6. Stefanutti C, Labbadia G, Morozzi C. Severe hypertriglyceridemia-related acute pancreatitis. Ther Apher Dial, 2013, 17(2):130-137.
7. Beger HG, Rau BM. Severe acute pancreatitis:Clinical course and management. World J Gastroenterol, 2007, 13(38):5043-5051.
8. 陈修涛, 邹德平, 何铁英, 等. B超引导下经皮穿刺置管引流治疗重症急性胰腺炎局部并发症.中国普通外科杂志, 2012, 21(3):257-261.
9. 卢进利, 严锋, 戴小平, 等.超声引导下经皮穿刺置管引流在重症急性胰腺炎治疗价值的探讨:附57例报告.中国普通外科杂志, 2012, 21(3):364-366.
10. 金炜东, 蔡逊, 胡逸林, 等.高脂血症性重症急性胰腺炎的临床特征分析.中国普通外科杂志, 2009, 18(3):209-211.
11. Li MQ, Shi ZX, Xu JY, et al. Hemodiafiltration combined with resin-mediated absorption as a therapy for hyperlipidemic acute pancreatitis. Cell Biochem Biophys, 2014, 69(3):699-702.
12. Yan MX, Li YQ, Meng M, et al. Long-term high-fat diet induces pancreatic injuries via pancreatic microcirculatory disturbances and oxidative stress in rats with hyperlipidemia. Biochem Biophys Res Commun, 2006, 347(1):192-199.
13. Ramos G, Kazimi N, Nghiem DX, et al. Platelet activating factor receptor binding plays a critical role in jet fuel-induced immune suppression. Toxicol Appl Pharmacol, 2004, 195(3):331-338.
14. Chen C, Xia SH, Chen H, et al, Therapy for acute pancreatitis with platelet-activating factor receptor antagonists. World J Gastroenterol, 2008, 14(30):4735-4738.
15. Jiang K, Chen XZ, Xia Q, et al. Cost-effectiveness analysis of early veno-venous hemofiltration for severe acute pancreatitis in China. World J Gastroenterol, 2008, 14(12):1872-1877.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Effect of B Ultrasound-Guided Percutaneous Catheter Drainage Combined with Veno-Venous Hemofiltration at Different Time Points and Multi-Site in Treatment of Hyperlipidemic Severe Acute Pancreatitis

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