Value on The Differential Diagnosis of Ultrasound Contrast in Hepatocellular Carcinoma and Hepatic Focal Nodular Hyperplasia_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 CHENHan-xun , LUMin-yan , SHUQi , FANGJie-ying , QIUYi-de

Ultrasonic Diagnosis and Treatment Ccenter, The First People's Hospital of Foshan City, Foshan 528000, Guangdong Province, China;

Corresponding author：

CHENHan-xun, Email: chx198004@126.com

Keywords：

Ultrasound contrast; Hepatocellular carcinoma; Hepatic focal nodular hyperplasia; Differential diagnosis

DOI：

10.7507/1007-9424.20150020

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To investigate the value of ultrasound contrast in the differential diagnosis for hepatocellular carcinoma (HCC) and hepatic focal nodular hyperplasia (FNH). Methods Twenty-three HCC patients and 23 cases hepatic FNH patients from January 1, 2012 to January 1, 2014 in our hospital were selected, all of them were underwent ultrasound contrast examination before operation. The ultrasound contrast results of 2 groups patients were comparative analyzed. Results In HCC group, the contrast arrival time was (3.8±1.9) s, peak time was (21.8±11.9) s, and peak strength was (28.8 ±3.1) dB; in hepatic FNH group, these indicators was (2.3±1.4) s, (35.3±14.8) s, and (22.3±7.9) dB, respectively. These indicators of HCC group was longer or shorter or higher than those of hepatic FNH group, respectively (P < 0.05). The sensitivity, specificity, and accuracy of ultrasound contrast diagnosed HCC was 91.3% (21/23), 87.0% (20/23), and 95.7% (22/23), and diagnosed hepatic FHN was 87.0% (20/23), 91.3% (21/23), and 91.3% (21/23), respectively, the difference were not statistically significant between the two groups (P > 0.05). Conclusion Ultrasound contrast has very important application value in the differential diagnosis of HCC and hepatic FNH, can be used in clinical application.

Citation： CHENHan-xun, LUMin-yan, SHUQi, FANGJie-ying, QIUYi-de. Value on The Differential Diagnosis of Ultrasound Contrast in Hepatocellular Carcinoma and Hepatic Focal Nodular Hyperplasia. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2015, 22(1): 85-87. doi: 10.7507/1007-9424.20150020 Copy

1.	朱峰, 张火俊.肝局灶性结节性增生与肝细胞癌MRI平扫及强化特征分析.中国医药导报, 2013, 10(30):138-140.
2.	徐莉莉, 盛复庚, 陆虹, 等.钆塞酸二钠在肝脏FNH诊断中的临床价值.医学影像学杂志, 2013, 23(5):715-718.
3.	陈娟, 刘慧, 张秀萍, 等. CT双期增强扫描在肝脏FNH和肝腺瘤中的诊断价值.医学临床研究, 2013, 30(5):902-904.
4.	Yoneda N, Matsui O, Kitao A, et al. Hepatocyte transporter expression in FNH and FNH-like nodule:correlation with signal intensity on gadoxetic acid enhanced magnetic resonance images. Jpn J Radiol, 2012, 30(6):499-508.
5.	Xiong W, Sun LP, Chen XM, et al. Comparison of microRNA expression profiles in HCC-derived microvesicles and the parental cells and evaluation of their roles in HCC. J Huazhong Univ Sci Technolog Med Sci, 2013, 33(3):346-352.
6.	周建华, 韩峰, 李安华, 等.超声造影定量分析动脉相血流灌注参数在肝局灶性结节增生和肝细胞肝癌鉴别诊断中的价值.中华医学超声杂志:电子版, 2009, 6(1):19-21.
7.	颜见, 潘楚芝, 姚志成, 等.肝癌家族史对原发性肝癌患者手术治疗预后的影响.中华普通外科杂志, 2012, 27(10):798-801.
8.	Liu YF, Cao LJ, Hillengass J, et al. Quantitative assessment of microcirculation and diffusion in the bone marrow of osteoporotic rats using VCT, DCE-MRI, DW-MRI, and histology. Acta Radiol, 2013, 54(2):205-213.
9.	魏秀华.肝脏局灶性结节增生(FNH)的影像诊断与鉴别.按摩与康复医学(中旬刊), 2012, 3(3):205.
10.	裴小青, 陈敏山, 刘隆中, 等.肝细胞癌与肝局灶性结节增生的超声造影动态灌注曲线对比分析.中国超声医学杂志, 2010, 26(5):444-448.
11.	刘建民, 杨林, 江山岳, 等.肝细胞癌门静脉癌检弦门静脉海绵样变性饲支循环的影像特征探讨.西部医学, 201l, 23(11):2240-2242.
12.	Qiao Y, Cao H, Zhang S, et al. Sonochemiluminescence observation of lipidand polymer-shelled ultrasound contrast agents in 1.2 MHz focused ultrasound field. Ultrason Sonochem, 2013, 20(1):162-170.
13.	彭成忠, 范小明, 王力.正常直肠腔内灌注超声造影和静脉超声造影表现.临床超声医学杂志, 2014, 16(2):14-16.
14.	贺宇平, 王晋, 田民.肝局灶性结节性增生患者螺旋CT多期增强扫描结果分析(附10例报告).山东医药, 2011, 51(14):38-39.
15.	于丽波.肝局灶性结节性增生与肝细胞癌MRI特征对比分析.中国医学创新, 2013, 10(14):82-83.
16.	张代桥, 明照亭.肝局灶性结节性增生的CT诊断.内蒙古中医药, 2013, 32(14):180.
17.	Quaia E, Calliada F, Bertolotto M, et al. Characterization of focal liver lesions with contrast-specific US modes and a sulfur hexafluoride-filled microbubble contrast agent:diagnostic performance and confidence. Radiology, 2004, 232(2):420-430.
18.	吴薇, 陈敏华, 戴莹, 等.超声造影在肝硬化增生结节病变中的应用.中华超声影像学杂志, 2010, 19(9):776-779.

1. 朱峰, 张火俊.肝局灶性结节性增生与肝细胞癌MRI平扫及强化特征分析.中国医药导报, 2013, 10(30):138-140.
2. 徐莉莉, 盛复庚, 陆虹, 等.钆塞酸二钠在肝脏FNH诊断中的临床价值.医学影像学杂志, 2013, 23(5):715-718.
3. 陈娟, 刘慧, 张秀萍, 等. CT双期增强扫描在肝脏FNH和肝腺瘤中的诊断价值.医学临床研究, 2013, 30(5):902-904.
4. Yoneda N, Matsui O, Kitao A, et al. Hepatocyte transporter expression in FNH and FNH-like nodule:correlation with signal intensity on gadoxetic acid enhanced magnetic resonance images. Jpn J Radiol, 2012, 30(6):499-508.
5. Xiong W, Sun LP, Chen XM, et al. Comparison of microRNA expression profiles in HCC-derived microvesicles and the parental cells and evaluation of their roles in HCC. J Huazhong Univ Sci Technolog Med Sci, 2013, 33(3):346-352.
6. 周建华, 韩峰, 李安华, 等.超声造影定量分析动脉相血流灌注参数在肝局灶性结节增生和肝细胞肝癌鉴别诊断中的价值.中华医学超声杂志:电子版, 2009, 6(1):19-21.
7. 颜见, 潘楚芝, 姚志成, 等.肝癌家族史对原发性肝癌患者手术治疗预后的影响.中华普通外科杂志, 2012, 27(10):798-801.
8. Liu YF, Cao LJ, Hillengass J, et al. Quantitative assessment of microcirculation and diffusion in the bone marrow of osteoporotic rats using VCT, DCE-MRI, DW-MRI, and histology. Acta Radiol, 2013, 54(2):205-213.
9. 魏秀华.肝脏局灶性结节增生(FNH)的影像诊断与鉴别.按摩与康复医学(中旬刊), 2012, 3(3):205.
10. 裴小青, 陈敏山, 刘隆中, 等.肝细胞癌与肝局灶性结节增生的超声造影动态灌注曲线对比分析.中国超声医学杂志, 2010, 26(5):444-448.
11. 刘建民, 杨林, 江山岳, 等.肝细胞癌门静脉癌检弦门静脉海绵样变性饲支循环的影像特征探讨.西部医学, 201l, 23(11):2240-2242.
12. Qiao Y, Cao H, Zhang S, et al. Sonochemiluminescence observation of lipidand polymer-shelled ultrasound contrast agents in 1.2 MHz focused ultrasound field. Ultrason Sonochem, 2013, 20(1):162-170.
13. 彭成忠, 范小明, 王力.正常直肠腔内灌注超声造影和静脉超声造影表现.临床超声医学杂志, 2014, 16(2):14-16.
14. 贺宇平, 王晋, 田民.肝局灶性结节性增生患者螺旋CT多期增强扫描结果分析(附10例报告).山东医药, 2011, 51(14):38-39.
15. 于丽波.肝局灶性结节性增生与肝细胞癌MRI特征对比分析.中国医学创新, 2013, 10(14):82-83.
16. 张代桥, 明照亭.肝局灶性结节性增生的CT诊断.内蒙古中医药, 2013, 32(14):180.
17. Quaia E, Calliada F, Bertolotto M, et al. Characterization of focal liver lesions with contrast-specific US modes and a sulfur hexafluoride-filled microbubble contrast agent:diagnostic performance and confidence. Radiology, 2004, 232(2):420-430.
18. 吴薇, 陈敏华, 戴莹, 等.超声造影在肝硬化增生结节病变中的应用.中华超声影像学杂志, 2010, 19(9):776-779.

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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Value on The Differential Diagnosis of Ultrasound Contrast in Hepatocellular Carcinoma and Hepatic Focal Nodular Hyperplasia

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