Prognosis of Different Treatments for Colorectal Liver Metastases_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 LIZhao ¹ , SUNCheng-bo ¹ , CHENZhi-da ¹ , YAOMeng-jie ¹ ,  DUXiao-hui ^1,2

1. Department of General Surgery, PLA General Hospital, Beijing 100853, China;
2. Department of General Surgery, Hainan Branch of PLA General Hospital, Sanya 572013, Hainan Province, China;

Corresponding author：

DUXiao-hui, Email: duxiaohui301@sina.com

Keywords：

Colorectal liver metastases; Surgery; Relapse-free survival time; Survival time

DOI：

10.7507/1007-9424.20150079

Video：

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Objective To analyze the influence of different surgical methods on survival and relapse-free survival in colorectal liver metastases. Methods Clinical data of 71 cases of colorectal liver metastases who treated in PLA General Hospital from January 2002 to may 2013 were collected retrospectively, to analyzed the effect of different surgical methods on survival and relapse-free survival of this kind of cases. Results All of primary lesions underwent radical resection. And for the liver metastases, 20 cases didn't received any intervention (non-intervention group), 20 cases underwent resection of liver metastases, 20 cases underwent radiofrequency ablation, and 11 cases underwent radiofrequency ablation and resection of liver metastases (all 61 cases who received intervention were classified to intervention group). Results of Cox proportional hazards model showed that, in the condition of controlling other confounding factors, intervention can improve the survival (HR=1.724, P=0.043) and relapse-free survival (HR=0.701, P=0.048) of cases of colorectal liver metastases, cases who received intervention had better survival situation and the relapse-free survival situation. Conclusion For cases of colorectal liver metastases, in condition of radical operation for colorectal cancer, the intervention for liver metastases can prolong the survival time and relapse-free survival time.

Citation： LIZhao, SUNCheng-bo, CHENZhi-da, YAOMeng-jie, DUXiao-hui. Prognosis of Different Treatments for Colorectal Liver Metastases. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2015, 22(3): 293-296. doi: 10.7507/1007-9424.20150079 Copy

1.	de Jong MC, Mayo SC, Pulitano C, et al. Repeat curative intent liver surgery is safe and effective for recurrent colorectal liver metastasis:results from an international multi-institutional analysis. J Gastrointest Surg, 2009, 13(12):2141-2151.
2.	季加孚. 结直肠癌肝转移的治疗策略. 中国实用外科杂志, 2004, 24(7):398-400.
3.	van Gijn W, Marijnen CA, Nagtegaal ID, et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer:12-year follow-up of the multicentre, randomised controlled TME trial. Lancet Oncol, 2011, 12(6):575-582.
4.	Charnley RM. Effect of specialist decision-making on treatment strategies for colorectal liver metastases. Br J Surg, 2012, 99(9):1269-1270.
5.	Pawlik TM, Scoggins CR, Zorzi D, et al. Effect of surgical margin status on survival and site of recurrence after hepatic resection for colorectal metastases. Ann Surg, 2005, 241(5):715-724.
6.	Bentrem DJ, Dematteo RP, Blumgart LH. Surgical therapy for metastatic disease to the liver. Annu Rev Med, 2005, 56:139-156.
7.	王正康. 结肠癌的转移与外科治疗. 中国实用外科杂志, 2002, 22(6):327-329.
8.	Kajiwara Y, Yamasaki F, Hama S, et al. Expression of survivin in astrocytic tumors:correlation with malignant grade and prognosis. Cancer, 2003, 97(4):1077-1083.
9.	王舒宝. 结肠癌术后复发及肝转移的外科治疗. 中国实用外科杂志, 2002, 22(4):207-209.
10.	Neumann J, Reu S, Kirchner T. Prognostic marker profiles for risk of distant metastases in colorectal cancer. Pathologe, 2012, 33(1):39-44.
11.	Niekel MC, Bipat S, Stoker J. Diagnostic imaging of colorectal liver metastases with CT, MR imaging, FDG PET, and/or FDG PET/CT:a meta-analysis of prospective studies including patients who have not previously undergone treatment. Radiology, 2010, 257(3):674-684.
12.	汪晓东, 曹霖, 罗德云, 等. 多学科协作诊治模式下运行结直肠癌综合治疗的临床对照研究. 中国普外基础与临床杂志, 2008, 15(1):63-66.
13.	王锡山. 结直肠癌综合治疗的规范化实施. 中国实用外科杂志, 2010, 30(4):260-264.
14.	崔彦, 王平, 董满库, 等. 经皮射频治疗结直肠癌肝转移31例. 中华普通外科杂志, 2006, 21(1):67-68.
15.	叶颖江, 王杉. 结直肠癌肝转移的现代治疗策略. 中国实用外科杂志, 2009, 29(9):728-732.
16.	吕新生, 邱氟, 詹勇强. 结直肠癌肝转移. 中国普通外科杂志, 2003, 12(11):801-803.
17.	程树群, 周信达. 结直肠癌肝转移外科治疗近况. 国外医学.外科学分册, 1992, (5):282-284.
18.	王学浩, 李相成. 结直肠癌肝转移外科治疗的争议. 中国实用外科杂志, 1999, 19(10):586-587.
19.	王存, 于永扬, 周总光. 腹腔镜下结直肠癌手术(二). 中国普外基础与临床杂志, 2008, 15(5):375-377.
20.	顾晋, 詹天成, 姚云峰. 结直肠癌的新辅助化疗. 中国普外基础与临床杂志, 2007, 14(6):628-629.
21.	叶颖江, 郭鹏. 科学把握结直肠癌肝转移的多学科序贯综合治疗. 中国普外基础与临床杂志, 2011, 18(5):469-472.
22.	钟芸诗, 许剑民, 韦烨, 等. 结直肠癌肝转移的外科手术治疗. 中华肝胆外科杂志, 2007, 13(2):104-107.
23.	许剑民, 钟芸诗, 秦新裕. 同时性结直肠癌肝转移的外科治疗进展. 中华普外科手术学杂志:电子版, 2010, 4(1):10-15.
24.	王剑, 周晔敏, 邵初晓, 等. 腹腔镜和手助腹腔镜结直肠手术18例报告. 中国普外基础与临床杂志, 2004, 11(3):206-207.
25.	齐洪峰, 李世拥, 安萍, 等. 结直肠癌患者血清可溶性E选择素的检测及其临床意义. 解放军医学杂志, 2006, 31(9):858-859.

1. de Jong MC, Mayo SC, Pulitano C, et al. Repeat curative intent liver surgery is safe and effective for recurrent colorectal liver metastasis:results from an international multi-institutional analysis. J Gastrointest Surg, 2009, 13(12):2141-2151.
2. 季加孚. 结直肠癌肝转移的治疗策略. 中国实用外科杂志, 2004, 24(7):398-400.
3. van Gijn W, Marijnen CA, Nagtegaal ID, et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer:12-year follow-up of the multicentre, randomised controlled TME trial. Lancet Oncol, 2011, 12(6):575-582.
4. Charnley RM. Effect of specialist decision-making on treatment strategies for colorectal liver metastases. Br J Surg, 2012, 99(9):1269-1270.
5. Pawlik TM, Scoggins CR, Zorzi D, et al. Effect of surgical margin status on survival and site of recurrence after hepatic resection for colorectal metastases. Ann Surg, 2005, 241(5):715-724.
6. Bentrem DJ, Dematteo RP, Blumgart LH. Surgical therapy for metastatic disease to the liver. Annu Rev Med, 2005, 56:139-156.
7. 王正康. 结肠癌的转移与外科治疗. 中国实用外科杂志, 2002, 22(6):327-329.
8. Kajiwara Y, Yamasaki F, Hama S, et al. Expression of survivin in astrocytic tumors:correlation with malignant grade and prognosis. Cancer, 2003, 97(4):1077-1083.
9. 王舒宝. 结肠癌术后复发及肝转移的外科治疗. 中国实用外科杂志, 2002, 22(4):207-209.
10. Neumann J, Reu S, Kirchner T. Prognostic marker profiles for risk of distant metastases in colorectal cancer. Pathologe, 2012, 33(1):39-44.
11. Niekel MC, Bipat S, Stoker J. Diagnostic imaging of colorectal liver metastases with CT, MR imaging, FDG PET, and/or FDG PET/CT:a meta-analysis of prospective studies including patients who have not previously undergone treatment. Radiology, 2010, 257(3):674-684.
12. 汪晓东, 曹霖, 罗德云, 等. 多学科协作诊治模式下运行结直肠癌综合治疗的临床对照研究. 中国普外基础与临床杂志, 2008, 15(1):63-66.
13. 王锡山. 结直肠癌综合治疗的规范化实施. 中国实用外科杂志, 2010, 30(4):260-264.
14. 崔彦, 王平, 董满库, 等. 经皮射频治疗结直肠癌肝转移31例. 中华普通外科杂志, 2006, 21(1):67-68.
15. 叶颖江, 王杉. 结直肠癌肝转移的现代治疗策略. 中国实用外科杂志, 2009, 29(9):728-732.
16. 吕新生, 邱氟, 詹勇强. 结直肠癌肝转移. 中国普通外科杂志, 2003, 12(11):801-803.
17. 程树群, 周信达. 结直肠癌肝转移外科治疗近况. 国外医学.外科学分册, 1992, (5):282-284.
18. 王学浩, 李相成. 结直肠癌肝转移外科治疗的争议. 中国实用外科杂志, 1999, 19(10):586-587.
19. 王存, 于永扬, 周总光. 腹腔镜下结直肠癌手术(二). 中国普外基础与临床杂志, 2008, 15(5):375-377.
20. 顾晋, 詹天成, 姚云峰. 结直肠癌的新辅助化疗. 中国普外基础与临床杂志, 2007, 14(6):628-629.
21. 叶颖江, 郭鹏. 科学把握结直肠癌肝转移的多学科序贯综合治疗. 中国普外基础与临床杂志, 2011, 18(5):469-472.
22. 钟芸诗, 许剑民, 韦烨, 等. 结直肠癌肝转移的外科手术治疗. 中华肝胆外科杂志, 2007, 13(2):104-107.
23. 许剑民, 钟芸诗, 秦新裕. 同时性结直肠癌肝转移的外科治疗进展. 中华普外科手术学杂志:电子版, 2010, 4(1):10-15.
24. 王剑, 周晔敏, 邵初晓, 等. 腹腔镜和手助腹腔镜结直肠手术18例报告. 中国普外基础与临床杂志, 2004, 11(3):206-207.
25. 齐洪峰, 李世拥, 安萍, 等. 结直肠癌患者血清可溶性E选择素的检测及其临床意义. 解放军医学杂志, 2006, 31(9):858-859.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Prognosis of Different Treatments for Colorectal Liver Metastases

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