• Department of General Surgery, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China;
XUXiu-qin, Email: xuxiuqingg@sina.com
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Objective To summarize the therapeutic targets of pancreatic cancer (PC). Methods The related literatures about the therapeutic targets of PC were reviewed. Results PC was one of the most challenging tumor in worldwide, and was characterized as a highly aggressive disease with poor overall prognosis and a high mortality rate. The hallmark of PC was its poor response to radio-and chemo-therapy. Current chemotherapeutic regimens could not provide substantial survival benefit with a clear increase in overall survival. Recently, several new approaches which could significantly improve the clinical outcome of PC had been described, involving signal-transduction pathways, immune response, stroma reaction, and epigenetic changes. Conclusions Many therapeutic targets are involved in the treatment of PC. As current therapies failed to significantly improve the progression and the survival of PC, new therapeutic approaches and clinical studies are strongly required.

Citation: YUWen, XUEWu-song, MENSi-ye, XUXiu-qin, LIUBao-qing, CHENZi-yan, ANJia-lin, YANGCheng-cheng. Therapeutic Targets of Pancreatic Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2015, 22(3): 369-373. doi: 10.7507/1007-9424.20150099 Copy

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