Effects of Huaier Granule Combined with Systemic Chemotherapy on Immunologic Function and Prognosis for Advanced Breast Cancer Patients_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 LIANGYue-qin ¹ , YINWen-jie ¹ , QIANWen ¹ , WANGHai-li ¹ , MAChi ¹ , DUHong-yu ²

1. Department of Pharmacy, Yan'an Hospital, Kunming 650051, Yunnan Province, China;
2. Department of Oncology, Yan'an Hospital, Kunming 650051, Yunnan Province, China;

Corresponding author：

LIANGYue-qin, Email: lyq201504@126.com

Keywords：

Huaier granule; Systemic chemotherapy; Advanced breast cancer; Immunologic function; Prognosis

DOI：

10.7507/1007-9424.20150386

Video：

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Objective To investigate the effects of Huaier granule combined with systemic chemotherapy on immunologic function and prognosis for advanced breast cancer patients. Methods Ninety-eight cases ofⅣstage breast cancer from March 2006 to March 2009 in this hospital were divided into control group and research group. Only systemic chemotherapy was performed in the control group, while Huaier granule combined with systemic chemotherapy was applied in the research group, and Huaier granule was given on day 1 systemic chemotherapy start. The changes of T lymphocyte subsets and IL-2 level were detected on day 1 before systemic chemotherapy and on month 6 after Huaier granule combined with systemic chemotherapy. The fatality rate and median survival time were also observed between two groups. Results Compared with the control group, the changes of T lymphocyte subsets and IL-2 level had no signi-ficant differences on day 1 before systemic chemotherapy between these two groups(P > 0.05). On month 6 after Huaier granule combined with systemic chemotherapy, the CD₄⁺, CD₄⁺/CD₈⁺ T lymphocyte, and IL-2 level were significantly increased, the CD₈⁺ T lymphocyte was significantly decreased in the research group as compared with the control group〔CD₄⁺:(47.35±6.23)% versus(41.33±5.61)%, P < 0.05; CD₄⁺/CD₈⁺: 1.84±0.42 versus 1.47±0.33, P < 0.05; IL-2 level:(1.78±0.45)μg/L versus(1.58±0.30)μg/L, P < 0.05; CD₈⁺:(23.26±3.25)% versus(29.77±4.12)%, P < 0.05〕. The rate of chemotherapy complications and fatality rate within 3 years were significantly decreased in the research group as compared with the control group〔rate of chemotherapy complications: 58.3%(28/48) versus 86.0%(43/50), P < 0.01; fatality rate within 3 years: 62.5%(30/48)versus 82.0%(41/50), P < 0.05〕. The median survival time in the research group was significantly longer than that in the control group(33.5 months versus 24.5 months, P < 0.01). Conclusions The preliminary results from this study show that Huaier granule combined with systemic chemotherapy could greatly enhance immune function, reduce side-toxicity of chemotherapy and improve prognosis in advanced breast cancer patients. It provides a beneficial exploration for cancer treatment by integration of traditional and western medicine.

Citation： LIANGYue-qin, YINWen-jie, QIANWen, WANGHai-li, MAChi, DUHong-yu. Effects of Huaier Granule Combined with Systemic Chemotherapy on Immunologic Function and Prognosis for Advanced Breast Cancer Patients. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2015, 22(12): 1482-1486. doi: 10.7507/1007-9424.20150386 Copy

1.	Kann S, Schmid SM, Eichholzer M, et al. The impact of overweight and obesity on breast cancer: data from Switzerland, so far a country little affected by the current global obesity epidemic. Gland Surg, 2014, 3(3): 181-197.
2.	Zhang T, Wang K, Zhang J, et al. Huaier aqueous extract inhibits colorectal cancer stem cell growth partially via downregulation of the Wnt/β-catenin pathway. Oncol Lett, 2013, 5(4): 1171-1176.
3.	Sun Y, Sun T, Wang F, et al. A polysaccharide from the fungi of Huaier exhibits anti-tumor potential and immunomodulatory effects. Carbohydr Polym, 2013, 92(1): 577-582.
4.	Abd El-Rahman AA, El-Shafei SM, Ivanova EV, et al. Cytotoxicity of trichoderma spp. cultural filtrate against human cervical and breast cancer cell lines. Asian Pac J Cancer Prev, 2014, 15(17): 7229-7234.
5.	Sternberg CN, Davis ID, Deen KC, et al. An open-label extension study to evaluate safety and efficacy of pazopanib in patients with advanced renal cell carcinoma. Oncology, 2014, 87(6): 342-350.
6.	Koido S, Kinoshita S, Mogami T, et al. Immunological assessment of cryotherapy in breast cancer patients. Anticancer Res, 2014, 34(9): 4869-4876.
7.	Bourdeanu L, Luu T. Targeted therapies in breast cancer: implica-tions for advanced oncology practice. J Adv Pract Oncol, 2014, 5(4): 246-260.
8.	Sardesai SD, Storniolo AM. Lapatinib: an oral dual tyrosine kinase inhibitor for HER-2-positive breast cancer. Womens Health(Lond Engl), 2015, 11(3): 281-294.
9.	Bryantseva ZhV, Kanaev SV, Semiglazov VF, et al. The role of scin-timammography with 99mTs-technetril to predict the pathologic status of regional lymph nodes in patients with locally advanced breast cancer after neoadjuvant chemotherapy. Vopr Onkol, 2015, 61(2): 185-188.
10.	Wu T, Chen W, Liu S, et al. Huaier suppresses proliferation and induces apoptosis in human pulmonary cancer cells via upregulation of miR-26b-5p. FEBS Lett, 2014, 588(12): 2107-2114.
11.	Zhang F, Zhang Z, Liu Z. Effects of huaier aqueous extract on proliferation and apoptosis in the melanoma cell line a875. Acta Histochem, 2013, 115(7): 705-711.
12.	Ortolani S, Ciccarese C, Cingarlini S, et al. Suppression of mTOR pathway in solid tumors: lessons learned from clinical experience in renal cell carcinoma and neuroendocrine tumors and new perspectives. Future Oncol, 2015, 11(12): 1809-1828.
13.	Ogundiran TO, Ayandipo OO, Adedapo KS, et al. Bone scintigraphy in breast cancer patients in ibadan, Nigeria. West Afr J Med, 2015, 33(3): 172-177.
14.	Matveeva OV, Kochneva GV, Netesov SV, et al. Mechanisms of oncolysis by paramyxovirus sendai. Acta Naturae, 2015, 7(2): 6-16.
15.	Munoz M, Recio S, Rosso M, et al. The antiproliferative action of [D-Arg(1), D-Phe(5), D-Trp(7, 9), LEU(11)] substance P analogue antagonist against small-cell-and non-small-cell lung cancer cells could be due to the pharmacological profile of its tachykinin receptor antagonist. J Physiol Pharmacol, 2015, 66(3): 421-426.
16.	Harakeh S, Abou-Khouzam R, Damanhouri GA, et al. Effects of nutrients on matrix metalloproteinases in human T-lymphotropic virus type 1 positive and negative malignant T-lymphocytes. Int J Oncol, 2014, 45(5): 2159-2166.
17.	Lv H, Jiang Y, Liao M, et al. In vitro and in vivo treatments of Echinococcus granulosus with Huaier aqueous extract and alben-dazole liposome. Parasitol Res, 2013, 112(1): 193-198.
18.	Wang X, Zhang N, Huo Q, et al. Huaier aqueous extract suppresses human breast cancer cell proliferation through inhibition of estrogen receptorαsignaling. Int J Oncol, 2013, 43(1): 321-328.
19.	Witkowska A, Zywiec J, Strozik A, et al. Interleukin 2 as a potential cancer marker in patients after kidney transplantation. Ann Agric Environ Med, 2015, 22(2): 320-324.
20.	Saxena R, Kaur J. Th1/Th2 cytokines and their genotypes as predictors of hepatitis B virus related hepatocellular carcinoma. World J Hepatol, 2015, 7(11): 1572-1580.
21.	Demir T, Ozel L, Gökçe AM, et al. Cancer screening of renal transplant patients undergoing long-term immunosuppressive therapy. Transplant Proc, 2015, 47(5): 1413-1417.
22.	Zgheib P, Daher CF, Mroueh M, et al. Daucus carota pentane/diethyl ether fraction inhibits motility and reduces invasion of cancer cells. Chemotherapy, 2015, 60(5): 302-309.
23.	Cunha SI, Bocci M, Lövrot J, et al. Endothelial ALK1 is a therapeutic target to block metastatic dissemination of breast cancer. Cancer Res, 2015, 75(12): 2445-2456.
24.	De Luca A, D'alessio A, Maiello MR, et al. Evaluation of the pharmacokinetics of ixabepilone for the treatment of breast cancer. Expert Opin Drug Metab Toxicol, 2015, 11(7): 1177-1185.
25.	Chen BQ, Parmar MP, Gartshore K. Supporting women with advanced breast cancer: the impact of altered functional status on their social roles. Can Oncol Nurs J, 2014, 24(3): 194-203.

1. Kann S, Schmid SM, Eichholzer M, et al. The impact of overweight and obesity on breast cancer: data from Switzerland, so far a country little affected by the current global obesity epidemic. Gland Surg, 2014, 3(3): 181-197.
2. Zhang T, Wang K, Zhang J, et al. Huaier aqueous extract inhibits colorectal cancer stem cell growth partially via downregulation of the Wnt/β-catenin pathway. Oncol Lett, 2013, 5(4): 1171-1176.
3. Sun Y, Sun T, Wang F, et al. A polysaccharide from the fungi of Huaier exhibits anti-tumor potential and immunomodulatory effects. Carbohydr Polym, 2013, 92(1): 577-582.
4. Abd El-Rahman AA, El-Shafei SM, Ivanova EV, et al. Cytotoxicity of trichoderma spp. cultural filtrate against human cervical and breast cancer cell lines. Asian Pac J Cancer Prev, 2014, 15(17): 7229-7234.
5. Sternberg CN, Davis ID, Deen KC, et al. An open-label extension study to evaluate safety and efficacy of pazopanib in patients with advanced renal cell carcinoma. Oncology, 2014, 87(6): 342-350.
6. Koido S, Kinoshita S, Mogami T, et al. Immunological assessment of cryotherapy in breast cancer patients. Anticancer Res, 2014, 34(9): 4869-4876.
7. Bourdeanu L, Luu T. Targeted therapies in breast cancer: implica-tions for advanced oncology practice. J Adv Pract Oncol, 2014, 5(4): 246-260.
8. Sardesai SD, Storniolo AM. Lapatinib: an oral dual tyrosine kinase inhibitor for HER-2-positive breast cancer. Womens Health(Lond Engl), 2015, 11(3): 281-294.
9. Bryantseva ZhV, Kanaev SV, Semiglazov VF, et al. The role of scin-timammography with 99mTs-technetril to predict the pathologic status of regional lymph nodes in patients with locally advanced breast cancer after neoadjuvant chemotherapy. Vopr Onkol, 2015, 61(2): 185-188.
10. Wu T, Chen W, Liu S, et al. Huaier suppresses proliferation and induces apoptosis in human pulmonary cancer cells via upregulation of miR-26b-5p. FEBS Lett, 2014, 588(12): 2107-2114.
11. Zhang F, Zhang Z, Liu Z. Effects of huaier aqueous extract on proliferation and apoptosis in the melanoma cell line a875. Acta Histochem, 2013, 115(7): 705-711.
12. Ortolani S, Ciccarese C, Cingarlini S, et al. Suppression of mTOR pathway in solid tumors: lessons learned from clinical experience in renal cell carcinoma and neuroendocrine tumors and new perspectives. Future Oncol, 2015, 11(12): 1809-1828.
13. Ogundiran TO, Ayandipo OO, Adedapo KS, et al. Bone scintigraphy in breast cancer patients in ibadan, Nigeria. West Afr J Med, 2015, 33(3): 172-177.
14. Matveeva OV, Kochneva GV, Netesov SV, et al. Mechanisms of oncolysis by paramyxovirus sendai. Acta Naturae, 2015, 7(2): 6-16.
15. Munoz M, Recio S, Rosso M, et al. The antiproliferative action of [D-Arg(1), D-Phe(5), D-Trp(7, 9), LEU(11)] substance P analogue antagonist against small-cell-and non-small-cell lung cancer cells could be due to the pharmacological profile of its tachykinin receptor antagonist. J Physiol Pharmacol, 2015, 66(3): 421-426.
16. Harakeh S, Abou-Khouzam R, Damanhouri GA, et al. Effects of nutrients on matrix metalloproteinases in human T-lymphotropic virus type 1 positive and negative malignant T-lymphocytes. Int J Oncol, 2014, 45(5): 2159-2166.
17. Lv H, Jiang Y, Liao M, et al. In vitro and in vivo treatments of Echinococcus granulosus with Huaier aqueous extract and alben-dazole liposome. Parasitol Res, 2013, 112(1): 193-198.
18. Wang X, Zhang N, Huo Q, et al. Huaier aqueous extract suppresses human breast cancer cell proliferation through inhibition of estrogen receptorαsignaling. Int J Oncol, 2013, 43(1): 321-328.
19. Witkowska A, Zywiec J, Strozik A, et al. Interleukin 2 as a potential cancer marker in patients after kidney transplantation. Ann Agric Environ Med, 2015, 22(2): 320-324.
20. Saxena R, Kaur J. Th1/Th2 cytokines and their genotypes as predictors of hepatitis B virus related hepatocellular carcinoma. World J Hepatol, 2015, 7(11): 1572-1580.
21. Demir T, Ozel L, Gökçe AM, et al. Cancer screening of renal transplant patients undergoing long-term immunosuppressive therapy. Transplant Proc, 2015, 47(5): 1413-1417.
22. Zgheib P, Daher CF, Mroueh M, et al. Daucus carota pentane/diethyl ether fraction inhibits motility and reduces invasion of cancer cells. Chemotherapy, 2015, 60(5): 302-309.
23. Cunha SI, Bocci M, Lövrot J, et al. Endothelial ALK1 is a therapeutic target to block metastatic dissemination of breast cancer. Cancer Res, 2015, 75(12): 2445-2456.
24. De Luca A, D'alessio A, Maiello MR, et al. Evaluation of the pharmacokinetics of ixabepilone for the treatment of breast cancer. Expert Opin Drug Metab Toxicol, 2015, 11(7): 1177-1185.
25. Chen BQ, Parmar MP, Gartshore K. Supporting women with advanced breast cancer: the impact of altered functional status on their social roles. Can Oncol Nurs J, 2014, 24(3): 194-203.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Effects of Huaier Granule Combined with Systemic Chemotherapy on Immunologic Function and Prognosis for Advanced Breast Cancer Patients

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