Experimental Study on Inhibiting Effect of Coix Seed Extract on IL-6 of C57 Mice Hepatoma Model_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 SHENFeng , SUNShao-hua , WUHong-wei , HUHong-sheng , ZHOUWen-bo ,  WANGFei

Department of Hepatobiliary Surgery, Affliated Dongfeng Hospital, Hubei University of Medicine, Shiyan 442000, Hubei Province, China;

Corresponding author：

WANGFei, Email: sywuhongwei@126.com

Keywords：

Coix seed extract; C57 mice; Hepatocellular carcinoma; Interleukin-6

DOI：

10.7507/1007-9424.20160010

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To discuss the effects of coix seed extract injection on rate of tumor of C57 mice liver cancer model, tumor size, and serum IL-6. Methods Using chemical carcinogens diethyl nitrosamine (DEN) to establish the mice model of liver cancer, liver cancer mouse model to coix seed extract was given observation of C57 mice liver cancer model come tumor formation rate, tumor growth, and the change of serum IL-6. Results C57 mice after intraperitoneal injection of coix seed extract injection model of liver cancer tumor rate (55.6%) significantly lower than the DEN group (87.5%), P < 0.01; tumor diameter[(0.3±0.05) cm] was lower than that in group DEN[(0.8±0.06) cm], P < 0.01. The serum level of IL-6 in C57 mice after treated with coix seed extract significantly lower than that in group DEN (P < 0.01). Conclusion Coix seed extract can effectively inhibit the tumor rate and the growth of tumor in hepatocellular carcinoma model of C57 mice, and decrease the level of serum IL-6.

Citation： SHENFeng, SUNShao-hua, WUHong-wei, HUHong-sheng, ZHOUWen-bo, WANGFei. Experimental Study on Inhibiting Effect of Coix Seed Extract on IL-6 of C57 Mice Hepatoma Model. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(1): 38-41. doi: 10.7507/1007-9424.20160010 Copy

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15.	姚庆华, 郭勇.薏苡仁甘油三醋康莱特治疗晚期恶性肿瘤患者机制研究进展.中国肿瘤临床, 2012, 39(16):1151-1154.
16.	甘霖, 于镜泊, 张海青, 等.康莱特注射液在乳腺癌新辅助化疗中的作用.肿瘤, 2009, 29(3):283-285.
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21.	Olivier S, Robe P, Bours V. Can NF-kappaB be a target for novel and efficient anti-cancer agents. Biochem Pharmacol, 2006, 72(9):1054-1068.
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1. Ferlay J, Shin HR, Bray F, et al. Estimates of worldwide burden of cancer in 2008:GLOBOCAN 2008. Int J Cancer, 2010, 127(12):2893-2917.
2. Candido J, Hagemann T. Cancer-related inflammation. J Clin Immunol, 2013, 33 Suppl 1:S79-S84.
3. Liu Y, Gao SJ, Du BX, et al. Association of IL-6 polymorphisms with hepatocellular carcinoma risk:evidences from a meta-analysis. Tumour Biol, 2014, 35(4):3551-3561.
4. Taniguchi K, Karin M. IL-6 and related cytokines as the critical lynchpins between inflammation and cancer. Semin Immunol, 2014, 26(1):54-74.
5. 姚小健.替吉奥联合康莱特注射液治疗老年晚期胰腺癌临床观察.肿瘤基础与临床, 2015, 28(4):350-352.
6. 史恩红, 徐梦, 王娜, 等.康莱特注射液对改善癌症晚期患者生存质量的临床观察.中国实用医药, 2015, 10(6):52-54.
7. Sansone P, Bromberg J. Environment inflammation and cancer. Curr Opin Genet Dev, 2011, 21(1):80-85.
8. Balkwill F, Mantovani A. Inflammation and cancer:back to Virchow? Lancet, 2001, 357(9255):539-545.
9. Karin M, Greten FR. NF-κB:linking inflammation and immunity to cancer development and progression. Nat Rev Immunol, 2005, 5(10):749-759.
10. 刘徽, 朱波, 林治华. IL-6信号通路与肿瘤.细胞与分子免疫学杂志, 2011, 27(3):353-355.
11. 万凌峰, 赵红兵, 薛博瑜.慢性肝脏炎症与肝癌关系的研究进展.世界华人消化杂志, 2014, 22(31):4757-4761.
12. Berasain C, Castillo J, Perugorria MJ, et al. Inflammation and liver cancer:new molecular links. Ann N Y Acad Sci, 2009, 1155:206-221.
13. Grzesiak JJ, Smith KC, Chalberg C, et al. TypeⅠcollagen and divalent cation shifts disrupt cell-cell adhesion, increase migration, and decrease PTHrP, IL-6, and IL-8 expression in pancreatic cancer cells. Int J Gastrointest Cancer, 2005, 36(3):131-146.
14. Su YW, Xie TX, Sano D, et al. IL-6 stabilizes Twist and enhances tumor cell motility in head and neck cancer cells through activation of casein kinase. PLoS One, 2011, 6(4):194-196.
15. 姚庆华, 郭勇.薏苡仁甘油三醋康莱特治疗晚期恶性肿瘤患者机制研究进展.中国肿瘤临床, 2012, 39(16):1151-1154.
16. 甘霖, 于镜泊, 张海青, 等.康莱特注射液在乳腺癌新辅助化疗中的作用.肿瘤, 2009, 29(3):283-285.
17. Naugler WE, Sakurai T, Kim S, et al. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science, 2007, 317(5834):121-124.
18. Grivennikov SI, Greten FR, Karin M. Immunity inflammation and cancer. Cell, 2010, 140(6):883-899.
19. Serova M, Ghoul A, Benhadji KA, et al. Preclinical and clinical development of novel agents that target the protein kinase C family. Semin Oncol, 2006, 33(4):466-478.
20. Calzado MA, Bacher S, Schmitz ML. NF-kappaB inhibitors for the treatment of inflammatory diseases and cancer. Curr Med Chem, 2007, 14(3):367-376.
21. Olivier S, Robe P, Bours V. Can NF-kappaB be a target for novel and efficient anti-cancer agents. Biochem Pharmacol, 2006, 72(9):1054-1068.
22. Kim YJ, Kim HC, Ko H, et al. Stercurensin inhibits nuclear factorka-ppaB-dependent inflammatory signals through attenuation of TAK1-TAB1 complex formation. J Cell Biochem, 2011, 112(2):548-558.
23. Mantovani A, Allavena P, Sica A, et al. Cancer-related inflamma-tion. Nature, 2008, 454(7203):436-444.

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Experimental Study on Inhibiting Effect of Coix Seed Extract on IL-6 of C57 Mice Hepatoma Model

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