The Role of Somatostatin in Gastrointestinal Function after Operation for Treatment of Abdominal Injury_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 LIPei-wu , WANGXian-kun , FUXu , WANGBin-jun , YANBo , CUIHong-bing , BAITian-shuo

The Trauma Surgery of Emergency Center, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China;

Corresponding author：

LIPei-wu, Email: wuzi360@126.com

Keywords：

Somatostatin; Abdominal injury; Gastrointestinal function

DOI：

10.7507/1007-9424.20160015

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To investigate the role of somatostatin in gastrointestinal function after operation for treatment of abdominal injury patients. Methods Sixty patients with abdominal trauma were divided into somatostatin in treatment group (n=30) and the conventional treatment control group (n=30). The amount of gastrointestinal decompression drainage, bowel sounds recovery time, exhaust time, defecation time, and the levels of serum C reactive protein, TNF-α, IL-6, and IL-8 after operation in two groups were observed. Results Somatostatin treatment group recovery time of bowel sounds, exhaust time, and defecation time were earlier than the control group, hospitalization time shortened, and the amount of gastrointestinal decompression drainage reduced (P < 0.05), The levels of serum C reactive protein, TNF-α, IL-6 and IL-8 of somatostatin treatment group were lower than those in control group (P < 0.05), and the magnitude of decline above index in the somatostatin treatment group were greater than that in the control group (P < 0.05). Conclusion Somatostatin can promote the recovery of gastrointestinal function in patients after operation in abdominal injury.

Citation： LIPei-wu, WANGXian-kun, FUXu, WANGBin-jun, YANBo, CUIHong-bing, BAITian-shuo. The Role of Somatostatin in Gastrointestinal Function after Operation for Treatment of Abdominal Injury. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(1): 56-59. doi: 10.7507/1007-9424.20160015 Copy

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3.	Yuan W, Yu X, Liu F, et al. Effects of trac element supplementation on the inflammatory response in a rabbit model of major trauma. J Trace Elem Med Biol, 2010, 24(1):36-41.
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5.	Watt DG, Horgan PG, McMillan DC. Routine clinical markers of the magnitude of the systemic inflammatory response after elective operation:a systematic review. Surgery, 2015, 157(2):362-380.
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9.	Tostivint H, Ocampo Daza D, Bergqvist CA, et al. Molecular evolution of GPCRs:Somatostatin/urotensinⅡreceptors. J Mol Endocrinol, 2014, 52(3):T61-86.
10.	Abdel-Rahman O, Lamarca A, Valle JW, et al. Somatostatin receptor expression in hepatocellular carcinoma:prognostic and therapeutic considerations. Endocr Relat Cancer, 2014, 21(6):R485-R493.
11.	郭景财, 张爱军, 郑向红, 等.腹部手术后肠蠕动功能变化的实验性研究.中国误诊学杂志, 2007, 7(13):2946-2948.
12.	Kirchhoff C, Biberthaler P, Mutschler WE, et al. Early down-regulation of the pro-inflammatory potential of monocytes is correlated to organ dysfunction in patients after severe multiple injury:a cohort study. Crit Care, 2009, 13(3):R88.
13.	Schroeder JE, Weiss YG, Mosheiff R. The current state in the evalua-tion and treatment of ARDS and SIRS. Injury, 2009, 40(Suppl 4):S82-S89.
14.	Dimopoulou I, Orfanos S, Kotanidou A, et al. Plasma pro-and anti-inflammatory cytokine levels and outcome prediction in unselected critically ill patients. Cytokine, 2008, 41(3):263-267.
15.	冯德元, 刘江伟, 吕月涛, 等. TNF-α和IL-6在腹部肠管火器伤后血清中的变化.临床军医杂志, 2009, 37(2):168-170.
16.	Buttenschoen K, Fathimani K, Buttenschoen DC. Effect of major abdominal surgery on the host immune response to infection. Curr Opin Infect Dis, 2010, 23(3):259-267.
17.	李之拓, 杜建波, 韩冰, 等.生长抑素联合抗生素对急性胆囊炎家兔血清肿瘤坏死因子-α和C反应蛋白的影响.中国普外基础与临床杂志, 2011, 18(8):835-839.
18.	Karnes JM, Daffner SD, Watkins CM. Multiple roles of tumor necrosis factor-alpha in fracture healing. Bone, 2015, 78:87-93.
19.	Giannoudis PV, Hildebrand F, Pape HC. Inflammatory serum markers in patients with multiple trauma. Can they predict outcome? J Bone Joint Surg Br, 2004, 86(3):313-323.
20.	Ozturk H, Yagmur Y, Ozturk H. The prognostic importance of serum IL-1β, IL-6, IL-8 and TNF-αlevels compared to trauma scoring systems for early mortality in children with blunt trauma. Pediatr Surg Int, 2008, 24(2):235-239.
21.	朱红, 郭永章, 杨鸿炜, 等.血管生长抑素基因联合生长抑素治疗人胰腺癌的体外研究.中国普外基础与临床杂志, 2009, 16(6):460-465.
22.	杨泽权. C反应蛋白水平对判断炎症和创伤及心肌梗死转归的临床价值.国际检验医学杂志, 2013, 34(7):880-881.
23.	黄津, 白雪, 张凯, 等.白细胞计数和C-反应蛋白对创伤患者细菌感染的诊断价值.郑州大学学报:医学版, 2011, 46(5):800-801.
24.	Mosli MH, Zou G, Garg SK et al. C-Reactive protein, fecal calpro-tectin, and stool lactoferrin for detection of endoscopic activity in symptomatic inflammatory bowel disease patients:a systematic review and meta-analysis. Am J Gastroenterol, 2015, 110(6):802-819.
25.	Stone PA, Kazil J. The relationships between serum C-reactive protein level and risk and progression of coronary and carotid atherosclerosis. Semin Vasc Surg, 2014, 27(3-4):138-142.

1. 黄小兰, 陈仿, 代喆, 等. 2200例腹部创伤住院患者流行病学分析.四川医学, 2012, 33(8):1471-1473.
2. Murphy KP, Maher MM, O'Connor OJ. Abdominal ablation techniques. Am J Roentgenol, 2015, 204(5):W495-W502.
3. Yuan W, Yu X, Liu F, et al. Effects of trac element supplementation on the inflammatory response in a rabbit model of major trauma. J Trace Elem Med Biol, 2010, 24(1):36-41.
4. Barbić J, Ivić D, Alkhamis T, et al. Kinetics of changes in serum concentrations of procalcitonin, interleukin-6, and C-reactive protein after elective abdominal surgery. Can it be used to detect postoperative complications? Coll Antropol, 2013, 37(1):195-203.
5. Watt DG, Horgan PG, McMillan DC. Routine clinical markers of the magnitude of the systemic inflammatory response after elective operation:a systematic review. Surgery, 2015, 157(2):362-380.
6. Shirah GR, O'Neill PJ. Intra-abdominal Infections. Surg Clin North Am, 2014, 94(6):1319-1333.
7. Wehner S, Vilz TO, Stoffels B, et al. Immune mediators of posto-perative ileus. Langenbecks Arch Surg, 2012, 397(4):591-601.
8. Rai U, Thrimawithana TR, Valery C, et al. Therapeutic uses of somatostatin and its analogues:Current view and potential applica-tions. Pharmacol Ther, 2015, 152:98-110.
9. Tostivint H, Ocampo Daza D, Bergqvist CA, et al. Molecular evolution of GPCRs:Somatostatin/urotensinⅡreceptors. J Mol Endocrinol, 2014, 52(3):T61-86.
10. Abdel-Rahman O, Lamarca A, Valle JW, et al. Somatostatin receptor expression in hepatocellular carcinoma:prognostic and therapeutic considerations. Endocr Relat Cancer, 2014, 21(6):R485-R493.
11. 郭景财, 张爱军, 郑向红, 等.腹部手术后肠蠕动功能变化的实验性研究.中国误诊学杂志, 2007, 7(13):2946-2948.
12. Kirchhoff C, Biberthaler P, Mutschler WE, et al. Early down-regulation of the pro-inflammatory potential of monocytes is correlated to organ dysfunction in patients after severe multiple injury:a cohort study. Crit Care, 2009, 13(3):R88.
13. Schroeder JE, Weiss YG, Mosheiff R. The current state in the evalua-tion and treatment of ARDS and SIRS. Injury, 2009, 40(Suppl 4):S82-S89.
14. Dimopoulou I, Orfanos S, Kotanidou A, et al. Plasma pro-and anti-inflammatory cytokine levels and outcome prediction in unselected critically ill patients. Cytokine, 2008, 41(3):263-267.
15. 冯德元, 刘江伟, 吕月涛, 等. TNF-α和IL-6在腹部肠管火器伤后血清中的变化.临床军医杂志, 2009, 37(2):168-170.
16. Buttenschoen K, Fathimani K, Buttenschoen DC. Effect of major abdominal surgery on the host immune response to infection. Curr Opin Infect Dis, 2010, 23(3):259-267.
17. 李之拓, 杜建波, 韩冰, 等.生长抑素联合抗生素对急性胆囊炎家兔血清肿瘤坏死因子-α和C反应蛋白的影响.中国普外基础与临床杂志, 2011, 18(8):835-839.
18. Karnes JM, Daffner SD, Watkins CM. Multiple roles of tumor necrosis factor-alpha in fracture healing. Bone, 2015, 78:87-93.
19. Giannoudis PV, Hildebrand F, Pape HC. Inflammatory serum markers in patients with multiple trauma. Can they predict outcome? J Bone Joint Surg Br, 2004, 86(3):313-323.
20. Ozturk H, Yagmur Y, Ozturk H. The prognostic importance of serum IL-1β, IL-6, IL-8 and TNF-αlevels compared to trauma scoring systems for early mortality in children with blunt trauma. Pediatr Surg Int, 2008, 24(2):235-239.
21. 朱红, 郭永章, 杨鸿炜, 等.血管生长抑素基因联合生长抑素治疗人胰腺癌的体外研究.中国普外基础与临床杂志, 2009, 16(6):460-465.
22. 杨泽权. C反应蛋白水平对判断炎症和创伤及心肌梗死转归的临床价值.国际检验医学杂志, 2013, 34(7):880-881.
23. 黄津, 白雪, 张凯, 等.白细胞计数和C-反应蛋白对创伤患者细菌感染的诊断价值.郑州大学学报:医学版, 2011, 46(5):800-801.
24. Mosli MH, Zou G, Garg SK et al. C-Reactive protein, fecal calpro-tectin, and stool lactoferrin for detection of endoscopic activity in symptomatic inflammatory bowel disease patients:a systematic review and meta-analysis. Am J Gastroenterol, 2015, 110(6):802-819.
25. Stone PA, Kazil J. The relationships between serum C-reactive protein level and risk and progression of coronary and carotid atherosclerosis. Semin Vasc Surg, 2014, 27(3-4):138-142.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

The Role of Somatostatin in Gastrointestinal Function after Operation for Treatment of Abdominal Injury

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