A New and Minimally Invasive Ablation Technology for Tumors——Irreversible Electro-poration_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 LAILong-xiang ^1,2 , SUJuan ² , CHENJun-zhou ¹ , LUHao ^1,2 ,  ZHOUNing-xin ¹

1. Department of Hepatobiliary, The Rockets Army General Hospital of PLA, Beijing 100088, China;
2. Department of Hepatobiliary, The Rockets Army General Hospital of PLA, The Affiliated Hospital, Soochow University, Suzhou 215006, Jiangsu Province, China;

Corresponding author：

ZHOUNing-xin, Email: zhounx301@163.com

Keywords：

Irreversible electroporation; Tumor; Ablation

DOI：

10.7507/1007-9424.20160096

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To summary the clinical application of a new and minimally invasive ablation technology for tumors—irreversible electroporation. Methods Related domestic and foreign literatures were reviewed. Results Compared with traditional ablation technology, irreversible electroporation had advantages of complete ablation with well-demarcated margin, preservation of vital structures, avoidance of heat/cold-sink effect, and short ablation time. Irreversible electroporation may play an import role in patients who couldn't tolerate surgery in reason of combining with other disease, who were not suitable for surgery due to late tumors, and who had solid tumors of less than 3 cm in diameter. Conclusion As a new and minimally invasive ablation technology for tumors, irreversible electroporation has high safety and efficacy.

Citation： LAILong-xiang, SUJuan, CHENJun-zhou, LUHao, ZHOUNing-xin. A New and Minimally Invasive Ablation Technology for Tumors——Irreversible Electro-poration. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(3): 365-368. doi: 10.7507/1007-9424.20160096 Copy

1.	Rubinsky B, Onik G, Mikus P. Irreversible electroporation: a new ablation modality-clinical implications. Technol Cancer Res Treat, 2007, 6(1): 37-48.
2.	Davalos RV, Mir IL, Rubunsky B. Tissue ablation with irreversible electroporation. Ann Biomed Eng, 2005, 33(2): 223-231.
3.	Al-Sakere B, Bernat C, Andre F, et al. A study of the immunological response to tumor ablation with irreversible electroporation. Technol Cancer Res Treat, 2007, 6(4):301-306.
4.	Neal RE 2nd, Davalos RV. The feasibility of irreversible electropora-tion for the treatment of breast cancer and other heterogeneous systems. Ann Biomed Eng, 2009, 37(12): 2615-2625.
5.	Xiao D, Yao C, Liu H, et al. Irreversible electroporation and apop-tosis in human liver cancer cells induced by nanosecond electric pulses. Bioelectromagnetics, 2013, 34(7): 512-520.
6.	Edd JF, Horowitz L, Davalos RV, et al. In vivo results of a new focal tissue ablation technique: irreversible electroporation. IEEE Trans Biomed Eng, 2006, 53(7):1409-1415.
7.	Arena CB, Sano MB, Rossmeisl JH Jr, et al. High-frequency irreversible electroporation (H-FIRE) for non-thermal ablation without muscle contraction. Biomed Eng Online, 2011, 10: 102.
8.	Adeyanju OO, Al-Angari HM, Sahakian AV. The optimization of needle electrode number and placement for irreversible electropora-tion of hepatocellular carcinoma. Radiol Oncol, 2012, 46(2):126-135.
9.	Maor E, Ivorra A, Leor J, et al. The effect of irreversible electropora-tion on blood vessels. Technol Cancer Res Treat, 2007, 6(4): 307-312.
10.	Ball C, Thomson KR, Kavnoudias H. Irreversible electroporation: a new challenge in ‘out of operating theater' anesthesia. Anesth Analg, 2010, 110(5): 1305-1309.
11.	Lee EW, Chen C, Prieto VE, et al. Advanced hepatic ablation techn-ique for creating complete cell death: irreversible electroporation. Radiology, 2010, 255(2): 426-433.
12.	Appelbaum L, Ben-David E, Sosna J, et al. US findings after irrever-sible electroporation ablation: radiologic-pathologic correlation. Radiology, 2012, 262(1):117-125.
13.	Liu Y, Xiong Z, Zhou W, et al. Percutaneous ultrasound-guided irreversible electroporation: a goat liver study. Oncol Lett, 2012, 4(3): 450-454.
14.	Schmidt CR, Shires P, Mootoo M. Real-time ultrasound imaging of irreversible electroporation in a porcine liver model adequately characterizes the zone of cellular necrosis. HPB(Oxford), 2012, 14(2): 98-102.
15.	Zhang Y, White SB, Nicolai JR, et al. Multimodality imaging to assess immediate response to irreversible electroporation in a rat liver tumor model. Radiology, 2014, 271(3): 721-729.
16.	Hjouj M, Lavee J, Last D, et al. The effect of blood flow on magnetic resonance imaging of non thermal irreversible electroporation. Sci Rep, 2013, 3: 3088.
17.	Narayanan G. Irreversible electroporation for treatment of liver cancer. Gastroenterol Hepatol (N Y), 2011, 7(5): 313-316.
18.	Tarek M. Membrane electroporation: a molecular dynamics simulation. Biophys J, 2006, 88(6): 4045-4053.
19.	Lee EW, Loh CT, Kee ST. Imaging guided percutaneous irreversible electroporation: ultrasound and immunohistological correlation. Technol Cancer Res Treat, 2007, 6(4): 287-294.
20.	Al-Sakere B, André F, Bernat C, et al. Tumor ablation with irrever-sible electroporation. PLoS One, 2007, 2(11): e1135.
21.	Onik G, Mikus P, Rubinsky B. Irreversible electroporation: implica-tions for prostate ablation. Technol Cancer Res Treat, 2007, 6(4): 295-300.
22.	Guo Y, Zhang Y, Klein R, et al. Irreversible electroporation therapyin the liver: longitudinal efficacy studies in a rat model of hepatoce-llular carcinoma. Cancer Res, 2010, 70(4): 1555-1563.
23.	刘颖, 周玮, 熊正爱, 等. 不可逆性电穿孔致山羊肝脏组织凋亡与坏死的实验研究. 解放军医学杂志, 2011, 36(4): 356-360.
24.	周玮, 熊正爱, 刘颖, 等. 不可逆性电穿孔致HeLa细胞凋亡与坏死的作用研究. 第三军医大学学报, 2010, 32(18): 1941-1944.
25.	杨晓燕, 熊正爱, 李成祥, 等. 陡脉冲不可逆性电击穿治疗兔肝脏肿瘤的研究. 西南大学学报: 自然科学版, 2009, 31(4): 120-145.
26.	中国科技网. 香港中文大学以“纳米刀”消灭肿瘤亚洲首例. 黑龙江科技信息, 2014, (1): Ⅳ.
27.	徐克成. 肿瘤消融新技术: 肿瘤消融新技术不可逆性电穿孔. 上海: 上海科学技术文献出版社, 2014.
28.	高杰,朱继业. 卫生部《原发性肝癌诊疗规范（2011年版）》解读. 中华普通外科杂志, 2012, 27(8): 693-695.
29.	Cheung W, Kavnoudias H, Roberts S, et al. Irreversible electropora-tion for unresectable hepatocellular carcinoma: initial experience and review of safety and outcomes. Technol Cancer Res Treat, 2013, 12(3): 233-241.
30.	Thomson K, Kee ST. Clinical research on irreversible electroporation of the liver. Clinical Aspects of Electroporation, 2011: 237-246.
31.	Narayanan G, Hosein PJ, Arora G, et al. Percutaneous irreversible electroporation for downstaging and control of unresectable pancreatic adenocarcinoma. J Vasc Interv Radiol, 2012, 23(12): 1613-1621.
32.	Martin RC 2nd, McFarland K, Ellis S, et al. Irreversible electropora-tion therapy in the managememt of locally advanced pancreatic adenocarcinoma. J Am Coll Surg, 2012, 215(3): 361-369.
33.	Forest V, Peoćh M, Campos L, et al. Effects of cryotherapy or chemotherapy on apoptosis in a non-small-cell lung cancer xenog-rafted into SCID mice. Cryobiology, 2005, 50(1): 29-37.
34.	Onik G, Rubinsky B. Irreversible electroporation: first patient experience focal therapy of prostate cancer. Series in Biomedical Engineering, 2010: 235-247.
35.	Lee EW, Wong D, Kee ST. Irreversible electroporation (IRE) on liver tumor ablation: a summary of preclinical translational research.New York: Springer, 2011: 219-230.
36.	Lee EW, Thai S, Kee ST. Irreversible electroporation: a novel image-guided cancer therapy. Gut Liver, 2010, 4 Suppl 1: S99-S104.
37.	Philips P, Hays D, Martin RC. Irreversible electroporation ablation (IRE) of unresectable soft tissue tumors: learning curve evaluation in the first 150 patients treated. PLoS One, 2013, 8(11): e76260.
38.	Thomson KR, Cheung W, Ellis SJ, et al. Investigation of the safety of irreversible electroporation in humans. J Vasc Interv Radiol, 2011, 22(5): 611-621.

1. Rubinsky B, Onik G, Mikus P. Irreversible electroporation: a new ablation modality-clinical implications. Technol Cancer Res Treat, 2007, 6(1): 37-48.
2. Davalos RV, Mir IL, Rubunsky B. Tissue ablation with irreversible electroporation. Ann Biomed Eng, 2005, 33(2): 223-231.
3. Al-Sakere B, Bernat C, Andre F, et al. A study of the immunological response to tumor ablation with irreversible electroporation. Technol Cancer Res Treat, 2007, 6(4):301-306.
4. Neal RE 2nd, Davalos RV. The feasibility of irreversible electropora-tion for the treatment of breast cancer and other heterogeneous systems. Ann Biomed Eng, 2009, 37(12): 2615-2625.
5. Xiao D, Yao C, Liu H, et al. Irreversible electroporation and apop-tosis in human liver cancer cells induced by nanosecond electric pulses. Bioelectromagnetics, 2013, 34(7): 512-520.
6. Edd JF, Horowitz L, Davalos RV, et al. In vivo results of a new focal tissue ablation technique: irreversible electroporation. IEEE Trans Biomed Eng, 2006, 53(7):1409-1415.
7. Arena CB, Sano MB, Rossmeisl JH Jr, et al. High-frequency irreversible electroporation (H-FIRE) for non-thermal ablation without muscle contraction. Biomed Eng Online, 2011, 10: 102.
8. Adeyanju OO, Al-Angari HM, Sahakian AV. The optimization of needle electrode number and placement for irreversible electropora-tion of hepatocellular carcinoma. Radiol Oncol, 2012, 46(2):126-135.
9. Maor E, Ivorra A, Leor J, et al. The effect of irreversible electropora-tion on blood vessels. Technol Cancer Res Treat, 2007, 6(4): 307-312.
10. Ball C, Thomson KR, Kavnoudias H. Irreversible electroporation: a new challenge in ‘out of operating theater' anesthesia. Anesth Analg, 2010, 110(5): 1305-1309.
11. Lee EW, Chen C, Prieto VE, et al. Advanced hepatic ablation techn-ique for creating complete cell death: irreversible electroporation. Radiology, 2010, 255(2): 426-433.
12. Appelbaum L, Ben-David E, Sosna J, et al. US findings after irrever-sible electroporation ablation: radiologic-pathologic correlation. Radiology, 2012, 262(1):117-125.
13. Liu Y, Xiong Z, Zhou W, et al. Percutaneous ultrasound-guided irreversible electroporation: a goat liver study. Oncol Lett, 2012, 4(3): 450-454.
14. Schmidt CR, Shires P, Mootoo M. Real-time ultrasound imaging of irreversible electroporation in a porcine liver model adequately characterizes the zone of cellular necrosis. HPB(Oxford), 2012, 14(2): 98-102.
15. Zhang Y, White SB, Nicolai JR, et al. Multimodality imaging to assess immediate response to irreversible electroporation in a rat liver tumor model. Radiology, 2014, 271(3): 721-729.
16. Hjouj M, Lavee J, Last D, et al. The effect of blood flow on magnetic resonance imaging of non thermal irreversible electroporation. Sci Rep, 2013, 3: 3088.
17. Narayanan G. Irreversible electroporation for treatment of liver cancer. Gastroenterol Hepatol (N Y), 2011, 7(5): 313-316.
18. Tarek M. Membrane electroporation: a molecular dynamics simulation. Biophys J, 2006, 88(6): 4045-4053.
19. Lee EW, Loh CT, Kee ST. Imaging guided percutaneous irreversible electroporation: ultrasound and immunohistological correlation. Technol Cancer Res Treat, 2007, 6(4): 287-294.
20. Al-Sakere B, André F, Bernat C, et al. Tumor ablation with irrever-sible electroporation. PLoS One, 2007, 2(11): e1135.
21. Onik G, Mikus P, Rubinsky B. Irreversible electroporation: implica-tions for prostate ablation. Technol Cancer Res Treat, 2007, 6(4): 295-300.
22. Guo Y, Zhang Y, Klein R, et al. Irreversible electroporation therapyin the liver: longitudinal efficacy studies in a rat model of hepatoce-llular carcinoma. Cancer Res, 2010, 70(4): 1555-1563.
23. 刘颖, 周玮, 熊正爱, 等. 不可逆性电穿孔致山羊肝脏组织凋亡与坏死的实验研究. 解放军医学杂志, 2011, 36(4): 356-360.
24. 周玮, 熊正爱, 刘颖, 等. 不可逆性电穿孔致HeLa细胞凋亡与坏死的作用研究. 第三军医大学学报, 2010, 32(18): 1941-1944.
25. 杨晓燕, 熊正爱, 李成祥, 等. 陡脉冲不可逆性电击穿治疗兔肝脏肿瘤的研究. 西南大学学报: 自然科学版, 2009, 31(4): 120-145.
26. 中国科技网. 香港中文大学以“纳米刀”消灭肿瘤亚洲首例. 黑龙江科技信息, 2014, (1): Ⅳ.
27. 徐克成. 肿瘤消融新技术: 肿瘤消融新技术不可逆性电穿孔. 上海: 上海科学技术文献出版社, 2014.
28. 高杰,朱继业. 卫生部《原发性肝癌诊疗规范（2011年版）》解读. 中华普通外科杂志, 2012, 27(8): 693-695.
29. Cheung W, Kavnoudias H, Roberts S, et al. Irreversible electropora-tion for unresectable hepatocellular carcinoma: initial experience and review of safety and outcomes. Technol Cancer Res Treat, 2013, 12(3): 233-241.
30. Thomson K, Kee ST. Clinical research on irreversible electroporation of the liver. Clinical Aspects of Electroporation, 2011: 237-246.
31. Narayanan G, Hosein PJ, Arora G, et al. Percutaneous irreversible electroporation for downstaging and control of unresectable pancreatic adenocarcinoma. J Vasc Interv Radiol, 2012, 23(12): 1613-1621.
32. Martin RC 2nd, McFarland K, Ellis S, et al. Irreversible electropora-tion therapy in the managememt of locally advanced pancreatic adenocarcinoma. J Am Coll Surg, 2012, 215(3): 361-369.
33. Forest V, Peoćh M, Campos L, et al. Effects of cryotherapy or chemotherapy on apoptosis in a non-small-cell lung cancer xenog-rafted into SCID mice. Cryobiology, 2005, 50(1): 29-37.
34. Onik G, Rubinsky B. Irreversible electroporation: first patient experience focal therapy of prostate cancer. Series in Biomedical Engineering, 2010: 235-247.
35. Lee EW, Wong D, Kee ST. Irreversible electroporation (IRE) on liver tumor ablation: a summary of preclinical translational research.New York: Springer, 2011: 219-230.
36. Lee EW, Thai S, Kee ST. Irreversible electroporation: a novel image-guided cancer therapy. Gut Liver, 2010, 4 Suppl 1: S99-S104.
37. Philips P, Hays D, Martin RC. Irreversible electroporation ablation (IRE) of unresectable soft tissue tumors: learning curve evaluation in the first 150 patients treated. PLoS One, 2013, 8(11): e76260.
38. Thomson KR, Cheung W, Ellis SJ, et al. Investigation of the safety of irreversible electroporation in humans. J Vasc Interv Radiol, 2011, 22(5): 611-621.

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A New and Minimally Invasive Ablation Technology for Tumors——Irreversible Electro-poration

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