Effect of Application of Thymopentin during Perioperative Period on Immune Function of Patients Undergoing Laparoscopic Assisted Radical Resection for Rectal Carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 XUJian , ZOUZhen-yu , XINGXiao-wei , MAYue , WANGLing-di , ZOUGui-jun , HUShi-dong ,  DUXiao-hui

Department of General Surgery, PLA General Hospital, Beijing 100853, China;

Corresponding author：

DUXiao-hui, Email: duxiaohui301@sina.com

Keywords：

Perioperative period; Rectal cancer; Thymopentin; Immune function

DOI：

10.7507/1007-9424.20160151

Video：

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Objective To investigate effect of application of thymopentin during perioperative period on immune function of patients undergoing laparoscopic assisted radical resection for rectal carcinoma. Methods Forty-two patients undergoing laparoscopic assisted radical resection for rectal carcinoma from January 2015 to April 2015 in this hospital were collected. These patients were divided into study group and control group. The patients were received routine treatment in the control group. In addition to routine treatment same as the control group, the patients were received 2 mg thymopentin every day for a week in the study group. The changes of lymphocyte count, T lymphocyte subsets (CD3⁺, CD4⁺, CD8⁺, and CD4⁺/CD8⁺), and immunoglobulin (IgG, IgA, and IgM) were compared on the 1st day before surgery and on the 1st day and 5th day after surgery. Results The lymphocyte count, T lymphocyte subsets, and immunoglobulin on the first day after surgery were significantly lower than those on the 1st day before surgery in these two groups (P < 0.05). The lymphocyte count, T lymphocyte subsets (except for CD4⁺/CD8⁺), and immunoglobulin (except for IgA) in the study group were significantly higher than those in the control group on the 5th day after surgery (P < 0.05). The changes of lymphocyte count, T lymphocyte subsets, and immunoglobulin in the study group had no significant differences between on the 5th day after surgery and on the 1st day before surgery (P > 0.05), but which on the 5th day afer surgery were significantly lower than those on the 1st day before surgery (P < 0.05) in the control group. Conclusion Application of thymopentin during perioperative period could accelerate recovery of immune function after operation in patients undergoing laparoscopic assisted radical resection for rectal carcinoma.

Citation： XUJian, ZOUZhen-yu, XINGXiao-wei, MAYue, WANGLing-di, ZOUGui-jun, HUShi-dong, DUXiao-hui. Effect of Application of Thymopentin during Perioperative Period on Immune Function of Patients Undergoing Laparoscopic Assisted Radical Resection for Rectal Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(5): 561-564. doi: 10.7507/1007-9424.20160151 Copy

1.	王旻, 陈学博, 王欢, 等. 直肠癌扩大根治术对患者外周血中细胞免疫功能的影响. 中国实验诊断学, 2011, 15(3):521-523.
2.	叶平江, 郭贵龙, 应晓江. 腹腔镜与开腹结直肠癌根治术对机体免疫系统影响的比较研究.中国内镜杂志, 2011, 17(5):478-480.
3.	郭宁宁, 王辉, 肖兰凤, 等. T细胞过继免疫治疗法在肿瘤疾病治疗中的应用进展. 广东药学院学报, 2011, 27(4):441-445.
4.	李媛. 胸腺五肽治疗支原体肺炎的疗效分析. 中国医学工程, 2014, 22(5):67.
5.	叶锐良. 胸腺五肽治疗初治肺结核的临床研究. 临床肺科杂志, 2015, 20(8):1493-1496.
6.	贾果珍. 中晚期肺癌化疗联合使用胸腺五肽临床观察. 中国药物与临床, 2014, 14(8):1103-1104.
7.	何文杰, 涂长玲, 江波. 胸腺五肽对老年晚期非小细胞肺癌患者免疫功能的影响研究. 实用心脑肺血管病杂志, 2015, 23(7):72-74.
8.	Bordón E, Henríquez-Hernández LA, Lara PC, et al. Role of CD4 and CD8 T-lymphocytes, B-lymphocytes and natural killer cells in the prediction of radiation-induced late toxicity in cervical cancer patients. Int J Radiat Biol, 2011, 87(4):424-431.
9.	王国俊, 高春芳. 腹腔镜直肠癌全直肠系膜切除术. 中国普外基础与临床杂志, 2011, 18(1):92-94.
10.	汪利群, 吴勇. 腹腔镜和开腹手术治疗卵巢良性肿瘤的疗效及对免疫功能的影响. 中国肿瘤临床与康复, 2012, 19(6):515-517.
11.	刘江文, 孙琳, 仝德峰, 等. 进展期胃癌腹腔镜辅助与开腹胃癌根治术对患者围手术期免疫功能影响的对比研究. 中国普外基础与临床杂志, 2014, 21(10):1232-1235.
12.	任宏伟. 腹腔镜手术治疗对直肠癌患者免疫功能的影响分析. 中华医药科学, 2015, 5(8):11-13.
13.	姜洪伟, 何玉宝, 王举. 直肠癌开腹手术与腹腔镜手术术后免疫功能的研究. 中国现代普通外科进展, 2012, 15(9):699-702.
14.	王勇, 黄鑫, 唐恬. 腹腔镜与开腹手术对直肠癌的治疗分析. 中国医学创新, 2013, 10(34):114-116.
15.	Wieder T, Braumuller H, Kneilling M, et al. T cell-mediated-help against tumors. Cell Cycle, 2008, 7(19):2974-2977.
16.	高扬. 创伤对老年机体免疫功能的影响. 医学综述, 2013, 19(19): 3500-3503.
17.	兰志伟, 赵浩亮, 贺杰峰, 等. 胸腺五肽对大鼠肝癌免疫微环境中T细胞及其亚群的影响. 中华临床医师杂志:电子版, 2014, 8(6):1086-1090.
18.	黄文华. 胸腺五肽注射液调节老年慢性病患者免疫功能的安全性和疗效. 求医问药, 2012, 10(4):429-430.
19.	谢婧, 张长平, 王咏梅, 等. 胸腺五肽辅助用药的临床有效性循证评价. 中国新药杂志, 2015, 24(22):2599-2605.
20.	王娟. 替比夫定联合胸腺五肽治疗慢性乙型肝炎的疗效观察. 医学信息, 2015, 28(5):308.
21.	郑小清, 黄锦葵, 苏伟强, 等. 雾化吸入痰热清注射液联合胸腺五肽治疗上呼吸道感染的疗效观察. 中国医药科学, 2014, 4(13): 81-83.
22.	欧阳俐颖, 廖伟, 陈映波, 等. 胸腺五肽辅助治疗食管癌术后重症肺炎的效果. 广东医学, 2014(17):2756-2758.
23.	宋法云, 邢志红. 胸腺五肽联合化疗对大肠癌患者细胞免疫功能和生存期的影响研究. 中国全科医学, 2013, 16(21):2501-2503.
24.	赵春玲. 胸腺五肽配合化疗治疗中晚期恶性肿瘤疗效观察. 中国营养保健, 2013, 23(4):612.
25.	柴宝, 郭亚荣. 胸腺五肽联合化疗对大肠癌患者免疫功能的影响. 山西医药杂志, 2012, 41(23):1229-1230.
26.	刘洪, 吴格怡, 彭文剑. 胸腺五肽在肺癌化疗后缓解期的免疫调节作用. 中国现代医药杂志, 2012, 14(9):83-84.
27.	周瑛, 李洪永. 胸腺五肽对晚期大肠癌患者化疗毒副反应的影响. 中国普通外科杂志, 2015, 24(4):597-599.

1. 王旻, 陈学博, 王欢, 等. 直肠癌扩大根治术对患者外周血中细胞免疫功能的影响. 中国实验诊断学, 2011, 15(3):521-523.
2. 叶平江, 郭贵龙, 应晓江. 腹腔镜与开腹结直肠癌根治术对机体免疫系统影响的比较研究.中国内镜杂志, 2011, 17(5):478-480.
3. 郭宁宁, 王辉, 肖兰凤, 等. T细胞过继免疫治疗法在肿瘤疾病治疗中的应用进展. 广东药学院学报, 2011, 27(4):441-445.
4. 李媛. 胸腺五肽治疗支原体肺炎的疗效分析. 中国医学工程, 2014, 22(5):67.
5. 叶锐良. 胸腺五肽治疗初治肺结核的临床研究. 临床肺科杂志, 2015, 20(8):1493-1496.
6. 贾果珍. 中晚期肺癌化疗联合使用胸腺五肽临床观察. 中国药物与临床, 2014, 14(8):1103-1104.
7. 何文杰, 涂长玲, 江波. 胸腺五肽对老年晚期非小细胞肺癌患者免疫功能的影响研究. 实用心脑肺血管病杂志, 2015, 23(7):72-74.
8. Bordón E, Henríquez-Hernández LA, Lara PC, et al. Role of CD4 and CD8 T-lymphocytes, B-lymphocytes and natural killer cells in the prediction of radiation-induced late toxicity in cervical cancer patients. Int J Radiat Biol, 2011, 87(4):424-431.
9. 王国俊, 高春芳. 腹腔镜直肠癌全直肠系膜切除术. 中国普外基础与临床杂志, 2011, 18(1):92-94.
10. 汪利群, 吴勇. 腹腔镜和开腹手术治疗卵巢良性肿瘤的疗效及对免疫功能的影响. 中国肿瘤临床与康复, 2012, 19(6):515-517.
11. 刘江文, 孙琳, 仝德峰, 等. 进展期胃癌腹腔镜辅助与开腹胃癌根治术对患者围手术期免疫功能影响的对比研究. 中国普外基础与临床杂志, 2014, 21(10):1232-1235.
12. 任宏伟. 腹腔镜手术治疗对直肠癌患者免疫功能的影响分析. 中华医药科学, 2015, 5(8):11-13.
13. 姜洪伟, 何玉宝, 王举. 直肠癌开腹手术与腹腔镜手术术后免疫功能的研究. 中国现代普通外科进展, 2012, 15(9):699-702.
14. 王勇, 黄鑫, 唐恬. 腹腔镜与开腹手术对直肠癌的治疗分析. 中国医学创新, 2013, 10(34):114-116.
15. Wieder T, Braumuller H, Kneilling M, et al. T cell-mediated-help against tumors. Cell Cycle, 2008, 7(19):2974-2977.
16. 高扬. 创伤对老年机体免疫功能的影响. 医学综述, 2013, 19(19): 3500-3503.
17. 兰志伟, 赵浩亮, 贺杰峰, 等. 胸腺五肽对大鼠肝癌免疫微环境中T细胞及其亚群的影响. 中华临床医师杂志:电子版, 2014, 8(6):1086-1090.
18. 黄文华. 胸腺五肽注射液调节老年慢性病患者免疫功能的安全性和疗效. 求医问药, 2012, 10(4):429-430.
19. 谢婧, 张长平, 王咏梅, 等. 胸腺五肽辅助用药的临床有效性循证评价. 中国新药杂志, 2015, 24(22):2599-2605.
20. 王娟. 替比夫定联合胸腺五肽治疗慢性乙型肝炎的疗效观察. 医学信息, 2015, 28(5):308.
21. 郑小清, 黄锦葵, 苏伟强, 等. 雾化吸入痰热清注射液联合胸腺五肽治疗上呼吸道感染的疗效观察. 中国医药科学, 2014, 4(13): 81-83.
22. 欧阳俐颖, 廖伟, 陈映波, 等. 胸腺五肽辅助治疗食管癌术后重症肺炎的效果. 广东医学, 2014(17):2756-2758.
23. 宋法云, 邢志红. 胸腺五肽联合化疗对大肠癌患者细胞免疫功能和生存期的影响研究. 中国全科医学, 2013, 16(21):2501-2503.
24. 赵春玲. 胸腺五肽配合化疗治疗中晚期恶性肿瘤疗效观察. 中国营养保健, 2013, 23(4):612.
25. 柴宝, 郭亚荣. 胸腺五肽联合化疗对大肠癌患者免疫功能的影响. 山西医药杂志, 2012, 41(23):1229-1230.
26. 刘洪, 吴格怡, 彭文剑. 胸腺五肽在肺癌化疗后缓解期的免疫调节作用. 中国现代医药杂志, 2012, 14(9):83-84.
27. 周瑛, 李洪永. 胸腺五肽对晚期大肠癌患者化疗毒副反应的影响. 中国普通外科杂志, 2015, 24(4):597-599.

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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Effect of Application of Thymopentin during Perioperative Period on Immune Function of Patients Undergoing Laparoscopic Assisted Radical Resection for Rectal Carcinoma

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