Effect of Laparoscopic Radical Gastrectomy on Gastrointestinal Motility and Gastrointestinal Hormones in Patients with Gastric Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 LIKun , CAOTing-bao , KONGYan-long , HANXiao-peng , SULin ,  LIUHong-bin

Department of General Surgery, General Hospital of Lanzhou PLA, Lanzhou 730050, Gansu Province, China;

Corresponding author：

LIUHong-bin, Email: liuhongbin999@163.com

Keywords：

Laparoscope; Radical gastrectomy; Gastrointestinal motility; Gastrointestinal hormones

DOI：

10.7507/1007-9424.20160245

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To investigate effect of laparoscopic radical gastrectomy on gastrointestinal motility and gastrointestinal hormones in patients with gastric cancer. Methods Two hundred and eighty-nine patients who underwent laparoscopic radical gastrectomy from December 2013 to December 2015 were selected as observation group, 325 patients underwent laparotomy radical gastrectomy during the same period were selected as control group. The postoperative bowel sounds recovery time, the first anal exhaust time, and gastrin, motilin and vasoactive intestinal peptide levels in blood at 12 h before operation and at 24 h after operation were compared between these two groups. Results The baselines had no significant differences between these two groups (P > 0.05). The postoperative bowel sounds recovery time and the first anal exhaust time in the observation group were significantly shorter than those in the control group (P < 0.05). Compared with the levels at 12 h before operation, the gastrin and motilin levels were significantly decreased and the vasoactive intestinal peptide level was significantly increased at 24 h after operation in these two groups (P < 0.05); Compared with the control group, the gastrin and motilin levels at 24 h after operation were significantly increased (P < 0.05) and the vasoactive intestinal peptide level was significantly decreased in the observation group (P < 0.05). Conclusions Postoperative gastrointestinal motility recovery time in patients undergoing laparoscopic radical gastrectomy is significantly faster than that of laparotomy radical gastrectomy. There is a certain relation between gastrin, motilin or vasoactive intestinal peptide change and operation mode, it might be one of mechanisms of faster recovery of gastrointestinal motility after laparoscopic radical gastrectomy for gastric cancer.

Citation： LIKun, CAOTing-bao, KONGYan-long, HANXiao-peng, SULin, LIUHong-bin. Effect of Laparoscopic Radical Gastrectomy on Gastrointestinal Motility and Gastrointestinal Hormones in Patients with Gastric Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(8): 936-939. doi: 10.7507/1007-9424.20160245 Copy

1.	Kitano S, Iso Y, Moriyama M, et al. Laparoscopy-assisted BillrothⅠgastrectomy. Surg Laparosc Endosc, 1994, 4(2): 146-148.
2.	余佩武, 罗华星.腹腔镜胃癌手术规范化实施的策略与技术.中华消化外科杂志, 2015, 14(3): 179-182.
3.	王红岩, 赵晓丹, 李国胜, 等.腹腔镜辅助与开腹胃癌D2根治术治疗局部进展期远端胃癌的安全性及近期疗效Meta分析.中国医科大学学报, 2015, 44(3): 252-258.
4.	李长风, 黄娜, 于涛.腹腔镜直肠癌根治术后胃肠功能的恢复优势及机制探讨.医学理论与实践, 2015, 28(18): 2469-2470.
5.	Coate KC, Kliewer SA, Mangelsdorf DJ. SnapShot: hormones of the gastrointestinal tract. Cell, 2014, 159(6): 1478-1478.e1.
6.	中华医学会外科分会腹腔镜与内镜外科学组.腹腔镜胃恶性肿瘤手术操作指南(2007版).外科理论与实践, 2007, 12(6): 610-614.
7.	谢翠, 赖丽莲.综合干预措施对肾癌术后患者胃肠道功能恢复的影响.世界华人消化杂志, 2015, 14(23): 2328-2332.
8.	曹晖, 卞育海, 赵刚.进一步认识和提高进展期胃癌综合治疗的理念.中华胃肠外科杂志, 2014, 17(11): 1051-1059.
9.	Piessen G, Lefèvre JH, Cabau M, et al. Laparoscopic versus open surgery for gastric gastrointestinal stromal tumors: what is the impact on postoperative outcome and oncologic results? Ann Surg, 2015, 262(5): 831-840.
10.	白洪祥, 刘现立.腹腔镜下结肠癌根治术安全性及对患者术后胃肠道功能的影响.中国老年学杂志, 2014, 34(14): 4039-4040.
11.	王锡山.腹部手术后不容忽视的问题—消化道功能障碍.中华胃肠外科杂志, 2015, 18(5): 509-511.
12.	Törnblom H, Simrén M, Abrahamsson H. Gastrointestinal motility and neurogastroenterology. Scand J Gastroenterol, 2015, 50(6): 685-697.
13.	王欢, 黄永坤, 刘梅.胃肠激素与胃肠道功能及疾病的关系.医学综述, 2013, 19(15): 2735-2738.
14.	Andreas S, Yvette T. Interaction between gastric and upper small intestinal hormones in the regulation of hunger and satiety: ghrelin and cholecystokinin take the central stage. Curr Protein Pept Sci, 2011, 12(4): 293-304.
15.	Sanger GJ. Ghrelin and motilin receptor agonists: time to introduce bias into drug design. Neurogastroenterol Motil, 2014, 26(2): 149-155.
16.	全俊, 严晋, 丁懿, 等. D-IBS与FD重叠征大鼠精神状态、胃肠激素水平改变.胃肠病学和肝病学杂志, 2015, 24(8): 930-934.
17.	Vu JP, Larauche M, Flores M, et al. Regulation of appetite, body composition, and metabolic hormones by vasoactive intestinal polypeptide (VIP). J Mol Neurosci, 2015, 56(2): 377-387.

1. Kitano S, Iso Y, Moriyama M, et al. Laparoscopy-assisted BillrothⅠgastrectomy. Surg Laparosc Endosc, 1994, 4(2): 146-148.
2. 余佩武, 罗华星.腹腔镜胃癌手术规范化实施的策略与技术.中华消化外科杂志, 2015, 14(3): 179-182.
3. 王红岩, 赵晓丹, 李国胜, 等.腹腔镜辅助与开腹胃癌D2根治术治疗局部进展期远端胃癌的安全性及近期疗效Meta分析.中国医科大学学报, 2015, 44(3): 252-258.
4. 李长风, 黄娜, 于涛.腹腔镜直肠癌根治术后胃肠功能的恢复优势及机制探讨.医学理论与实践, 2015, 28(18): 2469-2470.
5. Coate KC, Kliewer SA, Mangelsdorf DJ. SnapShot: hormones of the gastrointestinal tract. Cell, 2014, 159(6): 1478-1478.e1.
6. 中华医学会外科分会腹腔镜与内镜外科学组.腹腔镜胃恶性肿瘤手术操作指南(2007版).外科理论与实践, 2007, 12(6): 610-614.
7. 谢翠, 赖丽莲.综合干预措施对肾癌术后患者胃肠道功能恢复的影响.世界华人消化杂志, 2015, 14(23): 2328-2332.
8. 曹晖, 卞育海, 赵刚.进一步认识和提高进展期胃癌综合治疗的理念.中华胃肠外科杂志, 2014, 17(11): 1051-1059.
9. Piessen G, Lefèvre JH, Cabau M, et al. Laparoscopic versus open surgery for gastric gastrointestinal stromal tumors: what is the impact on postoperative outcome and oncologic results? Ann Surg, 2015, 262(5): 831-840.
10. 白洪祥, 刘现立.腹腔镜下结肠癌根治术安全性及对患者术后胃肠道功能的影响.中国老年学杂志, 2014, 34(14): 4039-4040.
11. 王锡山.腹部手术后不容忽视的问题—消化道功能障碍.中华胃肠外科杂志, 2015, 18(5): 509-511.
12. Törnblom H, Simrén M, Abrahamsson H. Gastrointestinal motility and neurogastroenterology. Scand J Gastroenterol, 2015, 50(6): 685-697.
13. 王欢, 黄永坤, 刘梅.胃肠激素与胃肠道功能及疾病的关系.医学综述, 2013, 19(15): 2735-2738.
14. Andreas S, Yvette T. Interaction between gastric and upper small intestinal hormones in the regulation of hunger and satiety: ghrelin and cholecystokinin take the central stage. Curr Protein Pept Sci, 2011, 12(4): 293-304.
15. Sanger GJ. Ghrelin and motilin receptor agonists: time to introduce bias into drug design. Neurogastroenterol Motil, 2014, 26(2): 149-155.
16. 全俊, 严晋, 丁懿, 等. D-IBS与FD重叠征大鼠精神状态、胃肠激素水平改变.胃肠病学和肝病学杂志, 2015, 24(8): 930-934.
17. Vu JP, Larauche M, Flores M, et al. Regulation of appetite, body composition, and metabolic hormones by vasoactive intestinal polypeptide (VIP). J Mol Neurosci, 2015, 56(2): 377-387.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Effect of Laparoscopic Radical Gastrectomy on Gastrointestinal Motility and Gastrointestinal Hormones in Patients with Gastric Cancer

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content