Expressions of IL-17 and IL-27 in Liver Tissue of Hepatic Alveolar Echinococcosis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 Yangdancairang ^1,2 , SHAOJun ³ , ZHANGYang ³ , RENLi ^1,2 , HOULi-zhao ^1,2 , WANGHai-jiu ^1,2 , ZHOUYing ^1,2 , WANGHu ⁴ ,  FANHai-ning ^1,2

1. Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Qinghai University, Xining 810001, Qinghai Province, China;
2. Qinghai Province Key Labrotory of Hydatid Disease Research, Xining 810001, Qinghai Province, China;
3. Medical College of Qinghai University, Xining 810001, Qinghai Province, China;
4. Qinghai Province Health & Family Planning Commission, Xining 810000, Qinghai Province, China;

Corresponding author：

FANHai-ning, Email: fanhaining@medmail.com.cn

Keywords：

Hepatic alveolar echinococcosis; Chemokine; Interleukin-17; Interleukin-27

DOI：

10.7507/1007-9424.20160247

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Objective To detect expressions of interleukin-17 (IL-17) and interleukin-27 (IL-27) proteins in liver tissue of hepatic alveolar echinococcosis. Methods The edge liver tissues (from the lesion edge 0.5 cm) and the normal liver tissues (from the lesion edge 5 cm) of 20 patients with hepatic alveolar echinococcosis in the Affiliated Hospital of Qinghai University were collected and stored at-80℃ freezer. The immunohistochemical method was used to detect the expressions of IL-17 and IL-27 proteins in these two tissues. Result The positive rates of IL-17 and IL-27 protein expressions in the edge liver tissues were significantly higher than those in the normal liver tissues[IL-17:80.0% (16/20) versus 10.0% (2/20), χ²=12.36, P < 0.01; IL-27:85.0% (17/20) versus 20.0% (4/20), χ²=12.36, P < 0.01]. Conclusion High expressions of IL-17 and IL-27 protein in edge liver tissue might participate in progress of hepatic alveolar echinococcosis.

Citation： Yangdancairang, SHAOJun, ZHANGYang, RENLi, HOULi-zhao, WANGHai-jiu, ZHOUYing, WANGHu, FANHai-ning. Expressions of IL-17 and IL-27 in Liver Tissue of Hepatic Alveolar Echinococcosis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(8): 944-947. doi: 10.7507/1007-9424.20160247 Copy

1.	周永昌, 郭万学.超声医学.第5版.北京:科学技术文献出版社, 2006:688.
2.	郑强, 王晓全, 曹岩, 等.国内泡型包虫病文献分布.预防医学情报杂志, 2006, 22(2):170-172.
3.	Wang J, Gottstein B. Immunoregulation in larval echinococcus multilocularis infection. Parasite Immunol, 2015 Nov 5. doi:10.1111/pim.12292.[Epub ahead of print].
4.	Chauchet A, Grenouillet F, Knapp J, et al. Increased incidence and characteristics of alveolar echinococcosis in patients with immunosuppression-associated conditions. Clin Infect Dis, 2014, 59(8):1095-1104.
5.	Pang N, Zhang F, Ma X, et al. TGF-beta/Smad signaling pathway regulates Th17/Treg balance during echinococcus multilocularis infection. Int Immunopharmacol, 2014, 20(1):248-257.
6.	La X, Zhang F, Li Y, et al. Upregulation of PD-1 on CD4(+) CD25 (+) T cells is associated with immunosuppression in liver of mice infected with echinococcus multilocularis. Int Immunopharmacol, 2015, 26(2):357-366.
7.	Li SH, Chen WJ, Yan M, et al. Expression of coinhibitory PD-L1 on CD4(+) CD25(+) FOXP3(+) regulatory T cells is elevated in patients with acute coronary syndrome. Coron Artery Dis, 2015, 26(7):598-603.
8.	Vuitton DA, Zhou H, Bresson-Hadni S, et al. Epidemiology of alveolar echinococcosis with particular reference to China and Europe. Parasitology, 2003, 127 Suppl:S87-S107.
9.	Grosso G, Gruttadauria S, Biondi A, et al. Worldwide epidemiology of liver hydatidosis including the Mediterranean area. World J Gastroenterol, 2012, 18(13):1425-1437.
10.	张亚飞, 陆宏伟, 吉鸿, 等.肝包虫病治疗的研究进展.中国普外基础与临床杂志, 2015, 22(2):162-165.
11.	廖泉, 何小东, 赵玉沛, 等.非牧区肝包虫病的诊断与治疗.中国普外基础与临床杂志, 2000, 7(4):249-251.
12.	张萍, 邓勇, 樊海宁, 等.相关细胞因子的表达与肝泡型棘球蚴侵袭转移关系的研究.重庆医学, 2013, 42(33):3989-3991.
13.	张龙, 张示杰, 曹玉文, 等.骨桥蛋白与肝泡型棘球蚴转移的相关性研究.中国寄生虫学与寄生虫病杂志, 2011, 29(1):33-36.
14.	高亮亮, 张示杰.肝包虫病相关因子的研究进展.中国人兽共患病学报, 2013, 29(1):79-81.
15.	赵娜, 邱宇杰, 朱理玮.白细胞介素-17参与固有免疫应答的研究进展.国际免疫学杂志, 2013, 3(3):212-215.
16.	Gaffen SL. An overview of IL-17 function and signaling. Cytokine, 2008, 43(3):402-407.
17.	Paradowska-Gorycka A, wojtecka-lukasik E, Trefler J, et al. Association between IL-17F gene polymorphisms and susceptibility to and severity of rheumatoid arthritis (RA). Scard J Immunol, 2010, 72(2):134-141.
18.	Chen B, Zeng Z, Hou J, et al. Association of interleukin-17F 7488 single nucleotide polymorphism and inflammatory bowel disease in the Chinese population. Scand J Gastroenterol, 2009, 44(6):720-726.
19.	Bazzi MD, Sultan MA, AI Tassan N, et al. Interleukin-17A and F and asthma in saudi Arabia:gene polymorphism and protein levels. J Investig allergol Clin Immunol, 2011, 21(7):551-555.
20.	余盼攀, 张胜初, 张启瑜. IL-17及其受体与肝脏疾病的关系.肝胆胰外科杂志, 2011, 23(3):262-264.
21.	陈曦, 朱波, 陈正堂. IL-17与IL-17R与恶性肿瘤.免疫学杂志, 2010, 26(4):366-369.
22.	施沛青, 朱书, 钱友存. IL-17的信号传导及功能研究.中国细胞生物学学报, 2011, 33(4):345-357.
23.	刘丽华, 单保恩. IL-27及其免疫调节作用研究进展.免疫学杂志, 2010, 26(1):81-86.
24.	郭月英, 李国忠.白细胞介素-27研究进展.中华临床医师杂志, 2013, 7(21):9662-9664.
25.	牛悦, 徐芳, 杜芳, 等.白细胞介素27与疾病易感性关联研究进展.检验医学与临床, 2014, 11(23):3361-3363.
26.	Rigano R, Profumo E, Bruschi F, et al. Modulation of human immune response by echinococcus granulosus antigen B and its possible role in evading host defense. Infect Immune, 2001, 69(1):288-296.
27.	Rigano R, Buttari B, Defalco E, et al. Echinococcus granulosuspecific T-cell lines derived from patients at various clinical stages of cystic echinococcosis. Parasite Immunol, 2004, 26(1):45-52.
28.	马尔丹·马合木, 提吐尔洪江·吐逊, 马海长, 等. IL-17mRNA在肝脏泡型包虫病中的表达及其临床意义.中国现代普通外科进展, 2014, 17(10):771-774.
29.	汪宏良, 翟中良, 张海燕, 等.白细胞介素-27的研究进展.检验医学与临床, 2010, 7(6):553-554.

1. 周永昌, 郭万学.超声医学.第5版.北京:科学技术文献出版社, 2006:688.
2. 郑强, 王晓全, 曹岩, 等.国内泡型包虫病文献分布.预防医学情报杂志, 2006, 22(2):170-172.
3. Wang J, Gottstein B. Immunoregulation in larval echinococcus multilocularis infection. Parasite Immunol, 2015 Nov 5. doi:10.1111/pim.12292.[Epub ahead of print].
4. Chauchet A, Grenouillet F, Knapp J, et al. Increased incidence and characteristics of alveolar echinococcosis in patients with immunosuppression-associated conditions. Clin Infect Dis, 2014, 59(8):1095-1104.
5. Pang N, Zhang F, Ma X, et al. TGF-beta/Smad signaling pathway regulates Th17/Treg balance during echinococcus multilocularis infection. Int Immunopharmacol, 2014, 20(1):248-257.
6. La X, Zhang F, Li Y, et al. Upregulation of PD-1 on CD4(+) CD25 (+) T cells is associated with immunosuppression in liver of mice infected with echinococcus multilocularis. Int Immunopharmacol, 2015, 26(2):357-366.
7. Li SH, Chen WJ, Yan M, et al. Expression of coinhibitory PD-L1 on CD4(+) CD25(+) FOXP3(+) regulatory T cells is elevated in patients with acute coronary syndrome. Coron Artery Dis, 2015, 26(7):598-603.
8. Vuitton DA, Zhou H, Bresson-Hadni S, et al. Epidemiology of alveolar echinococcosis with particular reference to China and Europe. Parasitology, 2003, 127 Suppl:S87-S107.
9. Grosso G, Gruttadauria S, Biondi A, et al. Worldwide epidemiology of liver hydatidosis including the Mediterranean area. World J Gastroenterol, 2012, 18(13):1425-1437.
10. 张亚飞, 陆宏伟, 吉鸿, 等.肝包虫病治疗的研究进展.中国普外基础与临床杂志, 2015, 22(2):162-165.
11. 廖泉, 何小东, 赵玉沛, 等.非牧区肝包虫病的诊断与治疗.中国普外基础与临床杂志, 2000, 7(4):249-251.
12. 张萍, 邓勇, 樊海宁, 等.相关细胞因子的表达与肝泡型棘球蚴侵袭转移关系的研究.重庆医学, 2013, 42(33):3989-3991.
13. 张龙, 张示杰, 曹玉文, 等.骨桥蛋白与肝泡型棘球蚴转移的相关性研究.中国寄生虫学与寄生虫病杂志, 2011, 29(1):33-36.
14. 高亮亮, 张示杰.肝包虫病相关因子的研究进展.中国人兽共患病学报, 2013, 29(1):79-81.
15. 赵娜, 邱宇杰, 朱理玮.白细胞介素-17参与固有免疫应答的研究进展.国际免疫学杂志, 2013, 3(3):212-215.
16. Gaffen SL. An overview of IL-17 function and signaling. Cytokine, 2008, 43(3):402-407.
17. Paradowska-Gorycka A, wojtecka-lukasik E, Trefler J, et al. Association between IL-17F gene polymorphisms and susceptibility to and severity of rheumatoid arthritis (RA). Scard J Immunol, 2010, 72(2):134-141.
18. Chen B, Zeng Z, Hou J, et al. Association of interleukin-17F 7488 single nucleotide polymorphism and inflammatory bowel disease in the Chinese population. Scand J Gastroenterol, 2009, 44(6):720-726.
19. Bazzi MD, Sultan MA, AI Tassan N, et al. Interleukin-17A and F and asthma in saudi Arabia:gene polymorphism and protein levels. J Investig allergol Clin Immunol, 2011, 21(7):551-555.
20. 余盼攀, 张胜初, 张启瑜. IL-17及其受体与肝脏疾病的关系.肝胆胰外科杂志, 2011, 23(3):262-264.
21. 陈曦, 朱波, 陈正堂. IL-17与IL-17R与恶性肿瘤.免疫学杂志, 2010, 26(4):366-369.
22. 施沛青, 朱书, 钱友存. IL-17的信号传导及功能研究.中国细胞生物学学报, 2011, 33(4):345-357.
23. 刘丽华, 单保恩. IL-27及其免疫调节作用研究进展.免疫学杂志, 2010, 26(1):81-86.
24. 郭月英, 李国忠.白细胞介素-27研究进展.中华临床医师杂志, 2013, 7(21):9662-9664.
25. 牛悦, 徐芳, 杜芳, 等.白细胞介素27与疾病易感性关联研究进展.检验医学与临床, 2014, 11(23):3361-3363.
26. Rigano R, Profumo E, Bruschi F, et al. Modulation of human immune response by echinococcus granulosus antigen B and its possible role in evading host defense. Infect Immune, 2001, 69(1):288-296.
27. Rigano R, Buttari B, Defalco E, et al. Echinococcus granulosuspecific T-cell lines derived from patients at various clinical stages of cystic echinococcosis. Parasite Immunol, 2004, 26(1):45-52.
28. 马尔丹·马合木, 提吐尔洪江·吐逊, 马海长, 等. IL-17mRNA在肝脏泡型包虫病中的表达及其临床意义.中国现代普通外科进展, 2014, 17(10):771-774.
29. 汪宏良, 翟中良, 张海燕, 等.白细胞介素-27的研究进展.检验医学与临床, 2010, 7(6):553-554.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expressions of IL-17 and IL-27 in Liver Tissue of Hepatic Alveolar Echinococcosis

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