Analysis of Curative Effect of Huaier Granule Combined with Transcatheter Arterial Chemoembolization Following Radical Resection of Primary Hepatocellular Carcinoma with Microvascular Invasion_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 HUAXiang-dong , SHANGHai , HEZhong-ye , HAOZhi-qiang , MAZuo-hong , FUXi-bo

Tumor Hospital of Liaoning Province, Shenyang 110042, Liaoning Province, China;

Corresponding author：

HUAXiang-dong, Email: huaxiangdong@cancerhosp-ln-cmu.com

Keywords：

Huaier granule; Primary hepatocellular carcinoma; Microvascular invasion; Transcatheter arterial chemoembolization

DOI：

10.7507/1007-9424.20160256

Video：

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Objective To evaluate therapeutical effects of Huaier granule combined with transcatheter arterial chemoembolization (TACE) following radical resection of primary hepatocellular carcinoma with microvascular invasion. Methods The clinical data of 45 cases of primary hepatocellular carcinoma with microvascular invasion underwent Huaier granule combined with transcatheter arterial chemoembolization (TACE) following radical resection from June 2010 to June 2013 in Liaoning Cancer Hospital were retrospectively analyzed. These patients were divided into Huaier granule plus TACE treatment group (20 cases) and simple TACE treatment group (25 cases) according to the postoperative treatment of the patients. The immune function (CD4⁺/CD8⁺ ratio and IL-2 level), 1and 3-year tumor recurrence rates and 3-year cumulative survival rate were compared between two groups after operation. Result ① The CD4⁺/CD8⁺ ratio and IL-2 level had no significant differences between the 2 groups before operation (P > 0.05), which in the Huaier granule plus TACE treatment group were significantly higher than those in the simple TACE treatment group (P < 0.05) on month 3, 6, and 12 after operation.② 1and 3-year tumor recurrence rates in the Huaier granule plus TACE treatment group were significantly lower than those in the simple TACE treatment group[15% (3/20) versus 48% (12/25), P < 0.05; 45% (9/20) versus 80% (20/25), P < 0.05]. ③ The 3-year cumulative survival rate was 75% and 68% in the Huaier granule plus TACE treatment group and the simple TACE treatment group, respectively. The survival curve analysis showed that the 3-year survival rate had a decreased trend, which in the Huaier granule plus TACE treatment group was slightly higher than that in the simple TACE treatment group, but the difference had no statistical significance between the 2 groups (P > 0.05). Conclusions Although the results of this study fails to confirm that Huaier granule plus TACE treatment for primary hepatocellular carcinoma with microvascular invasion following radical resection could significantly improve the 3-year cumulative survival rate, it could effectively decrease the recurrence rate. It is needed larger sample size to further explore in future research.

Citation： HUAXiang-dong, SHANGHai, HEZhong-ye, HAOZhi-qiang, MAZuo-hong, FUXi-bo. Analysis of Curative Effect of Huaier Granule Combined with Transcatheter Arterial Chemoembolization Following Radical Resection of Primary Hepatocellular Carcinoma with Microvascular Invasion. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(8): 982-986. doi: 10.7507/1007-9424.20160256 Copy

1.	金贇, 李江涛.肝细胞癌侵犯微血管的临床相关因素及分子标记物的研究进展.临床肝胆病杂志, 2013, 29(7):550-553.
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5.	马曾辰, 黄力文, 汤钊猷, 等.原发性肝癌的三级根治切除标准.中华肿瘤杂志, 2004, 26(1):33-35.
6.	周东, 刘胜, 严俊, 等.小肝癌微血管侵犯早期诊断指标的探讨.福建医科大学学报, 2012, 46(2):128-130.
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9.	陈中乾.高热碘油超选择肝动脉化疗栓塞治疗原发性肝癌中远期疗效分析.医学信息, 2015, 28(8):27-28.
10.	陈星, 李强, 荀晓东, 等.微血管侵犯对单发小肝癌患者术后无进展生存期的影响.中华肝胆外科杂志, 2016, 22(2):171-173.
11.	周林, 郑永根, 杜国盛.索拉非尼防治肝癌肝移植术后复发的研究进展.器官移植, 2014, 5(5):270-276.
12.	聂艳丽, 南克俊.分子靶向药物在肝细胞肝癌治疗中的研究进展.现代肿瘤医学, 2014, 22(8):1996-1999.
13.	何丽平, 翟凤钰.索拉非尼联合化疗治疗原发性肝癌的临床研究.中国医药科学, 2013, 3(22):63-64.
14.	李立新, 叶胜龙, 王梅红, 等.槐耳浸膏的实验研究及临床应用进展.中国肿瘤, 2007, 16(2):110-113.
15.	吴晖.槐耳颗粒联合化疗栓塞术治疗原发性肝癌96例.中国药业, 2014, 23(3):16-18.
16.	赵建军, 蔡建强, 毕新宇, 等.槐耳颗粒对原发性肝癌术后转移复发的影响.中国综合临床, 2007, 23(3):245-247.
17.	高慧婕, 李春霞, 刘树玲, 等.人参皂苷Rg3联合槐耳颗粒对免疫抑制小鼠的免疫调节作用.济宁医学院学报, 2014, 37(6):399-402.
18.	索龙龙, 杜国盛, 周林, 等.胸腺法新为基础的药物治疗对肝移植术后肿瘤复发及相关细胞因子的影响.世界华人消化杂志, 2016, 24(10):1587-1592.

1. 金贇, 李江涛.肝细胞癌侵犯微血管的临床相关因素及分子标记物的研究进展.临床肝胆病杂志, 2013, 29(7):550-553.
2. Kim H, Park MS, Park YN, et al. Preoperative radiologic and postoperative pathologic risk factors for early intra-hepatic recurrence in hepatocellular carcinoma patients who underwent curative resection. Yonsei Med J, 2009, 50(6):789-795.
3. Gouw AS, Balabaud C, Kusano H, et al. Markers for microvascular invasion in hepatocellular carcinoma:where do we stand? Liver Transpl, 2011, 17 Suppl 2:S72-S80.
4. 闫涛, 毕新宇, 方仪, 等.槐耳颗粒对原发性肝癌患者术后长期生存的影响.中华肝胆外科杂志, 2012, 18(2):99-102.
5. 马曾辰, 黄力文, 汤钊猷, 等.原发性肝癌的三级根治切除标准.中华肿瘤杂志, 2004, 26(1):33-35.
6. 周东, 刘胜, 严俊, 等.小肝癌微血管侵犯早期诊断指标的探讨.福建医科大学学报, 2012, 46(2):128-130.
7. 中国抗癌协会肝癌专业委员会.原发性肝癌规范化病理诊断指南(2015版).临床与实验病理学杂志, 2015, 31(3):241-246.
8. Abou Al-Shaar H, Macdonald KI, Labib MA. Glomangiopericytoma simulating an intracavernous meningioma. Surg Neurol Int, 2016, 7(Suppl 5):S142-S147.
9. 陈中乾.高热碘油超选择肝动脉化疗栓塞治疗原发性肝癌中远期疗效分析.医学信息, 2015, 28(8):27-28.
10. 陈星, 李强, 荀晓东, 等.微血管侵犯对单发小肝癌患者术后无进展生存期的影响.中华肝胆外科杂志, 2016, 22(2):171-173.
11. 周林, 郑永根, 杜国盛.索拉非尼防治肝癌肝移植术后复发的研究进展.器官移植, 2014, 5(5):270-276.
12. 聂艳丽, 南克俊.分子靶向药物在肝细胞肝癌治疗中的研究进展.现代肿瘤医学, 2014, 22(8):1996-1999.
13. 何丽平, 翟凤钰.索拉非尼联合化疗治疗原发性肝癌的临床研究.中国医药科学, 2013, 3(22):63-64.
14. 李立新, 叶胜龙, 王梅红, 等.槐耳浸膏的实验研究及临床应用进展.中国肿瘤, 2007, 16(2):110-113.
15. 吴晖.槐耳颗粒联合化疗栓塞术治疗原发性肝癌96例.中国药业, 2014, 23(3):16-18.
16. 赵建军, 蔡建强, 毕新宇, 等.槐耳颗粒对原发性肝癌术后转移复发的影响.中国综合临床, 2007, 23(3):245-247.
17. 高慧婕, 李春霞, 刘树玲, 等.人参皂苷Rg3联合槐耳颗粒对免疫抑制小鼠的免疫调节作用.济宁医学院学报, 2014, 37(6):399-402.
18. 索龙龙, 杜国盛, 周林, 等.胸腺法新为基础的药物治疗对肝移植术后肿瘤复发及相关细胞因子的影响.世界华人消化杂志, 2016, 24(10):1587-1592.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Analysis of Curative Effect of Huaier Granule Combined with Transcatheter Arterial Chemoembolization Following Radical Resection of Primary Hepatocellular Carcinoma with Microvascular Invasion

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