甲状腺微小乳头状癌淋巴结转移特点及处理策略_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 朱精强 , 雷建勇 , 姜可

四川大学华西医院甲状（旁）腺疾病诊治中心（四川成都 610041）;

Corresponding author：

朱精强, Email: zjq-wkys@163.com

Keywords：

DOI：

10.7507/1007-9424.20160298

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Citation： 朱精强, 雷建勇, 姜可. 甲状腺微小乳头状癌淋巴结转移特点及处理策略. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(10): 1160-1165. doi: 10.7507/1007-9424.20160298 Copy

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2.	Haugen BR, Alexander EK, Bible KC, et al. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer:The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid, 2016, 26(1):1-133.
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6.	高明. 甲状腺癌的诊疗进展及策略. 中华耳鼻咽喉头颈外科杂志, 2010, 45(11):887-890.
7.	Zhou YL, Gao EL, Zhang W, et al. Factors predictive of papillary thyroid micro-carcinoma with bilateral involvement and central lymph node metastasis:a retrospective study. World J Surg Oncol, 2012, 10:67.
8.	Lee CR, Son H, Lee S, et al. Lobectomy and prophylactic central neck dissection for papillary thyroid microcarcinoma:do involved lymph nodes mandate completion thyroidectomy? World J Surg, 2014, 38(4):872-877.
9.	Caliskan M, Park JH, Jeong JS, et al. Role of prophylactic ipsilateral central compartment lymph node dissection in papillary thyroid microcarcinoma. Endocr J, 2012, 59(4):305-311.
10.	彭冬梅, 晏晨, 苏安平, 等. cN0甲状腺微小乳头状癌右侧喉返神经浅面及深面淋巴结转移危险因素分析.中国实用外科杂志, 2016, 36(5):547-551.
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1. McLeod DS, Sawka AM, Cooper DS. Controversies in primary treatment of low-risk papillary thyroid cancer. Lancet, 2013, 381(9871):1046-1057.
2. Haugen BR, Alexander EK, Bible KC, et al. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer:The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid, 2016, 26(1):1-133.
3. Lee JH, Shin SW. Overdiagnosis and screening for thyroid cancer in Korea. Lancet, 2014, 384(9957):1848.
4. Park SH, Lee B, Lee S, et al. A qualitative study of women's views on overdiagnosis and screening for thyroid cancer in Korea. BMC Cancer, 2015, 15:858.
5. Mehanna H, Al-Maqbili T, Carter B, et al. Differences in the recurrence and mortality outcomes rates of incidental and nonincidental papillary thyroid microcarcinoma:a systematic review and meta-analysis of 21329 person-years of follow-up. J Clin Endocrinol Metab, 2014, 99(8):2834-2843.
6. 高明. 甲状腺癌的诊疗进展及策略. 中华耳鼻咽喉头颈外科杂志, 2010, 45(11):887-890.
7. Zhou YL, Gao EL, Zhang W, et al. Factors predictive of papillary thyroid micro-carcinoma with bilateral involvement and central lymph node metastasis:a retrospective study. World J Surg Oncol, 2012, 10:67.
8. Lee CR, Son H, Lee S, et al. Lobectomy and prophylactic central neck dissection for papillary thyroid microcarcinoma:do involved lymph nodes mandate completion thyroidectomy? World J Surg, 2014, 38(4):872-877.
9. Caliskan M, Park JH, Jeong JS, et al. Role of prophylactic ipsilateral central compartment lymph node dissection in papillary thyroid microcarcinoma. Endocr J, 2012, 59(4):305-311.
10. 彭冬梅, 晏晨, 苏安平, 等. cN0甲状腺微小乳头状癌右侧喉返神经浅面及深面淋巴结转移危险因素分析.中国实用外科杂志, 2016, 36(5):547-551.
11. Machens A, Holzhausen HJ, Dralle H. The prognostic value of primary tumor size in papillary and follicular thyroid carcinoma. Cancer, 2005, 103(11):p. 2269-2273.
12. Machens A, Hinze R, Thomusch O, et al. Pattern of nodal metastasis for primary and reoperative thyroid cancer. World J Surg, 2002, 26(1):22-28.
13. Kim EK, Yoon JH, Han KH, et al. Preoperative prediction of central lymph node metastasis in thyroid papillary microcarcinoma using clinicopathologic and sonographic features. World J Surg, 2013, 37(2):385-391.
14. Xu D, Lv X, Wang S, et al. Risk factors for predicting central lymph node metastasis in papillary thyroid microcarcinoma. Int J Clin Exp Pathol, 2014, 7(9):6199-6205.
15. Zhang L, Wei WJ, Ji QH, et al. Risk factors for neck nodal metastasis in papillary thyroid microcarcinoma:a study of 1066 patients. J Clin Endocrinol Metab, 2012, 97(4):1250-1257.
16. Lee KJ, Cho YJ, Kim SJ, et al. Analysis of the clinicopathologic features of papillary thyroid microcarcinoma based on 7-mm tumor size. World J Surg, 2011, 35(2):318-323.
17. Park JP, Roh JL, Lee JH, et al. Risk factors for central neck lymph node metastasis of clinically noninvasive, node-negative papillary thyroid microcarcinoma. Am J Surg, 2014, 208(3):412-418.
18. Al Afif A, Williams BA, Rigby MH, et al. Multifocal papillary thyroid cancer increases the risk of central lymph node metastasis. Thyroid, 2015, 25(9):1008-1012.
19. Katoh R, Sasaki J, Kurihara H, et al. Multiple thyroid involvement (intraglandular metastasis) in papillary thyroid carcinoma. A clinicopathologic study of 105 consecutive patients. Cancer, 1992, 70(6):1585-1590.
20. Salter KD, Andersen PE, Cohen JI, et al. Central nodal metastases in papillary thyroid carcinoma based on tumor histologic type and focality. Arch Otolaryngol Head Neck Surg, 2010, 136(7):692-696.
21. Hyun SM, Song HY, Kim SY, et al. Impact of combined prophylactic unilateral central neck dissection and hemithyroidectomy in patients with papillary thyroid microcarcinoma. Ann Surg Oncol, 2012, 19(2):591-596.
22. Lee SH, Lee SS, Jin SM, et al. Predictive factors for central compartment lymph node metastasis in thyroid papillary microcarcinoma. Laryngoscope, 2008, 118(4):659-662.
23. Arora N, Turbendian HK, Kato MA, et al. Papillary thyroid carcinoma and microcarcinoma:is there a need to distinguish the two? Thyroid, 2009, 19(5):473-477.
24. Mercante G, Frasoldati A, Pedroni C, et al. Prognostic factors affecting neck lymph node recurrence and distant metastasis in papillary microcarcinoma of the thyroid:results of a study in 445 patients. Thyroid, 2009, 19(7):707-716.
25. Besic N, Pilko G, Petric R, et al. Papillary thyroid microcarcinoma:prognostic factors and treatment. J Surg Oncol, 2008, 97(3):221-225.
26. Lombardi CP, Bellantone R, De Crea C, et al. Papillary thyroid microcarcinoma:extrathyroidal extension, lymph node metastases, and risk factors for recurrence in a high prevalence of goiter area. World J Surg, 2010, 34(6):1214-1221.
27. Moon HJ, Kim EK, Chung WY, et al. Minimal extrathyroidal extension in patients with papillary thyroid microcarcinoma:is it a real prognostic factor? Ann Surg Oncol, 2011, 18(7):1916-1923.
28. Mohebati A, Shaha AR. Anatomy of thyroid and parathyroid glands and neurovascular relations. Clin Anat, 2012, 25(1):19-31.
29. Suman P, Wang CH, Abadin SS, et al. Risk factors for central lymph node metastasis in papillary thyroid carcinoma:A National Cancer Data Base (NCDB) study. Surgery, 2016, 159(1):31-39.
30. Kwak JY, Kim EK, Kim MJ, et al. Papillary microcarcinoma of the thyroid:predicting factors of lateral neck node metastasis. Ann Surg Oncol, 2009, 16(5):1348-1355.
31. Lee YS, Shin SC, Lim YS, et al. Tumor location-dependent skip lateral cervical lymph node metastasis in papillary thyroid cancer. Head Neck, 2014, 36(6):887-891.
32. Karatzas T, Charitoudis G, Vasileiadis D, et al. Surgical treatment for dominant malignant nodules of the isthmus of the thyroid gland:A case control study. Int J Surg, 2015, 18:64-68.
33. Lee YS, Jeong JJ, Nam KH, et al. Papillary carcinoma located in the thyroid isthmus. World J Surg, 2010, 34(1):36-39.
34. Lei JY, Zhu JQ, Li ZH, et al. Surgical procedures for papillary thyroid carcinoma located in the thyroid isthmus:an intention-to-treat analysis. Onco Targets Ther, 2016, 9:5209-5216.
35. Xing M, Alzahrani AS, Carson KA, et al. Association between BRAFV600E mutation and mortality in patients with papillary thyroid cancer. Jama, 2013, 309(14):1493-1501.
36. Cancer Genome Atlas Research Network. Integrated genomic characterization of papillary thyroid carcinoma. Cell, 2014, 159(3):676-690.
37. Li F, Chen G, Sheng C, et al. BRAFV600E mutation in papillary thyroid microcarcinoma:a meta-analysis. Endocr Relat Cancer, 2015, 22(2):159-168.
38. Ma YJ, Deng XL, Li HQ. BRAFV600E mutation and its association with clinicopathological features of papillary thyroid microcarcinoma:A meta-analysis. J Huazhong Univ Sci Technolog Med Sci, 2015, 35(4):591-599.
39. Park VY, Kim EK, Lee HS,et al. Real-time PCR cycle threshold values for the BRAFV600E mutation in papillary thyroid microcarcinoma may be associated with central lymph node metastasis:a retrospective study. Medicine (Baltimore), 2015, 94(28):e1149.
40. Lin KL, Wang OC, Zhang XH, et al. The BRAF mutation is predictive of aggressive clinicopathological characteristics in papillary thyroid microcarcinoma. Ann Surg Oncol, 2010, 17(12):3294-300.
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