Research Progress of Relationship Between IGFBP Gene and Pancreatic Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 TANZhi-hui ,  ZHANGXian-lin

Department of General Surgery of Renhe Hospital, Three Gorges University, Yichang 443002, Hubei Province, China;

Corresponding author：

ZHANGXian-lin, Email: 706456093@qq.com

Keywords：

Insulin-like growth factor binding protein; Pancreatic cancer

DOI：

10.7507/1007-9424.20160330

Video：

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Objective To investigate the relationship between insulin-like growth factor binding protein (IGFBP) gene with pancreatic cancer. Methods The relevant literatures at home and abroad in recent years were reviewed. From the pancreatic cancer related genes, IGFBP related tumors and the correlation between IGFBP and pancreatic cancer research and other aspects of the previous research results were summaried. Results Most of the studies suggested that IGFBP could inhibit the function of tumor cells through the IGF dependent pathway, but the deletion or mutation of IGFBP gene and its regulation mechanism are still unclear. Conclusion IGFBP is closely related to the tumor, but its specific effects and mechanism of pancreatic cancer has not been settled. In order to affect the degree of cell differentiation, regulation of tumor growth and metastasis probability through the change of endogenous IGFBP gene level, the further studie is needed.

Citation： TAN Zhi-hui, ZHANG Xian-lin. Research Progress of Relationship Between IGFBP Gene and Pancreatic Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(10): 1285-1288. doi: 10.7507/1007-9424.20160330 Copy

1.	Zhang Q, Zeng L, Chen Y, et al. Pancreatic cancer epidemiology, detection, and management. Gastroenterol Res Pract, 2016, 2016:8962321.
2.	Tas F, Bilgin E, Tastekin D, et al. Serum IGF-1 and IGFBP-3 levels as clinical markers for patients with lung cancer. Biomed Rep, 2016, 4(5):609-614.
3.	Ho GY, Zheng SL, Cushman M, et al. Associations of insulin and IGFBP-3 with lung cancer susceptibility in current smokers. J Natl Cancer Inst, 2016, 108(7):pii:djw012.
4.	Li H, Zhao M, Wang Q, et al. Genetic polymorphisms of insulin-like growth factor 1 and insulin-like growth factor binding protein 3, xenoestrogen, phytoestrogen, and premenopausal breast cancer. Curr Oncol, 2016, 23(1):e17-e23.
5.	王玉柱,薛焕洲,付强,等. 小干扰RNA特异性沉默c-myc基因对人胰腺癌SW1990细胞生物学影响. 中华实验外科杂志, 2015, 32(2):330-332.
6.	林志川,陈谭根,李建国. 胰腺癌中人RUNT相关转录因子3基因启动子区甲基化及其临床意义. 上海交通大学学报:医学版, 2012, 32(8):1034-1037.
7.	田青水,张宝明,李德春. RECK基因在胰腺癌中的表达及其与预后的关系. 中华肝胆外科杂志, 2013, 19(8):580-585.
8.	Pasiliao CC, Chang CW, Sutherland BW, et al. The involvement of insulin-like growth factor 2 binding protein 3(IMP3) in pancreatic cancer cell migration, invasion, and adhesion. BMC Cancer, 2015, 15:266.
9.	Tian D, Mitchell I, Kreeger PK. Quantitative analysis of insulin-like growth factor 2 receptor and insulin-like growth factor binding proteins to identify control mechanisms for insulin-like growth factor 1 receptor phosphorylation. BMC Syst Biol, 2016, 10:15.
10.	康军朋,郭淑芹,张云良,等. 结直肠癌组织中IGF-1R、IGFBP-3的表达及意义. 临床与实验病理学杂志, 2014, 30(2):149-152.
11.	Rohrmann S, Linseisen J, Becker S, et al. Concentrations of IGF-I and IGFBP-3 and brain tumor risk in the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiol Biomarkers Prev, 2011, 20(10):2174-2182.
12.	刘丹丹,温秋婷,蒋淑婉,等. IGFBP-1在上皮性卵巢癌上的表达及与肿瘤分化的关系. 哈尔滨医科大学学报, 2012, 46(6):539-542.
13.	Hawsawi Y, Humphries MP, Wright A, et al. Deregulation of IGF-binding proteins -2 and -5 contributes to the development of endocrine resistant breast cancer in vitro. Oncotarget, 2016 Apr 1.[Epub ahead of print].
14.	闫晓娟,田瑛,王翠,等. IGFBP-2、-3在卵巢上皮性癌患者血液和卵巢肿瘤组织中的表达临床意义. 四川大学学报:医学版, 2009, 40(4):639-643.
15.	李艳辉,高颖,汪宏波,等. 子宫内膜癌肿瘤微环境内IGFBP-3表达及其对肿瘤侵袭能力的影响. 现代妇产科进展, 2014, 23(6):422-426.
16.	Grimberg A, Cohen P. Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis. J Cell Physiol, 2000, 183(1):1-9.
17.	Chen R Y, Chen H X, Jian P, et al. Intratumoral injection of pEGFC1-IGFBP7 inhibits malignant melanoma growth in C57BL/6J mice by inducing apoptosis and down-regulating VEGF expression. Oncol Rep, 2010, 23(4):981-988.
18.	Schrama D, Kneitz H, Willmes C, et al. Lack of correlation between IGFBP7 expression and BRAF mutational status in melanoma. J Invest Dermatol, 2010, 130(3):897-898.
19.	Tamura K, Yoshie M, Hashimoto K, et al. Inhibitory effect of insulin-like growth factor-binding protein-7(IGFBP7) on in vitro angiogenesis of vascular endothelial cells in the rat corpus luteum. J Reprod Dev, 2014, 60(6):447-453.
20.	Verhagen HJ, de Leeuw DC, Roemer MG, et al. IGFBP7 induces apoptosis of acute myeloid leukemia cells and synergizes with chemotherapy in suppression of leukemia cell survival. Cell Death Dis, 2014, 5:e1300.
21.	Pen A, Durocher Y, Slinn J, et al. Insulin-like growth factor binding protein 7 exhibits tumor suppressive and vessel stabilization properties in U87MG and T98G glioblastoma cell lines. Cancer Biol Ther, 2011, 12(7):634-646.
22.	袁磊,左曙光,范文娟,等. IGFBP7对人乳腺癌MCF-7细胞增殖的影响及其机制. 中国病理生理杂志, 2012, 28(10):1835-1840.
23.	Rao C, Lin SL, Ruan WJ, et al. High expression of IGFBP7 in fibroblasts induced by colorectal cancer cells is co-regulated by TGF-beta and Wnt signaling in a Smad2/3-Dvl2/3-dependent manner. PLoS One, 2014, 9(1):e85340.
24.	Liu L, Yang Z, Zhang W, et al. Decreased expression of IGFBP7 was a poor prognosis predictor for gastric cancer patients. Tumour Biol, 2014, 35(9):8875-8881.
25.	Sato Y, Inokuchi M, Takagi Y, et al. Relationship between expression of IGFBP7 and clinicopathological variables in gastric cancer. J Clin Pathol, 2015, 68(10):795-801.
26.	Smith E, Ruszkiewicz AR, Jamieson GG, et al. IGFBP7 is associated with poor prognosis in oesophageal adenocarcinoma and is regulated by promoter DNA methylation. Br J Cancer, 2014, 110(3):775-782.
27.	Gambaro K, Quinn MC, Caceres-Gorriti KY, et al. Low levels of IGFBP7 expression in high-grade serous ovarian carcinoma is associated with patient outcome. BMC Cancer, 2015, 15:135.
28.	Okamura J, Huang Y, Moon D, et al. Downregulation of insulin-like growth factor-binding protein 7 in cisplatin-resistant non-small cell lung cancer. Cancer Biol Ther, 2012, 13(3):148-155.
29.	Li F, Li Y, Liu H, et al. Transgenic Wuzhishan minipigs designed to express a dominant-negative porcine growth hormone receptor display small stature and a perturbed insulin/IGF-1 pathway. Transgenic Res, 2015, 24(6):1029-1042.
30.	Zhou H, Qian W, Uckun FM, et al. IGF1 receptor targeted theranostic nanoparticles for targeted and image-guided therapy of pancreatic cancer. ACS Nano, 2015, 9(8):7976-7991.
31.	Rosendahl AH, Gundewar C, Said HK, et al. Conditionally immortalized human pancreatic stellate cell lines demonstrate enhanced proliferation and migration in response to IGF-I. Exp Cell Res, 2015, 330(2):300-310.
32.	Miwa T, Kokuryo T, Yokoyama Y, et al. Therapeutic potential of targeting protein for Xklp2 silencing for pancreatic cancer. Cancer Med, 2015, 4(7):1091-1100.
33.	Fu T, Pappou EP, Guzzetta AA, et al. IGFBP-3 gene methylation in primary tumor predicts recurrence of stage Ⅱ Colorectal Cancers. Ann Surg, 2016, 263(2):337-344.
34.	Kendrick ZW, Firpo MA, Repko RC, et al. Serum IGFBP2 and MSLN as diagnostic and prognostic biomarkers for pancreatic cancer. HPB (Oxford), 2014, 16(7):670-676.
35.	An W, Ben QW, Chen HT, et al. Low expression of IGFBP7 is associated with poor outcome of pancreatic ductal adenocarcinoma. Ann Surg Oncol, 2012, 19(12):3971-3978.
36.	Grønborg M, Kristiansen TZ, Iwahori A, et al. Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach. Mol Cell Proteomics, 2006, 5(1):157-171.
37.	Sandhu MS, Dunger DB, Giovannucci EL. Insulin, insulin-like growth factor-I (IGF-I), IGF binding proteins, their biologic interactions, and colorectal cancer. J Natl Cancer Inst, 2002, 94(13):972-980.
38.	Ruan W, Xu E, Xu F, et al. IGFBP7 plays a potential tumorsuppressor role in colorectal carcinogenesis. Cancer Biol Ther, 2007, 6(3):354-359.

1. Zhang Q, Zeng L, Chen Y, et al. Pancreatic cancer epidemiology, detection, and management. Gastroenterol Res Pract, 2016, 2016:8962321.
2. Tas F, Bilgin E, Tastekin D, et al. Serum IGF-1 and IGFBP-3 levels as clinical markers for patients with lung cancer. Biomed Rep, 2016, 4(5):609-614.
3. Ho GY, Zheng SL, Cushman M, et al. Associations of insulin and IGFBP-3 with lung cancer susceptibility in current smokers. J Natl Cancer Inst, 2016, 108(7):pii:djw012.
4. Li H, Zhao M, Wang Q, et al. Genetic polymorphisms of insulin-like growth factor 1 and insulin-like growth factor binding protein 3, xenoestrogen, phytoestrogen, and premenopausal breast cancer. Curr Oncol, 2016, 23(1):e17-e23.
5. 王玉柱,薛焕洲,付强,等. 小干扰RNA特异性沉默c-myc基因对人胰腺癌SW1990细胞生物学影响. 中华实验外科杂志, 2015, 32(2):330-332.
6. 林志川,陈谭根,李建国. 胰腺癌中人RUNT相关转录因子3基因启动子区甲基化及其临床意义. 上海交通大学学报:医学版, 2012, 32(8):1034-1037.
7. 田青水,张宝明,李德春. RECK基因在胰腺癌中的表达及其与预后的关系. 中华肝胆外科杂志, 2013, 19(8):580-585.
8. Pasiliao CC, Chang CW, Sutherland BW, et al. The involvement of insulin-like growth factor 2 binding protein 3(IMP3) in pancreatic cancer cell migration, invasion, and adhesion. BMC Cancer, 2015, 15:266.
9. Tian D, Mitchell I, Kreeger PK. Quantitative analysis of insulin-like growth factor 2 receptor and insulin-like growth factor binding proteins to identify control mechanisms for insulin-like growth factor 1 receptor phosphorylation. BMC Syst Biol, 2016, 10:15.
10. 康军朋,郭淑芹,张云良,等. 结直肠癌组织中IGF-1R、IGFBP-3的表达及意义. 临床与实验病理学杂志, 2014, 30(2):149-152.
11. Rohrmann S, Linseisen J, Becker S, et al. Concentrations of IGF-I and IGFBP-3 and brain tumor risk in the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiol Biomarkers Prev, 2011, 20(10):2174-2182.
12. 刘丹丹,温秋婷,蒋淑婉,等. IGFBP-1在上皮性卵巢癌上的表达及与肿瘤分化的关系. 哈尔滨医科大学学报, 2012, 46(6):539-542.
13. Hawsawi Y, Humphries MP, Wright A, et al. Deregulation of IGF-binding proteins -2 and -5 contributes to the development of endocrine resistant breast cancer in vitro. Oncotarget, 2016 Apr 1.[Epub ahead of print].
14. 闫晓娟,田瑛,王翠,等. IGFBP-2、-3在卵巢上皮性癌患者血液和卵巢肿瘤组织中的表达临床意义. 四川大学学报:医学版, 2009, 40(4):639-643.
15. 李艳辉,高颖,汪宏波,等. 子宫内膜癌肿瘤微环境内IGFBP-3表达及其对肿瘤侵袭能力的影响. 现代妇产科进展, 2014, 23(6):422-426.
16. Grimberg A, Cohen P. Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis. J Cell Physiol, 2000, 183(1):1-9.
17. Chen R Y, Chen H X, Jian P, et al. Intratumoral injection of pEGFC1-IGFBP7 inhibits malignant melanoma growth in C57BL/6J mice by inducing apoptosis and down-regulating VEGF expression. Oncol Rep, 2010, 23(4):981-988.
18. Schrama D, Kneitz H, Willmes C, et al. Lack of correlation between IGFBP7 expression and BRAF mutational status in melanoma. J Invest Dermatol, 2010, 130(3):897-898.
19. Tamura K, Yoshie M, Hashimoto K, et al. Inhibitory effect of insulin-like growth factor-binding protein-7(IGFBP7) on in vitro angiogenesis of vascular endothelial cells in the rat corpus luteum. J Reprod Dev, 2014, 60(6):447-453.
20. Verhagen HJ, de Leeuw DC, Roemer MG, et al. IGFBP7 induces apoptosis of acute myeloid leukemia cells and synergizes with chemotherapy in suppression of leukemia cell survival. Cell Death Dis, 2014, 5:e1300.
21. Pen A, Durocher Y, Slinn J, et al. Insulin-like growth factor binding protein 7 exhibits tumor suppressive and vessel stabilization properties in U87MG and T98G glioblastoma cell lines. Cancer Biol Ther, 2011, 12(7):634-646.
22. 袁磊,左曙光,范文娟,等. IGFBP7对人乳腺癌MCF-7细胞增殖的影响及其机制. 中国病理生理杂志, 2012, 28(10):1835-1840.
23. Rao C, Lin SL, Ruan WJ, et al. High expression of IGFBP7 in fibroblasts induced by colorectal cancer cells is co-regulated by TGF-beta and Wnt signaling in a Smad2/3-Dvl2/3-dependent manner. PLoS One, 2014, 9(1):e85340.
24. Liu L, Yang Z, Zhang W, et al. Decreased expression of IGFBP7 was a poor prognosis predictor for gastric cancer patients. Tumour Biol, 2014, 35(9):8875-8881.
25. Sato Y, Inokuchi M, Takagi Y, et al. Relationship between expression of IGFBP7 and clinicopathological variables in gastric cancer. J Clin Pathol, 2015, 68(10):795-801.
26. Smith E, Ruszkiewicz AR, Jamieson GG, et al. IGFBP7 is associated with poor prognosis in oesophageal adenocarcinoma and is regulated by promoter DNA methylation. Br J Cancer, 2014, 110(3):775-782.
27. Gambaro K, Quinn MC, Caceres-Gorriti KY, et al. Low levels of IGFBP7 expression in high-grade serous ovarian carcinoma is associated with patient outcome. BMC Cancer, 2015, 15:135.
28. Okamura J, Huang Y, Moon D, et al. Downregulation of insulin-like growth factor-binding protein 7 in cisplatin-resistant non-small cell lung cancer. Cancer Biol Ther, 2012, 13(3):148-155.
29. Li F, Li Y, Liu H, et al. Transgenic Wuzhishan minipigs designed to express a dominant-negative porcine growth hormone receptor display small stature and a perturbed insulin/IGF-1 pathway. Transgenic Res, 2015, 24(6):1029-1042.
30. Zhou H, Qian W, Uckun FM, et al. IGF1 receptor targeted theranostic nanoparticles for targeted and image-guided therapy of pancreatic cancer. ACS Nano, 2015, 9(8):7976-7991.
31. Rosendahl AH, Gundewar C, Said HK, et al. Conditionally immortalized human pancreatic stellate cell lines demonstrate enhanced proliferation and migration in response to IGF-I. Exp Cell Res, 2015, 330(2):300-310.
32. Miwa T, Kokuryo T, Yokoyama Y, et al. Therapeutic potential of targeting protein for Xklp2 silencing for pancreatic cancer. Cancer Med, 2015, 4(7):1091-1100.
33. Fu T, Pappou EP, Guzzetta AA, et al. IGFBP-3 gene methylation in primary tumor predicts recurrence of stage Ⅱ Colorectal Cancers. Ann Surg, 2016, 263(2):337-344.
34. Kendrick ZW, Firpo MA, Repko RC, et al. Serum IGFBP2 and MSLN as diagnostic and prognostic biomarkers for pancreatic cancer. HPB (Oxford), 2014, 16(7):670-676.
35. An W, Ben QW, Chen HT, et al. Low expression of IGFBP7 is associated with poor outcome of pancreatic ductal adenocarcinoma. Ann Surg Oncol, 2012, 19(12):3971-3978.
36. Grønborg M, Kristiansen TZ, Iwahori A, et al. Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach. Mol Cell Proteomics, 2006, 5(1):157-171.
37. Sandhu MS, Dunger DB, Giovannucci EL. Insulin, insulin-like growth factor-I (IGF-I), IGF binding proteins, their biologic interactions, and colorectal cancer. J Natl Cancer Inst, 2002, 94(13):972-980.
38. Ruan W, Xu E, Xu F, et al. IGFBP7 plays a potential tumorsuppressor role in colorectal carcinogenesis. Cancer Biol Ther, 2007, 6(3):354-359.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Research Progress of Relationship Between IGFBP Gene and Pancreatic Cancer

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