The latest research progress of relation between microRNA-203 and tumors_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

FENG Lei ,  XU Mingqing

Department of Liver Surgery, West China Hospital, Sichuan University, Chengdu 610041, P.R.China;

Corresponding author：

XU Mingqing, Email: xumingqing0018@163.com

Keywords：

microRNA-203; target gene; tumor; research progress

DOI：

10.7507/1007-9424.201606045

Video：

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Objective To review generation, distribution of microRNA-203 (miR-203) and it’s relation with tumors. Method Domestic and international literatures were collected to summarize the generation, distribution of miR-203 and it’s relation with tumors. Result Although the previous studies of miR-203 have shown an encouraging result, but only a small portion of miR-203 biological functions are identified, the regulatory mechanism of downstream target genes also has not been fully elucidated. Conclusion With deepening of research, miR-203 might play an active role in classification, categorizing, diagnosis, treatment, and prognosis of tumors.

Citation： FENGLei, XUMingqing. The latest research progress of relation between microRNA-203 and tumors. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2017, 24(2): 259-263. doi: 10.7507/1007-9424.201606045 Copy

1.	Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell, 1993, 75(5): 843-854.
2.	Jovanovic M, Hengartner MO. miRNAs and apoptosis: RNAs to die for. Oncogene, 2006, 25(46): 6176-6187.
3.	Blenkiron C, Miska EA. miRNAs in cancer: approaches, aetiology, diagnostics and therapy. Hum Mol Genet, 2007, 16 Spec No 1: R106-R113.
4.	Chim CS, Wong KY, Leung CY,et al. Epigenetic inactivation of the hsa-miR-203 in haematological malignancies. J Cell Mol Med, 2011, 15(12): 2760-2767.
5.	Yanaihara N, Caplen N, Bowman E,et al. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell, 2006, 9(3): 189-198.
6.	Greither T, Grochola LF, Udelnow A,et al. Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival. Int J Cancer, 2010, 126(1): 73-80.
7.	Davis E, Caiment F, Tordoir X,et al. RNAi-mediated allelic trans-interaction at the imprinted Rtl1/Peg11 locus. Curr Biol, 2005, 15(8): 743-749.
8.	Meléndez B, Cuadros M, Robledo M,et al. Coincidental LOH regions in mouse and humans: evidence for novel tumor suppressor loci at 9q22-q34 in non-Hodgkin’s lymphomas. Leuk Res, 2003, 27(7): 627-633.
9.	Sonkoly E, Wei T, Janson PC,et al. MicroRNAs: novel regulators involved in the pathogenesis of psoriasis? PLoS One, 2007, 2(7): e610.
10.	崔晓宾, 陈云昭, 潘庆芳, 等. miR-203 及其靶基因与肿瘤关系的研究进展. 临床与实验病理学杂志, 2012, 28(2): 189-191.
11.	Yuan Y, Zeng ZY, Liu XH,et al. MicroRNA-203 inhibits cell proliferation by repressing ΔNp63 expression in human esophageal squamous cell carcinoma. BMC Cancer, 2011, 11: 57.
12.	Bueno MJ, Perez de Castro I, Gomez de Cedron M,et al. Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression. Cancer Cell, 2008, 13(6): 496-506.
13.	Li J, Chen Y, Zhao J,et al. miR-203 reverses chemoresistance in p53-mutated colon cancer cells through downregulation of Akt2 expression. Cancer Lett, 2011, 304(1): 52-59.
14.	Yang A, Kaghad M, Wang Y,et al. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell, 1998, 2(3): 305-316.
15.	Mangiulli M, Valletti A, Caratozzolo MF,et al. Identification and functional characterization of two new transcriptional variants of the human p63 gene. Nucleic Acids Res, 2009, 37(18): 6092-6104.
16.	Lena AM, Shalom-Feuerstein R, Rivetti di Val Cervo P,et al. miR-203 represses ‘stemness’ by repressing DeltaNp63. Cell Death Differ, 2008, 15(7): 1187-1195.
17.	Kurita T, Medina RT, Mills AA,et al. Role of p63 and basal cells in the prostate. Development, 2004, 131(20): 4955-4964.
18.	Porkka KP, Pfeiffer MJ, Waltering KK,et al. MicroRNA expression profiling in prostate cancer. Cancer Res, 2007, 67(13): 6130-6135.
19.	肖虹, 郑绘霞, 阴琰, 等. miR-203 在前列腺癌中的表达及其与预后的相关性. 肿瘤研究与临床, 2013, 26(6): 400-405.
20.	Saini S, Majid S, Yamamura S,et al. Regulatory role of mir-203 in prostate cancer progression and metastasis. Clin Cancer Res, 2011, 17(16): 5287-5298.
21.	Viticchie G, Lena AM, Latina A,et al. MiR-203 controls proliferation, migration and invasive potential of prostate cancer cell lines. Cell Cycle, 2011, 10(7): 1121-1131.
22.	Luo D, Wilson JM, Harvel N,et al. A systematic evaluation of miRNA mRNA interactions involved in the migration and invasion of breast cancer cells. J Transl Med, 2013, 11: 57.
23.	Iorio MV, Ferracin M, Liu CG,et al. MicroRNA gene expression deregulation in human breast cancer. Cancer Res, 2005, 65(16): 7065-7070.
24.	Thiery JP, Acloque H, Huang RY,et al. Epithelial-mesenchymal transitions in development and disease. Cell, 2009, 139(5): 871-890.
25.	van Kempen LC, van den Hurk K, Lazar V,et al. Loss of microRNA-200a and c, and microRNA-203 expression at the invasive front of primary cutaneous melanoma is associated with increased thickness and disease progression. Virchows Arch, 2012, 461(4): 441-448.
26.	Jin J, Deng J, Wang F,et al. The expression and function of microRNA-203 in lung cancer. Tumour Biol, 2013, 34(1): 349-357.
27.	Wang N, Liang H, Zhou Y,et al. miR-203 suppresses the proliferation and migration and promotes the apoptosis of lung cancer cells by targeting SRC. PloS One, 2014, 9(8): e105570.
28.	Zhang X, Nie Y, Du Y,et al. MicroRNA-181a promotes gastric cancer by negatively regulating tumor suppressor KLF6. Tumour Biol, 2012, 33(5): 1589-1597.
29.	Kim YK, Yu J, Han TS,et al. Functional links between clustered microRNAs: suppression of cell-cycle inhibitors by microRNA clusters in gastric cancer. Nucleic Acids Res, 2009, 37(5): 1672-1681.
30.	Petrocca F, Visone R, Onelli MR,et al. E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer. Cancer Cell, 2008, 13(3): 272-286.
31.	Cho WJ, Shin JM, Kim JS,et al. miR-372 regulates cell cycle and apoptosis of ags human gastric cancer cell line through direct regulation of LATS2. Mol Cell, 2009, 28(6): 521-527.
32.	Feng R, Chen X, Yu Y,et al. miR-126 functions as a tumour suppressor in human gastric cancer. Cancer Lett, 2010, 298(1): 50-63.
33.	Lai KW, Koh KX, Loh M,et al. MicroRNA-130b regulates the tumour suppressor RUNX3 in gastric cancer. Eur J Cancer, 2010, 46(8): 1456-1463.
34.	Zhang Z, Li Z, Gao C,et al. miR-21 plays a pivotal role in gastric cancer pathogenesis and progression. Lab Invest, 2008, 88(12): 1358-1366.
35.	Liao YL, Hu LY, Tsai KW,et al. Transcriptional regulation of miR-196b by ETS2 in gastric cancer cells. Carcinogenesis, 2012, 33(4): 760-769.
36.	Korpal M, Lee ES, Hu G,et al. The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Bio Chem, 2008, 283(22): 14910-14914.
37.	Chiang Y, Song Y, Wang Z,et al. Aberrant expression of miR-203 and its clinical significance in gastric and colorectal cancers. J Gastrointest Surg, 2010, 15(1): 63-70.
38.	Nugent M, Miller N, Kerin MJ. MicroRNAs in colorectal cancer: function, dysregulation and potential as novel biomarkers. Eur J Surg Oncol, 2011, 37(8): 649-654.
39.	姜允博, 王振宁. MiR-203 在胃肠癌中的异常表达及其临床意义. 中国医科大学, 2010.
40.	Li Z, Du L, Dong Z,et al. MiR-203 suppresses ZNF217 upregulation in colorectal cancer and its oncogenicity. PloS One, 2015, 10(1): e0116170.
41.	何玉琦, 盛剑秋. 雌激素诱导结肠癌细胞凋亡的表观遗传机制研究. 第三军医大学, 2013.
42.	Feber A, Xi L, Luketich JD,et al. MicroRNA expression profiles of esophageal cancer. J Thorac Cardiovasc Surg, 2008, 135(2): 255-260.
43.	梁佳, 董稚明, 李宏, 等. MicroRNA-203 在人食管鳞癌组织和细胞中的表达及其基因的甲基化状态. 中国肿瘤生物治疗杂志, 2014, 21(4): 376-382.
44.	Zhao S, Yao DS, Chen JY,et al. Aberrant expression of miR-20a and miR-203 in cervical cancer. Asian Pac J Cancer Prev, 2013, 14(4): 2289-2293.
45.	Zhao S, Yao DS, Chen JY,et al. Circulating miRNA-20a and miRNA-203 for screening lymph node metastasis in early stage cervical cancer. Genet Test Mol Biomarkers, 2013, 17(8): 631-636.
46.	Zhu X, Er K, Mao C,et al. miR-203 suppresses tumor growth and angiogenesis by targeting VEGFA in cervical cancer. Cell Physiol Biochem, 2013, 32(1): 64-73.
47.	Roskoski R Jr. Vascular endothelial growth factor (VEGF) signaling in tumor progression. Crit Rev Oncol Hematol, 2007, 62(3): 179-213.
48.	李晓霞, 李瑞平, 杜紫明, 等. 鼻咽癌差异表达 miRNAs 筛选研究. 中山大学学报(医学科学版), 2007, 28(6): 607-612.
49.	Siegel RL, Fedewa SA, Miller KD,et al. Cancer statistics for Hispanics/Latinos, 2015. CA Cancer J Clin, 2015, 65(6): 457-480.
50.	Murakami Y, Yasuda T, Saigo K,et al. Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues. Oncogene, 2006, 25(17): 2537-2545.
51.	Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med, 2003, 349(21): 2042-2054.
52.	Furuta M, Kozaki KI, Tanaka S,et al. miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma. Carcinogenesis, 2010, 31(5): 766-776.
53.	Chen HY, Han ZB, Fan JW,et al. miR-203 expression predicts outcome after liver transplantation for hepatocellular carcinoma in cirrhotic liver. Med Onco, 2012, 29(3): 1859-1865.

1. Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell, 1993, 75(5): 843-854.
2. Jovanovic M, Hengartner MO. miRNAs and apoptosis: RNAs to die for. Oncogene, 2006, 25(46): 6176-6187.
3. Blenkiron C, Miska EA. miRNAs in cancer: approaches, aetiology, diagnostics and therapy. Hum Mol Genet, 2007, 16 Spec No 1: R106-R113.
4. Chim CS, Wong KY, Leung CY,et al. Epigenetic inactivation of the hsa-miR-203 in haematological malignancies. J Cell Mol Med, 2011, 15(12): 2760-2767.
5. Yanaihara N, Caplen N, Bowman E,et al. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell, 2006, 9(3): 189-198.
6. Greither T, Grochola LF, Udelnow A,et al. Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival. Int J Cancer, 2010, 126(1): 73-80.
7. Davis E, Caiment F, Tordoir X,et al. RNAi-mediated allelic trans-interaction at the imprinted Rtl1/Peg11 locus. Curr Biol, 2005, 15(8): 743-749.
8. Meléndez B, Cuadros M, Robledo M,et al. Coincidental LOH regions in mouse and humans: evidence for novel tumor suppressor loci at 9q22-q34 in non-Hodgkin’s lymphomas. Leuk Res, 2003, 27(7): 627-633.
9. Sonkoly E, Wei T, Janson PC,et al. MicroRNAs: novel regulators involved in the pathogenesis of psoriasis? PLoS One, 2007, 2(7): e610.
10. 崔晓宾, 陈云昭, 潘庆芳, 等. miR-203 及其靶基因与肿瘤关系的研究进展. 临床与实验病理学杂志, 2012, 28(2): 189-191.
11. Yuan Y, Zeng ZY, Liu XH,et al. MicroRNA-203 inhibits cell proliferation by repressing ΔNp63 expression in human esophageal squamous cell carcinoma. BMC Cancer, 2011, 11: 57.
12. Bueno MJ, Perez de Castro I, Gomez de Cedron M,et al. Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression. Cancer Cell, 2008, 13(6): 496-506.
13. Li J, Chen Y, Zhao J,et al. miR-203 reverses chemoresistance in p53-mutated colon cancer cells through downregulation of Akt2 expression. Cancer Lett, 2011, 304(1): 52-59.
14. Yang A, Kaghad M, Wang Y,et al. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell, 1998, 2(3): 305-316.
15. Mangiulli M, Valletti A, Caratozzolo MF,et al. Identification and functional characterization of two new transcriptional variants of the human p63 gene. Nucleic Acids Res, 2009, 37(18): 6092-6104.
16. Lena AM, Shalom-Feuerstein R, Rivetti di Val Cervo P,et al. miR-203 represses ‘stemness’ by repressing DeltaNp63. Cell Death Differ, 2008, 15(7): 1187-1195.
17. Kurita T, Medina RT, Mills AA,et al. Role of p63 and basal cells in the prostate. Development, 2004, 131(20): 4955-4964.
18. Porkka KP, Pfeiffer MJ, Waltering KK,et al. MicroRNA expression profiling in prostate cancer. Cancer Res, 2007, 67(13): 6130-6135.
19. 肖虹, 郑绘霞, 阴琰, 等. miR-203 在前列腺癌中的表达及其与预后的相关性. 肿瘤研究与临床, 2013, 26(6): 400-405.
20. Saini S, Majid S, Yamamura S,et al. Regulatory role of mir-203 in prostate cancer progression and metastasis. Clin Cancer Res, 2011, 17(16): 5287-5298.
21. Viticchie G, Lena AM, Latina A,et al. MiR-203 controls proliferation, migration and invasive potential of prostate cancer cell lines. Cell Cycle, 2011, 10(7): 1121-1131.
22. Luo D, Wilson JM, Harvel N,et al. A systematic evaluation of miRNA mRNA interactions involved in the migration and invasion of breast cancer cells. J Transl Med, 2013, 11: 57.
23. Iorio MV, Ferracin M, Liu CG,et al. MicroRNA gene expression deregulation in human breast cancer. Cancer Res, 2005, 65(16): 7065-7070.
24. Thiery JP, Acloque H, Huang RY,et al. Epithelial-mesenchymal transitions in development and disease. Cell, 2009, 139(5): 871-890.
25. van Kempen LC, van den Hurk K, Lazar V,et al. Loss of microRNA-200a and c, and microRNA-203 expression at the invasive front of primary cutaneous melanoma is associated with increased thickness and disease progression. Virchows Arch, 2012, 461(4): 441-448.
26. Jin J, Deng J, Wang F,et al. The expression and function of microRNA-203 in lung cancer. Tumour Biol, 2013, 34(1): 349-357.
27. Wang N, Liang H, Zhou Y,et al. miR-203 suppresses the proliferation and migration and promotes the apoptosis of lung cancer cells by targeting SRC. PloS One, 2014, 9(8): e105570.
28. Zhang X, Nie Y, Du Y,et al. MicroRNA-181a promotes gastric cancer by negatively regulating tumor suppressor KLF6. Tumour Biol, 2012, 33(5): 1589-1597.
29. Kim YK, Yu J, Han TS,et al. Functional links between clustered microRNAs: suppression of cell-cycle inhibitors by microRNA clusters in gastric cancer. Nucleic Acids Res, 2009, 37(5): 1672-1681.
30. Petrocca F, Visone R, Onelli MR,et al. E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer. Cancer Cell, 2008, 13(3): 272-286.
31. Cho WJ, Shin JM, Kim JS,et al. miR-372 regulates cell cycle and apoptosis of ags human gastric cancer cell line through direct regulation of LATS2. Mol Cell, 2009, 28(6): 521-527.
32. Feng R, Chen X, Yu Y,et al. miR-126 functions as a tumour suppressor in human gastric cancer. Cancer Lett, 2010, 298(1): 50-63.
33. Lai KW, Koh KX, Loh M,et al. MicroRNA-130b regulates the tumour suppressor RUNX3 in gastric cancer. Eur J Cancer, 2010, 46(8): 1456-1463.
34. Zhang Z, Li Z, Gao C,et al. miR-21 plays a pivotal role in gastric cancer pathogenesis and progression. Lab Invest, 2008, 88(12): 1358-1366.
35. Liao YL, Hu LY, Tsai KW,et al. Transcriptional regulation of miR-196b by ETS2 in gastric cancer cells. Carcinogenesis, 2012, 33(4): 760-769.
36. Korpal M, Lee ES, Hu G,et al. The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Bio Chem, 2008, 283(22): 14910-14914.
37. Chiang Y, Song Y, Wang Z,et al. Aberrant expression of miR-203 and its clinical significance in gastric and colorectal cancers. J Gastrointest Surg, 2010, 15(1): 63-70.
38. Nugent M, Miller N, Kerin MJ. MicroRNAs in colorectal cancer: function, dysregulation and potential as novel biomarkers. Eur J Surg Oncol, 2011, 37(8): 649-654.
39. 姜允博, 王振宁. MiR-203 在胃肠癌中的异常表达及其临床意义. 中国医科大学, 2010.
40. Li Z, Du L, Dong Z,et al. MiR-203 suppresses ZNF217 upregulation in colorectal cancer and its oncogenicity. PloS One, 2015, 10(1): e0116170.
41. 何玉琦, 盛剑秋. 雌激素诱导结肠癌细胞凋亡的表观遗传机制研究. 第三军医大学, 2013.
42. Feber A, Xi L, Luketich JD,et al. MicroRNA expression profiles of esophageal cancer. J Thorac Cardiovasc Surg, 2008, 135(2): 255-260.
43. 梁佳, 董稚明, 李宏, 等. MicroRNA-203 在人食管鳞癌组织和细胞中的表达及其基因的甲基化状态. 中国肿瘤生物治疗杂志, 2014, 21(4): 376-382.
44. Zhao S, Yao DS, Chen JY,et al. Aberrant expression of miR-20a and miR-203 in cervical cancer. Asian Pac J Cancer Prev, 2013, 14(4): 2289-2293.
45. Zhao S, Yao DS, Chen JY,et al. Circulating miRNA-20a and miRNA-203 for screening lymph node metastasis in early stage cervical cancer. Genet Test Mol Biomarkers, 2013, 17(8): 631-636.
46. Zhu X, Er K, Mao C,et al. miR-203 suppresses tumor growth and angiogenesis by targeting VEGFA in cervical cancer. Cell Physiol Biochem, 2013, 32(1): 64-73.
47. Roskoski R Jr. Vascular endothelial growth factor (VEGF) signaling in tumor progression. Crit Rev Oncol Hematol, 2007, 62(3): 179-213.
48. 李晓霞, 李瑞平, 杜紫明, 等. 鼻咽癌差异表达 miRNAs 筛选研究. 中山大学学报(医学科学版), 2007, 28(6): 607-612.
49. Siegel RL, Fedewa SA, Miller KD,et al. Cancer statistics for Hispanics/Latinos, 2015. CA Cancer J Clin, 2015, 65(6): 457-480.
50. Murakami Y, Yasuda T, Saigo K,et al. Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues. Oncogene, 2006, 25(17): 2537-2545.
51. Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med, 2003, 349(21): 2042-2054.
52. Furuta M, Kozaki KI, Tanaka S,et al. miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma. Carcinogenesis, 2010, 31(5): 766-776.
53. Chen HY, Han ZB, Fan JW,et al. miR-203 expression predicts outcome after liver transplantation for hepatocellular carcinoma in cirrhotic liver. Med Onco, 2012, 29(3): 1859-1865.

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