<trans-title xml:lang="en"/>_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

廖辉雄 ¹ , 李志刚 ² ,  谢东伟 ²

1. ;
2. ;

Corresponding author：

谢东伟, Email: 1044126847@qq.com

Keywords：

降钙素原; 超敏C反应蛋白; 老年; 胃十二肠溃疡急性穿孔; 脓毒血症

DOI：

10.7507/1007-9424.201608040

Video：

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目的探讨血清降钙素原（PCT）与超敏C反应蛋白（hs-CRP）联合检测对老年胃十二肠溃疡急性穿孔合并腹膜炎的诊疗价值。方法选择老年胃十二肠溃疡急性穿孔患者共88例，所有患者于确诊胃十二肠溃疡急性穿孔使用抗菌药物前同时检测外周血PCT和hs-cRP水平，并同时进行白细胞计数和血培养。结果非脓毒症组、轻度脓毒症组和重度脓毒症组患者的血清PCT及hs-CRP水平依次升高，3 组间差异有统计学意义（P＜0.01）。非脓毒症组、轻度脓毒症组和重度脓毒症组白细胞计数依次升高，3 组间差异有统计学意义（P＜0.01）。非脓毒症组血培养结果阳性率为 0；轻度脓毒症组血培养结果阳性者 5 例，占全部血培养患者的5.68%；重度脓毒症组血培养结果阳性者38例，占全部血培养患者的43.18%，3 组间的差异有统计学意义（P＜0.01）。结论 PCTM与hs-CRP联合检测有助于老年胃十二肠溃疡急性穿孔合并腹膜炎患者感染状况的判断以及指导抗菌药物的使用。

Citation： XIEDongwei. . CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2017, 24(1): 101-103. doi: 10.7507/1007-9424.201608040 Copy

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11.	郭晓俊, 王青, 宋颖, 等. 新鲜血液白细胞计数参考方法的测量不确定度评定. 检验医学, 2015, 30(5): 512-516.
12.	Pepys MB, Hirschfield GM. C-reactive protein a critical update. J Clin Invest, 2003, 111(12): 1805-1812.
13.	侯伟伟, 肖倩茹, 江涟, 等. 血清降钙素原作为菌血症预示因子临床价值的研究. 检验医学, 2014, 29(8): 802-805.
14.	李龙, 王飞. 老年胃十二指肠溃疡穿孔的诊治. 中外医学研究, 2010, 8(17): 789-793.

1. 李荣, 罗成华. 老年人急腹症的诊断与剖腹探查. 中国实用外科杂志, 2003, 23(7): 401-403.
2. 覃关道, 潘枝婉, 覃振党. 螺旋CT诊断胃十二肠溃疡穿孔的价值分析. 2014, 35(1): 69-70.
3. 叶钢. 探讨脓毒血症预后评估中降钙素原和N末端前体脑钠肽的临床意义. 中华高血压杂志, 2015, 23(综合3): 337-338.
4. Hall KK, Lyman JA. Updated review of blood culture contamination. Clin Microbiol Rev, 2006, 19(4): 788-802.
5. Schuetz P, Mueller B, Trampuz A. Serum procalcitonin for discrimination of blood contamination from bloodstream infection due to coagulase-negative staphylococci. Infection, 2007, 35(5): 352-355.
6. Gendrel D, Bohuon C. Procalcitonin as a marker of bacterial infection. Pediatr Infect Dis J, 2000, 19(8): 679-687.
7. Vincen JL, DOnadello K, Schmit X. Biomarkers in the critically ill patient: C-reactive protein. Crit Care CLin, 2011, 27(2): 241-251.
8. Reinhart K, Karzai W, Meisner M. Procalcitonin as a marker of the systemic inflammatory response to infection. Intensive Care Med, 2000, 26(9): 1193-1200.
9. Meisner M, Schmidt J, Huttner H, et al. The natural elimination rate of procalcitonin in patients with normal and impaired renal function. Intensive Care Med, 2000, 26(Suppl 2): S212-S216.
10. Harbarth S, Holeckova K, Froidevaux C, et al. Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis. Am J Respir Crit Care Med, 2001, 164(3): 396-402.
11. 郭晓俊, 王青, 宋颖, 等. 新鲜血液白细胞计数参考方法的测量不确定度评定. 检验医学, 2015, 30(5): 512-516.
12. Pepys MB, Hirschfield GM. C-reactive protein a critical update. J Clin Invest, 2003, 111(12): 1805-1812.
13. 侯伟伟, 肖倩茹, 江涟, 等. 血清降钙素原作为菌血症预示因子临床价值的研究. 检验医学, 2014, 29(8): 802-805.
14. 李龙, 王飞. 老年胃十二指肠溃疡穿孔的诊治. 中外医学研究, 2010, 8(17): 789-793.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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