Ultrasonographic features of gastrointestinal stromal tumors_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 SHEN Shihua , LI Jianwei , WU Songsong , ZHU Lin , CHEN Sheng , YE Zhensheng

Department of Ultrasound, Fujian Provincial Hospital, Fuzhou 350001, P.R.China;

Corresponding author：

SHEN Shihua, Email: 13635264982@163.com

Keywords：

color Doppler; gastrointestinal stromal tumor; gastrointestinal cancer

DOI：

10.7507/1007-9424.201610001

Video：

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Objective To analyze features of color Doppler ultrasonography in gastrointestinal stromal tumors. Method The ultrasound images of gastrointestinal stromal tumors (51 cases) and gastrointestinal cancers (59 cases) confirmed by operation and pathology were compared and analyzed. Results The gastric stromal tumor mainly occurred at the bottom of the stomach and the body of the stomach (17 cases), the intestinal stromal tumor mainly occurred at the small intestine (24 cases). The gastric cancer mainly occurred at the gastric antrum (18 cases), the intestinal cancer all occurred at the colon (20 cases) and rectum (12 cases). Compared with the gastrointestinal cancers, the gastrointestinal cavity was not surrounded by tumor, the peripheral boundary was clear, the morphology was more regular, the internal echo was uneven, and there was no peripheral lymph node metastasis in the gastrointestinal stromal tumors, the differences were statistically significant (P<0.05). There were no significant differences in the degree of blood flow and tumor diameter between the gastrointestinal stromal tumors and the gastrointestinal cancers (P>0.05), but the blood flow of the intestinal stromal tumor was significantly more abundant as compared with the intestinal cancer (P<0.05). Conclusion Color Doppler ultrasonography, as a simple and rapid method, has a certain diagnostic value for differentiation of gastrointestinal stromal tumors and gastrointestinal cancers.

Citation： SHEN Shihua, LI Jianwei, WU Songsong, ZHU Lin, CHEN Sheng, YE Zhensheng. Ultrasonographic features of gastrointestinal stromal tumors. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2017, 24(5): 606-610. doi: 10.7507/1007-9424.201610001 Copy

1.	Orosz Z, Tornóczky T, Sápi Z. Gastrointestinal stromal tumors: a clinicopathologic and immunohistochemical study of 136 cases. Pathol Oncol Res, 2005, 11(1): 11-21.
2.	Joensuu H, Fletcher C, Dimitrijevic S, et al. Management of malignant gastrointestinal stromal tumours. Lancet Oncol, 2002, 3(11): 655-664.
3.	Ponsaing LG, Hansen MB. Therapeutic procedures for submucosal tumors in the gastrointestinal tract. World J Gastroenterol, 2007, 13(24): 3316-3322.
4.	El-Hanafy E, El-Hemaly M, Hamdy E, et al. Surgical management of gastric gastrointestinal stromal tumor: a single center experience. Saudi J Gastroenterol, 2011, 17(3): 189-193.
5.	Korenkov MK, Hong NJ, Raut CP. Individual surgery for gastric gastrointestinal stromal tumors. Surg Technol Int, 2014, 24: 139-145.
6.	牟一, 胡兵, 易航, 等. 内镜下切除与外科手术治疗胃肠道间质瘤的疗效比较. 中华消化杂志, 2013, 33(10): 705-706.
7.	CSCO胃肠间质瘤专家委员会. 中国胃肠间质瘤诊断治疗共识(2013 年版). 临床肿瘤学杂志, 2013, 18(11): 1025-1032.
8.	ESMO/European Sarcoma Network Working Group. Gastrointestinal stromal tumours: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol, 2014, 25 Suppl 3: iii21-iii6.
9.	曹晖, 汪明. NCCN《软组织肉瘤—胃肠间质瘤临床实践指南(2015 年第 1 版)》更新介绍与解读. 中国实用外科杂志, 2015, 35(6): 599-603.
10.	Adler DD, Carson PL, Rubin JM, et al. Doppler ultrasound color flow imaging in the study of breast cancer: preliminary findings. Ultrasound Med Biol, 1990, 16(6): 553-559.
11.	赵巧玲, 穆俊武, 王居颁, 等. 原发性小肠肿瘤的超声显像分析. 现代肿瘤学, 1997, 5(4): 200-201.
12.	程伏林, 魏正专. 103 例胃肠道间质瘤的临床病理与预后分析. 肿瘤防治研究, 2007, 34(11): 864-867.
13.	刘艳君, 王学梅. 胃肠道间质瘤的超声检查与病理检查对比分析. 中国医科大学学报, 2007, 36(4): 480-482.
14.	曹海根, 王金锐. 实用腹部超声诊断学. 北京: 人民卫生出版社, 1994: 408-412.
15.	朱建伟, 王雷, 郭杰芳, 等. 超声内镜在胃肠道间质瘤诊断中的应用价值. 中华消化内镜杂志, 2014, 31(6): 342-344.
16.	吴龙云, 彭春艳, 吕瑛, 等. 原发性胃小间质瘤的临床处理及评价: 一项单中心的回顾性研究. 中华消化内镜杂志, 2016, 33(7): 442-446.
17.	Logroño R, Jones DV, Faruqi S, et al. Recent advances in cell biology, diagnosis, and therapy of gastrointestinal stromal tumor (GIST). Cancer Biol Ther, 2004, 3(3): 251-258.
18.	李洪林, 郝玉芝, 陈宇, 等. 胃肠道间质瘤的超声诊断. 中国超声医学杂志, 2005, 21(12): 921-923.
19.	Naitoh I, Okayama Y, Hirai M, et al. Exophytic pedunculated gastrointestinal stromal tumor with remarkable cystic change. J Gastroenterol, 2003, 38(12): 1181-1184.
20.	Takao H, Yamahira K, DoiI, et al. Gastrointestinal stromal tumor of the retroperitoneum: CT and MR findings. Eur Radiol, 2004, 14(10): 1926-1929.
21.	李耀平, 梁小波, 原韶玲, 等. 超声在小肠间质瘤中的应用价值. 山西医科大学学报, 2007, 38(6): 537-539.
22.	Fang SH, Dong DJ, Zhang SZ, et al. Angiographic findings of gastrointestinal stromal tumor. World J Gastroenterol, 2004, 10(19): 2905-2907.
23.	Chung JC, Chu CW, Cho GS, et al. Management and outcome of gastrointestinal stromal tumors of the duodenum. J Gastrointest Surg, 2010, 14(5): 880-883.
24.	黄鹏, 吴河水. 胃肠道间质瘤 30 例外科诊治分析. 中国临床新医学, 2016, 9(4): 298-301.
25.	Johnston FM, Kneuertz PJ, Cameron JL, et al. Presentation and management of gastrointestinal stromal tumors of the duodenum: a multi-institutional analysis. Ann Surg Oncol, 2012, 19(11): 3351-3360.
26.	Miettinen M, Lasota J. Histopathology of gastrointestinal stromal tumor. J Surg Oncol, 2011, 104(8): 865-873.
27.	王黔, 严芝强, 王海斌, 等. 99 例胃肠道间质瘤临床分析. 中国现代普通外科进展, 2012, 15(6): 463-465.
28.	Dietrich C, Hartung E, Ignee A. The use of contrast-enhanced ultrasound in patients with GIST metastases that are negative in CT and PET. Ultraschall Med, 2008, 29 Suppl 5: 276-277.
29.	Burkill GJ, Badran M, Al-Muderis O, et al. Malignant gastrointestinal stromal tumor: distribution, imaging features, and pattern of metastatic spread. Radiology, 2003, 226(2): 527-532.
30.	李成明, 张瑜, 祝青松, 等. CT 诊断为间质瘤. 中国医学影像学杂志, 2008, 16(2): 145-146.
31.	刘长青, 谭诗云, 李军华, 等. 超声内镜联合 CT 对胃间质瘤的临床诊断价值. 世界华人消化杂志, 2012, 20(25): 2404-2406.
32.	王岑立. 胃肠道间质瘤 45 例临床分析. 中华内分泌外科杂志, 2014, 8(1): 62-63.
33.	彭春艳, 吕瑛, 徐桂芳, 等. 术前超声内镜对胃间质瘤的诊断及侵袭危险性评估价值研究. 中华消化内镜杂志, 2015, 32(6): 361-366.
34.	鄂连成. 胃肠道间质瘤的临床诊断和治疗分析. 中国实用医刊, 2014, 41(20): 82-84.
35.	丁伟超, 张蓬波, 张秀忠, 等. 胃肠道间质瘤的术前诊断分析. 中国肿瘤外科杂志, 2014, 6(1): 54-56.

1. Orosz Z, Tornóczky T, Sápi Z. Gastrointestinal stromal tumors: a clinicopathologic and immunohistochemical study of 136 cases. Pathol Oncol Res, 2005, 11(1): 11-21.
2. Joensuu H, Fletcher C, Dimitrijevic S, et al. Management of malignant gastrointestinal stromal tumours. Lancet Oncol, 2002, 3(11): 655-664.
3. Ponsaing LG, Hansen MB. Therapeutic procedures for submucosal tumors in the gastrointestinal tract. World J Gastroenterol, 2007, 13(24): 3316-3322.
4. El-Hanafy E, El-Hemaly M, Hamdy E, et al. Surgical management of gastric gastrointestinal stromal tumor: a single center experience. Saudi J Gastroenterol, 2011, 17(3): 189-193.
5. Korenkov MK, Hong NJ, Raut CP. Individual surgery for gastric gastrointestinal stromal tumors. Surg Technol Int, 2014, 24: 139-145.
6. 牟一, 胡兵, 易航, 等. 内镜下切除与外科手术治疗胃肠道间质瘤的疗效比较. 中华消化杂志, 2013, 33(10): 705-706.
7. CSCO胃肠间质瘤专家委员会. 中国胃肠间质瘤诊断治疗共识(2013 年版). 临床肿瘤学杂志, 2013, 18(11): 1025-1032.
8. ESMO/European Sarcoma Network Working Group. Gastrointestinal stromal tumours: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol, 2014, 25 Suppl 3: iii21-iii6.
9. 曹晖, 汪明. NCCN《软组织肉瘤—胃肠间质瘤临床实践指南(2015 年第 1 版)》更新介绍与解读. 中国实用外科杂志, 2015, 35(6): 599-603.
10. Adler DD, Carson PL, Rubin JM, et al. Doppler ultrasound color flow imaging in the study of breast cancer: preliminary findings. Ultrasound Med Biol, 1990, 16(6): 553-559.
11. 赵巧玲, 穆俊武, 王居颁, 等. 原发性小肠肿瘤的超声显像分析. 现代肿瘤学, 1997, 5(4): 200-201.
12. 程伏林, 魏正专. 103 例胃肠道间质瘤的临床病理与预后分析. 肿瘤防治研究, 2007, 34(11): 864-867.
13. 刘艳君, 王学梅. 胃肠道间质瘤的超声检查与病理检查对比分析. 中国医科大学学报, 2007, 36(4): 480-482.
14. 曹海根, 王金锐. 实用腹部超声诊断学. 北京: 人民卫生出版社, 1994: 408-412.
15. 朱建伟, 王雷, 郭杰芳, 等. 超声内镜在胃肠道间质瘤诊断中的应用价值. 中华消化内镜杂志, 2014, 31(6): 342-344.
16. 吴龙云, 彭春艳, 吕瑛, 等. 原发性胃小间质瘤的临床处理及评价: 一项单中心的回顾性研究. 中华消化内镜杂志, 2016, 33(7): 442-446.
17. Logroño R, Jones DV, Faruqi S, et al. Recent advances in cell biology, diagnosis, and therapy of gastrointestinal stromal tumor (GIST). Cancer Biol Ther, 2004, 3(3): 251-258.
18. 李洪林, 郝玉芝, 陈宇, 等. 胃肠道间质瘤的超声诊断. 中国超声医学杂志, 2005, 21(12): 921-923.
19. Naitoh I, Okayama Y, Hirai M, et al. Exophytic pedunculated gastrointestinal stromal tumor with remarkable cystic change. J Gastroenterol, 2003, 38(12): 1181-1184.
20. Takao H, Yamahira K, DoiI, et al. Gastrointestinal stromal tumor of the retroperitoneum: CT and MR findings. Eur Radiol, 2004, 14(10): 1926-1929.
21. 李耀平, 梁小波, 原韶玲, 等. 超声在小肠间质瘤中的应用价值. 山西医科大学学报, 2007, 38(6): 537-539.
22. Fang SH, Dong DJ, Zhang SZ, et al. Angiographic findings of gastrointestinal stromal tumor. World J Gastroenterol, 2004, 10(19): 2905-2907.
23. Chung JC, Chu CW, Cho GS, et al. Management and outcome of gastrointestinal stromal tumors of the duodenum. J Gastrointest Surg, 2010, 14(5): 880-883.
24. 黄鹏, 吴河水. 胃肠道间质瘤 30 例外科诊治分析. 中国临床新医学, 2016, 9(4): 298-301.
25. Johnston FM, Kneuertz PJ, Cameron JL, et al. Presentation and management of gastrointestinal stromal tumors of the duodenum: a multi-institutional analysis. Ann Surg Oncol, 2012, 19(11): 3351-3360.
26. Miettinen M, Lasota J. Histopathology of gastrointestinal stromal tumor. J Surg Oncol, 2011, 104(8): 865-873.
27. 王黔, 严芝强, 王海斌, 等. 99 例胃肠道间质瘤临床分析. 中国现代普通外科进展, 2012, 15(6): 463-465.
28. Dietrich C, Hartung E, Ignee A. The use of contrast-enhanced ultrasound in patients with GIST metastases that are negative in CT and PET. Ultraschall Med, 2008, 29 Suppl 5: 276-277.
29. Burkill GJ, Badran M, Al-Muderis O, et al. Malignant gastrointestinal stromal tumor: distribution, imaging features, and pattern of metastatic spread. Radiology, 2003, 226(2): 527-532.
30. 李成明, 张瑜, 祝青松, 等. CT 诊断为间质瘤. 中国医学影像学杂志, 2008, 16(2): 145-146.
31. 刘长青, 谭诗云, 李军华, 等. 超声内镜联合 CT 对胃间质瘤的临床诊断价值. 世界华人消化杂志, 2012, 20(25): 2404-2406.
32. 王岑立. 胃肠道间质瘤 45 例临床分析. 中华内分泌外科杂志, 2014, 8(1): 62-63.
33. 彭春艳, 吕瑛, 徐桂芳, 等. 术前超声内镜对胃间质瘤的诊断及侵袭危险性评估价值研究. 中华消化内镜杂志, 2015, 32(6): 361-366.
34. 鄂连成. 胃肠道间质瘤的临床诊断和治疗分析. 中国实用医刊, 2014, 41(20): 82-84.
35. 丁伟超, 张蓬波, 张秀忠, 等. 胃肠道间质瘤的术前诊断分析. 中国肿瘤外科杂志, 2014, 6(1): 54-56.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Ultrasonographic features of gastrointestinal stromal tumors

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