Research progression of relationship between integrin and invasion, metastasis, or prognosis of gastric cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHAI Chongyu ,  CHEN Junqiang

Department of Gastrointestinal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, P. R. China;

Corresponding author：

CHEN Junqiang, Email: gxmufh@163.com

Keywords：

integrin; gastric cancer; treatment; prognosis

DOI：

10.7507/1007-9424.201612098

Video：

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Objective To study relationship between integrins and carcinogenesis, development, treatment or prognosis of gastric cancer. Methods The literatures about integrins and gastric cancer in recent years were reviewed and analyzed. Results The current study found that the β1 subunit integrins and αν subline integrins are closely associated with the gastric cancer. The β1 subunit integrins are associated with the invasion and metastasis of the gastric cancer, the αν subline integrins are associated with the typing, grading, and staging of the gastric cancer, and the ανβ3, ανβ5 and ανβ6 are associated with the prognosis of the gastric cancer, further more, the ανβ6 could be used as an independent effective prognostic factor. Conclusions Integrins are associated with occurrence, development, treatment, and prognosis of gastric cancer. It′s mechanism such as signal transduction pathway is not completely clarified. With further in-depth research, it′s molecular mechanism would be gradually elucidated and provide new ideas and methods for diagnosis, treatment, and prognosis of gastric cancer.

Citation： ZHAI Chongyu, CHEN Junqiang. Research progression of relationship between integrin and invasion, metastasis, or prognosis of gastric cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2017, 24(9): 1145-1149. doi: 10.7507/1007-9424.201612098 Copy

1.	Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012. CA Cancer J Clin, 2015, 65(2): 87-108.
2.	Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin, 2016, 66(2): 115-132.
3.	Shattil SJ, Kim C, Ginsberg MH. The final steps of integrin activation: the end game. Nat Rev Mol Cell Biol, 2010, 11(4): 288-300.
4.	Acosta KB, Lorenzini Campos MN, Etcheverry SB, et al. α6β4 integrin genetic variations (A380T and R1281W) and breast cancer risk in an argentinian population. Int J Mol Sci, 2016, 17(10). pii: E1540.
5.	Varzavand A, Hacker W, Ma D, et al. α3β1 integrin suppresses prostate cancer metastasis via regulation of the hippo pathway. Cancer Res, 2016, 76(22): 6577-6587.
6.	Sun SJ, Wu CC, Sheu GT, et al. Integrin β3 and CD44 levels determine the effects of the OPN-a splicing variant on lung cancer cell growth. Oncotarget, 2016, 7(34): 55572-55584.
7.	Hsieh MT, Wang LM, Changou CA, et al. Crosstalk between integrin αvβ3 and ERα contributes to thyroid hormone-induced proliferation of ovarian cancer cells. Oncotarget, 2017, 8(15): 24237-24249.
8.	Pelillo C, Mollica H, Eble JA, et al. Inhibition of adhesion, migration and of α5β1 integrin in the HCT-116 colorectal cancer cells treated with the ruthenium drug NAMI-A. J Inorg Biochem, 2016, 160: 225-235.
9.	Aung W, Tsuji AB, Sudo H, et al. Immunotargeting of integrin α6β4 for single-photon emission computed tomography and near-infrared fluorescence imaging in a pancreatic cancer model. Mol Imaging, 2016, 15. pii: 1536012115624917.
10.	Sun C, Zargham R, Shao Q, et al. Association of CD98, integrin β1, integrin β3 and Fak with the progression and liver metastases of colorectal cancer. Pathol Res Pract, 2014, 210(10): 668-674.
11.	Tamkun JW, DeSimone DW, Fonda D, et al. Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin. Cell, 1986, 46(2): 271-82.
12.	Arnaout MA, Mahalingam B, Xiong JP. Integrin structure, allostery, and bidirectional signaling. Annu Rev Cell Dev Biol, 2005, 21: 381-410.
13.	Barczyk M, Carracedo S, Gullberg D. Integrins. Cell Tissue Res, 2010, 339(1): 269-280.
14.	Liu CC, Leclair P, Yap SQ, et al. The membrane-proximal KXGFFKR motif of α-integrin mediates chemoresistance. Mol Cell Biol, 2013, 33(21): 4334-4345.
15.	Hynes RO. Integrins: bidirectional, allosteric signaling machines. Cell, 2002, 110(6): 673-687.
16.	Adair BD, Yeager M. Electron microscopy of integrins. Methods Enzymol, 2007, 426: 337-373.
17.	Kim C, Ye F, Ginsberg MH. Regulation of integrin activation. Annu Rev Cell Dev Biol, 2011, 27: 321-345.
18.	Campbell ID, Humphries MJ. Integrin structure, activation, and interactions. Cold Spring Harb Perspect Biol, 2011, 3(3). pii: a004994.
19.	Ura H, Denno R, Hirata K, et al. Separate functions of α2β1 and α3β1 integrins in the metastatic process of human gastric carcinoma. Surg Today, 1998, 28(10): 1001-1006.
20.	Takatsuki H, Komatsu S, Sano R, et al. Adhesion of gastric carcinoma cells to peritoneum mediated by α3β1 integrin (VLA-3). Cancer Res, 2004, 64(17): 6065-6070.
21.	Saito Y, Sekine W, Sano R, et al. Potentiation of cell invasion and matrix metalloproteinase production by α3β1 integrin-mediated adhesion of gastric carcinoma cells to laminin-5. Clin Exp Metastasis, 2010, 27(4): 197-205.
22.	Chi F, Fu D, Zhang X, et al. Expression of the c-Met proto-oncogene and integrin α5β1 in human gastric cardia adenocarcinoma. Biosci Biotechnol Biochem, 2012, 76(8): 1471-1476.
23.	Ren J, Xu S, Guo D, et al. Increased expression of α5β1-integrin is a prognostic marker for patients with gastric cancer. Clin Transl Oncol, 2014, 16(7): 668-674.
24.	Caiado F, Dias S. Endothelial progenitor cells and integrins: adhesive needs. Fibrogenesis Tissue Repair, 2012, 5: 4.
25.	Kesanakurti D, Chetty C, Dinh DH, et al. Role of MMP-2 in the regulation of IL-6/Stat3 survival signaling via interaction with α5β1 integrin in glioma. Oncogene, 2013, 32(3): 327-340.
26.	Li L, Welser-Alves J, van der Flier A, et al. An angiogenic role for the α5β1 integrin in promoting endothelial cell proliferation during cerebral hypoxia. Exp Neurol, 2012, 237(1): 46-54.
27.	Yeh YC, Cheng HC, Yang HB, et al. H. pylori CagL-Y58/E59 prime higher integrin α5β1 in adverse pH condition to enhance hypochlorhydria vicious cycle for gastric carcinogenesis. PLoS One, 2013, 8(8): e72735.
28.	Chong Y, Tang D, Xiong Q, et al. Galectin-1 from cancer-associated fibroblasts induces epithelial-mesenchymal transition through β1 integrin-mediated upregulation of Gli1 in gastric cancer. J Exp Clin Cancer Res, 2016, 35(1): 175.
29.	Desgrosellier JS, Cheresh DA. Integrins in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer, 2010, 10(1): 9-22.
30.	Zhang ZY, Xu KS, Wang JS, et al. Integrin ανβ6 acts as a prognostic indicator in gastric carcinoma. Clin Oncol (R Coll Radiol), 2008, 20(1): 61-66.
31.	Zhuang Z, Zhou R, Xu X, et al. Clinical significance of integrin αvβ6 expression effects on gastric carcinoma invasiveness and progression via cancer-associated fibroblasts. Med Oncol, 2013, 30(3): 580.
32.	Lian PL, Liu Z, Yang GY, et al. Integrin αvβ6 and matrix metalloproteinase 9 correlate with survival in gastric cancer. World J Gastroenterol, 2016, 22(14): 3852-3859.
33.	Böger C, Warneke VS, Behrens HM, et al. Integrins αvβ3 and αvβ5 as prognostic, diagnostic, and therapeutic targets in gastric cancer. Gastric Cancer, 2015, 18(4): 784-795.
34.	Fukuda K, Saikawa Y, Yagi H, et al. Role of integrin α1 subunits in gastric cancer patients with peritoneal dissemination. Mol Med Rep, 2012, 5(2): 336-340.
35.	Yim DH, Zhang YW, Eom SY, et al. ITGA1 polymorphisms and haplotypes are associated with gastric cancer risk in a Korean population. World J Gastroenterol, 2013, 19(35): 5870-5876.
36.	Ishii Y, Ochiai A, Yamada T, et al. Integrin α6β4 as a suppressor and a predictive marker for peritoneal dissemination in human gastric cancer. Gastroenterology, 2000, 118(3): 497-506.
37.	Parikh D, Juergens CP. Abciximab as an adjunctive therapy for patients undergoing percutaneous coronary interventions. Expert Opin Biol Ther, 2011, 11(2): 235-246.
38.	Juwana YB, Suryapranata H, Ottervanger JP, et al. Tirofiban for myocardial infarction. Expert Opin Pharmacother, 2010, 11(5): 861-866.
39.	Coyle PK. The role of natalizumab in the treatment of multiple sclerosis. Am J Manag Care, 2010, 16(6 Suppl): S164-S170.
40.	Kim YM, Kim IH, Nam TJ. Capsosiphon fulvescens glycoprotein reduces AGS gastric cancer cell migration by downregulating transforming growth factor-β1 and integrin expression. Int J Oncol, 2013, 43(4): 1059-1065.
41.	Hung WY, Huang KH, Wu CW, et al. Mitochondrial dysfunction promotes cell migration via reactive oxygen species-enhanced β5-integrin expression in human gastric cancer SC-M1 cells. Biochim Biophys Acta, 2012, 1820(7): 1102-1110.
42.	Sato Y, Kubo T, Morimoto K, et al. High mannose-binding pseudomonas fluorescens lectin (PFL) downregulates cell surface integrin/EGFR and induces autophagy in gastric cancer cells. BMC Cancer, 2016, 16: 63.
43.	Haley ES, Au GG, Carlton BR, et al. Regional administration of oncolytic Echovirus 1 as a novel therapy for the peritoneal dissemination of gastric cancer. J Mol Med (Berl), 2009, 87(4): 385-399.
44.	Li DQ, Wang ZB, Bai J, et al. Effects of mifepristone on invasive and metastatic potential of human gastric adenocarcinoma cell line MKN-45 in vitro and in vivo. World J Gastroenterol, 2004, 10(12): 1726-1729.
45.	Cheng H, Chi C, Shang W, et al. Precise integrin-targeting near-infrared imaging-guided surgical method increases surgical qualification of peritoneal carcinomatosis from gastric cancer in mice. Oncotarget, 2017, 8(4): 6258-6272.

1. Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012. CA Cancer J Clin, 2015, 65(2): 87-108.
2. Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin, 2016, 66(2): 115-132.
3. Shattil SJ, Kim C, Ginsberg MH. The final steps of integrin activation: the end game. Nat Rev Mol Cell Biol, 2010, 11(4): 288-300.
4. Acosta KB, Lorenzini Campos MN, Etcheverry SB, et al. α6β4 integrin genetic variations (A380T and R1281W) and breast cancer risk in an argentinian population. Int J Mol Sci, 2016, 17(10). pii: E1540.
5. Varzavand A, Hacker W, Ma D, et al. α3β1 integrin suppresses prostate cancer metastasis via regulation of the hippo pathway. Cancer Res, 2016, 76(22): 6577-6587.
6. Sun SJ, Wu CC, Sheu GT, et al. Integrin β3 and CD44 levels determine the effects of the OPN-a splicing variant on lung cancer cell growth. Oncotarget, 2016, 7(34): 55572-55584.
7. Hsieh MT, Wang LM, Changou CA, et al. Crosstalk between integrin αvβ3 and ERα contributes to thyroid hormone-induced proliferation of ovarian cancer cells. Oncotarget, 2017, 8(15): 24237-24249.
8. Pelillo C, Mollica H, Eble JA, et al. Inhibition of adhesion, migration and of α5β1 integrin in the HCT-116 colorectal cancer cells treated with the ruthenium drug NAMI-A. J Inorg Biochem, 2016, 160: 225-235.
9. Aung W, Tsuji AB, Sudo H, et al. Immunotargeting of integrin α6β4 for single-photon emission computed tomography and near-infrared fluorescence imaging in a pancreatic cancer model. Mol Imaging, 2016, 15. pii: 1536012115624917.
10. Sun C, Zargham R, Shao Q, et al. Association of CD98, integrin β1, integrin β3 and Fak with the progression and liver metastases of colorectal cancer. Pathol Res Pract, 2014, 210(10): 668-674.
11. Tamkun JW, DeSimone DW, Fonda D, et al. Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin. Cell, 1986, 46(2): 271-82.
12. Arnaout MA, Mahalingam B, Xiong JP. Integrin structure, allostery, and bidirectional signaling. Annu Rev Cell Dev Biol, 2005, 21: 381-410.
13. Barczyk M, Carracedo S, Gullberg D. Integrins. Cell Tissue Res, 2010, 339(1): 269-280.
14. Liu CC, Leclair P, Yap SQ, et al. The membrane-proximal KXGFFKR motif of α-integrin mediates chemoresistance. Mol Cell Biol, 2013, 33(21): 4334-4345.
15. Hynes RO. Integrins: bidirectional, allosteric signaling machines. Cell, 2002, 110(6): 673-687.
16. Adair BD, Yeager M. Electron microscopy of integrins. Methods Enzymol, 2007, 426: 337-373.
17. Kim C, Ye F, Ginsberg MH. Regulation of integrin activation. Annu Rev Cell Dev Biol, 2011, 27: 321-345.
18. Campbell ID, Humphries MJ. Integrin structure, activation, and interactions. Cold Spring Harb Perspect Biol, 2011, 3(3). pii: a004994.
19. Ura H, Denno R, Hirata K, et al. Separate functions of α2β1 and α3β1 integrins in the metastatic process of human gastric carcinoma. Surg Today, 1998, 28(10): 1001-1006.
20. Takatsuki H, Komatsu S, Sano R, et al. Adhesion of gastric carcinoma cells to peritoneum mediated by α3β1 integrin (VLA-3). Cancer Res, 2004, 64(17): 6065-6070.
21. Saito Y, Sekine W, Sano R, et al. Potentiation of cell invasion and matrix metalloproteinase production by α3β1 integrin-mediated adhesion of gastric carcinoma cells to laminin-5. Clin Exp Metastasis, 2010, 27(4): 197-205.
22. Chi F, Fu D, Zhang X, et al. Expression of the c-Met proto-oncogene and integrin α5β1 in human gastric cardia adenocarcinoma. Biosci Biotechnol Biochem, 2012, 76(8): 1471-1476.
23. Ren J, Xu S, Guo D, et al. Increased expression of α5β1-integrin is a prognostic marker for patients with gastric cancer. Clin Transl Oncol, 2014, 16(7): 668-674.
24. Caiado F, Dias S. Endothelial progenitor cells and integrins: adhesive needs. Fibrogenesis Tissue Repair, 2012, 5: 4.
25. Kesanakurti D, Chetty C, Dinh DH, et al. Role of MMP-2 in the regulation of IL-6/Stat3 survival signaling via interaction with α5β1 integrin in glioma. Oncogene, 2013, 32(3): 327-340.
26. Li L, Welser-Alves J, van der Flier A, et al. An angiogenic role for the α5β1 integrin in promoting endothelial cell proliferation during cerebral hypoxia. Exp Neurol, 2012, 237(1): 46-54.
27. Yeh YC, Cheng HC, Yang HB, et al. H. pylori CagL-Y58/E59 prime higher integrin α5β1 in adverse pH condition to enhance hypochlorhydria vicious cycle for gastric carcinogenesis. PLoS One, 2013, 8(8): e72735.
28. Chong Y, Tang D, Xiong Q, et al. Galectin-1 from cancer-associated fibroblasts induces epithelial-mesenchymal transition through β1 integrin-mediated upregulation of Gli1 in gastric cancer. J Exp Clin Cancer Res, 2016, 35(1): 175.
29. Desgrosellier JS, Cheresh DA. Integrins in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer, 2010, 10(1): 9-22.
30. Zhang ZY, Xu KS, Wang JS, et al. Integrin ανβ6 acts as a prognostic indicator in gastric carcinoma. Clin Oncol (R Coll Radiol), 2008, 20(1): 61-66.
31. Zhuang Z, Zhou R, Xu X, et al. Clinical significance of integrin αvβ6 expression effects on gastric carcinoma invasiveness and progression via cancer-associated fibroblasts. Med Oncol, 2013, 30(3): 580.
32. Lian PL, Liu Z, Yang GY, et al. Integrin αvβ6 and matrix metalloproteinase 9 correlate with survival in gastric cancer. World J Gastroenterol, 2016, 22(14): 3852-3859.
33. Böger C, Warneke VS, Behrens HM, et al. Integrins αvβ3 and αvβ5 as prognostic, diagnostic, and therapeutic targets in gastric cancer. Gastric Cancer, 2015, 18(4): 784-795.
34. Fukuda K, Saikawa Y, Yagi H, et al. Role of integrin α1 subunits in gastric cancer patients with peritoneal dissemination. Mol Med Rep, 2012, 5(2): 336-340.
35. Yim DH, Zhang YW, Eom SY, et al. ITGA1 polymorphisms and haplotypes are associated with gastric cancer risk in a Korean population. World J Gastroenterol, 2013, 19(35): 5870-5876.
36. Ishii Y, Ochiai A, Yamada T, et al. Integrin α6β4 as a suppressor and a predictive marker for peritoneal dissemination in human gastric cancer. Gastroenterology, 2000, 118(3): 497-506.
37. Parikh D, Juergens CP. Abciximab as an adjunctive therapy for patients undergoing percutaneous coronary interventions. Expert Opin Biol Ther, 2011, 11(2): 235-246.
38. Juwana YB, Suryapranata H, Ottervanger JP, et al. Tirofiban for myocardial infarction. Expert Opin Pharmacother, 2010, 11(5): 861-866.
39. Coyle PK. The role of natalizumab in the treatment of multiple sclerosis. Am J Manag Care, 2010, 16(6 Suppl): S164-S170.
40. Kim YM, Kim IH, Nam TJ. Capsosiphon fulvescens glycoprotein reduces AGS gastric cancer cell migration by downregulating transforming growth factor-β1 and integrin expression. Int J Oncol, 2013, 43(4): 1059-1065.
41. Hung WY, Huang KH, Wu CW, et al. Mitochondrial dysfunction promotes cell migration via reactive oxygen species-enhanced β5-integrin expression in human gastric cancer SC-M1 cells. Biochim Biophys Acta, 2012, 1820(7): 1102-1110.
42. Sato Y, Kubo T, Morimoto K, et al. High mannose-binding pseudomonas fluorescens lectin (PFL) downregulates cell surface integrin/EGFR and induces autophagy in gastric cancer cells. BMC Cancer, 2016, 16: 63.
43. Haley ES, Au GG, Carlton BR, et al. Regional administration of oncolytic Echovirus 1 as a novel therapy for the peritoneal dissemination of gastric cancer. J Mol Med (Berl), 2009, 87(4): 385-399.
44. Li DQ, Wang ZB, Bai J, et al. Effects of mifepristone on invasive and metastatic potential of human gastric adenocarcinoma cell line MKN-45 in vitro and in vivo. World J Gastroenterol, 2004, 10(12): 1726-1729.
45. Cheng H, Chi C, Shang W, et al. Precise integrin-targeting near-infrared imaging-guided surgical method increases surgical qualification of peritoneal carcinomatosis from gastric cancer in mice. Oncotarget, 2017, 8(4): 6258-6272.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Research progression of relationship between integrin and invasion, metastasis, or prognosis of gastric cancer

Abstract Full text Figures/Tables Video References Cited by

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