Research progression of correlation of chronic lymphocytic thyroiditis and papillary thyroid carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHU Min ,  Sailike·Magaoweiya

Department of Vascular and Thyroid Surgery, The First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, P. R. China;

Corresponding author：

Sailike·Magaoweiya, Email: sairike@126.com

Keywords：

thyroid neoplasm; chronic lymphocytic thyroiditis; mechanism; treatment; prognosis

DOI：

10.7507/1007-9424.201612109

Video：

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Objective To summarize research status of correlation of chronic lymphocytic thyroiditis (CLT) and papillary thyroid carcinoma (PTC), in order to provide a basis for early diagnosis, prognosis, and prevention of PTC. Method The literatures about the recent studies of the correlation of the CLT and PTC were reviewed according to the results searched from PubMed database, SpringerLink database, Web of Science database, Wanfang database, CNKI database, and VIP database. Results The most of patients with CLT combined with PTC are young women, the characteristics are multifocal and occult, the prognosis is good. Its genesis might be related to the ionizing radiation, iodine intake, endocrine disorders, immune disorders, molecular biology, and other factors. But there are still different controversies about its specific pathogenesis and surgical treatment. Conclusions CLT is closely related to PTC. However, relationship between CLT combined with PTC and changing regularity of molecular biology, pathogenesis, or prognosis needs further to be studied and followed-up for a longer-term.

Citation： ZHU Min, Sailike·Magaoweiya. Research progression of correlation of chronic lymphocytic thyroiditis and papillary thyroid carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2017, 24(10): 1289-1294. doi: 10.7507/1007-9424.201612109 Copy

1.	Zhu Y, Zheng K, Zhang H, et al. The clinicopathologic differences of central lymph node metastasis in predicting lateral lymph node metastasis and prognosis in papillary thyroid cancer associated with or without Hashimoto’s thyroiditis. Tumour Biol, 2016, 37(6): 8037-8045.
2.	Kwak JY, Kim EK, Kim JK, et al. Dual priming oligonucleotide-based multiplex PCR analysis for detection of BRAF^V600E mutation in FNAB samples of thyroid nodules in BRAF^V600E mutation-prevalent area. Head Neck, 2010, 32(4): 490-498.
3.	Dailey ME, Lindsay S, Skahen R. Relation of thyroid neoplasms to Hashimoto disease of the thyroid gland. AMA Arch Surg, 1955, 70(2): 291-297.
4.	Anand A, Singh KR, Kushwaha JK, et al. Papillary thyroid cancer and Hashimoto’s thyroiditis: an association less understood. Indian J Surg Oncol, 2014, 5(3): 199-204.
5.	Kwon JH, Nam ES, Shin HS, et al. P2X7 receptor expression in coexistence of papillary thyroid carcinoma with Hashimoto’s thyroiditis. Korean J Pathol, 2014, 48(1): 30-35.
6.	李康, 于健春, 康维明. 碘摄入与甲状腺疾病. 中华地方病学杂志, 2016, 35(3): 166-169.0.
7.	Cheng V, Brainard J, Nasr C. Co-occurrence of papillary thyroid carcinoma and primary lymphoma of the thyroid in a patient with long-standing Hashimoto’s thyroiditis. Thyroid, 2012, 22(6): 647-650.
8.	Tamimi DM. The association between chronic lymphocytic thyroiditis and thyroid tumors. Int J Surg Pathol, 2002, 10(2): 141-146.
9.	Kebebew E, Treseler PA, Ituarte PH, et al. Coexisting chronic lymphocytic thyroiditis and papillary thyroid cancer revisited. World J Surg, 2001, 25(5): 632-637.
10.	Zhang Y, Dai J, Wu T, et al. The study of the coexistence of Hashimoto’s thyroiditis with papillary thyroid carcinoma. J Cancer Res Clin Oncol, 2014, 140(6): 1021-1026.
11.	刘捷. 甲状腺乳头状癌合并桥本氏甲状腺炎的临床病理特征. 现代肿瘤医学, 2016, 24(2): 222-225.0.
12.	Eisenberg BL, Hensley SD. Thyroid cancer with coexistent Hashimoto’s thyroiditis. Clinical assessment and management. Arch Surg, 1989, 124(9): 1045-1047.
13.	Ahn D, Heo SJ, Park JH, et al. Clinical relationship between Hashimoto’s thyroiditis and papillary thyroid cancer. Acta Oncol, 2011, 50(8): 1228-1234.
14.	Fiore E, Rago T, Latrofa F, et al. Hashimoto’s thyroiditis is associated with papillary thyroid carcinoma: role of TSH and of treatment with L-thyroxine. Endocr Relat Cancer, 2011, 18(4): 429-437.
15.	Singh B, Shaha AR, Trivedi H, et al. Coexistent Hashimoto’s thyroiditis with papillary thyroid carcinoma: impact on presentation, management, and outcome. Surgery, 1999, 126(6): 1070-1077.
16.	李惠. 桥本甲状腺炎合并乳头状甲状腺癌的临床病理特征. 复旦大学, 2012.
17.	Giagourta I, Evangelopoulou C, Papaioannou G, et al. Autoimmune thyroiditis in benign and malignant thyroid nodules: 16-year results. Head Neck, 2014, 36(4): 531-535.
18.	Jeong JS, Kim HK, Lee CR, et al. Coexistence of chronic lymphocytic thyroiditis with papillary thyroid carcinoma: clinical manifestation and prognostic outcome. J Korean Med Sci, 2012, 27(8): 883-889.
19.	Kim EY, Kim WG, Kim WB, et al. Coexistence of chronic lymphocytic thyroiditis is associated with lower recurrence rates in patients with papillary thyroid carcinoma. Clin Endocrinol (Oxf), 2009, 71(4): 581-586.
20.	Okayasu I, Fujiwara M, Hara Y, et al. Association of chronic lymphocytic thyroiditis and thyroid papillary carcinoma. A study of surgical cases among Japanese, and white and African Americans. Cancer, 1995, 76(11): 2312-2318.
21.	Okayasu I. The relationship of lymphocytic thyroiditis to the development of thyroid carcinoma. Endocr Pathol, 1997, 8(3): 225-230.
22.	Okayasu I, Hatakeyama S, Tanaka Y, et al. Is focal chronic autoimmune thyroiditis an age-related disease? Differences in incidence and severity between Japanese and British. J Pathol, 1991, 163(3): 257-264.
23.	Okayasu I, Hara Y, Nakamura K, et al. Racial and age-related differences in incidence and severity of focal autoimmune thyroiditis. Am J Clin Pathol, 1994, 101(6): 698-702.
24.	Jankovic B, Le KT, Hershman JM. Clinical review: Hashimoto’s thyroiditis and papillary thyroid carcinoma: is there a correlation? J Clin Endocrinol Metab, 2013, 98(2): 474-482.
25.	Cunha LL, Ferreira RC, Marcello MA, et al. Clinical and pathological implications of concurrent autoimmune thyroid disorders and papillary thyroid cancer. J Thyroid Res, 2011, 2011: 387062.
26.	Haymart MR, Glinberg SL, Liu J, et al. Higher serum TSH in thyroid cancer patients occurs independent of age and correlates with extrathyroidal extension. Clin Endocrinol (Oxf), 2009, 71(3): 434-439.
27.	Franco AT, Malaguarnera R, Refetoff S, et al. Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice. Proc Natl Acad Sci USA, 2011, 108(4): 1615-1620.
28.	Azizi G, Keller JM, Lewis M, et al. Association of Hashimoto’s thyroiditis with thyroid cancer. Endocr Relat Cancer, 2014, 21(6): 845-852.
29.	张昶, 郑立农, 徐金鑫. 甲状腺局部自身免疫作用在桥本甲状腺炎癌变中的作用. 中华内分泌杂志, 1999, 76(3): 160-163.0.
30.	赵远杰, 罗定存, 张煜, 等. 桥本氏病合并甲状腺乳头状癌机制的研究进展. 浙江医学, 2016, 38(17): 1460-1464.0.
31.	卜文瑾, 房秀霞. 超声在诊断甲状腺结节性病变的研究进展. 临床医学工程, 2012, 19(12): 2296-2298.0.
32.	Baker SR, Bhatti WA. The thyroid cancer epidemic: is it the dark side of the CT revolution? Eur J Radiol, 2006, 60(1): 67-69.
33.	Hatch M, Furukawa K, Brenner A, et al. Prevalence of hyperthyroidism after exposure during childhood or adolescence to radioiodines from the chornobyl nuclear accident: dose-response results from the Ukrainian-American Cohort Study. Radiat Res, 2010, 174(6): 763-772.
34.	欧阳鑫, 谢婉莹, 秦春宏. 甲状腺癌的流行病学特征及其危险因素. 实用医药杂志, 2015, 32(4): 312-315.0.
35.	Knobel M, Medeiros-Neto G. Relevance of iodine intake as a reputed predisposing factor for thyroid cancer. Arq Bras Endocrinol Metabol, 2007, 51(5): 701-712.
36.	Sohn SY, Choi JY, Jang HW, et al. Association between excessive urinary iodine excretion and failure of radioactive iodine thyroid ablation in patients with papillary thyroid cancer. Thyroid, 2013, 23(6): 741-747.
37.	Latrofa F, Fiore E, Rago T, et al. Iodine contributes to thyroid autoimmunity in humans by unmasking a cryptic epitope on thyroglobulin. J Clin Endocrinol Metab, 2013, 98(11): E1768-E1774.
38.	Kanno J, Onodera H, Furuta K, et al. Tumor-promoting effects of both iodine deficiency and iodine excess in the rat thyroid. Toxicol Pathol, 1992, 20(2): 226-235.
39.	刘卫怀, 李鹏飞, 张远炎, 等. 高碘、钠碘转运体及甲状腺肿瘤的关系. 中华内分泌外科杂志, 2014, 8(4): 293-295.0.
40.	马晔, 沈美萍. 高碘对钠碘转运体表达调节的研究进展. 江苏医药, 2011, 37(17): 2058-2060.0.
41.	王颜刚, 阎胜利, 赵世华, 等. 山东沿海居民桥本甲状腺炎与尿碘水平的关系. 中华内分泌代谢杂志, 2004, 20(4): 337-338.0.
42.	Büyükaşık O, Hasdemir AO, Yalçın E, et al. The association between thyroid malignancy and chronic lymphocytic thyroiditis: should it alter the surgical approach? Endokrynol Pol, 2011, 62(4): 303-308.
43.	Kim KH, Suh KS, Kang DW, et al. Mutations of the BRAF gene in papillary thyroid carcinoma and in Hashimoto’s thyroiditis. Pathol Int, 2005, 55(9): 540-545.
44.	Givens DJ, Buchmann LO, Agarwal AM, et al. BRAF V600E does not predict aggressive features of pediatric papillary thyroid carcinoma. Laryngoscope, 2014, 124(9): E389-E393.
45.	Cordioli MI, Cury AN, Nascimento AO, et al. Study of the histological profile of papillary thyroid carcinomas associated with Hashimoto’s thyroiditis. Arq Bras Endocrinol Metabol, 2013, 57(6): 445-449.
46.	Sica A, Allavena P, Mantovani A. Cancer related inflammation: the macrophage connection. Cancer Lett, 2008, 267(2): 204-215.
47.	Ryder M, Ghossein RA, Ricarte-Filho JC, et al. Increased density of tumor-associated macrophages is associated with decreased survival in advanced thyroid cancer. Endocr Relat Cancer, 2008, 15(4): 1069-1074.
48.	兰霞斌, 张浩. 《2015美国甲状腺学会成人甲状腺结节与分化型甲状腺癌诊治指南》外科治疗更新解读. 中华外科杂志, 2016, 54(3): 172-176.0.
49.	Lucas SD, Karlsson-Parra A, Nilsson B, et al. Tumor-specific deposition of immunoglobulin G and complement in papillary thyroid carcinoma. Hum Pathol, 1996, 27(12): 1329-1335.
50.	Villagelin DG, Santos RB, Romaldini JH. Is diffuse and peritumoral lymphocyte infiltration in papillary thyroid cancer a marker of good prognosis? J Endocrinol Invest, 2011, 34(11): e403-e408.
51.	杨晓晨, 周沁, 孙丽, 等. 甲状腺乳头状癌是否合并桥本甲状腺炎的临床病理学特征差异性分析. 中华临床医师杂志(电子版), 2016, 10(17): 2552-2555.0.
52.	俞建平, 陈润浩, 桂律, 等. 桥本氏病合并甲状腺乳头状腺癌. 中国癌症杂志, 2005, 15(1): 16-18.0.
53.	Ye ZQ, Gu DN, Hu HY, et al. Hashimoto’s thyroiditis, microcalcification and raised thyrotropin levels within normal range are associated with thyroid cancer. World J Surg Oncol, 2013, 11: 56.

1. Zhu Y, Zheng K, Zhang H, et al. The clinicopathologic differences of central lymph node metastasis in predicting lateral lymph node metastasis and prognosis in papillary thyroid cancer associated with or without Hashimoto’s thyroiditis. Tumour Biol, 2016, 37(6): 8037-8045.
2. Kwak JY, Kim EK, Kim JK, et al. Dual priming oligonucleotide-based multiplex PCR analysis for detection of BRAF^V600E mutation in FNAB samples of thyroid nodules in BRAF^V600E mutation-prevalent area. Head Neck, 2010, 32(4): 490-498.
3. Dailey ME, Lindsay S, Skahen R. Relation of thyroid neoplasms to Hashimoto disease of the thyroid gland. AMA Arch Surg, 1955, 70(2): 291-297.
4. Anand A, Singh KR, Kushwaha JK, et al. Papillary thyroid cancer and Hashimoto’s thyroiditis: an association less understood. Indian J Surg Oncol, 2014, 5(3): 199-204.
5. Kwon JH, Nam ES, Shin HS, et al. P2X7 receptor expression in coexistence of papillary thyroid carcinoma with Hashimoto’s thyroiditis. Korean J Pathol, 2014, 48(1): 30-35.
6. 李康, 于健春, 康维明. 碘摄入与甲状腺疾病. 中华地方病学杂志, 2016, 35(3): 166-169.0.
7. Cheng V, Brainard J, Nasr C. Co-occurrence of papillary thyroid carcinoma and primary lymphoma of the thyroid in a patient with long-standing Hashimoto’s thyroiditis. Thyroid, 2012, 22(6): 647-650.
8. Tamimi DM. The association between chronic lymphocytic thyroiditis and thyroid tumors. Int J Surg Pathol, 2002, 10(2): 141-146.
9. Kebebew E, Treseler PA, Ituarte PH, et al. Coexisting chronic lymphocytic thyroiditis and papillary thyroid cancer revisited. World J Surg, 2001, 25(5): 632-637.
10. Zhang Y, Dai J, Wu T, et al. The study of the coexistence of Hashimoto’s thyroiditis with papillary thyroid carcinoma. J Cancer Res Clin Oncol, 2014, 140(6): 1021-1026.
11. 刘捷. 甲状腺乳头状癌合并桥本氏甲状腺炎的临床病理特征. 现代肿瘤医学, 2016, 24(2): 222-225.0.
12. Eisenberg BL, Hensley SD. Thyroid cancer with coexistent Hashimoto’s thyroiditis. Clinical assessment and management. Arch Surg, 1989, 124(9): 1045-1047.
13. Ahn D, Heo SJ, Park JH, et al. Clinical relationship between Hashimoto’s thyroiditis and papillary thyroid cancer. Acta Oncol, 2011, 50(8): 1228-1234.
14. Fiore E, Rago T, Latrofa F, et al. Hashimoto’s thyroiditis is associated with papillary thyroid carcinoma: role of TSH and of treatment with L-thyroxine. Endocr Relat Cancer, 2011, 18(4): 429-437.
15. Singh B, Shaha AR, Trivedi H, et al. Coexistent Hashimoto’s thyroiditis with papillary thyroid carcinoma: impact on presentation, management, and outcome. Surgery, 1999, 126(6): 1070-1077.
16. 李惠. 桥本甲状腺炎合并乳头状甲状腺癌的临床病理特征. 复旦大学, 2012.
17. Giagourta I, Evangelopoulou C, Papaioannou G, et al. Autoimmune thyroiditis in benign and malignant thyroid nodules: 16-year results. Head Neck, 2014, 36(4): 531-535.
18. Jeong JS, Kim HK, Lee CR, et al. Coexistence of chronic lymphocytic thyroiditis with papillary thyroid carcinoma: clinical manifestation and prognostic outcome. J Korean Med Sci, 2012, 27(8): 883-889.
19. Kim EY, Kim WG, Kim WB, et al. Coexistence of chronic lymphocytic thyroiditis is associated with lower recurrence rates in patients with papillary thyroid carcinoma. Clin Endocrinol (Oxf), 2009, 71(4): 581-586.
20. Okayasu I, Fujiwara M, Hara Y, et al. Association of chronic lymphocytic thyroiditis and thyroid papillary carcinoma. A study of surgical cases among Japanese, and white and African Americans. Cancer, 1995, 76(11): 2312-2318.
21. Okayasu I. The relationship of lymphocytic thyroiditis to the development of thyroid carcinoma. Endocr Pathol, 1997, 8(3): 225-230.
22. Okayasu I, Hatakeyama S, Tanaka Y, et al. Is focal chronic autoimmune thyroiditis an age-related disease? Differences in incidence and severity between Japanese and British. J Pathol, 1991, 163(3): 257-264.
23. Okayasu I, Hara Y, Nakamura K, et al. Racial and age-related differences in incidence and severity of focal autoimmune thyroiditis. Am J Clin Pathol, 1994, 101(6): 698-702.
24. Jankovic B, Le KT, Hershman JM. Clinical review: Hashimoto’s thyroiditis and papillary thyroid carcinoma: is there a correlation? J Clin Endocrinol Metab, 2013, 98(2): 474-482.
25. Cunha LL, Ferreira RC, Marcello MA, et al. Clinical and pathological implications of concurrent autoimmune thyroid disorders and papillary thyroid cancer. J Thyroid Res, 2011, 2011: 387062.
26. Haymart MR, Glinberg SL, Liu J, et al. Higher serum TSH in thyroid cancer patients occurs independent of age and correlates with extrathyroidal extension. Clin Endocrinol (Oxf), 2009, 71(3): 434-439.
27. Franco AT, Malaguarnera R, Refetoff S, et al. Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice. Proc Natl Acad Sci USA, 2011, 108(4): 1615-1620.
28. Azizi G, Keller JM, Lewis M, et al. Association of Hashimoto’s thyroiditis with thyroid cancer. Endocr Relat Cancer, 2014, 21(6): 845-852.
29. 张昶, 郑立农, 徐金鑫. 甲状腺局部自身免疫作用在桥本甲状腺炎癌变中的作用. 中华内分泌杂志, 1999, 76(3): 160-163.0.
30. 赵远杰, 罗定存, 张煜, 等. 桥本氏病合并甲状腺乳头状癌机制的研究进展. 浙江医学, 2016, 38(17): 1460-1464.0.
31. 卜文瑾, 房秀霞. 超声在诊断甲状腺结节性病变的研究进展. 临床医学工程, 2012, 19(12): 2296-2298.0.
32. Baker SR, Bhatti WA. The thyroid cancer epidemic: is it the dark side of the CT revolution? Eur J Radiol, 2006, 60(1): 67-69.
33. Hatch M, Furukawa K, Brenner A, et al. Prevalence of hyperthyroidism after exposure during childhood or adolescence to radioiodines from the chornobyl nuclear accident: dose-response results from the Ukrainian-American Cohort Study. Radiat Res, 2010, 174(6): 763-772.
34. 欧阳鑫, 谢婉莹, 秦春宏. 甲状腺癌的流行病学特征及其危险因素. 实用医药杂志, 2015, 32(4): 312-315.0.
35. Knobel M, Medeiros-Neto G. Relevance of iodine intake as a reputed predisposing factor for thyroid cancer. Arq Bras Endocrinol Metabol, 2007, 51(5): 701-712.
36. Sohn SY, Choi JY, Jang HW, et al. Association between excessive urinary iodine excretion and failure of radioactive iodine thyroid ablation in patients with papillary thyroid cancer. Thyroid, 2013, 23(6): 741-747.
37. Latrofa F, Fiore E, Rago T, et al. Iodine contributes to thyroid autoimmunity in humans by unmasking a cryptic epitope on thyroglobulin. J Clin Endocrinol Metab, 2013, 98(11): E1768-E1774.
38. Kanno J, Onodera H, Furuta K, et al. Tumor-promoting effects of both iodine deficiency and iodine excess in the rat thyroid. Toxicol Pathol, 1992, 20(2): 226-235.
39. 刘卫怀, 李鹏飞, 张远炎, 等. 高碘、钠碘转运体及甲状腺肿瘤的关系. 中华内分泌外科杂志, 2014, 8(4): 293-295.0.
40. 马晔, 沈美萍. 高碘对钠碘转运体表达调节的研究进展. 江苏医药, 2011, 37(17): 2058-2060.0.
41. 王颜刚, 阎胜利, 赵世华, 等. 山东沿海居民桥本甲状腺炎与尿碘水平的关系. 中华内分泌代谢杂志, 2004, 20(4): 337-338.0.
42. Büyükaşık O, Hasdemir AO, Yalçın E, et al. The association between thyroid malignancy and chronic lymphocytic thyroiditis: should it alter the surgical approach? Endokrynol Pol, 2011, 62(4): 303-308.
43. Kim KH, Suh KS, Kang DW, et al. Mutations of the BRAF gene in papillary thyroid carcinoma and in Hashimoto’s thyroiditis. Pathol Int, 2005, 55(9): 540-545.
44. Givens DJ, Buchmann LO, Agarwal AM, et al. BRAF V600E does not predict aggressive features of pediatric papillary thyroid carcinoma. Laryngoscope, 2014, 124(9): E389-E393.
45. Cordioli MI, Cury AN, Nascimento AO, et al. Study of the histological profile of papillary thyroid carcinomas associated with Hashimoto’s thyroiditis. Arq Bras Endocrinol Metabol, 2013, 57(6): 445-449.
46. Sica A, Allavena P, Mantovani A. Cancer related inflammation: the macrophage connection. Cancer Lett, 2008, 267(2): 204-215.
47. Ryder M, Ghossein RA, Ricarte-Filho JC, et al. Increased density of tumor-associated macrophages is associated with decreased survival in advanced thyroid cancer. Endocr Relat Cancer, 2008, 15(4): 1069-1074.
48. 兰霞斌, 张浩. 《2015美国甲状腺学会成人甲状腺结节与分化型甲状腺癌诊治指南》外科治疗更新解读. 中华外科杂志, 2016, 54(3): 172-176.0.
49. Lucas SD, Karlsson-Parra A, Nilsson B, et al. Tumor-specific deposition of immunoglobulin G and complement in papillary thyroid carcinoma. Hum Pathol, 1996, 27(12): 1329-1335.
50. Villagelin DG, Santos RB, Romaldini JH. Is diffuse and peritumoral lymphocyte infiltration in papillary thyroid cancer a marker of good prognosis? J Endocrinol Invest, 2011, 34(11): e403-e408.
51. 杨晓晨, 周沁, 孙丽, 等. 甲状腺乳头状癌是否合并桥本甲状腺炎的临床病理学特征差异性分析. 中华临床医师杂志(电子版), 2016, 10(17): 2552-2555.0.
52. 俞建平, 陈润浩, 桂律, 等. 桥本氏病合并甲状腺乳头状腺癌. 中国癌症杂志, 2005, 15(1): 16-18.0.
53. Ye ZQ, Gu DN, Hu HY, et al. Hashimoto’s thyroiditis, microcalcification and raised thyrotropin levels within normal range are associated with thyroid cancer. World J Surg Oncol, 2013, 11: 56.

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Research progression of correlation of chronic lymphocytic thyroiditis and papillary thyroid carcinoma

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