The current research status of gastric schwannoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LI Zhongsheng ^1,2 ,  LI Guodong ^1,2 , LIU Ming ^1,2

1. Department of General Surgery, The Fourth Hospital of Harbin Medical University, Harbin 150001, P. R. China;
2. Bio-Bank of Department of General Surgery, The Fourth Hospital of Harbin Medical University, Harbin 150001, P. R. China;

Corresponding author：

LI Guodong, Email: jonathanlgd@163.com

Keywords：

gastric schwannoma; clinical diagnosis; treatment; review

DOI：

10.7507/1007-9424.201704030

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To summarize the research progress of gastric schwannoma (GS). Methods GS related researches and case reports were collected to make a review on general clinical manifestations, pathology characteristics, auxiliary examinations, differential diagnosis, and treatment. Results GS is rare in clinical reports, and it is lack of tissue specificity. Diagnosis is rely mainly on the expressions of S-100 protein and glial fibrillary acidic protein (GFAP). All kinds of auxiliary examinations, such as gastrointestinal angiography, ultrasound, endoscope, CT, an so on, could not independently as a diagnostic basis. Identification between GS and other gastric tumors is difficult, and GS is not sensitive to radiation and chemotherapy, the main treatment is surgery. Conclusions GS is a kind of rare tumor which occurs in gastric mucosa, immunohistochemistry is the most main examination for the diagnosis of GS. The surgical excision is the main treatment for GS, but the safety and efficacy of combination therapy of laparoscopy and endoscopy remains to be study.

Citation： LI Zhongsheng, LI Guodong, LIU Ming. The current research status of gastric schwannoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2017, 24(12): 1541-1545. doi: 10.7507/1007-9424.201704030 Copy

1.	Daimaru Y, Kido H, Hashimoto H, et al. Benign schwannoma of the gastrointestinal tract: a clinicopathologic and immunohistochemical study. Hum Pathol, 1988, 19(3): 257-264.
2.	Vargas Flores E, Bevia Pérez F, Ramirez Mendoza P, et al. Laparoscopic resection of a gastric schwannoma: a case report. Int J Surg Case Rep, 2016, 28: 335-339.
3.	Oh SJ, Suh BJ, Park JK. Gastric Schwannoma Mimicking Malignant Gastrointestinal Stromal Tumor Exhibiting Increased Fluorodeoxyglucose Uptake. Case Rep Oncol, 2016, 9(1): 228-234.
4.	邱静, 杨顺清, 梁晓东, 等. 胃间质瘤及神经鞘瘤的临床病理特征及鉴别诊断分析. 临床与实验病理学杂志, 2014, 30(8): 911-914.
5.	Hou YY, Tan YS, Xu JF, et al. Schwannoma of the gastrointestinal tract: a clinicopathological, immunohistochemical and ultrastructural study of 33 cases. Histopathology, 2006, 48(5): 536-545.
6.	胡宝光. 胃神经鞘瘤的研究现状. 消化肿瘤杂志(电子版), 2015, 7(3): 133-135.
7.	Ji JS, Lu CY, Mao WB, et al. Gastric schwannoma: CT findings and clinicopathologic correlation. Abdom Imaging, 2015, 40(5): 1164-1169.
8.	Watanabe A, Ojima H, Suzuki S, et al. An individual with gastric schwannoma with pathologically malignant potential surviving two years after laparoscopy-assisted partial gastrectomy. Case Rep Gastroenterol, 2011, 5(2): 502-507.
9.	Zheng L, Wu X, Kreis ME, et al. Clinicopathological and immunohistochemical characterisation of gastric schwannomas in 29 cases. Gastroenterol Res Pract, 2014, 2014: 202960.
10.	Yang JH, Zhang M, Zhao ZH, et al. Gastroduodenal intussusception due to gastric schwannoma treated by Billroth II distal gastrectomy: one case report. World J Gastroenterol, 2015, 21(7): 2225-2228.
11.	Patanella AK, Bianco A, Federico F, et al. Lambert-Eaton myasthenic syndrome associated with gastric schwannoma. Muscle Nerve, 2010, 41(4): 569-570.
12.	王军燕, 孙延豹. 胃神经鞘瘤的 CT 表现. 医学影像学杂志, 2015, 25(5): 815-817.
13.	Voltaggio L, Murray R, Lasota J, et al. Gastric schwannoma: a clinicopathologic study of 51 cases and critical review of the literature. Hum Pathol, 2012, 43(5): 650-659.
14.	Agaimy A, Märkl B, Kitz J, et al. Peripheral nerve sheath tumors of the gastrointestinal tract: a multicenter study of 58 patients including NF1-associated gastric schwannoma and unusual morphologic variants. Virchows Arch, 2010, 456(4): 411-422.
15.	Romdhane H, Cheikh M, Mzoughi Z, et al. Gastric Schwannoma: A Case Report. Clin Pract, 2016, 6(4): 849.
16.	Tatangelo F, Cantile M, Collina F, et al. Gastric schwannoma misdiagnosed as GIST: A case report with immunohistochemical and molecular study. Oncol Lett, 2016, 11(4): 2497-2501.
17.	Park HC, Son DJ, Oh HH, et al. Endoscopic ultrasonographic characteristics of gastric schwannoma distinguished from gastrointestinal stromal tumor. Korean J Gastroenterol, 2015, 65(1): 21-26.
18.	Yoon JM, Kim GH, Park DY, et al. Endosonographic Features of Gastric Schwannoma: A Single Center Experience. Clin Endosc, 2016, 49(6): 548-554.
19.	Fernández-Esparrach G, Sendino O, Solé M, et al. Endoscopic ultrasound-guided fine-needle aspiration and trucut biopsy in the diagnosis of gastric stromal tumors: a randomized crossover study. Endoscopy, 2010, 42(4): 292-299.
20.	Choi JW, Choi D, Kim KM, et al. Small submucosal tumors of the stomach: differentiation of gastric schwannoma from gastrointestinal stromal tumor with CT. Korean J Radiol, 2012, 13(4): 425-433.
21.	吴玉珍, 倪萍, 林燕, 等. 胃神经鞘瘤的 MSCT 影像学表现分析. 中国医疗设备, 2014, 29(10): 144-146.
22.	Akazawa Y, Ueyama H, Nagahara A, et al. Case of computed tomography (CT) gastrography for the detection of multiple gastric submucosal tumors: a case report. Nihon Shokakibyo Gakkai Zasshi, 2014, 111(10): 1968-1975.
23.	孟志霞. 胃神经鞘瘤的多层螺旋 CT 诊断与临床治疗. 中国继续医学教育, 2016, 8(23): 43-44.
24.	Zhang Y, Li B, Cai L, et al. Gastric Schwannoma mimicking malignant gastrointestinal stromal tumor and misdiagnosed by (18)F-FDG PET/CT. Hell J Nucl Med, 2015, 18(1): 74-76.
25.	Komatsu D, Koide N, Hiraga R, et al. Gastric schwannoma exhibiting increased fluorodeoxyglucose uptake. Gastric Cancer, 2009, 12(4): 225-228.
26.	Yap J, Huang YT, Lin M. Detection of synchronous gastric schwannoma on FDG PET/CT aided by discordant metabolic response. Clin Nucl Med, 2015, 40(5): e287-e289.
27.	Ohno T, Ogata K, Kogure N, et al. Gastric schwannomas show an obviously increased fluorodeoxyglucose uptake in positron emission tomography: report of two cases. Surg Today, 2011, 41(8): 1133-1137.
28.	Takeda M, Amano Y, Machida T, et al. CT, MRI, and PET findings of gastric schwannoma. Jpn J Radiol, 2012, 30(7): 602-605.
29.	姜胜东. 胃神经鞘瘤的多层螺旋 CT 诊断价值. 医学影像学杂志, 2013, 23(3): 424-426.
30.	盛卫忠, 刘寒, 纪元, 等. 腹腔镜手术治疗胃间叶源性肿瘤的临床研究. 外科理论与实践, 2012, 17(2): 143-146.
31.	Sreevathsa MR, Pipara G. Gastric Schwannoma: A Case Report and Review of Literature. Indian J Surg Oncol, 2015, 6(2): 123-126.
32.	孙龙. 胃神经鞘瘤临床病理分析. 中国现代医生, 2015, 53(29): 109-115.
33.	Schubert D, Kuhn R, Nestler G, et al. Laparoscopic-endoscopic rendezvous resection of upper gastrointestinal tumors. Dig Dis, 2005, 23(2): 106-112.
34.	Li Y, Xuan YH, Liu SS, et al. Short-term vagal nerve stimulation improves left ventricular function following chronic heart failure in rats. Mol Med Rep, 2015, 12(2): 1709-1716.
35.	Takemura M, Yoshida K, Takii M, et al. Gastric malignant schwannoma presenting with upper gastrointestinal bleeding: a case report. J Med Case Rep, 2012, 6: 37.

1. Daimaru Y, Kido H, Hashimoto H, et al. Benign schwannoma of the gastrointestinal tract: a clinicopathologic and immunohistochemical study. Hum Pathol, 1988, 19(3): 257-264.
2. Vargas Flores E, Bevia Pérez F, Ramirez Mendoza P, et al. Laparoscopic resection of a gastric schwannoma: a case report. Int J Surg Case Rep, 2016, 28: 335-339.
3. Oh SJ, Suh BJ, Park JK. Gastric Schwannoma Mimicking Malignant Gastrointestinal Stromal Tumor Exhibiting Increased Fluorodeoxyglucose Uptake. Case Rep Oncol, 2016, 9(1): 228-234.
4. 邱静, 杨顺清, 梁晓东, 等. 胃间质瘤及神经鞘瘤的临床病理特征及鉴别诊断分析. 临床与实验病理学杂志, 2014, 30(8): 911-914.
5. Hou YY, Tan YS, Xu JF, et al. Schwannoma of the gastrointestinal tract: a clinicopathological, immunohistochemical and ultrastructural study of 33 cases. Histopathology, 2006, 48(5): 536-545.
6. 胡宝光. 胃神经鞘瘤的研究现状. 消化肿瘤杂志(电子版), 2015, 7(3): 133-135.
7. Ji JS, Lu CY, Mao WB, et al. Gastric schwannoma: CT findings and clinicopathologic correlation. Abdom Imaging, 2015, 40(5): 1164-1169.
8. Watanabe A, Ojima H, Suzuki S, et al. An individual with gastric schwannoma with pathologically malignant potential surviving two years after laparoscopy-assisted partial gastrectomy. Case Rep Gastroenterol, 2011, 5(2): 502-507.
9. Zheng L, Wu X, Kreis ME, et al. Clinicopathological and immunohistochemical characterisation of gastric schwannomas in 29 cases. Gastroenterol Res Pract, 2014, 2014: 202960.
10. Yang JH, Zhang M, Zhao ZH, et al. Gastroduodenal intussusception due to gastric schwannoma treated by Billroth II distal gastrectomy: one case report. World J Gastroenterol, 2015, 21(7): 2225-2228.
11. Patanella AK, Bianco A, Federico F, et al. Lambert-Eaton myasthenic syndrome associated with gastric schwannoma. Muscle Nerve, 2010, 41(4): 569-570.
12. 王军燕, 孙延豹. 胃神经鞘瘤的 CT 表现. 医学影像学杂志, 2015, 25(5): 815-817.
13. Voltaggio L, Murray R, Lasota J, et al. Gastric schwannoma: a clinicopathologic study of 51 cases and critical review of the literature. Hum Pathol, 2012, 43(5): 650-659.
14. Agaimy A, Märkl B, Kitz J, et al. Peripheral nerve sheath tumors of the gastrointestinal tract: a multicenter study of 58 patients including NF1-associated gastric schwannoma and unusual morphologic variants. Virchows Arch, 2010, 456(4): 411-422.
15. Romdhane H, Cheikh M, Mzoughi Z, et al. Gastric Schwannoma: A Case Report. Clin Pract, 2016, 6(4): 849.
16. Tatangelo F, Cantile M, Collina F, et al. Gastric schwannoma misdiagnosed as GIST: A case report with immunohistochemical and molecular study. Oncol Lett, 2016, 11(4): 2497-2501.
17. Park HC, Son DJ, Oh HH, et al. Endoscopic ultrasonographic characteristics of gastric schwannoma distinguished from gastrointestinal stromal tumor. Korean J Gastroenterol, 2015, 65(1): 21-26.
18. Yoon JM, Kim GH, Park DY, et al. Endosonographic Features of Gastric Schwannoma: A Single Center Experience. Clin Endosc, 2016, 49(6): 548-554.
19. Fernández-Esparrach G, Sendino O, Solé M, et al. Endoscopic ultrasound-guided fine-needle aspiration and trucut biopsy in the diagnosis of gastric stromal tumors: a randomized crossover study. Endoscopy, 2010, 42(4): 292-299.
20. Choi JW, Choi D, Kim KM, et al. Small submucosal tumors of the stomach: differentiation of gastric schwannoma from gastrointestinal stromal tumor with CT. Korean J Radiol, 2012, 13(4): 425-433.
21. 吴玉珍, 倪萍, 林燕, 等. 胃神经鞘瘤的 MSCT 影像学表现分析. 中国医疗设备, 2014, 29(10): 144-146.
22. Akazawa Y, Ueyama H, Nagahara A, et al. Case of computed tomography (CT) gastrography for the detection of multiple gastric submucosal tumors: a case report. Nihon Shokakibyo Gakkai Zasshi, 2014, 111(10): 1968-1975.
23. 孟志霞. 胃神经鞘瘤的多层螺旋 CT 诊断与临床治疗. 中国继续医学教育, 2016, 8(23): 43-44.
24. Zhang Y, Li B, Cai L, et al. Gastric Schwannoma mimicking malignant gastrointestinal stromal tumor and misdiagnosed by (18)F-FDG PET/CT. Hell J Nucl Med, 2015, 18(1): 74-76.
25. Komatsu D, Koide N, Hiraga R, et al. Gastric schwannoma exhibiting increased fluorodeoxyglucose uptake. Gastric Cancer, 2009, 12(4): 225-228.
26. Yap J, Huang YT, Lin M. Detection of synchronous gastric schwannoma on FDG PET/CT aided by discordant metabolic response. Clin Nucl Med, 2015, 40(5): e287-e289.
27. Ohno T, Ogata K, Kogure N, et al. Gastric schwannomas show an obviously increased fluorodeoxyglucose uptake in positron emission tomography: report of two cases. Surg Today, 2011, 41(8): 1133-1137.
28. Takeda M, Amano Y, Machida T, et al. CT, MRI, and PET findings of gastric schwannoma. Jpn J Radiol, 2012, 30(7): 602-605.
29. 姜胜东. 胃神经鞘瘤的多层螺旋 CT 诊断价值. 医学影像学杂志, 2013, 23(3): 424-426.
30. 盛卫忠, 刘寒, 纪元, 等. 腹腔镜手术治疗胃间叶源性肿瘤的临床研究. 外科理论与实践, 2012, 17(2): 143-146.
31. Sreevathsa MR, Pipara G. Gastric Schwannoma: A Case Report and Review of Literature. Indian J Surg Oncol, 2015, 6(2): 123-126.
32. 孙龙. 胃神经鞘瘤临床病理分析. 中国现代医生, 2015, 53(29): 109-115.
33. Schubert D, Kuhn R, Nestler G, et al. Laparoscopic-endoscopic rendezvous resection of upper gastrointestinal tumors. Dig Dis, 2005, 23(2): 106-112.
34. Li Y, Xuan YH, Liu SS, et al. Short-term vagal nerve stimulation improves left ventricular function following chronic heart failure in rats. Mol Med Rep, 2015, 12(2): 1709-1716.
35. Takemura M, Yoshida K, Takii M, et al. Gastric malignant schwannoma presenting with upper gastrointestinal bleeding: a case report. J Med Case Rep, 2012, 6: 37.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

The current research status of gastric schwannoma

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content