MDT discussion of hepatoid adenocarcinoma of the stomach_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

SU Wei ^1,2 , ZHANG Shenglong ³ ,  WANG Wentao ¹ , CHEN Weixia ⁴ , LU Changli ⁵ , PENG Xingchen ⁶

1. Department of Liver Surgery, West China Hospital of Sichuan University, Chengdu 610041, P. R. China;
2. Department of Hepatobiliary Surgery, Qinghai Renji Hospital, Xining 810021, P. R. China;
3. Department of Hepatobiliary Surgery, Chengdu Second People's Hospital, Chengdu 610000, P. R. China;
4. Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, P. R. China;
5. Department of Pathology, West China Hospital of Sichuan University, Chengdu 610041, P. R. China;
6. Department of Oncology, West China Hospital of Sichuan University, Chengdu 610041, P. R. China;

Corresponding author：

WANG Wentao, Email: wwt02@163.com

Keywords：

hepatoid adenocarcinoma of the stomach; primary hepatocelluar carcinoma; alpha fetoprotein; multi-disciplinary team

DOI：

10.7507/1007-9424.201712015

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To discuss the clinical manifestations, diagnosis, and treatment of hepatoid adenocarcinoma of the stomach. Methods By summarizing the multi-disciplinary team results of 1 patient with hepatoid adenocarcinoma of the stomach, who underwent surgery in West China Hospital in October 2017, as well as reviewing the related literatures, to explore the clinicopathological features of hepatoid adenocarcinoma of the stomach. Results The clinical features of hepatoid adenocarcinoma of the stomach were often accompanied by early liver metastasis and alpha fetoprotein (AFP) significantly increased, which were easily misdiagnosed as primary hepatocellular carcinoma. The histopathological features of hepatoid adenocarcinoma of the stomach were characterized by two structures: hepatocellular carcinoma and adenocarcinoma. Conclusion Hepatoid adenocarcinoma of the stomach is a special type of gastric adenocarcinoma, and radical operation is the main treatment, but the prognosis of it is poor.

Citation： SU Wei, ZHANG Shenglong, WANG Wentao, CHEN Weixia, LU Changli, PENG Xingchen. MDT discussion of hepatoid adenocarcinoma of the stomach. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2018, 25(2): 213-220. doi: 10.7507/1007-9424.201712015 Copy

1.	Su JS, Chen YT, Wang RC, et al. Clinicopathological characteristics in the differential diagnosis of hepatoid adenocarcinoma: a literature review. World J Gastroenterol, 2013, 19(3): 321-327.
2.	Sureka B, Bansal K, Arora A. Clinicopathological features of gastric hepatoid adenocarcinoma. Biomed J, 2015, 38(5): 463.
3.	任为正, 苏茂生, 杜晓霞, 等. 胃肝样腺癌: 一种易误诊为原发性肝癌的特殊类型的胃腺癌. 中华肝胆外科杂志, 2016, 22(7): 500-502.
4.	Gaeta R, Ugolini C, Castagna M. Case report of an hepatoid adenocarcinoma of the stomach. Appl Immunohistochem Mol Morphol, 2016, 24(2): e6-e8.
5.	Xiao C, Wu F, Jiang H, et al. Hepatoid adenocarcinoma of the stomach: nine case reports and treatment outcomes. Oncol Lett, 2015, 10(3): 1605-1609.
6.	Søreide JA, Greve OJ, Gudlaugsson E, et al. Hepatoid adenocarcinoma of the stomach－proper identification and treatment remain a challenge. Scand J Gastroenterol, 2016, 51(6): 646-653.
7.	Ishikura H, Kirimoto K, Shamoto M, et al. Hepatoid adenocarcinomas of the stomach. An analysis of seven cases. Cancer, 1986, 58(1): 119-126.
8.	Cheng CY, Wu IC, Chen YT, et al. A rare hepatoid adenocarcinoma from the gastric remnant. Kaohsiung J Med Sci, 2016, 32(9): 482-483.
9.	Gallego DF, Muñoz C, Jimenez CA, et al. Hepatoid adenocarcinoma of the Urachus. Case Rep Pathol, 2016, 2016: 1871807.
10.	Valle L, Thomas J, Kim C, et al. Hepatoid adenocarcinoma of the lung metastasizing to the tonsil. Mol Clin Oncol, 2017, 6(5): 705-707.
11.	Marchegiani G, Gareer H, Parisi A, et al. Pancreatic hepatoid carcinoma: a review of the literature. Dig Surg, 2013, 30(4-6): 425-433.
12.	Liu XM, Chen GQ, Li SL, et al. Hepatoid adenocarcinoma of the stomach: a case report and literature review. Exp Ther Med, 2015, 9(6): 2133-2136.
13.	周少飞, 常成, 苗蕾, 等. 胃肝样腺癌八例临床分析. 中华胃肠外科杂志, 2016, 19(3): 341-342.
14.	Becq A, Mateescu C, Khayat D, et al. Atypical presentation of hepatocellular carcinoma mimicking a gastric hepatoid adenocarcinoma: a case report. Medicine (Baltimore), 2015, 94(27): e1101.
15.	Zhou RU, Cai Y, Yang YI, et al. Hepatoid adenocarcinoma of the stomach: a case report and review of the literature. Oncol Lett, 2015, 9(5): 2126-2128.
16.	付海啸, 邱磊, 宋军, 等. 血清 AFP 阴性胃肝样腺癌 1 例. 中国普通外科杂志, 2013, 22(1): 124-125.
17.	Lee MW, Lee JY, Kim YJ, et al. Gastric hepatoid adenocarcinoma: CT findings. Abdom Imaging, 2007, 32(3): 293-298.
18.	金鑫, 花荣, 曹晖. 胃肝样腺癌临床特点与诊治分析. 外科理论与实践, 2009, 14(3): 374-376.
19.	Fakhruddin N, Bahmad HF, Aridi T, et al. Hepatoid adenocarcinoma of the stomach: a challenging diagnostic and therapeutic disease through a case report and review of the literature. Front Med (Lausanne), 2017, 4: 164.
20.	Murakami T, Yao T, Mitomi H, et al. Clinicopathologic and immunohistochemical characteristics of gastric adenocarcinoma with enteroblastic differentiation: a study of 29 cases. Gastric Cancer, 2016, 19(2): 498-507.
21.	王雅坤, 张小田. 产甲胎蛋白胃癌和胃肝样腺癌. 中华肿瘤杂志, 2017, 39(11): 801-807.
22.	Bazeries P, Barral M, Labrife M, et al. Hepatic metastases from gastric hepatoid adenocarcinoma: an unusual cause of capsular retraction of the liver. Diagn Interv Imaging, 2016, 97(9): 931-934.
23.	Shen Z, Liu X, Lu B, et al. Hepatoid adenocarcinoma of the stomach: a case report of a rare type of gastric cancer. Oncol Lett, 2016, 11(2): 1077-1080.
24.	Lin YY, Chen CM, Huang YH, et al. Liver metastasis from hepatoid adenocarcinoma of the stomach mimicking hepatocellular carcinoma: dynamic computed tomography findings. World J Gastroenterol, 2015, 21(48): 13524-13531.
25.	Ren A, Cai F, Shang YN, et al. Gastric hepatoid adenocarcinoma: a computed tomography report of six cases. World J Gastroenterol, 2014, 20(40): 15001-15006.
26.	Nakao S, Nakata B, Tendo M, et al. Salvage surgery after chemotherapy with S-1 plus cisplatin for α-fetoprotein-producing gastric cancer with a portal vein tumor thrombus: a case report. BMC Surg, 2015, 15: 5.
27.	Gao YB, Zhang DF, Jin XL, et al. Preliminary study on the clinical and pathological relevance of gastric hepatoid adenocarcinoma. J Dig Dis, 2007, 8(1): 23-28.

1. Su JS, Chen YT, Wang RC, et al. Clinicopathological characteristics in the differential diagnosis of hepatoid adenocarcinoma: a literature review. World J Gastroenterol, 2013, 19(3): 321-327.
2. Sureka B, Bansal K, Arora A. Clinicopathological features of gastric hepatoid adenocarcinoma. Biomed J, 2015, 38(5): 463.
3. 任为正, 苏茂生, 杜晓霞, 等. 胃肝样腺癌: 一种易误诊为原发性肝癌的特殊类型的胃腺癌. 中华肝胆外科杂志, 2016, 22(7): 500-502.
4. Gaeta R, Ugolini C, Castagna M. Case report of an hepatoid adenocarcinoma of the stomach. Appl Immunohistochem Mol Morphol, 2016, 24(2): e6-e8.
5. Xiao C, Wu F, Jiang H, et al. Hepatoid adenocarcinoma of the stomach: nine case reports and treatment outcomes. Oncol Lett, 2015, 10(3): 1605-1609.
6. Søreide JA, Greve OJ, Gudlaugsson E, et al. Hepatoid adenocarcinoma of the stomach－proper identification and treatment remain a challenge. Scand J Gastroenterol, 2016, 51(6): 646-653.
7. Ishikura H, Kirimoto K, Shamoto M, et al. Hepatoid adenocarcinomas of the stomach. An analysis of seven cases. Cancer, 1986, 58(1): 119-126.
8. Cheng CY, Wu IC, Chen YT, et al. A rare hepatoid adenocarcinoma from the gastric remnant. Kaohsiung J Med Sci, 2016, 32(9): 482-483.
9. Gallego DF, Muñoz C, Jimenez CA, et al. Hepatoid adenocarcinoma of the Urachus. Case Rep Pathol, 2016, 2016: 1871807.
10. Valle L, Thomas J, Kim C, et al. Hepatoid adenocarcinoma of the lung metastasizing to the tonsil. Mol Clin Oncol, 2017, 6(5): 705-707.
11. Marchegiani G, Gareer H, Parisi A, et al. Pancreatic hepatoid carcinoma: a review of the literature. Dig Surg, 2013, 30(4-6): 425-433.
12. Liu XM, Chen GQ, Li SL, et al. Hepatoid adenocarcinoma of the stomach: a case report and literature review. Exp Ther Med, 2015, 9(6): 2133-2136.
13. 周少飞, 常成, 苗蕾, 等. 胃肝样腺癌八例临床分析. 中华胃肠外科杂志, 2016, 19(3): 341-342.
14. Becq A, Mateescu C, Khayat D, et al. Atypical presentation of hepatocellular carcinoma mimicking a gastric hepatoid adenocarcinoma: a case report. Medicine (Baltimore), 2015, 94(27): e1101.
15. Zhou RU, Cai Y, Yang YI, et al. Hepatoid adenocarcinoma of the stomach: a case report and review of the literature. Oncol Lett, 2015, 9(5): 2126-2128.
16. 付海啸, 邱磊, 宋军, 等. 血清 AFP 阴性胃肝样腺癌 1 例. 中国普通外科杂志, 2013, 22(1): 124-125.
17. Lee MW, Lee JY, Kim YJ, et al. Gastric hepatoid adenocarcinoma: CT findings. Abdom Imaging, 2007, 32(3): 293-298.
18. 金鑫, 花荣, 曹晖. 胃肝样腺癌临床特点与诊治分析. 外科理论与实践, 2009, 14(3): 374-376.
19. Fakhruddin N, Bahmad HF, Aridi T, et al. Hepatoid adenocarcinoma of the stomach: a challenging diagnostic and therapeutic disease through a case report and review of the literature. Front Med (Lausanne), 2017, 4: 164.
20. Murakami T, Yao T, Mitomi H, et al. Clinicopathologic and immunohistochemical characteristics of gastric adenocarcinoma with enteroblastic differentiation: a study of 29 cases. Gastric Cancer, 2016, 19(2): 498-507.
21. 王雅坤, 张小田. 产甲胎蛋白胃癌和胃肝样腺癌. 中华肿瘤杂志, 2017, 39(11): 801-807.
22. Bazeries P, Barral M, Labrife M, et al. Hepatic metastases from gastric hepatoid adenocarcinoma: an unusual cause of capsular retraction of the liver. Diagn Interv Imaging, 2016, 97(9): 931-934.
23. Shen Z, Liu X, Lu B, et al. Hepatoid adenocarcinoma of the stomach: a case report of a rare type of gastric cancer. Oncol Lett, 2016, 11(2): 1077-1080.
24. Lin YY, Chen CM, Huang YH, et al. Liver metastasis from hepatoid adenocarcinoma of the stomach mimicking hepatocellular carcinoma: dynamic computed tomography findings. World J Gastroenterol, 2015, 21(48): 13524-13531.
25. Ren A, Cai F, Shang YN, et al. Gastric hepatoid adenocarcinoma: a computed tomography report of six cases. World J Gastroenterol, 2014, 20(40): 15001-15006.
26. Nakao S, Nakata B, Tendo M, et al. Salvage surgery after chemotherapy with S-1 plus cisplatin for α-fetoprotein-producing gastric cancer with a portal vein tumor thrombus: a case report. BMC Surg, 2015, 15: 5.
27. Gao YB, Zhang DF, Jin XL, et al. Preliminary study on the clinical and pathological relevance of gastric hepatoid adenocarcinoma. J Dig Dis, 2007, 8(1): 23-28.

Previous Article
Caudate lobe-sparing subtotal hepatectomy in treatment of hepatolithiasis
Next Article
门静脉动脉化在肝门部胆管癌根治术中的应用价值

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

MDT discussion of hepatoid adenocarcinoma of the stomach

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content