Quality of life of pediatric living donor liver transplantation recipient and it’s influencing factors_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

YANG Yang ¹ ,  XIN Wenqiong ¹ , XIANG Bo ¹ , YANG Jiayin ² , JIN Shuguang ¹

1. Department of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;
2. Center of Liver Transplantation, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;

Corresponding author：

XIN Wenqiong, Email: xiaoerwaikehs@163.com

Keywords：

living donor liver transplantation; children; quality of life

DOI：

10.7507/1007-9424.201801076

Video：

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Objective To investigate quality of life of pediatric living donor liver transplantation recipient (PLDLTR) and analyze it’s influencing factors. Methods The convenient sampling method was adopted. Fifty-three PLDLTRs from May 2012 to January 2017 in the West China Hospital of Sichuan University were selected. At the same time, 56 children who participated in the physical examination and had no abnormality results were selected as reference (control group), their age and gender matched with the PLDLTRs. A general data inventory and a self-assessment scale for children’s quality of life (Pediatric Quality of Life Inventory 4 Generic Core Scales, PedsQL4.0) were used to evaluate the quality of life of the 53 PLDLTRs. Results A total of 53 questionnaires were distributed to all the 2 groups, all of them were effectively recovered. The points of quality of life of the physiological function, emotional function, social function, and school performance for the PLDLTRs were significantly higher than those of the control group (P<0.050), which for the PLDLTRs with male and more than 3 years after the operation were significantly higher than those of the PLDLTRs with female and within 1 year after the operation (P<0.050). For the PLDLTRs with age >4 years old, the points of the emotional function, social function, and school performance were significantly higher than those of the PLDLTRs with age ≤4 years old. For the PLDLTRs without postoperative complications, the points of quality of life of the physiological function, emotional function, and school performance were significantly higher than those of the PLDLTRs with Ⅱ grade of postoperative complications (P<0.050). Conclusions Life quality of PLDLTR is poorer than that of normal children. Postoperative time, postoperative complications, age, and gender are certainly associated with quality of life for PLDLTR.

Citation： YANG Yang, XIN Wenqiong, XIANG Bo, YANG Jiayin, JIN Shuguang. Quality of life of pediatric living donor liver transplantation recipient and it’s influencing factors. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2018, 25(8): 912-916. doi: 10.7507/1007-9424.201801076 Copy

1.	Junge N, Migal K, Goldschmidt I, et al. Transition after pediatric liver transplantation—Perceptions of adults, adolescents and parents. World J Gastroenterol, 2017, 23(13): 2365-2375.
2.	Khorsandi SE, Giorgakis E, Vilca-Melendez H, et al. Developing a donation after cardiac death risk index for adult and pediatric liver transplantation. World J Transplant, 2017, 7(3): 203-212.
3.	Jin SJ, Kim SK, Choi SS, et al. Risk factors for intraoperative massive transfusion in pediatric liver transplantation: a multivariate analysis. Int J Med Sci, 2017, 14(2): 173-180.
4.	Rawal N, Yazigi N. Pediatric liver transplantation. Pediatr Clin North Am, 2017, 64(3): 677-684.
5.	饶建华, 王学浩. 活体肝移植在中国的发展与前景. 中国普外基础与临床杂志, 2017, 24(8): 913-915.
6.	万平, 夏强. 小儿肝移植的进展与前沿. 实用器官移植电子杂志, 2017, 5(1): 7.
7.	Hardikar W, Smith AL, Angus P, et al. Paediatric liver transplantation [corrected] in Melbourne: the first 50 patients. Pediatr Surg Int, 2002, 18(5-6): 354-356.
8.	Heffron TG, Pillen T, Smallwood G, et al. Pediatric liver transplantation for acute liver failure at a single center: a 10-yr experience. Pediatr Transplant, 2010, 14(2): 228-232.
9.	Kerkar N, Danialifar T. Changing definitions of successful outcomes in pediatric liver transplantation. Curr Opin Organ Transplant, 2014, 19(5): 480-485.
10.	夏强, 何康. 儿童活体肝移植的发展概况. 中国普外基础与临床杂志, 2017, 24(8): 920-922.
11.	Anthony SJ, Annunziato RA, Fairey E, et al. Waiting for transplant: physical, psychosocial, and nutritional status considerations for pediatric candidates and implications for care. Pediatr Transplant, 2014, 18(5): 423-434.
12.	卢奕云, 田琪, 郝元涛, 等. 儿童生存质量测定量表 PedsQL4.0 中文版的信度和效度分析. 中山大学学报(医学科学版), 2008, 29(3): 328-331.
13.	Varni JW, Seid M, Rode CA. The PedsQL: measurement model for the pediatric quality of life inventory. Med Care, 1999, 37(2): 126-139.
14.	Ng V, Nicholas D, Dhawan A, et al. Development and validation of the pediatric liver transplantation quality of life: a disease-specific quality of life measure for pediatric liver transplant recipients. J Pediatr, 2014, 165(3): 547-555.
15.	Alba A, Uribe M, Hunter B, et al. Health-related quality of life after pediatric liver transplant: single-center experience in Chile. Transplant Proc, 2013, 45(10): 3728-3730.
16.	Ng VL, Alonso EM, Bucuvalas JC, et al. Health status of children alive 10 years after pediatric liver transplantation performed in the US and Canada: report of the studies of pediatric liver transplantation experience. J Pediatr, 2012, 160(5): 820-826.
17.	宋东建, 岳丽芳, 杨林, 等. 小儿肿瘤治疗中医学人文精神的融入. 医学与哲学, 2017, 38(16): 84-86.
18.	Fredericks EM. Family roles and routines after pediatric liver transplantation: implications for quality of life and beyond. Pediatr Transplant, 2012, 16(7): 688-691.
19.	Denny B, Beyerle K, Kienhuis M, et al. New insights into family functioning and quality of life after pediatric liver transplantation. Pediatr Transplant, 2012, 16(7): 711-715.
20.	李杨, 刘庚. 小儿活体肝移植术供体焦虑状态调查. 护理研究, 2016, 30(8): 1002-1004.
21.	王新艳, 彭守华, 张翠萍, 等. 神经外科急重症颅脑手术患者家属的心理危机干预研究. 新疆医科大学学报, 2016, 39(1): 111-113.
22.	张小强, 马家驰, 李一平, 等. 术后炎症性肠梗阻患者抑郁和焦虑情况调查. 中国普外基础与临床杂志, 2016, 23(9): 1084-1088.
23.	朱志军, 张海明, 沈中阳, 等. 再次肝移植的原因与预后分析. 中国普外基础与临床杂志, 2013, 20(3): 235-240.
24.	潘学勤, 周庆云. 内镜下逆行胰胆管造影治疗肝移植术后胆管并发症的围术期护理. 安徽医药, 2017, 21(1): 173-175.
25.	朱志军, 曾志贵. 儿童肝移植术后早期血管并发症的诊断、治疗及预防. 中国普外基础与临床杂志, 2015, (12): 1425-1427.
26.	Bucuvalas JC, Britto M, Krug S, et al. Health-related quality of life in pediatric liver transplant recipients: A single-center study. Liver Transpl, 2003, 9(1): 62-71.

1. Junge N, Migal K, Goldschmidt I, et al. Transition after pediatric liver transplantation—Perceptions of adults, adolescents and parents. World J Gastroenterol, 2017, 23(13): 2365-2375.
2. Khorsandi SE, Giorgakis E, Vilca-Melendez H, et al. Developing a donation after cardiac death risk index for adult and pediatric liver transplantation. World J Transplant, 2017, 7(3): 203-212.
3. Jin SJ, Kim SK, Choi SS, et al. Risk factors for intraoperative massive transfusion in pediatric liver transplantation: a multivariate analysis. Int J Med Sci, 2017, 14(2): 173-180.
4. Rawal N, Yazigi N. Pediatric liver transplantation. Pediatr Clin North Am, 2017, 64(3): 677-684.
5. 饶建华, 王学浩. 活体肝移植在中国的发展与前景. 中国普外基础与临床杂志, 2017, 24(8): 913-915.
6. 万平, 夏强. 小儿肝移植的进展与前沿. 实用器官移植电子杂志, 2017, 5(1): 7.
7. Hardikar W, Smith AL, Angus P, et al. Paediatric liver transplantation [corrected] in Melbourne: the first 50 patients. Pediatr Surg Int, 2002, 18(5-6): 354-356.
8. Heffron TG, Pillen T, Smallwood G, et al. Pediatric liver transplantation for acute liver failure at a single center: a 10-yr experience. Pediatr Transplant, 2010, 14(2): 228-232.
9. Kerkar N, Danialifar T. Changing definitions of successful outcomes in pediatric liver transplantation. Curr Opin Organ Transplant, 2014, 19(5): 480-485.
10. 夏强, 何康. 儿童活体肝移植的发展概况. 中国普外基础与临床杂志, 2017, 24(8): 920-922.
11. Anthony SJ, Annunziato RA, Fairey E, et al. Waiting for transplant: physical, psychosocial, and nutritional status considerations for pediatric candidates and implications for care. Pediatr Transplant, 2014, 18(5): 423-434.
12. 卢奕云, 田琪, 郝元涛, 等. 儿童生存质量测定量表 PedsQL4.0 中文版的信度和效度分析. 中山大学学报(医学科学版), 2008, 29(3): 328-331.
13. Varni JW, Seid M, Rode CA. The PedsQL: measurement model for the pediatric quality of life inventory. Med Care, 1999, 37(2): 126-139.
14. Ng V, Nicholas D, Dhawan A, et al. Development and validation of the pediatric liver transplantation quality of life: a disease-specific quality of life measure for pediatric liver transplant recipients. J Pediatr, 2014, 165(3): 547-555.
15. Alba A, Uribe M, Hunter B, et al. Health-related quality of life after pediatric liver transplant: single-center experience in Chile. Transplant Proc, 2013, 45(10): 3728-3730.
16. Ng VL, Alonso EM, Bucuvalas JC, et al. Health status of children alive 10 years after pediatric liver transplantation performed in the US and Canada: report of the studies of pediatric liver transplantation experience. J Pediatr, 2012, 160(5): 820-826.
17. 宋东建, 岳丽芳, 杨林, 等. 小儿肿瘤治疗中医学人文精神的融入. 医学与哲学, 2017, 38(16): 84-86.
18. Fredericks EM. Family roles and routines after pediatric liver transplantation: implications for quality of life and beyond. Pediatr Transplant, 2012, 16(7): 688-691.
19. Denny B, Beyerle K, Kienhuis M, et al. New insights into family functioning and quality of life after pediatric liver transplantation. Pediatr Transplant, 2012, 16(7): 711-715.
20. 李杨, 刘庚. 小儿活体肝移植术供体焦虑状态调查. 护理研究, 2016, 30(8): 1002-1004.
21. 王新艳, 彭守华, 张翠萍, 等. 神经外科急重症颅脑手术患者家属的心理危机干预研究. 新疆医科大学学报, 2016, 39(1): 111-113.
22. 张小强, 马家驰, 李一平, 等. 术后炎症性肠梗阻患者抑郁和焦虑情况调查. 中国普外基础与临床杂志, 2016, 23(9): 1084-1088.
23. 朱志军, 张海明, 沈中阳, 等. 再次肝移植的原因与预后分析. 中国普外基础与临床杂志, 2013, 20(3): 235-240.
24. 潘学勤, 周庆云. 内镜下逆行胰胆管造影治疗肝移植术后胆管并发症的围术期护理. 安徽医药, 2017, 21(1): 173-175.
25. 朱志军, 曾志贵. 儿童肝移植术后早期血管并发症的诊断、治疗及预防. 中国普外基础与临床杂志, 2015, (12): 1425-1427.
26. Bucuvalas JC, Britto M, Krug S, et al. Health-related quality of life in pediatric liver transplant recipients: A single-center study. Liver Transpl, 2003, 9(1): 62-71.

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Quality of life of pediatric living donor liver transplantation recipient and it’s influencing factors

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