Clinical study on metastatic lung cancer to thyroid gland_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 ZHANG Liyang , LI Xiaoyi , LIU Yuewu , GAO Weisheng

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, P. R. China;

Corresponding author：

ZHANG Liyang, Email: liyangzhang25@hotmail.com

Keywords：

thyroid; metastatic lung cancer; prognosis

DOI：

10.7507/1007-9424.201802008

Video：

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Objective To analyze and summarize clinical characteristics, diagnostic method, choice of treatment, and prognosis of metastatic lung cancer to thyroid gland. Method The clinical materials of the 15 patients presenting with secondary thyroid cancer were analyzed retrospectively. Results There were 10 females and 5 males in the 15 patients, with the female to male ratio of 2 : 1. The age ranged from 36 to 79 years old with an average 59 years old. The diagnoses of 12 cases were made by the surgery or the fine needle aspiration biopsy (FNAB), 3 cases by the clinic. The interval from the diagnosis of the primary tumor to the thyroid metastasis varied from 0 month to 21 months with an average 4 months. Three patients received the thyroidectomy, 5 patients received the chemotherapy or chemoradiotherapy, and 7 patients gave up the treatment. The average survival time was 10 months. Conclusions Metastatic lung cancer to thyroid gland is rare, and FNAB is a useful tool for diagnosis. Thyroidectomy may not be recommended because of poor prognosis.

Citation： ZHANG Liyang, LI Xiaoyi, LIU Yuewu, GAO Weisheng. Clinical study on metastatic lung cancer to thyroid gland. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2018, 25(9): 1107-1109. doi: 10.7507/1007-9424.201802008 Copy

1.	Mazzaferri EL, Sipos J. Should all patients with subcentimeter thyroid nodules undergo fine-needle aspiration biopsy and preoperative neck ultrasonography to define the extent of tumor invasion? Thyroid, 2008, 18(6): 597-602.
2.	McCabe DP, Farrar WB, Petkov TM, et al. Clinical and pathologic correlations in disease metastatic to the thyroid gland. Am J Surg, 1985, 150(4): 519-523.
3.	Chen H, Nicol TL, Udelsman R. Clinically significant, isolated metastatic disease to the thyroid gland. World J Surg, 1999, 23(2): 177-181.
4.	Czech JM, Lichtor TR, Carney JA, et al. Neoplasms metastatic to the thyroid gland. Surg Gynecol Obstet, 1982, 155(4): 503-505.
5.	Chung AY, Tran TB, Brumund KT, et al. Metastases to the thyroid: a review of the literature from the last decade. Thyroid, 2012, 22(3): 258-268.
6.	于跃, 王晓雷, 徐震纲, 等. 甲状腺转移癌 35 例的临床特点及诊治分析. 中华普通外科杂志, 2011, 26(8): 644-647.
7.	Zhang LY, Liu YW, Li XY, et al. Metastases to the thyroid gland: A report of 32 cases in PUMCH. Medicine (Baltimore), 2017, 96(36): e7927.
8.	Barczyński M, Jamski J, Cichoń S, et al. Diagnosis, treatment and prognosis in cases of renal clear cell carcinoma metastases into the thyroid gland. Przegl Lek, 2000, 57(3): 157-159.
9.	Bayram F, Soyuer I, Atmaca H, et al. Prostatic adenocarcinoma metastasis in the thyroid gland. Endocr J, 2004, 51(4): 445-448.
10.	Berge T, Lundberg S. Cancer in Malmö 1958–1969. An autopsy study. Acta Pathol Microbiol Scand Suppl, 1977, (260): 1-235.
11.	Heffess CS, Wenig BM, Thompson LD. Metastatic renal cell carcinoma to the thyroid gland: a clinicopathologic study of 36 cases. Cancer, 2002, 95(9): 1869-1878.
12.	赵瑞娜, 张波, 姜玉新, 等. 甲状腺转移癌的超声征象. 协和医学杂志, 2014, 5(1): 17-21.
13.	May M, Marusch F, Kaufmann O, et al. Solitary renal cell carcinoma metastasis to the thyroid gland—a paradigm of metastasectomy? Chirurg, 2003, 74(8): 768-774.

1. Mazzaferri EL, Sipos J. Should all patients with subcentimeter thyroid nodules undergo fine-needle aspiration biopsy and preoperative neck ultrasonography to define the extent of tumor invasion? Thyroid, 2008, 18(6): 597-602.
2. McCabe DP, Farrar WB, Petkov TM, et al. Clinical and pathologic correlations in disease metastatic to the thyroid gland. Am J Surg, 1985, 150(4): 519-523.
3. Chen H, Nicol TL, Udelsman R. Clinically significant, isolated metastatic disease to the thyroid gland. World J Surg, 1999, 23(2): 177-181.
4. Czech JM, Lichtor TR, Carney JA, et al. Neoplasms metastatic to the thyroid gland. Surg Gynecol Obstet, 1982, 155(4): 503-505.
5. Chung AY, Tran TB, Brumund KT, et al. Metastases to the thyroid: a review of the literature from the last decade. Thyroid, 2012, 22(3): 258-268.
6. 于跃, 王晓雷, 徐震纲, 等. 甲状腺转移癌 35 例的临床特点及诊治分析. 中华普通外科杂志, 2011, 26(8): 644-647.
7. Zhang LY, Liu YW, Li XY, et al. Metastases to the thyroid gland: A report of 32 cases in PUMCH. Medicine (Baltimore), 2017, 96(36): e7927.
8. Barczyński M, Jamski J, Cichoń S, et al. Diagnosis, treatment and prognosis in cases of renal clear cell carcinoma metastases into the thyroid gland. Przegl Lek, 2000, 57(3): 157-159.
9. Bayram F, Soyuer I, Atmaca H, et al. Prostatic adenocarcinoma metastasis in the thyroid gland. Endocr J, 2004, 51(4): 445-448.
10. Berge T, Lundberg S. Cancer in Malmö 1958–1969. An autopsy study. Acta Pathol Microbiol Scand Suppl, 1977, (260): 1-235.
11. Heffess CS, Wenig BM, Thompson LD. Metastatic renal cell carcinoma to the thyroid gland: a clinicopathologic study of 36 cases. Cancer, 2002, 95(9): 1869-1878.
12. 赵瑞娜, 张波, 姜玉新, 等. 甲状腺转移癌的超声征象. 协和医学杂志, 2014, 5(1): 17-21.
13. May M, Marusch F, Kaufmann O, et al. Solitary renal cell carcinoma metastasis to the thyroid gland—a paradigm of metastasectomy? Chirurg, 2003, 74(8): 768-774.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Clinical study on metastatic lung cancer to thyroid gland

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