胰十二指肠切除术后胰瘘的防治_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

王铮 ,  仵正

西安交通大学第一附属医院肝胆外科（西安 710061）;

Corresponding author：

仵正, Email: wuzheng@126.com

Keywords：

DOI：

10.7507/1007-9424.201805029

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Citation： 王铮, 仵正. 胰十二指肠切除术后胰瘘的防治. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2018, 25(6): 661-666. doi: 10.7507/1007-9424.201805029 Copy

1.	Iacono C, Verlato G, Ruzzenente A, et al. Systematic review of central pancreatectomy and meta-analysis of central versus distal pancreatectomy. Br J Surg, 2013, 100(7): 873-885.
2.	Berger AC, Howard TJ, Kennedy EP, et al. Does type of pancreaticojejunostomy after pancreaticoduodenectomy decrease rate of pancreatic fistula? A randomized, prospective, dual-institution trial. J Am Coll Surg, 2009, 208(5): 738-747.
3.	Pedrazzoli S. Pancreatoduodenectomy (PD) and postoperative pancreatic fistula (POPF): a systematic review and analysis of the POPF-related mortality rate in 60,739 patients retrieved from the English literature published between 1990 and 2015. Medicine (Baltimore), 2017, 96(19): e6858.
4.	Aston SJ, Longmire WP Jr. Management of the pancreas after pancreaticoduodenectomy. Ann Surg, 1974, 179(3): 322-327.
5.	中华医学会外科学分会胰腺外科学组, 中国研究型医院学会胰腺病专业委员会, 中华外科杂志编辑部. 胰腺术后外科常见并发症诊治及预防的专家共识(2017). 中华外科杂志, 2017, 55(5): 328-334.
6.	Bassi C, Marchegiani G, Dervenis C, et al. The 2016 update of the International Study Group (ISGPS) definition and grading of postoperative pancreatic fistula: 11 years after. Surgery, 2017, 161(3): 584-591.
7.	张磊, 楼文晖. 《胰腺术后外科常见并发症诊治及预防的专家共识(2017)》胰瘘部分更新介绍及解读. 浙江医学, 2017, 39(17): 1405-1407.
8.	韩显林, 徐竞, 吴文铭, 等. 2016 新版胰瘘定义和分级系统对胰腺术后胰瘘评价的影响. 中华外科杂志, 2017, 55(7): 528-531.
9.	Silver JK, Baima J. Cancer prehabilitation: an opportunity to decrease treatment-related morbidity, increase cancer treatment options, and improve physical and psychological health outcomes. Am J Phys Med Rehabil, 2013, 92(8): 715-727.
10.	Di Carlo V, Gianotti L, Balzano G, et al. Complications of pancreatic surgery and the role of perioperative nutrition. Dig Surg, 1999, 16(4): 320-326.
11.	Ishikawa O, Ohigashi H, Imaoka S, et al. Concomitant benefit of preoperative irradiation in preventing pancreas fistula formation after pancreatoduodenectomy. Arch Surg, 1991, 126(7): 885-889.
12.	Van Buren G 2^nd, Bloomston M, Hughes SJ, et al. A randomized prospective multicenter trial of pancreaticoduodenectomy with and without routine intraperitoneal drainage. Ann Surg, 2014, 259(4): 605-612.
13.	Weniger M, D’Haese JG, Crispin A, et al. Autologous but not fibrin sealant patches for stump coverage reduce clinically relevant pancreatic fistula in distal pancreatectomy: a systematic review and meta-analysis. World J Surg, 2016, 40(11): 2771-2781.
14.	Aranha GV, Hodul P, Golts E, et al. A comparison of pancreaticogastrostomy and pancreaticojejunostomy following pancreaticoduodenectomy. J Gastrointest Surg, 2003, 7(5): 672-682.
15.	Ven Fong Z, Correa-Gallego C, Ferrone CR, et al. Early drain removal－the middle ground between the drain versus no drain debate in patients undergoing pancreaticoduodenectomy: a prospective validation study. Ann Surg, 2015, 262(2): 378-383.
16.	Bassi C, Molinari E, Malleo G, et al. Early versus late drain removal after standard pancreatic resections: results of a prospective randomized trial. Ann Surg, 2010, 252(2): 207-214.
17.	Sugimoto M, Takahashi S, Kobayashi T, et al. Pancreatic perfusion data and post-pancreaticoduodenectomy outcomes. J Surg Res, 2015, 194(2): 441-449.
18.	Kang JH, Park JS, Yu JS, et al. Prediction of pancreatic fistula after pancreatoduodenectomy by preoperative dynamic CT and fecal elastase-1 levels. PLoS One, 2017, 12(5): e0177052.
19.	Miller BC, Christein JD, Behrman SW, et al. A multi-institutional external validation of the fistula risk score for pancreatoduodenectomy. J Gastrointest Surg, 2014, 18(1): 172-179.
20.	Nahm CB, de Reuver PR, Hugh TJ, et al. Intra-operative amylase concentration in peri-pancreatic fluid predicts pancreatic fistula after distal pancreatectomy. J Gastrointest Surg, 2017, 21(6): 1031-1037.
21.	Dalla Valle R, De Bellis M, Pedrazzi G, et al. Can early serum lipase measurement be routinely implemented to rule out clinically significant pancreatic fistula after pancreaticoduodenectomy? Int J Surg, 2015, 21 Suppl 1: S50-S54.
22.	Ansorge C, Regner S, Segersvärd R, et al. Early intraperitoneal metabolic changes and protease activation as indicators of pancreatic fistula after pancreaticoduodenectomy. Br J Surg, 2012, 99(1): 104-111.
23.	Räty S, Sand J, Nordback I. Detection of postoperative pancreatitis after pancreatic surgery by urine trypsinogen strip test. Br J Surg, 2007, 94(1): 64-69.
24.	Pancreatic cancer registration committee of the Japan Pancreas Society. Report of nationwide registration of pancreatic cancer patients in 1981–90. Japan Pancreas Society: Tokyo, 1991: 49-92.
25.	Farley DR, Schwall G, Trede M. Completion pancreatectomy for surgical complications after pancreaticoduodenectomy. Br J Surg, 1996, 83(2): 176-179.
26.	Räty S, Sand J, Lantto E, et al. Postoperative acute pancreatitis as a major determinant of postoperative delayed gastric emptying after pancreaticoduodenectomy. J Gastrointest Surg, 2006, 10(8): 1131-1139.
27.	Strasberg SM, Drebin JA, Mokadam NA, et al. Prospective trial of a blood supply-based technique of pancreaticojejunostomy: effect on anastomotic failure in the Whipple procedure. J Am Coll Surg, 2002, 194(6): 746-758.
28.	Connor S. Defining post-operative pancreatitis as a new pancreatic specific complication following pancreatic resection. HPB (Oxford), 2016, 18(8): 642-651.
29.	Nahm CB, Brown KM, Townend PJ, et al. Acinar cell density at the pancreatic resection margin is associated with post-pancreatectomy pancreatitis and the development of postoperative pancreatic fistula. HPB (Oxford), 2018, 20(5): 432-440.
30.	Sato N, Tamura T, Minagawa N, et al. Preoperative body mass index-to-prognostic nutritional index ratio predicts pancreatic fistula after pancreaticoduodenectomy. Hepatobiliary Surg Nutr, 2016, 5(3): 256-262.
31.	Nishida Y, Kato Y, Kudo M, et al. Preoperative sarcopenia strongly influences the risk of postoperative pancreatic fistula formation after pancreaticoduodenectomy. J Gastrointest Surg, 2016, 20(9): 1586-1594.
32.	Cheng TY, Sheth K, White RR, et al. Effect of neoadjuvant chemoradiation on operative mortality and morbidity for pancreaticoduodenectomy. Ann Surg Oncol, 2006, 13(1): 66-74.
33.	Keck T, Wellner UF, Bahra M, et al. Pancreatogastrostomy versus pancreatojejunostomy for RECOnstruction after PANCreatoduodenectomy (RECOPANC, DRKS 00000767): perioperative and long-term results of a multicenter randomized controlled trial. Ann Surg, 2016, 263(3): 440-449.
34.	Que W, Fang H, Yan B, et al. Pancreaticogastrostomy versus pancreaticojejunostomy after pancreaticoduodenectomy: a meta-analysis of randomized controlled trials. Am J Surg, 2015, 209(6): 1074-1082.
35.	Singh AN, Pal S, Mangla V, et al. Pancreaticojejunostomy: does the technique matter? A randomized trial. J Surg Oncol, 2018, 117(3): 389-396.
36.	王铮, 雷建军, 徐军, 等. 连续贯穿端侧胰肠吻合术的临床观察. 中华外科杂志, 2016, 54(1): 49-50.
37.	Tani M, Kawai M, Hirono S, et al. A prospective randomized controlled trial of internal versus external drainage with pancreaticojejunostomy for pancreaticoduodenectomy. Am J Surg, 2010, 199(6): 759-764.
38.	Conlon KC, Labow D, Leung D, et al. Prospective randomized clinical trial of the value of intraperitoneal drainage after pancreatic resection. Ann Surg, 2001, 234(4): 487-493.
39.	Montorsi M, Zago M, Mosca F, et al. Efficacy of octreotide in the prevention of pancreatic fistula after elective pancreatic resections: a prospective, controlled, randomized clinical trial. Surgery, 1995, 117(1): 26-31.
40.	Closset J, Journe S, Mboti F, et al. Randomized controlled trial comparing somatostatin with octreotide in the prevention of complications after pancreatectomy. Hepatogastroenterology, 2008, 55(86-87): 1818-1823.
41.	Lowy AM, Lee JE, Pisters PW, et al. Prospective, randomized trial of octreotide to prevent pancreatic fistula after pancreaticoduodenectomy for malignant disease. Ann Surg, 1997, 226(5): 632-641.
42.	McMillan MT, Christein JD, Callery MP, et al. Prophylactic octreotide for pancreatoduodenectomy: more harm than good? HPB (Oxford), 2014, 16(10): 954-962.
43.	Ma LW, Dominguez-Rosado I, Gennarelli RL, et al. The cost of postoperative pancreatic fistula versus the cost of pasireotide: results from a prospective randomized trial. Ann Surg, 2017, 265(1): 11-16.
44.	Dominguez-Rosado I, Fields RC, Woolsey CA, et al. Prospective evaluation of pasireotide in patients undergoing pancreaticoduodenectomy: the Washington University Experience. J Am Coll Surg, 2018, 226(2): 147-154.
45.	Behman R, Karanicolas PJ, Lemke M, et al. The effect of early postoperative non-steroidal anti-inflammatory drugs on pancreatic fistula following pancreaticoduodenectomy. J Gastrointest Surg, 2015, 19(9): 1632-1639.
46.	Bruns H, Kortendieck V, Raab HR, et al. Intraoperative fluid excess is a risk factor for pancreatic fistula after partial pancreaticoduodenectomy. HPB Surg, 2016, 2016: 1601340.
47.	Lavu H, Sell NM, Carter TI, et al. The HYSLAR trial: a prospective randomized controlled trial of the use of a restrictive fluid regimen with 3% hypertonic saline versus lactated Ringers in patients undergoing pancreaticoduodenectomy. Ann Surg, 2014, 260(3): 445-453.
48.	Schäfer M, Heinrich S, Pfammatter T, et al. Management of delayed major visceral arterial bleeding after pancreatic surgery. HPB (Oxford), 2011, 13(2): 132-138.
49.	van Berge Henegouwen MI, De Wit LT, Van Gulik TM, et al. Incidence, risk factors, and treatment of pancreatic leakage after pancreaticoduodenectomy: drainage versus resection of the pancreatic remnant. J Am Coll Surg, 1997, 185(1): 18-24.

1. Iacono C, Verlato G, Ruzzenente A, et al. Systematic review of central pancreatectomy and meta-analysis of central versus distal pancreatectomy. Br J Surg, 2013, 100(7): 873-885.
2. Berger AC, Howard TJ, Kennedy EP, et al. Does type of pancreaticojejunostomy after pancreaticoduodenectomy decrease rate of pancreatic fistula? A randomized, prospective, dual-institution trial. J Am Coll Surg, 2009, 208(5): 738-747.
3. Pedrazzoli S. Pancreatoduodenectomy (PD) and postoperative pancreatic fistula (POPF): a systematic review and analysis of the POPF-related mortality rate in 60,739 patients retrieved from the English literature published between 1990 and 2015. Medicine (Baltimore), 2017, 96(19): e6858.
4. Aston SJ, Longmire WP Jr. Management of the pancreas after pancreaticoduodenectomy. Ann Surg, 1974, 179(3): 322-327.
5. 中华医学会外科学分会胰腺外科学组, 中国研究型医院学会胰腺病专业委员会, 中华外科杂志编辑部. 胰腺术后外科常见并发症诊治及预防的专家共识(2017). 中华外科杂志, 2017, 55(5): 328-334.
6. Bassi C, Marchegiani G, Dervenis C, et al. The 2016 update of the International Study Group (ISGPS) definition and grading of postoperative pancreatic fistula: 11 years after. Surgery, 2017, 161(3): 584-591.
7. 张磊, 楼文晖. 《胰腺术后外科常见并发症诊治及预防的专家共识(2017)》胰瘘部分更新介绍及解读. 浙江医学, 2017, 39(17): 1405-1407.
8. 韩显林, 徐竞, 吴文铭, 等. 2016 新版胰瘘定义和分级系统对胰腺术后胰瘘评价的影响. 中华外科杂志, 2017, 55(7): 528-531.
9. Silver JK, Baima J. Cancer prehabilitation: an opportunity to decrease treatment-related morbidity, increase cancer treatment options, and improve physical and psychological health outcomes. Am J Phys Med Rehabil, 2013, 92(8): 715-727.
10. Di Carlo V, Gianotti L, Balzano G, et al. Complications of pancreatic surgery and the role of perioperative nutrition. Dig Surg, 1999, 16(4): 320-326.
11. Ishikawa O, Ohigashi H, Imaoka S, et al. Concomitant benefit of preoperative irradiation in preventing pancreas fistula formation after pancreatoduodenectomy. Arch Surg, 1991, 126(7): 885-889.
12. Van Buren G 2^nd, Bloomston M, Hughes SJ, et al. A randomized prospective multicenter trial of pancreaticoduodenectomy with and without routine intraperitoneal drainage. Ann Surg, 2014, 259(4): 605-612.
13. Weniger M, D’Haese JG, Crispin A, et al. Autologous but not fibrin sealant patches for stump coverage reduce clinically relevant pancreatic fistula in distal pancreatectomy: a systematic review and meta-analysis. World J Surg, 2016, 40(11): 2771-2781.
14. Aranha GV, Hodul P, Golts E, et al. A comparison of pancreaticogastrostomy and pancreaticojejunostomy following pancreaticoduodenectomy. J Gastrointest Surg, 2003, 7(5): 672-682.
15. Ven Fong Z, Correa-Gallego C, Ferrone CR, et al. Early drain removal－the middle ground between the drain versus no drain debate in patients undergoing pancreaticoduodenectomy: a prospective validation study. Ann Surg, 2015, 262(2): 378-383.
16. Bassi C, Molinari E, Malleo G, et al. Early versus late drain removal after standard pancreatic resections: results of a prospective randomized trial. Ann Surg, 2010, 252(2): 207-214.
17. Sugimoto M, Takahashi S, Kobayashi T, et al. Pancreatic perfusion data and post-pancreaticoduodenectomy outcomes. J Surg Res, 2015, 194(2): 441-449.
18. Kang JH, Park JS, Yu JS, et al. Prediction of pancreatic fistula after pancreatoduodenectomy by preoperative dynamic CT and fecal elastase-1 levels. PLoS One, 2017, 12(5): e0177052.
19. Miller BC, Christein JD, Behrman SW, et al. A multi-institutional external validation of the fistula risk score for pancreatoduodenectomy. J Gastrointest Surg, 2014, 18(1): 172-179.
20. Nahm CB, de Reuver PR, Hugh TJ, et al. Intra-operative amylase concentration in peri-pancreatic fluid predicts pancreatic fistula after distal pancreatectomy. J Gastrointest Surg, 2017, 21(6): 1031-1037.
21. Dalla Valle R, De Bellis M, Pedrazzi G, et al. Can early serum lipase measurement be routinely implemented to rule out clinically significant pancreatic fistula after pancreaticoduodenectomy? Int J Surg, 2015, 21 Suppl 1: S50-S54.
22. Ansorge C, Regner S, Segersvärd R, et al. Early intraperitoneal metabolic changes and protease activation as indicators of pancreatic fistula after pancreaticoduodenectomy. Br J Surg, 2012, 99(1): 104-111.
23. Räty S, Sand J, Nordback I. Detection of postoperative pancreatitis after pancreatic surgery by urine trypsinogen strip test. Br J Surg, 2007, 94(1): 64-69.
24. Pancreatic cancer registration committee of the Japan Pancreas Society. Report of nationwide registration of pancreatic cancer patients in 1981–90. Japan Pancreas Society: Tokyo, 1991: 49-92.
25. Farley DR, Schwall G, Trede M. Completion pancreatectomy for surgical complications after pancreaticoduodenectomy. Br J Surg, 1996, 83(2): 176-179.
26. Räty S, Sand J, Lantto E, et al. Postoperative acute pancreatitis as a major determinant of postoperative delayed gastric emptying after pancreaticoduodenectomy. J Gastrointest Surg, 2006, 10(8): 1131-1139.
27. Strasberg SM, Drebin JA, Mokadam NA, et al. Prospective trial of a blood supply-based technique of pancreaticojejunostomy: effect on anastomotic failure in the Whipple procedure. J Am Coll Surg, 2002, 194(6): 746-758.
28. Connor S. Defining post-operative pancreatitis as a new pancreatic specific complication following pancreatic resection. HPB (Oxford), 2016, 18(8): 642-651.
29. Nahm CB, Brown KM, Townend PJ, et al. Acinar cell density at the pancreatic resection margin is associated with post-pancreatectomy pancreatitis and the development of postoperative pancreatic fistula. HPB (Oxford), 2018, 20(5): 432-440.
30. Sato N, Tamura T, Minagawa N, et al. Preoperative body mass index-to-prognostic nutritional index ratio predicts pancreatic fistula after pancreaticoduodenectomy. Hepatobiliary Surg Nutr, 2016, 5(3): 256-262.
31. Nishida Y, Kato Y, Kudo M, et al. Preoperative sarcopenia strongly influences the risk of postoperative pancreatic fistula formation after pancreaticoduodenectomy. J Gastrointest Surg, 2016, 20(9): 1586-1594.
32. Cheng TY, Sheth K, White RR, et al. Effect of neoadjuvant chemoradiation on operative mortality and morbidity for pancreaticoduodenectomy. Ann Surg Oncol, 2006, 13(1): 66-74.
33. Keck T, Wellner UF, Bahra M, et al. Pancreatogastrostomy versus pancreatojejunostomy for RECOnstruction after PANCreatoduodenectomy (RECOPANC, DRKS 00000767): perioperative and long-term results of a multicenter randomized controlled trial. Ann Surg, 2016, 263(3): 440-449.
34. Que W, Fang H, Yan B, et al. Pancreaticogastrostomy versus pancreaticojejunostomy after pancreaticoduodenectomy: a meta-analysis of randomized controlled trials. Am J Surg, 2015, 209(6): 1074-1082.
35. Singh AN, Pal S, Mangla V, et al. Pancreaticojejunostomy: does the technique matter? A randomized trial. J Surg Oncol, 2018, 117(3): 389-396.
36. 王铮, 雷建军, 徐军, 等. 连续贯穿端侧胰肠吻合术的临床观察. 中华外科杂志, 2016, 54(1): 49-50.
37. Tani M, Kawai M, Hirono S, et al. A prospective randomized controlled trial of internal versus external drainage with pancreaticojejunostomy for pancreaticoduodenectomy. Am J Surg, 2010, 199(6): 759-764.
38. Conlon KC, Labow D, Leung D, et al. Prospective randomized clinical trial of the value of intraperitoneal drainage after pancreatic resection. Ann Surg, 2001, 234(4): 487-493.
39. Montorsi M, Zago M, Mosca F, et al. Efficacy of octreotide in the prevention of pancreatic fistula after elective pancreatic resections: a prospective, controlled, randomized clinical trial. Surgery, 1995, 117(1): 26-31.
40. Closset J, Journe S, Mboti F, et al. Randomized controlled trial comparing somatostatin with octreotide in the prevention of complications after pancreatectomy. Hepatogastroenterology, 2008, 55(86-87): 1818-1823.
41. Lowy AM, Lee JE, Pisters PW, et al. Prospective, randomized trial of octreotide to prevent pancreatic fistula after pancreaticoduodenectomy for malignant disease. Ann Surg, 1997, 226(5): 632-641.
42. McMillan MT, Christein JD, Callery MP, et al. Prophylactic octreotide for pancreatoduodenectomy: more harm than good? HPB (Oxford), 2014, 16(10): 954-962.
43. Ma LW, Dominguez-Rosado I, Gennarelli RL, et al. The cost of postoperative pancreatic fistula versus the cost of pasireotide: results from a prospective randomized trial. Ann Surg, 2017, 265(1): 11-16.
44. Dominguez-Rosado I, Fields RC, Woolsey CA, et al. Prospective evaluation of pasireotide in patients undergoing pancreaticoduodenectomy: the Washington University Experience. J Am Coll Surg, 2018, 226(2): 147-154.
45. Behman R, Karanicolas PJ, Lemke M, et al. The effect of early postoperative non-steroidal anti-inflammatory drugs on pancreatic fistula following pancreaticoduodenectomy. J Gastrointest Surg, 2015, 19(9): 1632-1639.
46. Bruns H, Kortendieck V, Raab HR, et al. Intraoperative fluid excess is a risk factor for pancreatic fistula after partial pancreaticoduodenectomy. HPB Surg, 2016, 2016: 1601340.
47. Lavu H, Sell NM, Carter TI, et al. The HYSLAR trial: a prospective randomized controlled trial of the use of a restrictive fluid regimen with 3% hypertonic saline versus lactated Ringers in patients undergoing pancreaticoduodenectomy. Ann Surg, 2014, 260(3): 445-453.
48. Schäfer M, Heinrich S, Pfammatter T, et al. Management of delayed major visceral arterial bleeding after pancreatic surgery. HPB (Oxford), 2011, 13(2): 132-138.
49. van Berge Henegouwen MI, De Wit LT, Van Gulik TM, et al. Incidence, risk factors, and treatment of pancreatic leakage after pancreaticoduodenectomy: drainage versus resection of the pancreatic remnant. J Am Coll Surg, 1997, 185(1): 18-24.

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胰十二指肠切除术后胰瘘的防治

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