Association between FGFR2 rs2981582 polymorphism and the risk of breast cancer in Chinese population: a meta-analysis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHANG Zhitao ¹ , YANG Zhongjun ¹ , WANG Xiaoqiong ² ,  YAN Peng ¹

1. Department of Oncology Surgery, Zhangye People’s Hospital of Hexi College, Zhangye, Gansu 730000, P. R. China;
2. Department of Breast, Zhangye People’s Hospital of Hexi College, Zhangye, Gansu 730000, P. R. China;

Corresponding author：

YAN Peng, Email: 36483802@qq.com

Keywords：

breast cancer; fibroblast growth factor receptor 2; rs2981582 polymorphism; meta-analysis

DOI：

10.7507/1007-9424.201806048

Video：

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Objective To evaluate the association between fibroblast growth factor receptor 2 (FGFR2) rs2981582 polymorphism and the risk of breast cancer in Chinese population. Methods PubMed, Embase, Cochrane Library, Chinese Science and Technology Academic Journal, Chinese Biomedical Literature Database, Chinese Journal Full-Text Database, and Wanfang Database were searched to identify relevant articles that investigated the association of FGFR2 rs2981582 polymorphism with breast cancer risk from their inception to March 2018. A meta-analysis was performed by using the Stata 12.0 software. Results A total of 11 case-control studies were included in the present meta-analysis, including 5 921 breast cancer cases and 5 909 healthy controls. The pooled results indicated that, there was significant association between FGFR2 rs2981582 polymorphism and susceptibility of breast cancer in Chinese population under allele model ［C vs. T: OR=1.07, 95% CI was (1.01, 1.14), P=0.027］, heterozygote model ［CC vs. CT: OR=1.12, 95% CI was (1.01, 1.24), P=0.026］, homozygous model ［CC vs. TT: OR=1.19, 95% CI was (1.05, 1.34), P=0.005］, dominant model ［CC vs. CT+TT: OR=1.10, 95% CI was (1.00, 1.21), P=0.040］, and recessive model ［TT vs. CC+CT: OR=1.19, 95% CI was (1.10, 1.30), P<0.001］. Conclusion FGFR2 rs2981582 polymorphism was associated with the risk of breast cancer in Chinese population.

Citation： ZHANG Zhitao, YANG Zhongjun, WANG Xiaoqiong, YAN Peng. Association between FGFR2 rs2981582 polymorphism and the risk of breast cancer in Chinese population: a meta-analysis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2018, 25(10): 1227-1235. doi: 10.7507/1007-9424.201806048 Copy

1.	Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin, 2016, 66(2): 115-132.
2.	Hunter DJ, Kraft P, Jacobs KB, et al. A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet, 2007, 39(7): 870-874.
3.	Brooks AN, Kilgour E, Smith PD. Molecular pathways: fibroblast growth factor signaling: a new therapeutic opportunity in cancer. Clin Cancer Res, 2012, 18(7): 1855-1862.
4.	Tannheimer SL, Rehemtulla A, Ethier SP. Characterization of fibroblast growth factor receptor 2 overexpression in the human breast cancer cell line SUM-52PE. Breast Cancer Res, 2000, 2(4): 311-320.
5.	Cui F, Wu D, Wang W, et al. Variants of FGFR2 and their associations with breast cancer risk: a HUGE systematic review and meta-analysis. Breast Cancer Res Treat, 2016, 155(2): 313-335.
6.	Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol, 2010, 25(9): 603-605.
7.	Liang J, Chen P, Hu Z, et al. Genetic variants in fibroblast growth factor receptor 2(FGFR2) contribute to susceptibility of breast cancer in Chinese women. Carcinogenesis, 2008, 29(12): 2341-2346.
8.	赵洪猛, 张斌, 姚慧, 等. FGFR2 基因多态性与乳腺癌易感性的相关性研究. 中国肿瘤临床, 2010, 37(11): 626-629.
9.	张敬平, 钱云, 王福如, 等. 成纤维细胞生长因子受体 2(FGFR2)多态性与乳腺癌易感性的关联研究. 中华疾病控制杂志, 2010, 14(8): 764-767.
10.	胡飞飞, 周菁, 庞柯, 等. 湖北地区人群乳腺癌易感基因 FGFR2 多态性研究. 中华肿瘤防治杂志, 2011, 18(2): 89-91.
11.	Chen F, Lu M, Xue Y, et al. Genetic variants of fibroblast growth factor receptor 2 (FGFR2) are associated with breast cancer risk in Chinese women of the Han nationality. Immunogenetics, 2012, 64(1): 71-76.
12.	Fu F, Wang C, Huang M, et al. Polymorphisms in second intron of the FGFR2 gene are associated with the risk of early-onset breast cancer in Chinese Han women. Tohoku J Exp Med, 2012, 226(3): 221-229.
13.	Chan M, Ji SM, Liaw CS, et al. Association of common genetic variants with breast cancer risk and clinicopathological characteristics in a Chinese population. Breast Cancer Res Treat, 2012, 136(1): 209-220.
14.	Liu CL, Hu XP, Guo WD, et al. Case-control study on the fibroblast growth factor receptor 2 gene polymorphisms associated with breast cancer in Chinese han women. J Breast Cancer, 2013, 16(4): 366-371.
15.	潘琳, 胡小平, 郭卫东, 等. FGFR2 基因 rs2981582 和 rs1219648 与乳腺癌相关性研究. 宁夏医科大学学报, 2014, 36(8): 853-856.
16.	Xi J, Su Y, Beeghly Fadiel A, et al. Association of physical activity and polymorphisms in FGFR2 and DNA methylation related genes with breast cancer risk. Cancer Epidemiol, 2014, 38(6): 708-714.
17.	沈国双, 郑方超, 曹成珠, 等. 青海地区藏族 FGFR2 基因多态性与乳腺癌的相关性研究. 重庆医学, 2016, 45(16): 2209-2211.
18.	Siddiqui S, Chattopadhyay S, Akhtar MS, et al. A study on genetic variants of fibroblast growth factor receptor 2 (FGFR2) and the risk of breast cancer from North India. PLoS One, 2014, 9(10): e110426.
19.	Katoh Y, Katoh M. FGFR2-related pathogenesis and FGFR2-targeted therapeutics (review). Int J Mol Med, 2009, 23(3): 307-311.
20.	Yang YB, Zhao ZX, Huang W, et al. Association between fibroblast growth factor receptor-2 gene polymorphism and risk of breast cancer in Chinese populations: a HuGE review and meta-analysis. J Cancer Res Ther, 2016, 12(2): 543-549.
21.	Easton DF, Pooley KA, Dunning AM, et al. Genome-wide association study identifies novel breast cancer susceptibility loci. Nature, 2007, 447(7148): 1087-1093.
22.	Garcia-Closas M, Hall P, Nevanlinna H, et al. Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics. PLoS Genet, 2008, 4(4): e1000054.
23.	查国松, 左文述. BRCA1 与乳腺癌的研究进展. 中国普外基础与临床杂志, 2017, 24(7): 900-904.
24.	Antoniou AC, Spurdle AB, Sinilnikova OM, et al. Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers. Am J Hum Genet, 2008, 82(4): 937-948.
25.	陈洁, 吕青, 王竹, 等. 乳腺癌分子病理学指标分布的异质性. 中国普外基础与临床杂志, 2016, 23(6): 761-766.

1. Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin, 2016, 66(2): 115-132.
2. Hunter DJ, Kraft P, Jacobs KB, et al. A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet, 2007, 39(7): 870-874.
3. Brooks AN, Kilgour E, Smith PD. Molecular pathways: fibroblast growth factor signaling: a new therapeutic opportunity in cancer. Clin Cancer Res, 2012, 18(7): 1855-1862.
4. Tannheimer SL, Rehemtulla A, Ethier SP. Characterization of fibroblast growth factor receptor 2 overexpression in the human breast cancer cell line SUM-52PE. Breast Cancer Res, 2000, 2(4): 311-320.
5. Cui F, Wu D, Wang W, et al. Variants of FGFR2 and their associations with breast cancer risk: a HUGE systematic review and meta-analysis. Breast Cancer Res Treat, 2016, 155(2): 313-335.
6. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol, 2010, 25(9): 603-605.
7. Liang J, Chen P, Hu Z, et al. Genetic variants in fibroblast growth factor receptor 2(FGFR2) contribute to susceptibility of breast cancer in Chinese women. Carcinogenesis, 2008, 29(12): 2341-2346.
8. 赵洪猛, 张斌, 姚慧, 等. FGFR2 基因多态性与乳腺癌易感性的相关性研究. 中国肿瘤临床, 2010, 37(11): 626-629.
9. 张敬平, 钱云, 王福如, 等. 成纤维细胞生长因子受体 2(FGFR2)多态性与乳腺癌易感性的关联研究. 中华疾病控制杂志, 2010, 14(8): 764-767.
10. 胡飞飞, 周菁, 庞柯, 等. 湖北地区人群乳腺癌易感基因 FGFR2 多态性研究. 中华肿瘤防治杂志, 2011, 18(2): 89-91.
11. Chen F, Lu M, Xue Y, et al. Genetic variants of fibroblast growth factor receptor 2 (FGFR2) are associated with breast cancer risk in Chinese women of the Han nationality. Immunogenetics, 2012, 64(1): 71-76.
12. Fu F, Wang C, Huang M, et al. Polymorphisms in second intron of the FGFR2 gene are associated with the risk of early-onset breast cancer in Chinese Han women. Tohoku J Exp Med, 2012, 226(3): 221-229.
13. Chan M, Ji SM, Liaw CS, et al. Association of common genetic variants with breast cancer risk and clinicopathological characteristics in a Chinese population. Breast Cancer Res Treat, 2012, 136(1): 209-220.
14. Liu CL, Hu XP, Guo WD, et al. Case-control study on the fibroblast growth factor receptor 2 gene polymorphisms associated with breast cancer in Chinese han women. J Breast Cancer, 2013, 16(4): 366-371.
15. 潘琳, 胡小平, 郭卫东, 等. FGFR2 基因 rs2981582 和 rs1219648 与乳腺癌相关性研究. 宁夏医科大学学报, 2014, 36(8): 853-856.
16. Xi J, Su Y, Beeghly Fadiel A, et al. Association of physical activity and polymorphisms in FGFR2 and DNA methylation related genes with breast cancer risk. Cancer Epidemiol, 2014, 38(6): 708-714.
17. 沈国双, 郑方超, 曹成珠, 等. 青海地区藏族 FGFR2 基因多态性与乳腺癌的相关性研究. 重庆医学, 2016, 45(16): 2209-2211.
18. Siddiqui S, Chattopadhyay S, Akhtar MS, et al. A study on genetic variants of fibroblast growth factor receptor 2 (FGFR2) and the risk of breast cancer from North India. PLoS One, 2014, 9(10): e110426.
19. Katoh Y, Katoh M. FGFR2-related pathogenesis and FGFR2-targeted therapeutics (review). Int J Mol Med, 2009, 23(3): 307-311.
20. Yang YB, Zhao ZX, Huang W, et al. Association between fibroblast growth factor receptor-2 gene polymorphism and risk of breast cancer in Chinese populations: a HuGE review and meta-analysis. J Cancer Res Ther, 2016, 12(2): 543-549.
21. Easton DF, Pooley KA, Dunning AM, et al. Genome-wide association study identifies novel breast cancer susceptibility loci. Nature, 2007, 447(7148): 1087-1093.
22. Garcia-Closas M, Hall P, Nevanlinna H, et al. Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics. PLoS Genet, 2008, 4(4): e1000054.
23. 查国松, 左文述. BRCA1 与乳腺癌的研究进展. 中国普外基础与临床杂志, 2017, 24(7): 900-904.
24. Antoniou AC, Spurdle AB, Sinilnikova OM, et al. Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers. Am J Hum Genet, 2008, 82(4): 937-948.
25. 陈洁, 吕青, 王竹, 等. 乳腺癌分子病理学指标分布的异质性. 中国普外基础与临床杂志, 2016, 23(6): 761-766.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Association between FGFR2 rs2981582 polymorphism and the risk of breast cancer in Chinese population: a meta-analysis

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