公民逝世器官捐献肝移植胆道并发症及其预防策略_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 霍枫 , 陈建雄 , 郑于剑

解放军广州总医院肝胆外科、肝脏移植中心（广州 510010）;

Corresponding author：

霍枫, Email: gzhuofeng@163.com

Keywords：

DOI：

10.7507/1007-9424.201807099

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Citation： 霍枫, 陈建雄, 郑于剑. 公民逝世器官捐献肝移植胆道并发症及其预防策略. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2018, 25(9): 1035-1038. doi: 10.7507/1007-9424.201807099 Copy

1.	中国肝移植注册 (CLTR) 年度报告. https://www.cltr.org/.
2.	Kochhar G, Parungao JM, Hanouneh IA, et al. Biliary complications following liver transplantation. World J Gastroenterol, 2013, 19(19): 2841-2846.
3.	Nemes B, Gaman G, Doros A. Biliary complications after liver trans plantation. Expert Rev Gastroenterol Hepatol, 2015, 9(4): 447-466.
4.	Kienlein S, Schoening W, Andert A. Biliary complications in liver transplantation: Impact of anastomotic technique and ischemic time on short- and long-term outcome. World J Transplant, 2015, 5(4): 300-309.
5.	秦建杰, 夏永祥, 武正山, 等. 肝移植术后胆道并发症的处理措施. 中国当代医药, 2009, 16(4): 12-14.
6.	蒋伟伟, 李俊, 陈虹, 等. 肝移植术后中远期胆道并发症 47 例临床分析. 器官移植, 2015, 6(2): 93-97.
7.	Londoño MC, Balderramo D, Cárdenas A. Management of biliary complications after orthotopic liver transplantation: the role of endoscopy. World J Gastroenterol, 2008, 14(4): 493-497.
8.	Thuluvath PJ, Pfau PR, Kimmey MB, et al. Biliary complications after liver transplantation: the role of endoscopy. Endoscopy, 2005, 37(9): 857-863.
9.	Sharma S, Gurakar A, Jabbour N. Biliary strictures following liver transplantation: past, present and preventive strategies. Liver Transpl, 2008, 14(6): 759-769.
10.	Jay CL, Lyuksemburg V, Ladner DP, et al. Ischemic cholangiopathy after controlled donation after cardiac death liver transplantation: a meta-analysis. Ann Surg, 2011, 253(2): 259-264.
11.	O’Neill S, Roebuck A, Khoo E, et al. A meta-analysis and meta-regre ssion of outcomes including biliary complications in donation after cardiac death liver transplantation. Transpl Int, 2014, 27(11): 1159-1174.
12.	Sawyer RG, Punch JD. Incidence and management of biliary complications after 291 liver transplants following the introduction of transcystic stenting. Transplantation, 1998, 66(9): 1201-1207.
13.	Foley DP, Fernandez LA, Leverson G, et al. Biliary complications after liver transplantation from donation after cardiac death donors: an analysis of risk factors and long-term outcomes from a single center. Ann Surg, 2011, 253(4): 817-825.
14.	Heidenhain C, Pratschke J, Puhl G, et al. Incidence of and risk factors for ischemic-type biliary lesions following orthotopic liver transplantation. Transpl Int, 2010, 23(1): 14-22.
15.	Lee KW, Simpkins CE, Montgomery RA, et al. Factors affecting graft survival after liver transplantation from donation after cardiac death donors. Transplantation, 2006, 82(12): 1683-1688.
16.	Hoekstra H, Porte RJ, Tian Y, et al. Bile salt toxicity aggravates cold ischemic injury of bile ducts after liver transplantation in Mdr2+/- mice. Hepatology, 2006, 43(5): 1022-1031.
17.	霍胜军, 范松青, 谭善彰. 肝外胆管供血动脉在临床肝移植的应用解剖研究. 中华器官移植杂志, 2005, 26(2): 103-104.
18.	Zhang Y, Liu D, Ma Q, et al. Factors influencing the prevalence of gallstones in liver cirrhosis. J Gastroenterol Hepatol, 2006, 21(9): 1455-1458.
19.	Mancero JM, D’Albuquerque LA, Gonzalez AM, et al. Laparo scopic cholecystectomy in cirrhotic patients with symptomatic chole lithiasis: a case-control study. World J Surg, 2008, 32(2): 267-270.
20.	霍枫, 汪邵平, 蒲淼水, 等. 肝移植围胆道重建环节技巧与细节对胆道并发症的影响研究. 中国实用外科杂志, 2011, 31(11): 1035-1037.
21.	汪根树, 李华, 姜楠, 等. 胆管空肠吻合术重建胆道对肝移植患者术后胆道并发症的影响. 中华肝脏外科手术学电子杂志, 2012, 1(3): 182-186.
22.	Davidson BR, Rai R, Kurzawinski TR, et al. Prospective randomized trial of end-to-end versus side-to-side biliary reconstruction after orthotopic liver transplantation. Br J Surg, 1999, 86(4): 447-452.
23.	Totsukali E, Fung JJ, Ishizawa Y, et al. Synergistic effect of cold and warm ischemia time on postoperative graft outcome in human liver transplantation. Hepatogastroenterology, 2004, 51(59): 1413-1416.
24.	Sankary HN, McChesney L, Frye E, et al. A simple modification in operative technique can reduce the incidence of nonanastomotic biliary strictures after orthotopic liver transplantation. Hepatology, 1995, 21(1): 63-69.
25.	中华人民共和国卫生部. 卫生部办公厅关于启动心脏死亡捐献器官移植试点工作的通知. 中华移植杂志 (电子版), 2011, 5(2): 173-174.
26.	de Vera ME, Lopez-Solis R, Dvorchik I, et al. Liver transplantation using donation after cardiac death donors: long-term follow-up from a single center. Am J Transplant, 2009, 9(4): 773-781.
27.	Guichelaar MM, Benson JT, Malinchoc M, et al. Risk factors for and clinical course of non-anastomotic biliary strictures after liver transplantation. Am J Transplant, 2003, 3(7): 885-890.
28.	Chan EY, Olson LC, Kisthard JA, et al. Ischemic cholangiopathy following liver transplantation from donation after cardiac death donors. Liver Transpl, 2008, 14(5): 604-610.
29.	Park JB, Kwon CH, Choi GS, et al. Prolonged cold ischemic time is a risk factor for biliary strictures in duct-to-duct biliary reconstruc tion in living donor liver transplantation. Transplantation, 2008, 86(11): 1536-1542.
30.	Detry O, Donckier V, Lucidi V, et al. Liver transplantation from donation after cardiac death donors: initial Belgian experience 2003—2007. Transpl Int, 2010, 23(6): 611-618.
31.	蒙建源, 徐静, 樊奇, 等. 肝移植术后胆道并发症危险因素的 Meta 分析. 中华肝胆外科杂志, 2012, 18(11): 816-822.
32.	DeOliveira ML, Jassem W, Valente R, et al. Biliary complications after liver transplantation using grafts from donors after cardiac death: results from a matched control study in a single large volume center. Ann Surg, 2011, 254(5): 716-722.
33.	Frongillo F, Lirosi MC, Sganga G, et al. Graft steatosis as a risk factor of ischemic-type biliary lesions in liver transplantation. Transplant Proc, 2014, 46(7): 2293-2294.
34.	Axelrod DA, Dzebisashvili N, Lentine KL, et al. Variation in biliary complication rates following liver transplantation: implications for cost and outcome. Am J Transplant, 2015, 15(1): 170-179.
35.	Tootstra C, Daemen JH, Omen AP. Categories of non-heart-beating donors. Transplant Proc, 1995, 27(5): 2893-2894.
36.	Rojas-Peña A, Sall LE, Gravel MT, et al. Donation after circulatory determination of death: the University of michigan experience with extracorporeal support. Transplantation, 2014, 98(3): 328-334.
37.	Fondevila C. Is extracorporeal support becoming the new standard for the preservation of DCD grafts? Am J Transplant, 2010, 10: 1341-1342.
38.	Oniscu GC, Randle LV, Muiesan P, et al. In situ normothermic regio nal perfusion for controlled donation after circulatory death—the United Kingdom experience. Am J Transplant, 2014, 14(12): 2846-2854.
39.	霍枫, 汪邵平, 李鹏, 等. 公民心死亡器官捐献肝移植. 中华消化外科杂志, 2012, 11(1): 72-75.
40.	Guarrera JV, Henry SD, Samstein B, et al. Hypothermic machine preservation in human liver transplantation: the first clinical series. Am J Transplant, 2010, 10(2): 372-381.
41.	Guarrera JV, Henry SD, Samstein B, et al. Hypothermic machine preser vation facilitates successful transplantation of " orphan” extended criteria donor liv ers. Am J Transplant, 2015, 15(1): 161-169.
42.	Dutkowski P, Polak WG, Muiesan P, et al. First comparison of hypothermic oxygenated perfusion versus static cold storage of human donation after cardiac death liver transplants: an inter national-matched case analysis. Ann Surg, 2015, 262(5): 764-771.
43.	Hansen TN, Dawson PE, Brockbank KG. Effects of hypothermia upon endothelial cells: mechanisms and clinical importance. Cryobiology, 1994, 31(1): 101-106.
44.	Perera T, Mergental H, Stephenson B, et al. First human liver transplantation using a marginal allograft resuscitated by normo thermic machine perfusion. Liver Transpl, 2016, 22(1): 120-124.
45.	Mergental H, Perera MT, Laing RW, et al. Transplantation of declined liver allografts following normothermic ex-situ evaluation. Am J Transplant, 2016, 16(11): 3235-3245.
46.	Nasralla D, Coussios CC, Mergental H, et al. A randomized trial of normothermic preservation in liver transplantation. Nature, 2018, 557(7703): 50-56.

1. 中国肝移植注册 (CLTR) 年度报告. https://www.cltr.org/.
2. Kochhar G, Parungao JM, Hanouneh IA, et al. Biliary complications following liver transplantation. World J Gastroenterol, 2013, 19(19): 2841-2846.
3. Nemes B, Gaman G, Doros A. Biliary complications after liver trans plantation. Expert Rev Gastroenterol Hepatol, 2015, 9(4): 447-466.
4. Kienlein S, Schoening W, Andert A. Biliary complications in liver transplantation: Impact of anastomotic technique and ischemic time on short- and long-term outcome. World J Transplant, 2015, 5(4): 300-309.
5. 秦建杰, 夏永祥, 武正山, 等. 肝移植术后胆道并发症的处理措施. 中国当代医药, 2009, 16(4): 12-14.
6. 蒋伟伟, 李俊, 陈虹, 等. 肝移植术后中远期胆道并发症 47 例临床分析. 器官移植, 2015, 6(2): 93-97.
7. Londoño MC, Balderramo D, Cárdenas A. Management of biliary complications after orthotopic liver transplantation: the role of endoscopy. World J Gastroenterol, 2008, 14(4): 493-497.
8. Thuluvath PJ, Pfau PR, Kimmey MB, et al. Biliary complications after liver transplantation: the role of endoscopy. Endoscopy, 2005, 37(9): 857-863.
9. Sharma S, Gurakar A, Jabbour N. Biliary strictures following liver transplantation: past, present and preventive strategies. Liver Transpl, 2008, 14(6): 759-769.
10. Jay CL, Lyuksemburg V, Ladner DP, et al. Ischemic cholangiopathy after controlled donation after cardiac death liver transplantation: a meta-analysis. Ann Surg, 2011, 253(2): 259-264.
11. O’Neill S, Roebuck A, Khoo E, et al. A meta-analysis and meta-regre ssion of outcomes including biliary complications in donation after cardiac death liver transplantation. Transpl Int, 2014, 27(11): 1159-1174.
12. Sawyer RG, Punch JD. Incidence and management of biliary complications after 291 liver transplants following the introduction of transcystic stenting. Transplantation, 1998, 66(9): 1201-1207.
13. Foley DP, Fernandez LA, Leverson G, et al. Biliary complications after liver transplantation from donation after cardiac death donors: an analysis of risk factors and long-term outcomes from a single center. Ann Surg, 2011, 253(4): 817-825.
14. Heidenhain C, Pratschke J, Puhl G, et al. Incidence of and risk factors for ischemic-type biliary lesions following orthotopic liver transplantation. Transpl Int, 2010, 23(1): 14-22.
15. Lee KW, Simpkins CE, Montgomery RA, et al. Factors affecting graft survival after liver transplantation from donation after cardiac death donors. Transplantation, 2006, 82(12): 1683-1688.
16. Hoekstra H, Porte RJ, Tian Y, et al. Bile salt toxicity aggravates cold ischemic injury of bile ducts after liver transplantation in Mdr2+/- mice. Hepatology, 2006, 43(5): 1022-1031.
17. 霍胜军, 范松青, 谭善彰. 肝外胆管供血动脉在临床肝移植的应用解剖研究. 中华器官移植杂志, 2005, 26(2): 103-104.
18. Zhang Y, Liu D, Ma Q, et al. Factors influencing the prevalence of gallstones in liver cirrhosis. J Gastroenterol Hepatol, 2006, 21(9): 1455-1458.
19. Mancero JM, D’Albuquerque LA, Gonzalez AM, et al. Laparo scopic cholecystectomy in cirrhotic patients with symptomatic chole lithiasis: a case-control study. World J Surg, 2008, 32(2): 267-270.
20. 霍枫, 汪邵平, 蒲淼水, 等. 肝移植围胆道重建环节技巧与细节对胆道并发症的影响研究. 中国实用外科杂志, 2011, 31(11): 1035-1037.
21. 汪根树, 李华, 姜楠, 等. 胆管空肠吻合术重建胆道对肝移植患者术后胆道并发症的影响. 中华肝脏外科手术学电子杂志, 2012, 1(3): 182-186.
22. Davidson BR, Rai R, Kurzawinski TR, et al. Prospective randomized trial of end-to-end versus side-to-side biliary reconstruction after orthotopic liver transplantation. Br J Surg, 1999, 86(4): 447-452.
23. Totsukali E, Fung JJ, Ishizawa Y, et al. Synergistic effect of cold and warm ischemia time on postoperative graft outcome in human liver transplantation. Hepatogastroenterology, 2004, 51(59): 1413-1416.
24. Sankary HN, McChesney L, Frye E, et al. A simple modification in operative technique can reduce the incidence of nonanastomotic biliary strictures after orthotopic liver transplantation. Hepatology, 1995, 21(1): 63-69.
25. 中华人民共和国卫生部. 卫生部办公厅关于启动心脏死亡捐献器官移植试点工作的通知. 中华移植杂志 (电子版), 2011, 5(2): 173-174.
26. de Vera ME, Lopez-Solis R, Dvorchik I, et al. Liver transplantation using donation after cardiac death donors: long-term follow-up from a single center. Am J Transplant, 2009, 9(4): 773-781.
27. Guichelaar MM, Benson JT, Malinchoc M, et al. Risk factors for and clinical course of non-anastomotic biliary strictures after liver transplantation. Am J Transplant, 2003, 3(7): 885-890.
28. Chan EY, Olson LC, Kisthard JA, et al. Ischemic cholangiopathy following liver transplantation from donation after cardiac death donors. Liver Transpl, 2008, 14(5): 604-610.
29. Park JB, Kwon CH, Choi GS, et al. Prolonged cold ischemic time is a risk factor for biliary strictures in duct-to-duct biliary reconstruc tion in living donor liver transplantation. Transplantation, 2008, 86(11): 1536-1542.
30. Detry O, Donckier V, Lucidi V, et al. Liver transplantation from donation after cardiac death donors: initial Belgian experience 2003—2007. Transpl Int, 2010, 23(6): 611-618.
31. 蒙建源, 徐静, 樊奇, 等. 肝移植术后胆道并发症危险因素的 Meta 分析. 中华肝胆外科杂志, 2012, 18(11): 816-822.
32. DeOliveira ML, Jassem W, Valente R, et al. Biliary complications after liver transplantation using grafts from donors after cardiac death: results from a matched control study in a single large volume center. Ann Surg, 2011, 254(5): 716-722.
33. Frongillo F, Lirosi MC, Sganga G, et al. Graft steatosis as a risk factor of ischemic-type biliary lesions in liver transplantation. Transplant Proc, 2014, 46(7): 2293-2294.
34. Axelrod DA, Dzebisashvili N, Lentine KL, et al. Variation in biliary complication rates following liver transplantation: implications for cost and outcome. Am J Transplant, 2015, 15(1): 170-179.
35. Tootstra C, Daemen JH, Omen AP. Categories of non-heart-beating donors. Transplant Proc, 1995, 27(5): 2893-2894.
36. Rojas-Peña A, Sall LE, Gravel MT, et al. Donation after circulatory determination of death: the University of michigan experience with extracorporeal support. Transplantation, 2014, 98(3): 328-334.
37. Fondevila C. Is extracorporeal support becoming the new standard for the preservation of DCD grafts? Am J Transplant, 2010, 10: 1341-1342.
38. Oniscu GC, Randle LV, Muiesan P, et al. In situ normothermic regio nal perfusion for controlled donation after circulatory death—the United Kingdom experience. Am J Transplant, 2014, 14(12): 2846-2854.
39. 霍枫, 汪邵平, 李鹏, 等. 公民心死亡器官捐献肝移植. 中华消化外科杂志, 2012, 11(1): 72-75.
40. Guarrera JV, Henry SD, Samstein B, et al. Hypothermic machine preservation in human liver transplantation: the first clinical series. Am J Transplant, 2010, 10(2): 372-381.
41. Guarrera JV, Henry SD, Samstein B, et al. Hypothermic machine preser vation facilitates successful transplantation of " orphan” extended criteria donor liv ers. Am J Transplant, 2015, 15(1): 161-169.
42. Dutkowski P, Polak WG, Muiesan P, et al. First comparison of hypothermic oxygenated perfusion versus static cold storage of human donation after cardiac death liver transplants: an inter national-matched case analysis. Ann Surg, 2015, 262(5): 764-771.
43. Hansen TN, Dawson PE, Brockbank KG. Effects of hypothermia upon endothelial cells: mechanisms and clinical importance. Cryobiology, 1994, 31(1): 101-106.
44. Perera T, Mergental H, Stephenson B, et al. First human liver transplantation using a marginal allograft resuscitated by normo thermic machine perfusion. Liver Transpl, 2016, 22(1): 120-124.
45. Mergental H, Perera MT, Laing RW, et al. Transplantation of declined liver allografts following normothermic ex-situ evaluation. Am J Transplant, 2016, 16(11): 3235-3245.
46. Nasralla D, Coussios CC, Mergental H, et al. A randomized trial of normothermic preservation in liver transplantation. Nature, 2018, 557(7703): 50-56.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

公民逝世器官捐献肝移植胆道并发症及其预防策略

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