Application of MDT in the diagnosis and treatment of a huge retroperitoneal small cell carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHAO Huiqi , DONG Xiaohua , DONG Baolong , HE Yu , GAO Peng ,  YANG Xiaojun

Department of General Surgery, Gansu Provincial Hospital, Lanzhou 730000, P. R. China;

Corresponding author：

YANG Xiaojun, Email: yangxjmd@aliyun.com

Keywords：

small cell carcinoma; surgically radical surgery; MDT

DOI：

10.7507/1007-9424.201810074

Video：

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Objective To explore the application of MDT mode in the diagnosis and treatment of a large retroperitoneal small cell carcinoma.Methods A huge retroperitoneal tumor about 25 cm×18 cm was found by the preoperative abdominal MRI examination, which was considered as the malignant tumor. Considering the patient’s condition, MDT consultation of the specialists in radiology, oncology, vascular surgery, urinary surgery, and anesthesiology was conducted.Results By MDT discussion, the general condition of patient was good. At present, the diagnosis of the huge retroperitoneal tumor was confirmed. Although the tumor was surrounded with related organs closely, yet the radical operation was finished smoothly and the R0 resection was achieved through the collaboration of MDT. The operation lasted 365 minutes, and the intraoperative blood loss was about 200 mL. Postoperative pathology confirmed that the tumor margin was negative and no postoperative complication occurred. The total number of hospital stays was 23 days. The patient’s return to the hospital for review in 4 months after discharge revealed a tumor recurrence. Then, combined with radiotherapy and chemotherapy, the patient’s condition was stable during treatment.Conclusion For rare cases of retroperitoneal small cell carcinoma involving multiple disciplines, the treatment based on MDT is able to bring better clinical outcome to patients due to safer and more feasible.

Citation： ZHAO Huiqi, DONG Xiaohua, DONG Baolong, HE Yu, GAO Peng, YANG Xiaojun. Application of MDT in the diagnosis and treatment of a huge retroperitoneal small cell carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2019, 26(2): 207-211. doi: 10.7507/1007-9424.201810074 Copy

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2.	李自强, 俞志刚. 腹膜后小细胞癌 1 例. 实用医学杂志, 2010, 26(5): 731.
3.	Grabowski P, Schönfelder J, Ahnert-Hilger G, et al. Expression of neuroendocrine markers: a signature of human undifferentiated carcinoma of the colon and rectum. Virchows Arch, 2002, 441(3): 256-263.
4.	Remick SC, Ruckdeschel JC. Extrapulmonary and pulmonary small-cell carcinoma: tumor biology, therapy, and outcome. Med Pediatr Oncol, 1992, 20(2): 89-99.
5.	Duquid JB, Kennedy AM. Oat-cell tumors of mediasatinal glands. J Pathological Bacteriol, 1930, 33: 93-99.
6.	Galanis E, Frytak S, Lloyd RV. Extrapulmonary small cell carcinoma. Cancer, 1997, 79(9): 1729-1736.
7.	Brammer JE, Lulla P, Lynch GR. Retrospective review of extra-pulmonary small cell carcinoma and prognostic factors. Int J Clin Oncol, 2014, 19(5): 822-828.
8.	戴永美, 徐驯宇, 黄郴, 等. 肺外小细胞癌的临床病理特征及综合治疗策略. 中外医疗, 2016, 35(31): 37-39.
9.	孙红梅, 陈文彰, 燕丽香, 等. 肺外小细胞癌的诊断和治疗. 中华老年多器官疾病杂志, 2011, 10(5): 474-477.
10.	Frazier SR, Kaplan PA, Loy TS. The pathology of extrapulmonary small cell carcinoma. Semin Oncol, 2007, 34(1): 30-38.
11.	李玲, 白志强, 李鹏, 等. 人巨细胞病毒感染对人神经干细胞定向星形胶质细胞分化过程中 Notch 相关信号分子表达的影响. 医学研究生学报, 2010, 23(10): 1013-1019.
12.	Weijzen S, Rizzo P, Braid M, et al. Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells. Nat Med, 2002, 8(9): 979-986.

1. Hammar SP, Bolen JW. Undifferentiated retroperitoneal small cell carcinoma. Ultrastruct Pathol, 1985, 9(1-2): 71-76.
2. 李自强, 俞志刚. 腹膜后小细胞癌 1 例. 实用医学杂志, 2010, 26(5): 731.
3. Grabowski P, Schönfelder J, Ahnert-Hilger G, et al. Expression of neuroendocrine markers: a signature of human undifferentiated carcinoma of the colon and rectum. Virchows Arch, 2002, 441(3): 256-263.
4. Remick SC, Ruckdeschel JC. Extrapulmonary and pulmonary small-cell carcinoma: tumor biology, therapy, and outcome. Med Pediatr Oncol, 1992, 20(2): 89-99.
5. Duquid JB, Kennedy AM. Oat-cell tumors of mediasatinal glands. J Pathological Bacteriol, 1930, 33: 93-99.
6. Galanis E, Frytak S, Lloyd RV. Extrapulmonary small cell carcinoma. Cancer, 1997, 79(9): 1729-1736.
7. Brammer JE, Lulla P, Lynch GR. Retrospective review of extra-pulmonary small cell carcinoma and prognostic factors. Int J Clin Oncol, 2014, 19(5): 822-828.
8. 戴永美, 徐驯宇, 黄郴, 等. 肺外小细胞癌的临床病理特征及综合治疗策略. 中外医疗, 2016, 35(31): 37-39.
9. 孙红梅, 陈文彰, 燕丽香, 等. 肺外小细胞癌的诊断和治疗. 中华老年多器官疾病杂志, 2011, 10(5): 474-477.
10. Frazier SR, Kaplan PA, Loy TS. The pathology of extrapulmonary small cell carcinoma. Semin Oncol, 2007, 34(1): 30-38.
11. 李玲, 白志强, 李鹏, 等. 人巨细胞病毒感染对人神经干细胞定向星形胶质细胞分化过程中 Notch 相关信号分子表达的影响. 医学研究生学报, 2010, 23(10): 1013-1019.
12. Weijzen S, Rizzo P, Braid M, et al. Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells. Nat Med, 2002, 8(9): 979-986.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Application of MDT in the diagnosis and treatment of a huge retroperitoneal small cell carcinoma

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