Research progress of drug-eluting beads in arterial chemoembolization for hepatocellular carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

JIN Hongyu ^1,2 ,  YUAN Chi ² , LIAO Mingheng ¹ , WANG Menghua ² , CAI Qiuyu ² , LIU Siyu ² ,  ZENG Yong ¹

1. Department of Liver Surgery & Liver Transplantation Center, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;
2. West China School of Medicine, Sichuan University, Chengdu 610041, P. R. China;

Corresponding author：

ZENG Yong, Email: zengyong@medmail.com.cn

Keywords：

hepatocellular carcinoma; transcatheter arterial chemoembolization; drug-eluting bead

DOI：

10.7507/1007-9424.201905100

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To summarize the research progress of four mainstream drug-eluting beads (DEB) in transcathete arterial chemoembolization (TACE) for hepatocellular carcinoma in recent years.Method Through retrieving relevant literatures at home and abroad, the physicochemical properties, pharmacokinetics, effectiveness, and safety of four mainstream DEBs were reviewed.Results The current mainstream DEBs on the market had the characteristics of high drug loading rate and sustained release of drugs, which could reduce the adverse reactions after the embolization to a certain extent. The safety and tolerance of patients receiving DEB-TACE were slightly higher than those receiving traditional TACE (c-TACE). There were no serious complications after the DEB-TACE, but the short-term and long-term efficacies between the two methods were not significantly different.Conclusions At present, most studies believe that the safety and tolerance of DEB are slightly higher than that of c-TACE, but whether the former is more effective than the latter is still controversial at home and abroad, and more high-quality multicenter randomized controlled trials are needed to confirm it.

Citation： JIN Hongyu, YUAN Chi, LIAO Mingheng, WANG Menghua, CAI Qiuyu, LIU Siyu, ZENG Yong. Research progress of drug-eluting beads in arterial chemoembolization for hepatocellular carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2020, 27(2): 232-238. doi: 10.7507/1007-9424.201905100 Copy

1.	Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2018, 68(6): 394-424.
2.	中华人民共和国卫生和计划生育委员会医政医管局. 原发性肝癌诊疗规范 (2017 年版). 传染病信息, 2017, 16(7): 705-720.
3.	陈猛, 陈晓明. 2017 年载药微球化疗栓塞治疗肝癌临床研究进展. 循证医学, 2018, 18(1): 26-28.
4.	Raoul JL, Forner A, Bolondi L, et al. Updated use of TACE for hepatocellular carcinoma treatment: How and when to use it based on clinical evidence. Cancer Treat Rev, 2019, 72: 28-36.
5.	Baur J, Ritter CO, Germer CT, et al. Transarterial chemoembolization with drug-eluting beads versus conventional transarterial chemoembolization in locally advanced hepatocellular carcinoma. Hepat Med, 2016, 8: 69-74.
6.	Popovic P, Stabuc B, Jansa R, et al. Survival of patients with intermediate stage hepatocellular carcinoma treated with superselective transarterial chemoembolization using doxorubicin-loaded DC Bead under cone-beam computed tomography control. Radiol Oncol, 2016, 50(4): 418-426.
7.	Liu YS, Lin CY, Chuang MT, et al. Five-year outcome of conventional and drug-eluting transcatheter arterial chemoembolization in patients with hepatocellular carcinoma. BMC Gastroenterol, 2018, 18(1): 124.
8.	陈圣群, 张岳林, 周官辉, 等. 国产载药微球治疗肝癌的近期疗效分析. 心理医生, 2018, 24(16): 82-83.
9.	朴相浩, 曾健滢, 杨清峰, 等. Hepasphere®载药微球栓塞治疗中晚期肝细胞肝癌的安全性及疗效分析. 现代肿瘤医学, 2018, 26(11): 1732-1736.
10.	Melchiorre F, Patella F, Pescatori L, et al. DEB-TACE: a standard review. Future Oncol, 2018, 14(28): 2969-2984.
11.	Chang PY, Huang CC, Hung CH, et al. Multidisciplinary Taiwan consensus recommendations for the use of DEBDOX-TACE in hepatocellular carcinoma treatment. Liver cancer, 2018, 7(4): 312-322.
12.	Weng L, Tseng HJ, Rostamzadeh P, et al. In vitro comparative study of drug loading and delivery properties of bioresorbable microspheres and LC bead. J Mater Sci Mater Med, 2016, 27(12): 174.
13.	Lahti S, Ludwig JM, Xing M, et al. In vitro biologic efficacy of sunitinib drug-eluting beads on human colorectal and hepatocellular carcinoma—A pilot study. PLoS One, 2017, 12(4): e0174539.
14.	Hong K, Khwaja A, Liapi E, et al. New intra-arterial drug delivery system for the treatment of liver cancer: preclinical assessment in a rabbit model of liver cancer. Clin Cancer Res, 2006, 12(8): 2563-2567.
15.	Liu DM, Kos S, Buczkowski A, et al. Optimization of doxorubicin loading for superabsorbent polymer microspheres: in vitro analysis. Cardiovasc Intervent Radiol, 2012, 35(2): 391-398.
16.	Sottani C, Poggi G, Quaretti P, et al. Serum pharmacokinetics in patients treated with transarterial chemoembolization (TACE) using two types of epirubicin-loaded microspheres. Anticancer Res, 2012, 32(5): 1769-1774.
17.	Zhou GH, Han J, Sun JH, et al. Efficacy and safety profile of drug-eluting beads transarterial chemoembolization by CalliSpheres® beads in Chinese hepatocellular carcinoma patients. BMC Cancer, 2018, 18(1): 644.
18.	Zhang S, Huang C, Li Z, et al. Comparison of pharmacokinetics and drug release in tissues after transarterial chemoembolization with doxorubicin using diverse lipiodol emulsions and CalliSpheres Beads in rabbit livers. Drug delivery, 2017, 24(1): 1011-1017.
19.	Delicque J, Guiu B, Boulin M, et al. Liver chemoembolization of hepatocellular carcinoma using TANDEM. Future Oncol, 2018, 14(26): 2761-2772.
20.	Malagari K, Kiakidis T, Pomoni M, et al. Pharmacokinetics, safety, and efficacy of chemoembolization with doxorubicin-loaded tightly calibrated small microspheres in patients with hepatocellular carcinoma. Cardiovasc Intervent Radiol, 2016, 39(10): 1379-1391.
21.	de Baere T, Plotkin S, Yu R, et al. An in vitro evaluation of four types of drug-eluting microspheres loaded with doxorubicin. J Vasc Interv Radiol, 2016, 27(9): 1425-1431.
22.	Hagan A, Phillips GJ, Macfarlane WM, et al. Preparation and characterisation of vandetanib-eluting radiopaque beads for locoregional treatment of hepatic malignancies. Eur J Pharm Sci, 2017, 101: 22-30.
23.	Cho H, Cho Y, Yu SJ, et al. The efficacy and safety of doxorubicin-eluting bead transarterial chemoembolization over sorafenib for unresectable hepatocellular carcinoma with portal vein invasion. Hepatology, 2016, 64(1 Supplement 1): 637A.
24.	Lee M, Chung JW, Lee KH, et al. Korean multicenter registry of transcatheter arterial chemoembolization with drug-eluting embolic agents for nodular hepatocellular carcinomas: six-month outcome analysis. J Vasc Interv Radiol, 2017, 28(4): 502-512.
25.	Lammer J, Malagari K, Vogl T, et al. Prospective randomized study of doxorubicin-eluting-bead embolization in the treatment of hepatocellular carcinoma: results of the PRECISION Ⅴ study. Cardiovasc Intervent Radiol, 2010, 33(1): 41-52.
26.	Malagari K, Pomoni M, Spyridopoulos TN, et al. Safety profile of sequential transcatheter chemoembolization with DC Bead^TM: results of 237 hepatocellular carcinoma (HCC) patients. Cardiovasc Intervent Radiol, 2011, 34(4): 774-785.
27.	Monier A, Guiu B, Duran R, et al. Liver and biliary damages following transarterial chemoembolization of hepatocellular carcinoma: comparison between drug-eluting beads and lipiodol emulsion. Eur Radiol, 2017, 27(4): 1431-1439.
28.	Duan F, Wang EQ, Lam MG, et al. Superselective Chemo-embolization of HCC: Comparison of Short-term Safety and Efficacy between Drug-eluting LC Beads, QuadraSpheres, and Conventional Ethiodized Oil Emulsion. Radiology, 2016, 278(2): 612-621.
29.	Zurstrassen CE, Gireli LPO, Tyng CJ, et al. Safety and efficacy of HepaSphere 50-100? μm in the treatment of hepatocellular carcinoma. Minim Invasive Ther Allied Technol, 2017, 26(4): 212-219.
30.	Xiang H, Long L, Yao Y, et al. CalliSpheres drug-eluting bead transcatheter arterial chemoembolization presents with better efficacy and equal safety compared to conventional TACE in treating patients with hepatocellular carcinoma. Technol Cancer Res Treat, 2019, 18: 1533033819830751.
31.	Wu B, Zhou J, Ling G, et al. CalliSpheres drug-eluting beads versus lipiodol transarterial chemoembolization in the treatment of hepatocellular carcinoma: a short-term efficacy and safety study. World J Surg Oncol, 2018, 16(1): 69.
32.	周永祥, 张j景俊, 罗志刚, 等. CalliSpheres®载药微球栓塞治疗高龄肝癌患者的安全性分析. 广东医学, 2018, 39(10): 1561-1565.
33.	陈刚, 张鼎, 应亚草, 等. 国产载药微球经动脉化疗栓塞治疗不可切除原发性肝癌的临床研究. 浙江大学学报 (医学版), 2017, 46(1): 44-51.
34.	Rahman FA, Naidu J, Ngiu CS, et al. Conventional versus doxorubicin-eluting beads transarterial chemoembolization for unresectable hepatocellular carcinoma: a tertiary medical centre experience in Malaysia. Asian Pac J Cancer Prev, 2016, 17(8): 4037-4041.
35.	Best J, Schotten C, Theysohn JM, et al. Novel implications in the treatment of hepatocellular carcinoma. Ann Gastroenterol, 2017, 30(1): 23-32.
36.	Nicolini D, Svegliati-Baroni G, Candelari R, et al. Doxorubicin-eluting bead vs conventional transcatheter arterial chemoembolization for hepatocellular carcinoma before liver transplantation. World J Gastroenterol, 2013, 19(34): 5622-5632.
37.	Song MJ, Chun HJ, Song DS, et al. Comparative study between doxorubicin-eluting beads and conventional transarterial chemoembolization for treatment of hepatocellular carcinoma. J Hepatol, 2012, 57(6): 1244-1250.
38.	Sattler T, Bredt C, Surwald S, et al. Efficacy and safety of drug eluting bead TACE with microspheres. Anticancer Res, 2018, 38(2): 1025-1032.
39.	Lee S, Kim KM, Lee SJ, et al. Hepatic arterial damage after transarterial chemoembolization for the treatment of hepatocellular carcinoma: comparison of drug-eluting bead and conventional chemoembolization in a retrospective controlled study. Acta Radiol, 2017, 58(2): 131-139.
40.	邱力戈, 梁若斯, 李勇, 等. HepaSphere®载药微球与碘油化疗栓塞大肝癌的不良反应比较. 中华介入放射学电子杂志, 2018, 6(2): 99-103.
41.	Kucukay F, Badem S, Karan A, et al. A single-center retrospective comparison of doxorubicin-loaded HepaSphere transarterial chemoembolization with conventional transarterial chemoembolization for patients with unresectable hepatocellular carcinoma. J Vasc Interv Radiol, 2015, 26(11): 1622-1629.
42.	曹国洪, 王凯, 李佳琪, 等. CalliSpheres®载药微球经动脉导管化疗栓塞治疗肝癌患者的有效性及安全性分析. 中国介入影像与治疗学, 2018, 15(1): 42-46.
43.	Greco G, Cascella T, Facciorusso A, et al. Transarterial chemoembolization using 40 μm drug eluting beads for hepatocellular carcinoma. World J Radiol, 2017, 9(5): 245-252.
44.	Kloeckner R, Pitton MB, Dueber C, et al. Validation of clinical scoring systems ART and ABCR after transarterial chemoembolization of hepatocellular carcinoma. J Vasc Interv Radiol, 2017, 28(1): 94-102.
45.	Xing M, Webber G, Prajapati HJ, et al. Preservation of quality of life with doxorubicin drug-eluting bead transarterial chemoembolization for unresectable hepatocellular carcinoma: Longitudinal prospective study. J Gastroenterol Hepatol, 2015, 30(7): 1167-1174.
46.	Cucchetti A, Trevisani F, Cappelli A, et al. Cost-effectiveness of doxorubicin-eluting beads versus conventional trans-arterial chemo-embolization for hepatocellular carcinoma. Dig Liver Dis, 2016, 48(7): 798-805.
47.	Vadot L, Boulin M, Guiu B, et al. Clinical and economic impact of drug eluting beads in transarterial chemoembolization for hepatocellular carcinoma. J Clin Pharm Ther, 2015, 40(1): 83-90.
48.	Pieper CC, Meyer C, Vollmar B, et al. Temporary arterial embolization of liver parenchyma with degradable starch microspheres (EmboCept^®S) in a swine model. Cardiovasc Intervent Radiol, 2015, 38(2): 435-441.
49.	Weng L, Rostamzadeh P, Nooryshokry N, et al. In vitro and in vivo evaluation of biodegradable embolic microspheres with tunable anticancer drug release. Acta Biomater, 2013, 9(6): 6823-6833.
50.	徐浩. 聚乙烯醇栓塞微球可载药微球介入治疗中晚期肝癌的临床疗效及安全性观察. 实用癌症杂志, 2017, 32(12): 1999-2001.
51.	刘墨, 黄伍奎, 刘登尧, 等. 国产海藻酸钠载药微球在原发性肝癌 TACE 治疗中的安全性分析. 中国实用医药, 2017, 12(1): 37-39.
52.	Aliberti C, Carandina R, Sarti D, et al. Transarterial chemoembolization with DC Bead LUMI^TM radiopaque beads for primary liver cancer treatment: preliminary experience. Future Oncol, 2017, 13(25): 2243-2252.

1. Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2018, 68(6): 394-424.
2. 中华人民共和国卫生和计划生育委员会医政医管局. 原发性肝癌诊疗规范 (2017 年版). 传染病信息, 2017, 16(7): 705-720.
3. 陈猛, 陈晓明. 2017 年载药微球化疗栓塞治疗肝癌临床研究进展. 循证医学, 2018, 18(1): 26-28.
4. Raoul JL, Forner A, Bolondi L, et al. Updated use of TACE for hepatocellular carcinoma treatment: How and when to use it based on clinical evidence. Cancer Treat Rev, 2019, 72: 28-36.
5. Baur J, Ritter CO, Germer CT, et al. Transarterial chemoembolization with drug-eluting beads versus conventional transarterial chemoembolization in locally advanced hepatocellular carcinoma. Hepat Med, 2016, 8: 69-74.
6. Popovic P, Stabuc B, Jansa R, et al. Survival of patients with intermediate stage hepatocellular carcinoma treated with superselective transarterial chemoembolization using doxorubicin-loaded DC Bead under cone-beam computed tomography control. Radiol Oncol, 2016, 50(4): 418-426.
7. Liu YS, Lin CY, Chuang MT, et al. Five-year outcome of conventional and drug-eluting transcatheter arterial chemoembolization in patients with hepatocellular carcinoma. BMC Gastroenterol, 2018, 18(1): 124.
8. 陈圣群, 张岳林, 周官辉, 等. 国产载药微球治疗肝癌的近期疗效分析. 心理医生, 2018, 24(16): 82-83.
9. 朴相浩, 曾健滢, 杨清峰, 等. Hepasphere®载药微球栓塞治疗中晚期肝细胞肝癌的安全性及疗效分析. 现代肿瘤医学, 2018, 26(11): 1732-1736.
10. Melchiorre F, Patella F, Pescatori L, et al. DEB-TACE: a standard review. Future Oncol, 2018, 14(28): 2969-2984.
11. Chang PY, Huang CC, Hung CH, et al. Multidisciplinary Taiwan consensus recommendations for the use of DEBDOX-TACE in hepatocellular carcinoma treatment. Liver cancer, 2018, 7(4): 312-322.
12. Weng L, Tseng HJ, Rostamzadeh P, et al. In vitro comparative study of drug loading and delivery properties of bioresorbable microspheres and LC bead. J Mater Sci Mater Med, 2016, 27(12): 174.
13. Lahti S, Ludwig JM, Xing M, et al. In vitro biologic efficacy of sunitinib drug-eluting beads on human colorectal and hepatocellular carcinoma—A pilot study. PLoS One, 2017, 12(4): e0174539.
14. Hong K, Khwaja A, Liapi E, et al. New intra-arterial drug delivery system for the treatment of liver cancer: preclinical assessment in a rabbit model of liver cancer. Clin Cancer Res, 2006, 12(8): 2563-2567.
15. Liu DM, Kos S, Buczkowski A, et al. Optimization of doxorubicin loading for superabsorbent polymer microspheres: in vitro analysis. Cardiovasc Intervent Radiol, 2012, 35(2): 391-398.
16. Sottani C, Poggi G, Quaretti P, et al. Serum pharmacokinetics in patients treated with transarterial chemoembolization (TACE) using two types of epirubicin-loaded microspheres. Anticancer Res, 2012, 32(5): 1769-1774.
17. Zhou GH, Han J, Sun JH, et al. Efficacy and safety profile of drug-eluting beads transarterial chemoembolization by CalliSpheres® beads in Chinese hepatocellular carcinoma patients. BMC Cancer, 2018, 18(1): 644.
18. Zhang S, Huang C, Li Z, et al. Comparison of pharmacokinetics and drug release in tissues after transarterial chemoembolization with doxorubicin using diverse lipiodol emulsions and CalliSpheres Beads in rabbit livers. Drug delivery, 2017, 24(1): 1011-1017.
19. Delicque J, Guiu B, Boulin M, et al. Liver chemoembolization of hepatocellular carcinoma using TANDEM. Future Oncol, 2018, 14(26): 2761-2772.
20. Malagari K, Kiakidis T, Pomoni M, et al. Pharmacokinetics, safety, and efficacy of chemoembolization with doxorubicin-loaded tightly calibrated small microspheres in patients with hepatocellular carcinoma. Cardiovasc Intervent Radiol, 2016, 39(10): 1379-1391.
21. de Baere T, Plotkin S, Yu R, et al. An in vitro evaluation of four types of drug-eluting microspheres loaded with doxorubicin. J Vasc Interv Radiol, 2016, 27(9): 1425-1431.
22. Hagan A, Phillips GJ, Macfarlane WM, et al. Preparation and characterisation of vandetanib-eluting radiopaque beads for locoregional treatment of hepatic malignancies. Eur J Pharm Sci, 2017, 101: 22-30.
23. Cho H, Cho Y, Yu SJ, et al. The efficacy and safety of doxorubicin-eluting bead transarterial chemoembolization over sorafenib for unresectable hepatocellular carcinoma with portal vein invasion. Hepatology, 2016, 64(1 Supplement 1): 637A.
24. Lee M, Chung JW, Lee KH, et al. Korean multicenter registry of transcatheter arterial chemoembolization with drug-eluting embolic agents for nodular hepatocellular carcinomas: six-month outcome analysis. J Vasc Interv Radiol, 2017, 28(4): 502-512.
25. Lammer J, Malagari K, Vogl T, et al. Prospective randomized study of doxorubicin-eluting-bead embolization in the treatment of hepatocellular carcinoma: results of the PRECISION Ⅴ study. Cardiovasc Intervent Radiol, 2010, 33(1): 41-52.
26. Malagari K, Pomoni M, Spyridopoulos TN, et al. Safety profile of sequential transcatheter chemoembolization with DC Bead^TM: results of 237 hepatocellular carcinoma (HCC) patients. Cardiovasc Intervent Radiol, 2011, 34(4): 774-785.
27. Monier A, Guiu B, Duran R, et al. Liver and biliary damages following transarterial chemoembolization of hepatocellular carcinoma: comparison between drug-eluting beads and lipiodol emulsion. Eur Radiol, 2017, 27(4): 1431-1439.
28. Duan F, Wang EQ, Lam MG, et al. Superselective Chemo-embolization of HCC: Comparison of Short-term Safety and Efficacy between Drug-eluting LC Beads, QuadraSpheres, and Conventional Ethiodized Oil Emulsion. Radiology, 2016, 278(2): 612-621.
29. Zurstrassen CE, Gireli LPO, Tyng CJ, et al. Safety and efficacy of HepaSphere 50-100? μm in the treatment of hepatocellular carcinoma. Minim Invasive Ther Allied Technol, 2017, 26(4): 212-219.
30. Xiang H, Long L, Yao Y, et al. CalliSpheres drug-eluting bead transcatheter arterial chemoembolization presents with better efficacy and equal safety compared to conventional TACE in treating patients with hepatocellular carcinoma. Technol Cancer Res Treat, 2019, 18: 1533033819830751.
31. Wu B, Zhou J, Ling G, et al. CalliSpheres drug-eluting beads versus lipiodol transarterial chemoembolization in the treatment of hepatocellular carcinoma: a short-term efficacy and safety study. World J Surg Oncol, 2018, 16(1): 69.
32. 周永祥, 张j景俊, 罗志刚, 等. CalliSpheres®载药微球栓塞治疗高龄肝癌患者的安全性分析. 广东医学, 2018, 39(10): 1561-1565.
33. 陈刚, 张鼎, 应亚草, 等. 国产载药微球经动脉化疗栓塞治疗不可切除原发性肝癌的临床研究. 浙江大学学报 (医学版), 2017, 46(1): 44-51.
34. Rahman FA, Naidu J, Ngiu CS, et al. Conventional versus doxorubicin-eluting beads transarterial chemoembolization for unresectable hepatocellular carcinoma: a tertiary medical centre experience in Malaysia. Asian Pac J Cancer Prev, 2016, 17(8): 4037-4041.
35. Best J, Schotten C, Theysohn JM, et al. Novel implications in the treatment of hepatocellular carcinoma. Ann Gastroenterol, 2017, 30(1): 23-32.
36. Nicolini D, Svegliati-Baroni G, Candelari R, et al. Doxorubicin-eluting bead vs conventional transcatheter arterial chemoembolization for hepatocellular carcinoma before liver transplantation. World J Gastroenterol, 2013, 19(34): 5622-5632.
37. Song MJ, Chun HJ, Song DS, et al. Comparative study between doxorubicin-eluting beads and conventional transarterial chemoembolization for treatment of hepatocellular carcinoma. J Hepatol, 2012, 57(6): 1244-1250.
38. Sattler T, Bredt C, Surwald S, et al. Efficacy and safety of drug eluting bead TACE with microspheres. Anticancer Res, 2018, 38(2): 1025-1032.
39. Lee S, Kim KM, Lee SJ, et al. Hepatic arterial damage after transarterial chemoembolization for the treatment of hepatocellular carcinoma: comparison of drug-eluting bead and conventional chemoembolization in a retrospective controlled study. Acta Radiol, 2017, 58(2): 131-139.
40. 邱力戈, 梁若斯, 李勇, 等. HepaSphere®载药微球与碘油化疗栓塞大肝癌的不良反应比较. 中华介入放射学电子杂志, 2018, 6(2): 99-103.
41. Kucukay F, Badem S, Karan A, et al. A single-center retrospective comparison of doxorubicin-loaded HepaSphere transarterial chemoembolization with conventional transarterial chemoembolization for patients with unresectable hepatocellular carcinoma. J Vasc Interv Radiol, 2015, 26(11): 1622-1629.
42. 曹国洪, 王凯, 李佳琪, 等. CalliSpheres®载药微球经动脉导管化疗栓塞治疗肝癌患者的有效性及安全性分析. 中国介入影像与治疗学, 2018, 15(1): 42-46.
43. Greco G, Cascella T, Facciorusso A, et al. Transarterial chemoembolization using 40 μm drug eluting beads for hepatocellular carcinoma. World J Radiol, 2017, 9(5): 245-252.
44. Kloeckner R, Pitton MB, Dueber C, et al. Validation of clinical scoring systems ART and ABCR after transarterial chemoembolization of hepatocellular carcinoma. J Vasc Interv Radiol, 2017, 28(1): 94-102.
45. Xing M, Webber G, Prajapati HJ, et al. Preservation of quality of life with doxorubicin drug-eluting bead transarterial chemoembolization for unresectable hepatocellular carcinoma: Longitudinal prospective study. J Gastroenterol Hepatol, 2015, 30(7): 1167-1174.
46. Cucchetti A, Trevisani F, Cappelli A, et al. Cost-effectiveness of doxorubicin-eluting beads versus conventional trans-arterial chemo-embolization for hepatocellular carcinoma. Dig Liver Dis, 2016, 48(7): 798-805.
47. Vadot L, Boulin M, Guiu B, et al. Clinical and economic impact of drug eluting beads in transarterial chemoembolization for hepatocellular carcinoma. J Clin Pharm Ther, 2015, 40(1): 83-90.
48. Pieper CC, Meyer C, Vollmar B, et al. Temporary arterial embolization of liver parenchyma with degradable starch microspheres (EmboCept^®S) in a swine model. Cardiovasc Intervent Radiol, 2015, 38(2): 435-441.
49. Weng L, Rostamzadeh P, Nooryshokry N, et al. In vitro and in vivo evaluation of biodegradable embolic microspheres with tunable anticancer drug release. Acta Biomater, 2013, 9(6): 6823-6833.
50. 徐浩. 聚乙烯醇栓塞微球可载药微球介入治疗中晚期肝癌的临床疗效及安全性观察. 实用癌症杂志, 2017, 32(12): 1999-2001.
51. 刘墨, 黄伍奎, 刘登尧, 等. 国产海藻酸钠载药微球在原发性肝癌 TACE 治疗中的安全性分析. 中国实用医药, 2017, 12(1): 37-39.
52. Aliberti C, Carandina R, Sarti D, et al. Transarterial chemoembolization with DC Bead LUMI^TM radiopaque beads for primary liver cancer treatment: preliminary experience. Future Oncol, 2017, 13(25): 2243-2252.

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Research progress of drug-eluting beads in arterial chemoembolization for hepatocellular carcinoma

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