Summary in etiologies, prevention and treatment strategies of recurrent acute pancreatitis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

KANG Hongxin , LI Junyi , TANG Wenfu ,  WAN Meihua

Department of Integartive Medicine, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;

Corresponding author：

WAN Meihua, Email: meihuawan@hotmail.com

Keywords：

recurrent acute pancreatitis; etiologies; prevention and treatment strategies; review

DOI：

10.7507/1007-9424.201911007

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To summarize and analyze the etiologies of recurrent acute pancreatitis (RAP) and then conclude the prevention and treatment strategies.Method Searching relevant literatures of PubMed, CNKI, Wanfang data and other databases in recent years, the etiologies of RAP were analysed and reviewed, then the prevention and treatment strategies were developed.Results The causes of RAP included abnormal function and structure of biliopancreatic duct, metabolic factors, bad living habits, genetic factors and so on. Then based on etiologies of RAP, prevention and treatment strategies of it were summarized.Conclusions With the developments of related researches and clinical diagnosis and treatment technologies, the etiologies of RAP are gradually revealed. It is of great significance to clarify the etiologies of RAP and make prevention and treatment strategies for reducing the recurrence of acute pancreatitis.

Citation： KANG Hongxin, LI Junyi, TANG Wenfu, WAN Meihua. Summary in etiologies, prevention and treatment strategies of recurrent acute pancreatitis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2020, 27(7): 895-900. doi: 10.7507/1007-9424.201911007 Copy

1.	Garg PK, Singh VP. Organ failure due to systemic injury in acute pancreatitis. Gastroenterology, 2019, 156(7): 2008-2023.
2.	彭莉, 彭燕, 蒲垠全, 等. 671 例复发性急性胰腺炎临床特点及危险因素分析. 实用医学杂志, 2019, 35(18): 2924-2928.
3.	Sankaran SJ, Xiao AY, Wu LM, et al. Frequency of progression from acute to chronic pancreatitis and risk factors: a meta-analysis. Gastroenterology, 2015, 149(6): 1490-1500.
4.	班猛猛, 史炼钢, 王东, 等. 复发性急性胰腺炎危险因素研究进展. 大连医科大学学报, 2018, 27(2): 171-175, 180.
5.	季钧淘, 张菂, 辛磊, 等. 复发性急性胰腺炎诊断与治疗研究进展. 中华胰腺病杂志, 2016, 16(3): 203-205.
6.	高艳景, 李延青, 黄柳业, 等. 山东省 157 例复发性急性胰腺炎病因和复发特征分析. 山东大学学报(医学版), 2005, 43(7): 605-608.
7.	温彦丽, 郝婷婷, 戴光荣, 等. 急性复发性胰腺炎 288 例病因分析. 陕西医学杂志, 2015, 44(1): 68-70.
8.	那宾. 复发性急性胰腺炎病因学分析. 武汉: 华中科技大学, 2012: 3-10.
9.	何希平, 胡康, 刘洙秀. 复发性胰腺炎的病因与治疗. 吉林医学, 2014, 35(20): 4520.
10.	陈灏珠, 林果为, 王吉耀. 实用内科学. 第 14 版. 北京:人民卫生出版社, 2014: 2015-2057.
11.	毕旭东, 付晓光, 唐树相, 等. 急性胰腺炎反复发作病因的临床研究. 锦州医学院学报, 2003, 24(6): 12-13.
12.	张肇达, 严律南, 刘续宝. 急性胰腺炎. 北京: 人民卫生出版社, 2006: 54-55.
13.	曾庆煜, 汪丽燕. Oddi 括约肌功能障碍研究新进展. 世界最新医学信息文摘, 2019, 19(99): 100-102.
14.	Afghani E, Lo SK, Covington PS, et al. Sphincter of Oddi function and risk factors for dysfunction. Front Nutr, 2017, 4(1): 1-9.
15.	Brawman-Mintzer O, Durkalski V, Wu Q, et al. Psychosocial characteristics and pain burden of patients with suspected sphincter of Oddi dysfunction in the EPISOD multicenter trial. Am J Gastroenterol, 2014, 109(3): 436-442.
16.	Sonoda Y, Kawamoto M, Woods CN, et al. Sphincter of Oddi function in the Australian brush-tailed possum is inhibited by intragastric ethanol. Neurogastroenterol Motil, 2007, 19(5): 401-10.
17.	Mousavi S, Toussy J, Zahmatkesh M. Opium addiction as a new risk factor of sphincter of Oddi dysfunction. Med Sci Monit, 2007, 13(11): CR528-CR531.
18.	Fernandes SR, Correia LA, Antunes T, et al. Intraductal papillary mucinous neoplasm presenting with recurrent pancreatitis: a report of a painful 3-decade-long history. BMJ Case Rep, 2016, 2016. pii: bcr2016214640.
19.	Bolado F, Tarifa A, Zazpe C, et al. Acute recurrent pancreatitis secondary to hepatocellular carcinoma invading the biliary tree. Pancreatology, 2015, 15(2): 191-193.
20.	Tadic M, Cabrijan Z, Stoos-Veic T, et al. Lymphangioma as a rare cause of acute recurrent pancreatitis. Endoscopy, 2014, 46 Suppl 1 UCTN: E598-E599.
21.	Asimakopoulou NI, Papakonstantinou PE, Lasithiotakis KG, et al. Recurrent episodes of acute pancreatitis due to duodenal gangliocytic paraganglioma: report of a case. JOP, 2014, 15(2): 201-205.
22.	Patel YA, Dhalla S, Olson MT, et al. Pancreatic metastasis from a solitary fibrous tumor of the kidney: a rare cause of acute recurrent pancreatitis. Pancreatology, 2013, 13(6): 631-633.
23.	吴长安, 陈丽娜. 高脂血症性急性胰腺炎的临床特点分析. 临床医学, 2019, 39(6): 7-9.
24.	丁岩冰, 路国涛, 蓝宇, 等. 高脂血症性急性胰腺炎 130 例. 世界华人消化杂志, 2013, 21(3): 266-271.
25.	杜奕奇, 陈其奎, 李宏宇, 等. 中国急性胰腺炎诊治指南(2019 年, 沈阳). 临床肝胆病杂志, 2019, 35(12): 2706-2711.
26.	李左军, 张晔. 高脂血症与胰腺炎关系及治疗. 疾病监测与控制, 2017, 11(1): 69-70.
27.	刘东, 付文广, 李秋. 高脂血症性急性胰腺炎发病机制研究进展. 现代医药卫生, 2015, 31(23): 3585-3588.
28.	牛蕾, 葛春. 急性复发性胰腺炎与高脂血症的互为因果关系及临床特点. 世界华人消化杂志, 2016, 24(30): 4205-4210.
29.	Ward JB, Petersen OH, Jenkins SA, et al. Is an elevated concentration of acinar cytosolic free ionised calcium the trigger for acute pancreatitis. Lancet, 1995, 346(8981): 1016-1019.
30.	陈伟, 姜琦, 周国雄. 高脂血症性急性胰腺炎微循环障碍研究进展. 中国血液流变学杂志, 2014, 24(1): 182-185.
31.	Takeyama Y. Long-term prognosis of acute pancreatitis in Japan. Clin Gastroenterol Hepatol, 2009, 7(11 Suppl): S15-S17.
32.	李文婷, 党彤. 复发性急性胰腺炎病因的研究进展. 胃肠病学, 2018, 23(6): 378-381.
33.	Nikkola J, Räty S, Laukkarinen J, et al. Abstinence after first acute alcohol-associated pancreatitis protects against recurrent pancreatitis and minimizes the risk of pancreatic dysfunction. Alcohol Alcohol, 2013, 48(4): 483-486.
34.	Sadr-Azodi O, Andrén-Sandberg Å, Orsini N, et al. Cigarette smoking, smoking cessation and acute pancreatitis: a prospective population-based study. Gut, 2012, 61(2): 262-267.
35.	Martínez-Barona S, Ribes-Koninckx C. Genetics in idiopathic pancreatitis and acute recurrent pancreatitis. Rev Esp Enferm Dig, 2017, 109(6): 478-479.
36.	Avanthi US, Bale G, Aslam M, et al. PRSS1 (R122H) mutation in an Indian family with low penetrance is associated with pancreatitis phenotype. Indian J Gastroenterol, 2018, 37(1): 67-69.
37.	Németh BC, Sahin-Tóth M. Human cationic trypsinogen (PRSS1) variants and chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol, 2014, 306(6): G466-G473.
38.	Lee YJ, Kim KM, Choi JH, et al. High incidence of PRSS1 and SPINK1 mutations in Korean children with acute recurrent and chronic pancreatitis. J Pediatr Gastroenterol Nutr, 2011, 52(4): 478-481.
39.	Aoun E, Muddana V, Papachristou GI, et al. SPINK1 N34S is strongly associated with recurrent acute pancreatitis but is not a risk factor for the first or sentinel acute pancreatitis event. Am J Gastroenterol, 2010, 105(2): 446-451.
40.	Liu X, Tu M, Dai X, et al. PRSS1 and SPINK1 Mutations in Alcoholic and Idiopathic Chronic Pancreatitis. J Nanosci Nanotechnol, 2017, 17(4): 2358-2362.
41.	Woods GN, Saitman A, Gao H, et al. A young woman with recurrent gestational hypercalcemia and acute pancreatitis caused by CYP24A1 deficiency. J Bone Miner Res, 2016, 31(10): 1841-1844.
42.	徐铭益, 王兴鹏, 吴恺. 高脂血症性急性胰腺炎脂蛋白脂酶基因多态性研究. 中华消化杂志, 2008, 28(9): 600-603.
43.	朱世峰, 李娟, 赵先林, 等. 熟大黄调控酒精性胰腺炎性损伤记忆的表观遗传机制研究. 第十二次全国中西医结合实验医学专业委员会暨第七次湖南省中西医结合神经科专业委员会学术年会, 长沙, 2015: 42-44.
44.	尚海涛, 李忠廉. 自身免疫性胰腺炎的诊断. 天津医药, 2019, 47(7): 771-776.
45.	Kaurich T. Drug-induced acute pancreatitis. Proc (Bayl Univ Med Cent), 2008, 21(1): 77-81.
46.	何文华, 吕农华. 药物性胰腺炎. 临床内科杂志, 2012, 29(2): 79-81.
47.	郑本波, 刘山, 阳勇. 复发性急性胰腺炎的临床特点及其常见病因分析. 中国普外基础与临床杂志, 2012, 19(10): 1102-1104.
48.	刘山, 郑本波, 何永林. 早期血浆置换联合连续血液滤过治疗高血脂性重症急性胰腺炎的效果观察. 中国现代医学杂志, 2009, 19(21): 3323-3325.
49.	Uhl W, Warshaw A, Imrie C, et al. IAP guidelines for the surgical management of acute pancreatitis. Pancreatology, 2002, 2(6): 565-573.
50.	李军祥, 陈誩, 唐文富. 急性胰腺炎中西医结合诊疗共识意见(2017 年). 中国中西医结合消化杂志, 2017, 25(12): 901-909.
51.	Puri R, Choudhary NS, Sud R. Recurrent acute pancreatitis secondary to pancreatic neuroendocrine tumor: role of endoscopic ultrasound. Trop Gastroenterol, 2014, 35(3): 202-203.
52.	Evans WB, Draganov P. Is empiric cholecystectomy a reasonable treatment option for idiopathic acute pancreatitis. Nat Clin Pract Gastroenterol Hepatol, 2006, 3(7): 356-357.
53.	刘臻. 基于“治未病”思想探讨脓毒症的防治思路. 河南中医, 2019, 39(9): 1319-1322.
54.	游真, 车德亚. 加味蒿芩清胆汤治疗复发性急性胰腺炎临床分析. 四川中医, 2017, 35(3): 138-140.
55.	苏振政, 李小兰, 林海. 疏肝利胆法预防急性胆源性胰腺炎复发 64 例. 中国中西医结合消化杂志, 2013, 21(12): 659.

1. Garg PK, Singh VP. Organ failure due to systemic injury in acute pancreatitis. Gastroenterology, 2019, 156(7): 2008-2023.
2. 彭莉, 彭燕, 蒲垠全, 等. 671 例复发性急性胰腺炎临床特点及危险因素分析. 实用医学杂志, 2019, 35(18): 2924-2928.
3. Sankaran SJ, Xiao AY, Wu LM, et al. Frequency of progression from acute to chronic pancreatitis and risk factors: a meta-analysis. Gastroenterology, 2015, 149(6): 1490-1500.
4. 班猛猛, 史炼钢, 王东, 等. 复发性急性胰腺炎危险因素研究进展. 大连医科大学学报, 2018, 27(2): 171-175, 180.
5. 季钧淘, 张菂, 辛磊, 等. 复发性急性胰腺炎诊断与治疗研究进展. 中华胰腺病杂志, 2016, 16(3): 203-205.
6. 高艳景, 李延青, 黄柳业, 等. 山东省 157 例复发性急性胰腺炎病因和复发特征分析. 山东大学学报(医学版), 2005, 43(7): 605-608.
7. 温彦丽, 郝婷婷, 戴光荣, 等. 急性复发性胰腺炎 288 例病因分析. 陕西医学杂志, 2015, 44(1): 68-70.
8. 那宾. 复发性急性胰腺炎病因学分析. 武汉: 华中科技大学, 2012: 3-10.
9. 何希平, 胡康, 刘洙秀. 复发性胰腺炎的病因与治疗. 吉林医学, 2014, 35(20): 4520.
10. 陈灏珠, 林果为, 王吉耀. 实用内科学. 第 14 版. 北京:人民卫生出版社, 2014: 2015-2057.
11. 毕旭东, 付晓光, 唐树相, 等. 急性胰腺炎反复发作病因的临床研究. 锦州医学院学报, 2003, 24(6): 12-13.
12. 张肇达, 严律南, 刘续宝. 急性胰腺炎. 北京: 人民卫生出版社, 2006: 54-55.
13. 曾庆煜, 汪丽燕. Oddi 括约肌功能障碍研究新进展. 世界最新医学信息文摘, 2019, 19(99): 100-102.
14. Afghani E, Lo SK, Covington PS, et al. Sphincter of Oddi function and risk factors for dysfunction. Front Nutr, 2017, 4(1): 1-9.
15. Brawman-Mintzer O, Durkalski V, Wu Q, et al. Psychosocial characteristics and pain burden of patients with suspected sphincter of Oddi dysfunction in the EPISOD multicenter trial. Am J Gastroenterol, 2014, 109(3): 436-442.
16. Sonoda Y, Kawamoto M, Woods CN, et al. Sphincter of Oddi function in the Australian brush-tailed possum is inhibited by intragastric ethanol. Neurogastroenterol Motil, 2007, 19(5): 401-10.
17. Mousavi S, Toussy J, Zahmatkesh M. Opium addiction as a new risk factor of sphincter of Oddi dysfunction. Med Sci Monit, 2007, 13(11): CR528-CR531.
18. Fernandes SR, Correia LA, Antunes T, et al. Intraductal papillary mucinous neoplasm presenting with recurrent pancreatitis: a report of a painful 3-decade-long history. BMJ Case Rep, 2016, 2016. pii: bcr2016214640.
19. Bolado F, Tarifa A, Zazpe C, et al. Acute recurrent pancreatitis secondary to hepatocellular carcinoma invading the biliary tree. Pancreatology, 2015, 15(2): 191-193.
20. Tadic M, Cabrijan Z, Stoos-Veic T, et al. Lymphangioma as a rare cause of acute recurrent pancreatitis. Endoscopy, 2014, 46 Suppl 1 UCTN: E598-E599.
21. Asimakopoulou NI, Papakonstantinou PE, Lasithiotakis KG, et al. Recurrent episodes of acute pancreatitis due to duodenal gangliocytic paraganglioma: report of a case. JOP, 2014, 15(2): 201-205.
22. Patel YA, Dhalla S, Olson MT, et al. Pancreatic metastasis from a solitary fibrous tumor of the kidney: a rare cause of acute recurrent pancreatitis. Pancreatology, 2013, 13(6): 631-633.
23. 吴长安, 陈丽娜. 高脂血症性急性胰腺炎的临床特点分析. 临床医学, 2019, 39(6): 7-9.
24. 丁岩冰, 路国涛, 蓝宇, 等. 高脂血症性急性胰腺炎 130 例. 世界华人消化杂志, 2013, 21(3): 266-271.
25. 杜奕奇, 陈其奎, 李宏宇, 等. 中国急性胰腺炎诊治指南(2019 年, 沈阳). 临床肝胆病杂志, 2019, 35(12): 2706-2711.
26. 李左军, 张晔. 高脂血症与胰腺炎关系及治疗. 疾病监测与控制, 2017, 11(1): 69-70.
27. 刘东, 付文广, 李秋. 高脂血症性急性胰腺炎发病机制研究进展. 现代医药卫生, 2015, 31(23): 3585-3588.
28. 牛蕾, 葛春. 急性复发性胰腺炎与高脂血症的互为因果关系及临床特点. 世界华人消化杂志, 2016, 24(30): 4205-4210.
29. Ward JB, Petersen OH, Jenkins SA, et al. Is an elevated concentration of acinar cytosolic free ionised calcium the trigger for acute pancreatitis. Lancet, 1995, 346(8981): 1016-1019.
30. 陈伟, 姜琦, 周国雄. 高脂血症性急性胰腺炎微循环障碍研究进展. 中国血液流变学杂志, 2014, 24(1): 182-185.
31. Takeyama Y. Long-term prognosis of acute pancreatitis in Japan. Clin Gastroenterol Hepatol, 2009, 7(11 Suppl): S15-S17.
32. 李文婷, 党彤. 复发性急性胰腺炎病因的研究进展. 胃肠病学, 2018, 23(6): 378-381.
33. Nikkola J, Räty S, Laukkarinen J, et al. Abstinence after first acute alcohol-associated pancreatitis protects against recurrent pancreatitis and minimizes the risk of pancreatic dysfunction. Alcohol Alcohol, 2013, 48(4): 483-486.
34. Sadr-Azodi O, Andrén-Sandberg Å, Orsini N, et al. Cigarette smoking, smoking cessation and acute pancreatitis: a prospective population-based study. Gut, 2012, 61(2): 262-267.
35. Martínez-Barona S, Ribes-Koninckx C. Genetics in idiopathic pancreatitis and acute recurrent pancreatitis. Rev Esp Enferm Dig, 2017, 109(6): 478-479.
36. Avanthi US, Bale G, Aslam M, et al. PRSS1 (R122H) mutation in an Indian family with low penetrance is associated with pancreatitis phenotype. Indian J Gastroenterol, 2018, 37(1): 67-69.
37. Németh BC, Sahin-Tóth M. Human cationic trypsinogen (PRSS1) variants and chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol, 2014, 306(6): G466-G473.
38. Lee YJ, Kim KM, Choi JH, et al. High incidence of PRSS1 and SPINK1 mutations in Korean children with acute recurrent and chronic pancreatitis. J Pediatr Gastroenterol Nutr, 2011, 52(4): 478-481.
39. Aoun E, Muddana V, Papachristou GI, et al. SPINK1 N34S is strongly associated with recurrent acute pancreatitis but is not a risk factor for the first or sentinel acute pancreatitis event. Am J Gastroenterol, 2010, 105(2): 446-451.
40. Liu X, Tu M, Dai X, et al. PRSS1 and SPINK1 Mutations in Alcoholic and Idiopathic Chronic Pancreatitis. J Nanosci Nanotechnol, 2017, 17(4): 2358-2362.
41. Woods GN, Saitman A, Gao H, et al. A young woman with recurrent gestational hypercalcemia and acute pancreatitis caused by CYP24A1 deficiency. J Bone Miner Res, 2016, 31(10): 1841-1844.
42. 徐铭益, 王兴鹏, 吴恺. 高脂血症性急性胰腺炎脂蛋白脂酶基因多态性研究. 中华消化杂志, 2008, 28(9): 600-603.
43. 朱世峰, 李娟, 赵先林, 等. 熟大黄调控酒精性胰腺炎性损伤记忆的表观遗传机制研究. 第十二次全国中西医结合实验医学专业委员会暨第七次湖南省中西医结合神经科专业委员会学术年会, 长沙, 2015: 42-44.
44. 尚海涛, 李忠廉. 自身免疫性胰腺炎的诊断. 天津医药, 2019, 47(7): 771-776.
45. Kaurich T. Drug-induced acute pancreatitis. Proc (Bayl Univ Med Cent), 2008, 21(1): 77-81.
46. 何文华, 吕农华. 药物性胰腺炎. 临床内科杂志, 2012, 29(2): 79-81.
47. 郑本波, 刘山, 阳勇. 复发性急性胰腺炎的临床特点及其常见病因分析. 中国普外基础与临床杂志, 2012, 19(10): 1102-1104.
48. 刘山, 郑本波, 何永林. 早期血浆置换联合连续血液滤过治疗高血脂性重症急性胰腺炎的效果观察. 中国现代医学杂志, 2009, 19(21): 3323-3325.
49. Uhl W, Warshaw A, Imrie C, et al. IAP guidelines for the surgical management of acute pancreatitis. Pancreatology, 2002, 2(6): 565-573.
50. 李军祥, 陈誩, 唐文富. 急性胰腺炎中西医结合诊疗共识意见(2017 年). 中国中西医结合消化杂志, 2017, 25(12): 901-909.
51. Puri R, Choudhary NS, Sud R. Recurrent acute pancreatitis secondary to pancreatic neuroendocrine tumor: role of endoscopic ultrasound. Trop Gastroenterol, 2014, 35(3): 202-203.
52. Evans WB, Draganov P. Is empiric cholecystectomy a reasonable treatment option for idiopathic acute pancreatitis. Nat Clin Pract Gastroenterol Hepatol, 2006, 3(7): 356-357.
53. 刘臻. 基于“治未病”思想探讨脓毒症的防治思路. 河南中医, 2019, 39(9): 1319-1322.
54. 游真, 车德亚. 加味蒿芩清胆汤治疗复发性急性胰腺炎临床分析. 四川中医, 2017, 35(3): 138-140.
55. 苏振政, 李小兰, 林海. 疏肝利胆法预防急性胆源性胰腺炎复发 64 例. 中国中西医结合消化杂志, 2013, 21(12): 659.

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Summary in etiologies, prevention and treatment strategies of recurrent acute pancreatitis

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