Diagnostic and prognostic value of TRIM21 in gastric cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WANG Jianli , YU Zeyuan , SU Ade , CHEN Zhitao , NIE Junsheng ,  JIAO Zuoyi

Department of General Surgery, Lanzhou University Second Hospital, Lanzhou 730000, P. R. China;

Corresponding author：

JIAO Zuoyi, Email: jiaozy@lzu.edu.cn

Keywords：

tripartite motif 21; gastric cancer; clinicopathologic features; prognosis

DOI：

10.7507/1007-9424.202004047

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To investigate the expression of tripartite motif 21 (TRIM21) in gastric cancer tissues and its relationship with clinical pathological characteristics and clinical prognosis.Methods Public database was used to analyze the expression level of TRIM21 in gastric cancer tissues and the relationship between its expression and clinical prognosis. Gene set enrichment analysis (GSEA) was used to analyze the signaling pathways that TRIM21 might participate in. The expressions of TRIM21 in 80 gastric cancer tissues and 30 para-cancer tissues were detected by immunohistochemical staining, and the relationship between TRIM21 expression and clinicopathologic characteristics was analyzed.Results TRIM21was significantly low-expression in gastric cancer tissues, and the clinical prognosis of patients with low TRIM21 expression was significantly worse (P<0.05); GSEA showed that TRIM21 was involved in the regulation of helper T cell differentiation in gastric cancer patients (P<0.000 1, FDR<0.000 1).Conclusions TRIM21 is poorly expressed in gastric cancer tissues and indicates the poor clinical prognosis. Moreover, TRIM21 is involved in the regulation of helper T cell differentiation and has a negative regulatory effect on the occurrence and development of gastric cancer.

Citation： WANG Jianli, YU Zeyuan, SU Ade, CHEN Zhitao, NIE Junsheng, JIAO Zuoyi. Diagnostic and prognostic value of TRIM21 in gastric cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2021, 28(1): 33-37. doi: 10.7507/1007-9424.202004047 Copy

1.	Zeng HM, Zheng RS, Guo YM, et al. Cancer survival in China, 2003–2005: a population-based study. Int J Cancer, 2015, 136(8): 1921-1930.
2.	Chen WQ, Zheng RS, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin, 2016, 66(2): 115-132.
3.	Gao K, Wu J. 中国胃癌死亡率趋势(2003–2015): 一项基于人群的研究. 癌症, 2019, 38(9): 385-389.
4.	Kim YJ, Hwang KC, Kim SW, et al. Potential miRNA-target interactions for the screening of gastric carcinoma development in gastric denoma/dysplasia. Int J Med Sci, 2018, 15(6): 610-616.
5.	Hatakeyama S. TRIM proteins and cancer. Nat Rev Cancer, 2011, 11(11): 792-804.
6.	Mandell MA, Saha B, Thompson TA. The tripartite nexus: autophagy, cancer, and tripartite motif-containing protein family members. Front Pharmacol, 2020, 11: 308.
7.	Venuto S, Merla G. E3 ubiquitin ligase TRIM proteins, cell cycle and mitosis. Cells, 2019, 8(5): 510.
8.	Gu L, Zhu Y, Lin X, et al. Stabilization of FASN by ACAT1-mediated GNPAT acetylation promotes lipid metabolism and hepatocarcinogenesis. Oncogene, 2020, 39(11): 2437-2449.
9.	Vasaikar SV, Straub P, Wang J, et al. LinkedOmics: analyzing multi-omics data within and across 32 cancer types. Nucleic Acids Res, 2018, 46(D1): D956-D963.
10.	Cerami E, Gao J, Dogrusoz U, et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov, 2012, 2(5): 401-404.
11.	Kang MH, Choi H, Oshima M, et al. Author Eorrection: Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer. Nat Commun, 2018, 9(1): 3599.
12.	于萍步, 王华, 赵高平, 等. 免疫组化结果的图像分析与人工计数方法的对比研究. 生物医学工程学杂志, 2003, 20(2): 288-290.
13.	刘凤林, 秦新裕. 胃癌根治术现状与展望. 中国普外基础与临床杂志, 2019, 26(7): 769-771.
14.	王勇, 李国苗, 李志斌, 等. 多西他赛联合氟尿嘧啶、顺铂方案与多西他赛联合氟尿嘧啶、洛铂方案治疗胃癌的疗效比较. 现代肿瘤医学, 2020, 28(10): 1712-1714.
15.	Mehta R, Kommalapati A, Kim RD. The impact of ramucirumab treatment on survival and quality of life in patients with gastric cancer. Cancer Manag Res, 2020, 12: 51-57.
16.	Zhou W, Zhang Y, Zhong C, et al. Decreased expression of TRIM21 indicates unfavorable outcome and promotes cell growth in breast cancer. Cancer Manag Res, 2018, 10: 3687-3696.
17.	Lin X, Dinglin X, Cao S, et al. Enhancer-driven lncRNA BDNF-AS induces endocrine resistance and malignant progression of breast cancer through the RNH1/TRIM21/mTOR cascade. Cell Rep, 2020, 31(10): 107753.
18.	Jin Y, Zhao X, Zhang Q, et al. Cancer-associated mutation abolishes the impact of TRIM21 on the invasion of breast cancer cells. Int J Biol Macromol, 2020, 142: 782-789.
19.	Jin Y, Zhang Y, Li B, et al. TRIM21 mediates ubiquitination of Snail and modulates epithelial to mesenchymal transition in breast cancer cells. Int J Biol Macromol, 2019, 124: 846-853.
20.	Ding Q, He D, He K, et al. Downregulation of TRIM21 contributes to hepatocellular carcinoma carcinogenesis and indicates poor prognosis of cancers. Tumour Biol, 2015, 36(11): 8761-8772.
21.	Blessie EJ, Wruck W, Abbey BA, et al. Transcriptomic analysis of marine endophytic fungi extract identifies highly enriched anti-fungal fractions targeting cancer pathways in HepG2 cell lines. BMC Genomics, 2020, 21(1): 265.
22.	李涛. 三结构域蛋白21通过下调自噬相关蛋白4B抑制肝细胞癌细胞增殖的实验研究. 第三军医大学学报, 2019, 41(9): 815-822.
23.	Lambert JM, Berkenblit A. Antibody-drug conjugates for cancer treatment. Annu Rev Med, 2018, 69: 191-207.
24.	Yang L, Zhang T, Zhang C, et al. Upregulated E3 ligase tripartite motif-containing protein 21 in psoriatic epidermis ubiquitylates nuclear factor-κB p65 subunit and promotes inflammation in keratinocytes. Br J Dermatol, 2020. Online ahead of print.
25.	Rhodes DA, Isenberg DA. TRIM21 and the function of antibodies inside cells. Trends Immunol, 2017, 38(12): 916-926.

1. Zeng HM, Zheng RS, Guo YM, et al. Cancer survival in China, 2003–2005: a population-based study. Int J Cancer, 2015, 136(8): 1921-1930.
2. Chen WQ, Zheng RS, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin, 2016, 66(2): 115-132.
3. Gao K, Wu J. 中国胃癌死亡率趋势(2003–2015): 一项基于人群的研究. 癌症, 2019, 38(9): 385-389.
4. Kim YJ, Hwang KC, Kim SW, et al. Potential miRNA-target interactions for the screening of gastric carcinoma development in gastric denoma/dysplasia. Int J Med Sci, 2018, 15(6): 610-616.
5. Hatakeyama S. TRIM proteins and cancer. Nat Rev Cancer, 2011, 11(11): 792-804.
6. Mandell MA, Saha B, Thompson TA. The tripartite nexus: autophagy, cancer, and tripartite motif-containing protein family members. Front Pharmacol, 2020, 11: 308.
7. Venuto S, Merla G. E3 ubiquitin ligase TRIM proteins, cell cycle and mitosis. Cells, 2019, 8(5): 510.
8. Gu L, Zhu Y, Lin X, et al. Stabilization of FASN by ACAT1-mediated GNPAT acetylation promotes lipid metabolism and hepatocarcinogenesis. Oncogene, 2020, 39(11): 2437-2449.
9. Vasaikar SV, Straub P, Wang J, et al. LinkedOmics: analyzing multi-omics data within and across 32 cancer types. Nucleic Acids Res, 2018, 46(D1): D956-D963.
10. Cerami E, Gao J, Dogrusoz U, et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov, 2012, 2(5): 401-404.
11. Kang MH, Choi H, Oshima M, et al. Author Eorrection: Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer. Nat Commun, 2018, 9(1): 3599.
12. 于萍步, 王华, 赵高平, 等. 免疫组化结果的图像分析与人工计数方法的对比研究. 生物医学工程学杂志, 2003, 20(2): 288-290.
13. 刘凤林, 秦新裕. 胃癌根治术现状与展望. 中国普外基础与临床杂志, 2019, 26(7): 769-771.
14. 王勇, 李国苗, 李志斌, 等. 多西他赛联合氟尿嘧啶、顺铂方案与多西他赛联合氟尿嘧啶、洛铂方案治疗胃癌的疗效比较. 现代肿瘤医学, 2020, 28(10): 1712-1714.
15. Mehta R, Kommalapati A, Kim RD. The impact of ramucirumab treatment on survival and quality of life in patients with gastric cancer. Cancer Manag Res, 2020, 12: 51-57.
16. Zhou W, Zhang Y, Zhong C, et al. Decreased expression of TRIM21 indicates unfavorable outcome and promotes cell growth in breast cancer. Cancer Manag Res, 2018, 10: 3687-3696.
17. Lin X, Dinglin X, Cao S, et al. Enhancer-driven lncRNA BDNF-AS induces endocrine resistance and malignant progression of breast cancer through the RNH1/TRIM21/mTOR cascade. Cell Rep, 2020, 31(10): 107753.
18. Jin Y, Zhao X, Zhang Q, et al. Cancer-associated mutation abolishes the impact of TRIM21 on the invasion of breast cancer cells. Int J Biol Macromol, 2020, 142: 782-789.
19. Jin Y, Zhang Y, Li B, et al. TRIM21 mediates ubiquitination of Snail and modulates epithelial to mesenchymal transition in breast cancer cells. Int J Biol Macromol, 2019, 124: 846-853.
20. Ding Q, He D, He K, et al. Downregulation of TRIM21 contributes to hepatocellular carcinoma carcinogenesis and indicates poor prognosis of cancers. Tumour Biol, 2015, 36(11): 8761-8772.
21. Blessie EJ, Wruck W, Abbey BA, et al. Transcriptomic analysis of marine endophytic fungi extract identifies highly enriched anti-fungal fractions targeting cancer pathways in HepG2 cell lines. BMC Genomics, 2020, 21(1): 265.
22. 李涛. 三结构域蛋白21通过下调自噬相关蛋白4B抑制肝细胞癌细胞增殖的实验研究. 第三军医大学学报, 2019, 41(9): 815-822.
23. Lambert JM, Berkenblit A. Antibody-drug conjugates for cancer treatment. Annu Rev Med, 2018, 69: 191-207.
24. Yang L, Zhang T, Zhang C, et al. Upregulated E3 ligase tripartite motif-containing protein 21 in psoriatic epidermis ubiquitylates nuclear factor-κB p65 subunit and promotes inflammation in keratinocytes. Br J Dermatol, 2020. Online ahead of print.
25. Rhodes DA, Isenberg DA. TRIM21 and the function of antibodies inside cells. Trends Immunol, 2017, 38(12): 916-926.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Diagnostic and prognostic value of TRIM21 in gastric cancer

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content