Clinical status of advanced pancreatic cancer treated with high intensity focused ultrasound_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

CHEN Cheng ¹ ,  WU Yakun ²

1. Graduate School of Zunyi Medical University, Zunyi, Guizhou 563003, P. R. China;
2. Department of Hepatobiliary Surgery, Suining Central Hospital, Suining, Sichuan 629000, P. R. China;

Corresponding author：

WU Yakun, Email: 353827514@qq.com

Keywords：

high intensity focused ultrasound; advanced pancreatic cancer; review

DOI：

10.7507/1007-9424.202005042

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To explore the application value of high intensity focused ultrasound (HIFU) in the treatment of advanced pancreatic cancer.Method The domestic and foreign literatures about studies of HIFU treating advanced pancreatic cancer in recent years were retrieved and summarized.Results HIFU could prolong the survival time, control pain, and enhance the body’s immune function in patients with advanced pancreatic cancer. There were no obvious serious complications during the treatment process. The combined treatment with radiotherapy, chemotherapy, and traditional Chinese medicine could obviously prolong the survival time and improve the quality of life for the patients with advanced pancreatic cancer.Conclusions HIFU is an important component in the comprehensive treatment of advanced pancreatic cancer. However, because there is no uniform standard for the dosage of HIFU treatment, the sample size of many related studies is small, so the research results have certain limitations, so more studies are needed to improve their understanding of advanced pancreatic cancer in order to better serve clinical workin future.

Citation： CHEN Cheng, WU Yakun. Clinical status of advanced pancreatic cancer treated with high intensity focused ultrasound. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2021, 28(2): 271-275. doi: 10.7507/1007-9424.202005042 Copy

1.	Rahib L, Smith BD, Aizenberg R, et al. Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res, 2014, 74(11): 2913-2921.
2.	Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin, 2019, 69(1): 7-34.
3.	Zeng H, Chen W, Zheng R, et al. Changing cancer survival in China during 2003-15: a pooled analysis of 17 population-based cancer registries. Lancet Glob Health, 2018, 6(5): e555-e567.
4.	郑荣寿, 孙可欣, 张思维, 等. 2015年中国恶性肿瘤流行情况分析. 中华肿瘤杂志, 2019, 41(1): 19-28.
5.	Lambert A, Schwarz L, Borbath I, et al. An update on treatment options for pancreatic adenocarcinoma. Ther Adv Med Oncol, 2019, 11: 1758835919875568.
6.	Fogel EL, Shahda S, Sandrasegaran K, et al. A multidisciplinary approach to pancreas cancer in 2016: a review. Am J Gastroenterol, 2017, 112(4): 537-554.
7.	Siedek F, Yeo SY, Heijman E, et al. Magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU): technical background and overview of current clinical applications (Part 1). Rofo, 2019, 191(6): 522-530.
8.	Saccomandi P, Lapergola A, Longo F, et al. Thermal ablation of pancreatic cancer: A systematic literature review of clinical practice and pre-clinical studies. Int J Hyperthermia, 2018, 35(1): 398-418.
9.	贾淑平, 赵亮蒋, 荷娟. 高强度聚焦超声消融术在肿瘤治疗方面的应用进展. 中国医疗器械信息, 2019, 25(9): 48-50.
10.	Mauri G, Nicosia L, Xu Z, et al. Focused ultrasound: tumour ablation and its potential to enhance immunological therapy to cancer. Br J Radiol, 2018, 91(1083): 20170641.
11.	刘梦奇, 吉顺荣, 徐晓武, 等. 2019年胰腺癌研究及诊疗新进展. 中国癌症杂志, 2020, 30(1): 1-10.
12.	Ji Y, Zhang Y, Zhu J, et al. Response of patients with locally advanced pancreatic adenocarcinoma to high-intensity focused ultrasound treatment: a single-center, prospective, case series in China. Cancer Manag Res, 2018, 10: 4439-4446.
13.	Marinova M, Huxold HC, Henseler J, et al. Clinical effectiveness and potential survival benefit of us-guided high-intensity focused ultrasound therapy in patients with advanced-stage pancreatic cancer. Ultraschall Med, 2019, 40(5): 625-637.
14.	Zhu B, Li J, Diao L, et al. High-intensity focused ultrasound ablation for advanced pancreatic cancer. J Cancer Res Ther, 2019, 15(4): 831-835.
15.	Koulouris AI, Banim P, Hart AR. Pain in patients with pancreatic cancer: prevalence, mechanisms, management and future developments. Dig Dis Sci, 2017, 62(4): 861-870.
16.	Choe JW, Hyun JJ. Relief of cancer pain in patients with pancreatic cancer. Korean J Gastroenterol, 2019, 74(2): 81-86.
17.	di Mola FF, di Sebastiano P. Pain and pain generation in pancreatic cancer. Langenbecks Arch Surg, 2008, 393(6): 919-922.
18.	严鹏飞. 高强度聚焦超声在胰腺癌疼痛中的治疗现状. 郑州: 第八届中原肝病论坛论文集, 2017: 64-66.
19.	Thudium M, Bette B, Tonguc T, et al. Multidisciplinary management and outcome in pancreatic cancer patients treated with high-intensity focused ultrasound. Int J Hyperthermia, 2020, 37(1): 456-462.
20.	Dababou S, Marrocchio C, Rosenberg J, et al. A meta-analysis of palliative treatment of pancreatic cancer with high intensity focused ultrasound. J Ther Ultrasound, 2017, 5: 9.
21.	Marinova M, Strunk HM, Rauch M, et al. High-intensity focused ultrasound (HIFU) for tumor pain relief in inoperable pancreatic cancer : Evaluation with the pain sensation scale (SES). Schmerz, 2017, 31(1): 31-39.
22.	Marinova M, Wilhelm-Buchstab T, Strunk H. Advanced pancreatic cancer: high-intensity focused ultrasound (HIFU) and other local ablative therapies. Rofo, 2019, 191(3): 216-227.
23.	Cirincione R, Di Maggio FM, Forte GI, et al. High-intensity focused ultrasound- and radiation therapy-induced immuno-modulation: comparison and potential opportunities. Ultrasound Med Biol, 2017, 43(2): 398-411.
24.	Wolf GL. Macrophages hold the key to cancer’s inner sanctum. Med Hypotheses, 2019, 122: 111-114.
25.	Eichmüller SB, Osen W, Mandelboim O, et al. Immune modulatory microRNAs involved in tumor attack and tumor immune escape. J Natl Cancer Inst, 2017, 109(10).
26.	Wu F, Wang ZB, Lu P, et al. Activated anti-tumor immunity in cancer patients after high intensity focused ultrasound ablation. Ultrasound Med Biol, 2004, 30(9): 1217-1222.
27.	Zhou Q, Zhu XQ, Zhang J, et al. Changes in circulating immunosuppressive cytokine levels of cancer patients after high intensity focused ultrasound treatment. Ultrasound Med Biol, 2008, 34(1): 81-87.
28.	Zhou Y. High-intensity focused ultrasound treatment for advanced pancreatic cancer. Gastroenterol Res Pract, 2014, 2014: 205325.
29.	Ma B, Liu X, Yu Z. The effect of high intensity focused ultrasound on the treatment of liver cancer and patients’ immunity. Cancer Biomark, 2019, 24(1): 85-90.
30.	卓萌, 焦锋, 王理伟. 胰腺癌微环境治疗策略的进展与思考. 中国肿瘤临床, 2018, 45(6): 271-276.
31.	李俊博, 李生伟. 高强度聚焦超声治疗晚期胰腺癌的临床现状. 国际外科学杂志, 2019, 46(1): 64-67.
32.	Ning Z, Xie J, Chen Q, et al. HIFU is safe, effective, and feasible in pancreatic cancer patients: a monocentric retrospective study among 523 patients. Onco Targets Ther, 2019, 12: 1021-1029.
33.	Tao SF, Gu WH, Gu JC, et al. A retrospective case series of high-intensity focused ultrasound (HIFU) in combination with gemcitabine and oxaliplatin (Gemox) on treating elderly middle and advanced pancreatic cancer. Onco Targets Ther, 2019, 12: 9735-9745.
34.	石乔, 刘垒, 张晓艺, 等. 国内应用吉西他滨联合高强度聚焦超声治疗中晚期胰腺癌疗效的Meta分析. 临床外科杂志, 2019, 27(8): 680-683.
35.	Li CC, Wang YQ, Li YP, et al. High-intensity focused ultrasound for treatment of pancreatic cancer: a systematic review. J Evid Based Med, 2014, 7(4): 270-281.
36.	Tan Z, Xu J, Zhang B, et al. Hypoxia: a barricade to conquer the pancreatic cancer. Cell Mol Life Sci, 2020, 77(16): 3077-3083.
37.	李婧. 高强度聚焦超声联合放疗对晚期胰腺癌患者肿瘤恶性程度的影响及毒副作用评价. 海南医学院学报, 2017, 23(2): 217-220.
38.	吉永烁, 赵洪, 朱绫琳, 等. 放疗联合高强度聚焦超声治疗中晚期胰腺癌的疗效和安全性. 肿瘤, 2015, 35(12): 1368-1373.
39.	Li YJ, Huang GL, Sun XL, et al. The combination therapy of high-intensity focused ultrasound with radiotherapy in locally advanced pancreatic carcinoma. World J Surg Oncol, 2016, 14: 60.
40.	樊逸夫, 张慧卿, 陈明骏, 等. 中医药在胰腺癌多学科综合治疗模式中的应用探究. 中医药导报, 2019, 25(15): 68-70.
41.	Nie J, Zhao C, Deng LI, et al. Efficacy of traditional Chinese medicine in treating cancer. Biomed Rep, 2016, 4(1): 3-14.
42.	张丽, 单国用, 刘兴安, 等. 高强度超声聚焦刀联合复方苦参注射液治疗局部晚期胰腺癌的疗效. 辽宁中医杂志, 2019, 46(11): 2375-2377.
43.	Ning Z, Zhu Z, Wang H, et al. High-intensity focused ultrasound enhances the effect of bufalin by inducing apoptosis in pancreatic cancer cells. Onco Targets Ther, 2019, 12: 1161-1170.
44.	Duc NM, Keserci B. Emerging clinical applications of high-intensity focused ultrasound. Diagn Interv Radiol, 2019, 25(5): 398-409.

1. Rahib L, Smith BD, Aizenberg R, et al. Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res, 2014, 74(11): 2913-2921.
2. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin, 2019, 69(1): 7-34.
3. Zeng H, Chen W, Zheng R, et al. Changing cancer survival in China during 2003-15: a pooled analysis of 17 population-based cancer registries. Lancet Glob Health, 2018, 6(5): e555-e567.
4. 郑荣寿, 孙可欣, 张思维, 等. 2015年中国恶性肿瘤流行情况分析. 中华肿瘤杂志, 2019, 41(1): 19-28.
5. Lambert A, Schwarz L, Borbath I, et al. An update on treatment options for pancreatic adenocarcinoma. Ther Adv Med Oncol, 2019, 11: 1758835919875568.
6. Fogel EL, Shahda S, Sandrasegaran K, et al. A multidisciplinary approach to pancreas cancer in 2016: a review. Am J Gastroenterol, 2017, 112(4): 537-554.
7. Siedek F, Yeo SY, Heijman E, et al. Magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU): technical background and overview of current clinical applications (Part 1). Rofo, 2019, 191(6): 522-530.
8. Saccomandi P, Lapergola A, Longo F, et al. Thermal ablation of pancreatic cancer: A systematic literature review of clinical practice and pre-clinical studies. Int J Hyperthermia, 2018, 35(1): 398-418.
9. 贾淑平, 赵亮蒋, 荷娟. 高强度聚焦超声消融术在肿瘤治疗方面的应用进展. 中国医疗器械信息, 2019, 25(9): 48-50.
10. Mauri G, Nicosia L, Xu Z, et al. Focused ultrasound: tumour ablation and its potential to enhance immunological therapy to cancer. Br J Radiol, 2018, 91(1083): 20170641.
11. 刘梦奇, 吉顺荣, 徐晓武, 等. 2019年胰腺癌研究及诊疗新进展. 中国癌症杂志, 2020, 30(1): 1-10.
12. Ji Y, Zhang Y, Zhu J, et al. Response of patients with locally advanced pancreatic adenocarcinoma to high-intensity focused ultrasound treatment: a single-center, prospective, case series in China. Cancer Manag Res, 2018, 10: 4439-4446.
13. Marinova M, Huxold HC, Henseler J, et al. Clinical effectiveness and potential survival benefit of us-guided high-intensity focused ultrasound therapy in patients with advanced-stage pancreatic cancer. Ultraschall Med, 2019, 40(5): 625-637.
14. Zhu B, Li J, Diao L, et al. High-intensity focused ultrasound ablation for advanced pancreatic cancer. J Cancer Res Ther, 2019, 15(4): 831-835.
15. Koulouris AI, Banim P, Hart AR. Pain in patients with pancreatic cancer: prevalence, mechanisms, management and future developments. Dig Dis Sci, 2017, 62(4): 861-870.
16. Choe JW, Hyun JJ. Relief of cancer pain in patients with pancreatic cancer. Korean J Gastroenterol, 2019, 74(2): 81-86.
17. di Mola FF, di Sebastiano P. Pain and pain generation in pancreatic cancer. Langenbecks Arch Surg, 2008, 393(6): 919-922.
18. 严鹏飞. 高强度聚焦超声在胰腺癌疼痛中的治疗现状. 郑州: 第八届中原肝病论坛论文集, 2017: 64-66.
19. Thudium M, Bette B, Tonguc T, et al. Multidisciplinary management and outcome in pancreatic cancer patients treated with high-intensity focused ultrasound. Int J Hyperthermia, 2020, 37(1): 456-462.
20. Dababou S, Marrocchio C, Rosenberg J, et al. A meta-analysis of palliative treatment of pancreatic cancer with high intensity focused ultrasound. J Ther Ultrasound, 2017, 5: 9.
21. Marinova M, Strunk HM, Rauch M, et al. High-intensity focused ultrasound (HIFU) for tumor pain relief in inoperable pancreatic cancer : Evaluation with the pain sensation scale (SES). Schmerz, 2017, 31(1): 31-39.
22. Marinova M, Wilhelm-Buchstab T, Strunk H. Advanced pancreatic cancer: high-intensity focused ultrasound (HIFU) and other local ablative therapies. Rofo, 2019, 191(3): 216-227.
23. Cirincione R, Di Maggio FM, Forte GI, et al. High-intensity focused ultrasound- and radiation therapy-induced immuno-modulation: comparison and potential opportunities. Ultrasound Med Biol, 2017, 43(2): 398-411.
24. Wolf GL. Macrophages hold the key to cancer’s inner sanctum. Med Hypotheses, 2019, 122: 111-114.
25. Eichmüller SB, Osen W, Mandelboim O, et al. Immune modulatory microRNAs involved in tumor attack and tumor immune escape. J Natl Cancer Inst, 2017, 109(10).
26. Wu F, Wang ZB, Lu P, et al. Activated anti-tumor immunity in cancer patients after high intensity focused ultrasound ablation. Ultrasound Med Biol, 2004, 30(9): 1217-1222.
27. Zhou Q, Zhu XQ, Zhang J, et al. Changes in circulating immunosuppressive cytokine levels of cancer patients after high intensity focused ultrasound treatment. Ultrasound Med Biol, 2008, 34(1): 81-87.
28. Zhou Y. High-intensity focused ultrasound treatment for advanced pancreatic cancer. Gastroenterol Res Pract, 2014, 2014: 205325.
29. Ma B, Liu X, Yu Z. The effect of high intensity focused ultrasound on the treatment of liver cancer and patients’ immunity. Cancer Biomark, 2019, 24(1): 85-90.
30. 卓萌, 焦锋, 王理伟. 胰腺癌微环境治疗策略的进展与思考. 中国肿瘤临床, 2018, 45(6): 271-276.
31. 李俊博, 李生伟. 高强度聚焦超声治疗晚期胰腺癌的临床现状. 国际外科学杂志, 2019, 46(1): 64-67.
32. Ning Z, Xie J, Chen Q, et al. HIFU is safe, effective, and feasible in pancreatic cancer patients: a monocentric retrospective study among 523 patients. Onco Targets Ther, 2019, 12: 1021-1029.
33. Tao SF, Gu WH, Gu JC, et al. A retrospective case series of high-intensity focused ultrasound (HIFU) in combination with gemcitabine and oxaliplatin (Gemox) on treating elderly middle and advanced pancreatic cancer. Onco Targets Ther, 2019, 12: 9735-9745.
34. 石乔, 刘垒, 张晓艺, 等. 国内应用吉西他滨联合高强度聚焦超声治疗中晚期胰腺癌疗效的Meta分析. 临床外科杂志, 2019, 27(8): 680-683.
35. Li CC, Wang YQ, Li YP, et al. High-intensity focused ultrasound for treatment of pancreatic cancer: a systematic review. J Evid Based Med, 2014, 7(4): 270-281.
36. Tan Z, Xu J, Zhang B, et al. Hypoxia: a barricade to conquer the pancreatic cancer. Cell Mol Life Sci, 2020, 77(16): 3077-3083.
37. 李婧. 高强度聚焦超声联合放疗对晚期胰腺癌患者肿瘤恶性程度的影响及毒副作用评价. 海南医学院学报, 2017, 23(2): 217-220.
38. 吉永烁, 赵洪, 朱绫琳, 等. 放疗联合高强度聚焦超声治疗中晚期胰腺癌的疗效和安全性. 肿瘤, 2015, 35(12): 1368-1373.
39. Li YJ, Huang GL, Sun XL, et al. The combination therapy of high-intensity focused ultrasound with radiotherapy in locally advanced pancreatic carcinoma. World J Surg Oncol, 2016, 14: 60.
40. 樊逸夫, 张慧卿, 陈明骏, 等. 中医药在胰腺癌多学科综合治疗模式中的应用探究. 中医药导报, 2019, 25(15): 68-70.
41. Nie J, Zhao C, Deng LI, et al. Efficacy of traditional Chinese medicine in treating cancer. Biomed Rep, 2016, 4(1): 3-14.
42. 张丽, 单国用, 刘兴安, 等. 高强度超声聚焦刀联合复方苦参注射液治疗局部晚期胰腺癌的疗效. 辽宁中医杂志, 2019, 46(11): 2375-2377.
43. Ning Z, Zhu Z, Wang H, et al. High-intensity focused ultrasound enhances the effect of bufalin by inducing apoptosis in pancreatic cancer cells. Onco Targets Ther, 2019, 12: 1161-1170.
44. Duc NM, Keserci B. Emerging clinical applications of high-intensity focused ultrasound. Diagn Interv Radiol, 2019, 25(5): 398-409.

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Clinical status of advanced pancreatic cancer treated with high intensity focused ultrasound

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