• 1. Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, P. R. China;
  • 2. Clinical Center for Acute Pancreatitis, Capital Medical University, Beijing 100053, P. R. China;
LI Fei, Email: feili36@ccmu.edu.cn
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Objective To summarize the research progress of mesenchymal stem cells in acute pancreatitis animal models, and to explore the potential of mesenchymal stem cells in the treatment of acute pancreatitis.Method Wecollected domestic and foreign studies on mesenchymal stem cells in acute pancreatitis animal models and made a review.Results In the animal model of acute pancreatitis, the infusion of mesenchymal stem cells could reduce the expression of inflammatory factors, regulate the expression of immune cells, inhibit pancreatic cell apoptosis and autophagy, resist oxidative stress, and promote angiogenesis. Mesenchymal stem cells had a relieving effect on acute pancreatitis.Conclusion The infusion of mesenchymal stem cells can relieve acute pancreatitis in animal models, and has great potential in the clinical application of acute pancreatitis.

Citation: QU Yuanxu, DING Yixuan, ZHENG Zhi, LU Jiongdi, LI Fei. Advancement of mesenchymal stem cells in relieving acute pancreatitis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2021, 28(10): 1365-1371. doi: 10.7507/1007-9424.202011100 Copy

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