《欧洲血管外科学会（ESVS）2021 年静脉血栓管理临床实践指南》解读_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

吴洲鹏 ,  赵纪春 , 马玉奎

四川大学华西医院血管外科（成都 610041）;

Corresponding author：

赵纪春, Email: zhaojc3@126.com

Keywords：

DOI：

10.7507/1007-9424.202101019

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Citation： 吴洲鹏, 赵纪春, 马玉奎. 《欧洲血管外科学会（ESVS）2021 年静脉血栓管理临床实践指南》解读. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2021, 28(2): 165-170. doi: 10.7507/1007-9424.202101019 Copy

1.	Kakkos SK, Gohel M, Baekgaard N, et al. European Society for Vascular Surgery (ESVS) 2021 clinical practice guidelines on the management of venous thrombosis. Eur J Vasc Endovasc Surg, 2020: S1078-5884(20)30868-6.
2.	Wanhainen A, Verzini F, Van Herzeele I, et al. Editor’s choice—European Society for Vascular Surgery (ESVS) 2019 Clinical Practice Guidelines on the management of abdominal aorto-iliac artery aneurysms. Eur J Vasc Endovasc Surg, 2019, 57(1): 8-93.
3.	Heit JA, Spencer FA, White RH. The epidemiology of venous thromboembolism. J Thromb Thrombolysis, 2016, 41(1): 3-14.
4.	Spencer FA, Emery C, Joffe SW, et al. Incidence rates, clinical profile, and outcomes of patients with venous thromboembolism. The Worcester VTE study. J Thromb Thrombolysis, 2009, 28(4): 401-409.
5.	Kearon C, Akl EA, Ornelas J, et al. Antithrombotic therapy for VTE disease: CHEST guideline. Chest, 2016, 149(2): 315-352.
6.	Cogo A, Lensing AW, Koopman MM, et al. Compression ultrasonography for diagnostic management of patients with clinically suspected deep vein thrombosis: prospective cohort study. BMJ, 1998, 316(7124): 17-20.
7.	Ageno W, Camporese G, Riva N, et al. Analysis of an algorithm incorporating limited and whole-leg assessment of the deep venous system in symptomatic outpatients with suspected deep-vein thrombosis (PALLADIO): a prospective, multicentre, cohort study. Lancet Haematol, 2015, 2(11): e474-e480.
8.	Karande GY, Hedgire SS, Sanchez Y, et al. Advanced imaging in acute and chronic deep vein thrombosis. Cardiovasc Diagn Ther, 2016, 6(6): 493-507.
9.	Sampson FC, Goodacre SW, Thomas SM, et al. The accuracy of MRI in diagnosis of suspected deep vein thrombosis: systematic review and meta-analysis. Eur Radiol, 2007, 17(1): 175-181.
10.	Dronkers CE, Klok FA, Huisman MV. Current and future perspectives in imaging of venous thromboembolism. J Thromb Haemost, 2016, 14(9): 1696-1710.
11.	Schellong SM, Schwarz T, Halbritter K, et al. Complete compression ultrasonography of the leg veins as a single test for the diagnosis of deep vein thrombosis. Thromb Haemost, 2003, 89(2): 228-234.
12.	Geersing GJ, Zuithoff NP, Kearon C, et al. Exclusion of deep vein thrombosis using the Wells rule in clinically important subgroups: individual patient data meta-analysis. BMJ, 2014, 348: g1340.
13.	Kelly J, Hunt BJ. The utility of pretest probability assessment in patients with clinically suspected venous thromboembolism. J Thromb Haemost, 2003, 1(9): 1888-1896.
14.	Garcia-Fuster MJ, Fabia MJ, Furio E, et al. Should we look for silent pulmonary embolism in patients with deep venous thrombosis? BMC Cardiovasc Disord, 2014, 14: 178.
15.	Zhou M, Zhang L, Ding Y, et al. Extensive screening for occult malignancy in unprovoked venous thromboembolism: A meta-analysis. Thromb Res, 2017, 157: 147-153.
16.	Klein A, Shepshelovich D, Spectre G, et al. Screening for occult cancer in idiopathic venous thromboembolism—Systemic review and meta-analysis. Eur J Intern Med, 2017, 42: 74-80.
17.	Kleinjan A, van Doormaal FF, Prins MH, et al. Limitations of screening for occult cancer in patients with idiopathic venous thromboembolism. Neth J Med, 2012, 70(7): 311-317.
18.	Stevens SM, Woller SC, Bauer KA, et al. Guidance for the evaluation and treatment of hereditary and acquired thrombophilia. J Thromb Thrombolysis, 2016, 41(1): 154-164.
19.	Connors JM. Thrombophilia testing and venous thrombosis. N Engl J Med, 2017, 377(12): 1177-1187.
20.	Garcia-Horton A, Kovacs MJ, Abdulrehman J, et al. Impact of thrombophilia screening on venous thromboembolism management practices. Thromb Res, 2017, 149: 76-80.
21.	Moll S. Thrombophilia: clinical-practical aspects. J Thromb Thrombolysis, 2015, 39(3): 367-378.
22.	Levine M, Gent M, Hirsh J, et al. A comparison of low-molecular-weight heparin administered primarily at home with unfractionated heparin administered in the hospital for proximal deep-vein thrombosis. N Engl J Med, 1996, 334(11): 677-681.
23.	Koopman MM, Prandoni P, Piovella F, et al. Treatment of venous thrombosis with intravenous unfractionated heparin administered in the hospital as compared with subcutaneous low-molecular-weight heparin administered at home. The Tasman Study Group. N Engl J Med, 1996, 334(11): 682-687.
24.	Othieno R, Okpo E, Forster R. Home versus in-patient treatment for deep vein thrombosis. Cochrane Database Syst Rev, 2018, (3): CD003076.
25.	Boutitie F, Pinede L, Schulman S, et al. Influence of preceding length of anticoagulant treatment and initial presentation of venous thromboembolism on risk of recurrence after stopping treatment: analysis of individual participants’ data from seven trials. BMJ, 2011, 342: d3036.
26.	Kearon C, Ginsberg JS, Anderson DR, et al. Comparison of1 month with 3 months of anticoagulation for a first episode of venous thromboembolism associated with a transient risk factor. J Thromb Haemost, 2004, 2(5): 743-749.
27.	Pinede L, Ninet J, Duhaut P, et al. Comparison of 3 and 6 months of oral anticoagulant therapy after a first episode of proximal deep vein thrombosis or pulmonary embolism and comparison of 6 and 12 weeks of therapy after isolated calf deep vein thrombosis. Circulation, 2001, 103(20): 2453-2460.
28.	Kirkilesis GI, Kakkos SK, Tsolakis IA. Editor’s choice —A systematic review and meta-analysis of the efficacy and safety of anticoagulation in the treatment of venous thromboembolism in patients with cancer. Eur J Vasc Endovasc Surg, 2019, 57(5): 685-701.
29.	Prins MH, Lensing AWA, Prandoni P, et al. Risk of recurrent venous thromboembolism according to baseline risk factor profiles. Blood Adv, 2018, 2(7): 788-796.
30.	Agnelli G, Buller HR, Cohen A, et al. Apixaban for extended treatment of venous thromboembolism. N Engl J Med, 2013, 368(8): 699-708.
31.	Weitz JI, Lensing AWA, Prins MH, et al. Rivaroxaban or aspirin for extended treatment of venous thromboembolism. N Engl J Med, 2017, 376(13): 1211-1222.
32.	Brighton TA, Eikelboom JW, Mann K, et al. Low-dose aspirin for preventing recurrent venous thromboembolism. N Engl J Med, 2012, 367(21): 1979-1987.
33.	Becattini C, Agnelli G, Schenone A, et al. Aspirin for preventing the recurrence of venous thromboembolism. N Engl J Med, 2012, 366(21): 1959-1967.
34.	Shaw JR, Douketis J, Le Gal G, et al. Periprocedural interruption of anticoagulation in patients with cancer-associated venous thromboembolism: An analysis of thrombotic and bleeding outcomes. J Thromb Haemost, 2019, 17(7): 1171-1178.
35.	Meissner MH. Duplex follow-up of patients with DVT: does it have clinical significance? Semin Vasc Surg, 2001, 14(3): 215-221.
36.	Ascher E, Depippo PS, Hingorani A, et al. Does repeat duplex ultrasound for lower extremity deep vein thrombosis influence patient management? Vasc Endovascular Surg, 2004, 38(6): 525-531.
37.	Schulman S, Granqvist S, Holmström M, et al. The duration of oral anticoagulant therapy after a second episode of venous thromboembolism. The Duration of Anticoagulation Trial Study Group. N Engl J Med, 1997, 336(6): 393-398.
38.	Kyrle PA. How I treat recurrent deep-vein thrombosis. Blood, 2016, 127(6): 696-702.
39.	Schulman S. How I treat recurrent venous thromboembolism in patients receiving anticoagulant therapy. Blood, 2017, 129(25): 3285-3293.
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1. Kakkos SK, Gohel M, Baekgaard N, et al. European Society for Vascular Surgery (ESVS) 2021 clinical practice guidelines on the management of venous thrombosis. Eur J Vasc Endovasc Surg, 2020: S1078-5884(20)30868-6.
2. Wanhainen A, Verzini F, Van Herzeele I, et al. Editor’s choice—European Society for Vascular Surgery (ESVS) 2019 Clinical Practice Guidelines on the management of abdominal aorto-iliac artery aneurysms. Eur J Vasc Endovasc Surg, 2019, 57(1): 8-93.
3. Heit JA, Spencer FA, White RH. The epidemiology of venous thromboembolism. J Thromb Thrombolysis, 2016, 41(1): 3-14.
4. Spencer FA, Emery C, Joffe SW, et al. Incidence rates, clinical profile, and outcomes of patients with venous thromboembolism. The Worcester VTE study. J Thromb Thrombolysis, 2009, 28(4): 401-409.
5. Kearon C, Akl EA, Ornelas J, et al. Antithrombotic therapy for VTE disease: CHEST guideline. Chest, 2016, 149(2): 315-352.
6. Cogo A, Lensing AW, Koopman MM, et al. Compression ultrasonography for diagnostic management of patients with clinically suspected deep vein thrombosis: prospective cohort study. BMJ, 1998, 316(7124): 17-20.
7. Ageno W, Camporese G, Riva N, et al. Analysis of an algorithm incorporating limited and whole-leg assessment of the deep venous system in symptomatic outpatients with suspected deep-vein thrombosis (PALLADIO): a prospective, multicentre, cohort study. Lancet Haematol, 2015, 2(11): e474-e480.
8. Karande GY, Hedgire SS, Sanchez Y, et al. Advanced imaging in acute and chronic deep vein thrombosis. Cardiovasc Diagn Ther, 2016, 6(6): 493-507.
9. Sampson FC, Goodacre SW, Thomas SM, et al. The accuracy of MRI in diagnosis of suspected deep vein thrombosis: systematic review and meta-analysis. Eur Radiol, 2007, 17(1): 175-181.
10. Dronkers CE, Klok FA, Huisman MV. Current and future perspectives in imaging of venous thromboembolism. J Thromb Haemost, 2016, 14(9): 1696-1710.
11. Schellong SM, Schwarz T, Halbritter K, et al. Complete compression ultrasonography of the leg veins as a single test for the diagnosis of deep vein thrombosis. Thromb Haemost, 2003, 89(2): 228-234.
12. Geersing GJ, Zuithoff NP, Kearon C, et al. Exclusion of deep vein thrombosis using the Wells rule in clinically important subgroups: individual patient data meta-analysis. BMJ, 2014, 348: g1340.
13. Kelly J, Hunt BJ. The utility of pretest probability assessment in patients with clinically suspected venous thromboembolism. J Thromb Haemost, 2003, 1(9): 1888-1896.
14. Garcia-Fuster MJ, Fabia MJ, Furio E, et al. Should we look for silent pulmonary embolism in patients with deep venous thrombosis? BMC Cardiovasc Disord, 2014, 14: 178.
15. Zhou M, Zhang L, Ding Y, et al. Extensive screening for occult malignancy in unprovoked venous thromboembolism: A meta-analysis. Thromb Res, 2017, 157: 147-153.
16. Klein A, Shepshelovich D, Spectre G, et al. Screening for occult cancer in idiopathic venous thromboembolism—Systemic review and meta-analysis. Eur J Intern Med, 2017, 42: 74-80.
17. Kleinjan A, van Doormaal FF, Prins MH, et al. Limitations of screening for occult cancer in patients with idiopathic venous thromboembolism. Neth J Med, 2012, 70(7): 311-317.
18. Stevens SM, Woller SC, Bauer KA, et al. Guidance for the evaluation and treatment of hereditary and acquired thrombophilia. J Thromb Thrombolysis, 2016, 41(1): 154-164.
19. Connors JM. Thrombophilia testing and venous thrombosis. N Engl J Med, 2017, 377(12): 1177-1187.
20. Garcia-Horton A, Kovacs MJ, Abdulrehman J, et al. Impact of thrombophilia screening on venous thromboembolism management practices. Thromb Res, 2017, 149: 76-80.
21. Moll S. Thrombophilia: clinical-practical aspects. J Thromb Thrombolysis, 2015, 39(3): 367-378.
22. Levine M, Gent M, Hirsh J, et al. A comparison of low-molecular-weight heparin administered primarily at home with unfractionated heparin administered in the hospital for proximal deep-vein thrombosis. N Engl J Med, 1996, 334(11): 677-681.
23. Koopman MM, Prandoni P, Piovella F, et al. Treatment of venous thrombosis with intravenous unfractionated heparin administered in the hospital as compared with subcutaneous low-molecular-weight heparin administered at home. The Tasman Study Group. N Engl J Med, 1996, 334(11): 682-687.
24. Othieno R, Okpo E, Forster R. Home versus in-patient treatment for deep vein thrombosis. Cochrane Database Syst Rev, 2018, (3): CD003076.
25. Boutitie F, Pinede L, Schulman S, et al. Influence of preceding length of anticoagulant treatment and initial presentation of venous thromboembolism on risk of recurrence after stopping treatment: analysis of individual participants’ data from seven trials. BMJ, 2011, 342: d3036.
26. Kearon C, Ginsberg JS, Anderson DR, et al. Comparison of1 month with 3 months of anticoagulation for a first episode of venous thromboembolism associated with a transient risk factor. J Thromb Haemost, 2004, 2(5): 743-749.
27. Pinede L, Ninet J, Duhaut P, et al. Comparison of 3 and 6 months of oral anticoagulant therapy after a first episode of proximal deep vein thrombosis or pulmonary embolism and comparison of 6 and 12 weeks of therapy after isolated calf deep vein thrombosis. Circulation, 2001, 103(20): 2453-2460.
28. Kirkilesis GI, Kakkos SK, Tsolakis IA. Editor’s choice —A systematic review and meta-analysis of the efficacy and safety of anticoagulation in the treatment of venous thromboembolism in patients with cancer. Eur J Vasc Endovasc Surg, 2019, 57(5): 685-701.
29. Prins MH, Lensing AWA, Prandoni P, et al. Risk of recurrent venous thromboembolism according to baseline risk factor profiles. Blood Adv, 2018, 2(7): 788-796.
30. Agnelli G, Buller HR, Cohen A, et al. Apixaban for extended treatment of venous thromboembolism. N Engl J Med, 2013, 368(8): 699-708.
31. Weitz JI, Lensing AWA, Prins MH, et al. Rivaroxaban or aspirin for extended treatment of venous thromboembolism. N Engl J Med, 2017, 376(13): 1211-1222.
32. Brighton TA, Eikelboom JW, Mann K, et al. Low-dose aspirin for preventing recurrent venous thromboembolism. N Engl J Med, 2012, 367(21): 1979-1987.
33. Becattini C, Agnelli G, Schenone A, et al. Aspirin for preventing the recurrence of venous thromboembolism. N Engl J Med, 2012, 366(21): 1959-1967.
34. Shaw JR, Douketis J, Le Gal G, et al. Periprocedural interruption of anticoagulation in patients with cancer-associated venous thromboembolism: An analysis of thrombotic and bleeding outcomes. J Thromb Haemost, 2019, 17(7): 1171-1178.
35. Meissner MH. Duplex follow-up of patients with DVT: does it have clinical significance? Semin Vasc Surg, 2001, 14(3): 215-221.
36. Ascher E, Depippo PS, Hingorani A, et al. Does repeat duplex ultrasound for lower extremity deep vein thrombosis influence patient management? Vasc Endovascular Surg, 2004, 38(6): 525-531.
37. Schulman S, Granqvist S, Holmström M, et al. The duration of oral anticoagulant therapy after a second episode of venous thromboembolism. The Duration of Anticoagulation Trial Study Group. N Engl J Med, 1997, 336(6): 393-398.
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《欧洲血管外科学会（ESVS）2021 年静脉血栓管理临床实践指南》解读

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