Research progress of hepatic artery infusion chemotherapy in the treatment of colorectal cancer liver metastasis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LU Xin ,  LUO Shiqiao

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P. R. China;

Corresponding author：

LUO Shiqiao, Email: shiqiaoluo@qq.com

Keywords：

colorectal cancer liver metastasis; hepatic arterial infusion chemotherapy; treatment; review

DOI：

10.7507/1007-9424.202101060

Video：

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Objective To summarize the research progress and clinical efficacy of hepatic artery infusion chemotherapy in the treatment of colorectal cancer liver metastasis.Method The literatures of hepatic artery infusion chemotherapy for colorectal cancer liver metastasis were collected and reviewed.Results The incidence of colorectal cancer liver metastasis was high, which affected the prognosis of patients. Surgical treatment was the preferred treatment for colorectal cancer liver metastasis. Hepatic arterial infusion chemotherapy could be used for preoperative neoadjuvant therapy and postoperative adjuvant therapy.Conclusions Hepatic arterial infusion chemotherapy is an effective local treatment for colorectal cancer liver metastasis and can be used as a supplement to surgical treatment. Compared with systemic chemotherapy, hepatic arterial infusion chemotherapy combined with systemic chemotherapy can improve the overall survival and disease-free survival, reduce the risk of intrahepatic recurrence, and improve the prognosis of patients.

Citation： LU Xin, LUO Shiqiao. Research progress of hepatic artery infusion chemotherapy in the treatment of colorectal cancer liver metastasis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2021, 28(12): 1666-1671. doi: 10.7507/1007-9424.202101060 Copy

1.	中华人民共和国国家卫生健康委员会医政医管局, 中华医学会肿瘤学分会. 中国结直肠癌诊疗规范(2020 年版). 中国实用外科杂志, 2020, 27(1): 601-625.
2.	中华医学会外科分会胃肠外科学组, 中华医学会外科分会结直肠外科学组, 中国抗癌协会大肠癌专业委员会, 等. 结直肠癌肝转移诊断和综合治疗指南(V2018). 中华结直肠疾病电子杂志, 2018, 7(4): 302-314.
3.	Qiang W, Shi H, Wu J, et al. Hepatic arterial infusion combined with systemic chemotherapy for patients with extensive liver metastases from gastric cancer. Cancer Manag Res, 2020, 12: 2911-2916 .
4.	Lyu N, Kong Y, Mu L, et al. Hepatic arterial infusion of oxaliplatin plus fluorouracil/leucovorin vs. sorafenib for advanced hepatocellular carcinoma. J Hepatol, 2018, 69(1): 60-69.
5.	Ahn YE, Suh SJ, Yim HJ, et al. Comparison of sorafenib versus hepatic arterial infusion chemotherapy-based treatment for advanced hepatocellular carcinoma with portal vein tumor thrombosis. Gut Liver, 2021, 15(2): 284-294.
6.	Cercek A, Boerner T, Tan BR, et al. Assessment of hepatic arterial infusion of floxuridine in combination with systemic gemcitabine and oxaliplatin in patients with unresectable intrahepatic cholangiocarcinoma: a phase 2 clinical trial. JAMA Oncol, 2020, 6(1): 60-67.
7.	Lewis HL, Bloomston M. Hepatic artery infusional chemotherapy. Surg Clin North Am, 2016, 96(2): 341-355.
8.	Creasy JM, Sadot E, Koerkamp BG, et al. Actual 10-year survival after hepatic resection of colorectal liver metastases: what factors preclude cure? Surgery, 2018, 163(6): 1238-1244.
9.	Viganò L, Ferrero A, Lo Tesoriere R, et al. Liver surgery for colorectal metastases: results after 10 years of follow-up. Long-term survivors, late recurrences, and prognostic role of morbidity. Ann Surg Oncol, 2008, 15(9): 2458-2464.
10.	Pulitanò C, Castillo F, Aldrighetti L, et al. What defines ‘cure’ after liver resection for colorectal metastases? Results after 10 years of follow-up. HPB (Oxford), 2010, 12(4): 244-249.
11.	Dhir M, Jones HL, Shuai Y, et al. Hepatic arterial infusion in combination with modern systemic chemotherapy is associated with improved survival compared with modern systemic chemotherapy alone in patients with isolated unresectable colorectal liver metastases: A case-control study. Ann Surg Oncol, 2017, 24(1): 150-158.
12.	Lim A, Le Sourd S, Senellart H, et al. Hepatic arterial infusion chemotherapy for unresectable liver metastases of colorectal cancer: A multicenter retrospective study. Clin Colorectal Cancer, 2017, 16(4): 308-315.
13.	Muaddi H, D’Angelica M, Wiseman JT, et al. Safety and feasibility of initiating a hepatic artery infusion pump chemotherapy program for unresectable colorectal liver metastases: A multicenter, retrospective cohort study. J Surg Oncol, 2021, 123(1): 252-260.
14.	Pak LM, Kemeny NE, Capanu M, et al. Prospective phase Ⅱ trial of combination hepatic artery infusion and systemic chemotherapy for unresectable colorectal liver metastases: Long term results and curative potential. J Surg Oncol, 2018, 117(4): 634-643.
15.	Ye LC, Liu TS, Ren L, et al. Randomized controlled trial of cetuximab plus chemotherapy for patients with KRAS wild-type unresectable colorectal liver-limited metastases. J Clin Oncol, 2013, 31(16): 1931-1938.
16.	Boilève A, De Cuyper A, Larive A, et al. Hepatic arterial infusion of oxaliplatin plus systemic chemotherapy and targeted therapy for unresectable colorectal liver metastases. Eur J Cancer, 2020, 138: 89-98 .
17.	Sato Y, Inaba Y, Aramaki T, et al. Hepatic arterial infusion chemotherapy of 5-Fluorouracil for patients with unresectable liver metastases from colorectal cancer refractory to standard systemic chemotherapy: A multicenter retrospective study. Oncology, 2020, 98(5): 267-272.
18.	Cercek A, Boucher TM, Gluskin JS, et al. Response rates of hepatic arterial infusion pump therapy in patients with metastatic colorectal cancer liver metastases refractory to all standard chemotherapies. J Surg Oncol, 2016, 114(6): 655-663.
19.	D’Angelica M, Kornprat P, Gonen M, et al. Effect on outcome of recurrence patterns after hepatectomy for colorectal metastases. Ann Surg Oncol, 2011, 18(4): 1096-1103.
20.	Buisman FE, Galjart B, van der Stok EP, et al. The impact of hepatic arterial infusion pump chemotherapy on hepatic recurrences and survival in patients with resected colorectal liver metastases. HPB (Oxford), 2020, 22(9): 1271-1279.
21.	Srouji R, Narayan R, Boerner T, et al. Addition of adjuvant hepatic artery infusion to systemic chemotherapy following resection of colorectal liver metastases is associated with reduced liver-related mortality. J Surg Oncol, 2020, 121(8): 1314-1319.
22.	Goéré D, Benhaim L, Bonnet S, et al. Adjuvant chemotherapy after resection of colorectal liver metastases in patients at high risk of hepatic recurrence. Ann Surg, 2013, 257(1): 114-120.
23.	Groot Koerkamp B, Sadot E, Kemeny NE, et al. Perioperative hepatic arterial infusion pump chemotherapy is associated with longer survival after resection of colorectal liver metastases: A propensity score analysis. J Clin Oncol, 2017, 35(17): 1938-1944.
24.	Kemeny NE, Chou JF, Boucher TM, et al. Updated long-term survival for patients with metastatic colorectal cancer treated with liver resection followed by hepatic arterial infusion and systemic chemotherapy. J Surg Oncol, 2016, 113(5): 477-484.
25.	Gholami S, Kemeny NE, Boucher TM, et al. Adjuvant hepatic artery infusion chemotherapy is associated with improved survival regardless of KRAS mutation status in patients with resected colorectal liver metastases: A retrospective analysis of 674 patients. Ann Surg, 2020, 272(2): 352-356.
26.	Buisman FE, Homs MYV, Grünhagen DJ, et al. Adjuvant hepatic arterial infusion pump chemotherapy and resection versus resection alone in patients with low-risk resectable colorectal liver metastases - the multicenter randomized controlled PUMP trial. BMC Cancer, 2019, 19(1): 327.
27.	Qadan M, D’Angelica MI, Kemeny NE, et al. Robotic hepatic arterial infusion pump placement. HPB (Oxford), 2017, 19(5): 429-435 .
28.	Thiels CA, D’Angelica MI. Hepatic artery infusion pumps. J Surg Oncol, 2020, 122(1): 70-77.
29.	Hu J, Zhu X, Wang X, et al. Evaluation of percutaneous unilateral trans-femoral implantation of side-hole port-catheter system with coil only fixed-catheter-tip for hepatic arterial infusion chemotherapy. Cancer Imaging, 2019, 19(1): 15.
30.	Imamine R, Shibata T, Shinozuka K, et al. Complications in hepatic arterial infusion chemotherapy: retrospective comparison of catheter tip placement in the right/left hepatic artery vs. the gastroduodenal artery. Surg Today, 2017, 47(7): 851-858.
31.	Creasy JM, Napier KJ, Reed SA, et al. Implementation of a hepatic artery infusion program: initial patient selection and perioperative outcomes of concurrent hepatic artery infusion and systemic chemotherapy for colorectal liver metastases. Ann Surg Oncol, 2020, 27(13): 5086-5095.
32.	Ueda M, Sai K, Sonoda T, et al. Complications arising from transfemoral, percutaneous implantation of an indwelling port-catheter system for hepatic infusion chemotherapy: Case series of the management and salvage of the system. Int J Surg Case Rep, 2019, 65: 78-82.
33.	Ensminger WD, Rosowsky A, Raso V, et al. A clinical-pharmacological evaluation of hepatic arterial infusions of 5-fluoro-2’-deoxyuridine and 5-fluorouracil. Cancer Res, 1978, 38(11 Pt 1): 3784-3792.
34.	Sigurdson ER, Ridge JA, Kemeny N, et al. Tumor and liver drug uptake following hepatic artery and portal vein infusion. J Clin Oncol, 1987, 5(11): 1836-1840.
35.	Dizon DS, Schwartz J, Kemeny N. Regional chemotherapy: a focus on hepatic artery infusion for colorectal cancer liver metastases. Surg Oncol Clin N Am, 2008, 17(4): 759-771.
36.	Dzodic R, Gomez-Abuin G, Rougier P, et al. Pharmacokinetic advantage of intra-arterial hepatic oxaliplatin administration: comparative results with cisplatin using a rabbit VX2 tumor model. Anticancer Drugs, 2004, 15(6): 647-650.
37.	Kerbage F, Grinda T, Smolenschi C, et al. Is intra-arterial hepatic chemotherapy painful? Support Care Cancer, 2020, 28(10): 4585-4587.
38.	Skitzki JJ, Chang AE. Hepatic artery chemotherapy for colorectal liver metastases: technical considerations and review of clinical trials. Surg Oncol, 2002, 11(3): 123-135.

1. 中华人民共和国国家卫生健康委员会医政医管局, 中华医学会肿瘤学分会. 中国结直肠癌诊疗规范(2020 年版). 中国实用外科杂志, 2020, 27(1): 601-625.
2. 中华医学会外科分会胃肠外科学组, 中华医学会外科分会结直肠外科学组, 中国抗癌协会大肠癌专业委员会, 等. 结直肠癌肝转移诊断和综合治疗指南(V2018). 中华结直肠疾病电子杂志, 2018, 7(4): 302-314.
3. Qiang W, Shi H, Wu J, et al. Hepatic arterial infusion combined with systemic chemotherapy for patients with extensive liver metastases from gastric cancer. Cancer Manag Res, 2020, 12: 2911-2916 .
4. Lyu N, Kong Y, Mu L, et al. Hepatic arterial infusion of oxaliplatin plus fluorouracil/leucovorin vs. sorafenib for advanced hepatocellular carcinoma. J Hepatol, 2018, 69(1): 60-69.
5. Ahn YE, Suh SJ, Yim HJ, et al. Comparison of sorafenib versus hepatic arterial infusion chemotherapy-based treatment for advanced hepatocellular carcinoma with portal vein tumor thrombosis. Gut Liver, 2021, 15(2): 284-294.
6. Cercek A, Boerner T, Tan BR, et al. Assessment of hepatic arterial infusion of floxuridine in combination with systemic gemcitabine and oxaliplatin in patients with unresectable intrahepatic cholangiocarcinoma: a phase 2 clinical trial. JAMA Oncol, 2020, 6(1): 60-67.
7. Lewis HL, Bloomston M. Hepatic artery infusional chemotherapy. Surg Clin North Am, 2016, 96(2): 341-355.
8. Creasy JM, Sadot E, Koerkamp BG, et al. Actual 10-year survival after hepatic resection of colorectal liver metastases: what factors preclude cure? Surgery, 2018, 163(6): 1238-1244.
9. Viganò L, Ferrero A, Lo Tesoriere R, et al. Liver surgery for colorectal metastases: results after 10 years of follow-up. Long-term survivors, late recurrences, and prognostic role of morbidity. Ann Surg Oncol, 2008, 15(9): 2458-2464.
10. Pulitanò C, Castillo F, Aldrighetti L, et al. What defines ‘cure’ after liver resection for colorectal metastases? Results after 10 years of follow-up. HPB (Oxford), 2010, 12(4): 244-249.
11. Dhir M, Jones HL, Shuai Y, et al. Hepatic arterial infusion in combination with modern systemic chemotherapy is associated with improved survival compared with modern systemic chemotherapy alone in patients with isolated unresectable colorectal liver metastases: A case-control study. Ann Surg Oncol, 2017, 24(1): 150-158.
12. Lim A, Le Sourd S, Senellart H, et al. Hepatic arterial infusion chemotherapy for unresectable liver metastases of colorectal cancer: A multicenter retrospective study. Clin Colorectal Cancer, 2017, 16(4): 308-315.
13. Muaddi H, D’Angelica M, Wiseman JT, et al. Safety and feasibility of initiating a hepatic artery infusion pump chemotherapy program for unresectable colorectal liver metastases: A multicenter, retrospective cohort study. J Surg Oncol, 2021, 123(1): 252-260.
14. Pak LM, Kemeny NE, Capanu M, et al. Prospective phase Ⅱ trial of combination hepatic artery infusion and systemic chemotherapy for unresectable colorectal liver metastases: Long term results and curative potential. J Surg Oncol, 2018, 117(4): 634-643.
15. Ye LC, Liu TS, Ren L, et al. Randomized controlled trial of cetuximab plus chemotherapy for patients with KRAS wild-type unresectable colorectal liver-limited metastases. J Clin Oncol, 2013, 31(16): 1931-1938.
16. Boilève A, De Cuyper A, Larive A, et al. Hepatic arterial infusion of oxaliplatin plus systemic chemotherapy and targeted therapy for unresectable colorectal liver metastases. Eur J Cancer, 2020, 138: 89-98 .
17. Sato Y, Inaba Y, Aramaki T, et al. Hepatic arterial infusion chemotherapy of 5-Fluorouracil for patients with unresectable liver metastases from colorectal cancer refractory to standard systemic chemotherapy: A multicenter retrospective study. Oncology, 2020, 98(5): 267-272.
18. Cercek A, Boucher TM, Gluskin JS, et al. Response rates of hepatic arterial infusion pump therapy in patients with metastatic colorectal cancer liver metastases refractory to all standard chemotherapies. J Surg Oncol, 2016, 114(6): 655-663.
19. D’Angelica M, Kornprat P, Gonen M, et al. Effect on outcome of recurrence patterns after hepatectomy for colorectal metastases. Ann Surg Oncol, 2011, 18(4): 1096-1103.
20. Buisman FE, Galjart B, van der Stok EP, et al. The impact of hepatic arterial infusion pump chemotherapy on hepatic recurrences and survival in patients with resected colorectal liver metastases. HPB (Oxford), 2020, 22(9): 1271-1279.
21. Srouji R, Narayan R, Boerner T, et al. Addition of adjuvant hepatic artery infusion to systemic chemotherapy following resection of colorectal liver metastases is associated with reduced liver-related mortality. J Surg Oncol, 2020, 121(8): 1314-1319.
22. Goéré D, Benhaim L, Bonnet S, et al. Adjuvant chemotherapy after resection of colorectal liver metastases in patients at high risk of hepatic recurrence. Ann Surg, 2013, 257(1): 114-120.
23. Groot Koerkamp B, Sadot E, Kemeny NE, et al. Perioperative hepatic arterial infusion pump chemotherapy is associated with longer survival after resection of colorectal liver metastases: A propensity score analysis. J Clin Oncol, 2017, 35(17): 1938-1944.
24. Kemeny NE, Chou JF, Boucher TM, et al. Updated long-term survival for patients with metastatic colorectal cancer treated with liver resection followed by hepatic arterial infusion and systemic chemotherapy. J Surg Oncol, 2016, 113(5): 477-484.
25. Gholami S, Kemeny NE, Boucher TM, et al. Adjuvant hepatic artery infusion chemotherapy is associated with improved survival regardless of KRAS mutation status in patients with resected colorectal liver metastases: A retrospective analysis of 674 patients. Ann Surg, 2020, 272(2): 352-356.
26. Buisman FE, Homs MYV, Grünhagen DJ, et al. Adjuvant hepatic arterial infusion pump chemotherapy and resection versus resection alone in patients with low-risk resectable colorectal liver metastases - the multicenter randomized controlled PUMP trial. BMC Cancer, 2019, 19(1): 327.
27. Qadan M, D’Angelica MI, Kemeny NE, et al. Robotic hepatic arterial infusion pump placement. HPB (Oxford), 2017, 19(5): 429-435 .
28. Thiels CA, D’Angelica MI. Hepatic artery infusion pumps. J Surg Oncol, 2020, 122(1): 70-77.
29. Hu J, Zhu X, Wang X, et al. Evaluation of percutaneous unilateral trans-femoral implantation of side-hole port-catheter system with coil only fixed-catheter-tip for hepatic arterial infusion chemotherapy. Cancer Imaging, 2019, 19(1): 15.
30. Imamine R, Shibata T, Shinozuka K, et al. Complications in hepatic arterial infusion chemotherapy: retrospective comparison of catheter tip placement in the right/left hepatic artery vs. the gastroduodenal artery. Surg Today, 2017, 47(7): 851-858.
31. Creasy JM, Napier KJ, Reed SA, et al. Implementation of a hepatic artery infusion program: initial patient selection and perioperative outcomes of concurrent hepatic artery infusion and systemic chemotherapy for colorectal liver metastases. Ann Surg Oncol, 2020, 27(13): 5086-5095.
32. Ueda M, Sai K, Sonoda T, et al. Complications arising from transfemoral, percutaneous implantation of an indwelling port-catheter system for hepatic infusion chemotherapy: Case series of the management and salvage of the system. Int J Surg Case Rep, 2019, 65: 78-82.
33. Ensminger WD, Rosowsky A, Raso V, et al. A clinical-pharmacological evaluation of hepatic arterial infusions of 5-fluoro-2’-deoxyuridine and 5-fluorouracil. Cancer Res, 1978, 38(11 Pt 1): 3784-3792.
34. Sigurdson ER, Ridge JA, Kemeny N, et al. Tumor and liver drug uptake following hepatic artery and portal vein infusion. J Clin Oncol, 1987, 5(11): 1836-1840.
35. Dizon DS, Schwartz J, Kemeny N. Regional chemotherapy: a focus on hepatic artery infusion for colorectal cancer liver metastases. Surg Oncol Clin N Am, 2008, 17(4): 759-771.
36. Dzodic R, Gomez-Abuin G, Rougier P, et al. Pharmacokinetic advantage of intra-arterial hepatic oxaliplatin administration: comparative results with cisplatin using a rabbit VX2 tumor model. Anticancer Drugs, 2004, 15(6): 647-650.
37. Kerbage F, Grinda T, Smolenschi C, et al. Is intra-arterial hepatic chemotherapy painful? Support Care Cancer, 2020, 28(10): 4585-4587.
38. Skitzki JJ, Chang AE. Hepatic artery chemotherapy for colorectal liver metastases: technical considerations and review of clinical trials. Surg Oncol, 2002, 11(3): 123-135.

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Research progress of hepatic artery infusion chemotherapy in the treatment of colorectal cancer liver metastasis

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