Correlation between Treg/Th17 cell immune balance disorder and disease progression of acute pancreatitis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHANG Tao ¹ , LI Zhiwei ² ,  XU Hui ¹

1. Department of Pancreatic Surgery, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, P. R. China;
2. Department of Clinical Laboratory Center, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, P. R. China;

Corresponding author：

XU Hui, Email: xuhui197371@sina.com

Keywords：

acute pancreatitis; regulatory T cell; helper T cell 17; interleukin-10; interleukin-17

DOI：

10.7507/1007-9424.202110012

Video：

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Objective To analyze the relation between regulatory T cell (Treg)/ helper T cell 17 (Th17) imbalance and the pathogenesis of acute pancreatitis (AP) and to explore the relation between Treg/Th17 cell imbalance and helper T cells 1, helper T cells 2 and cytokines in patients with AP, so as to provide a new therapeutic target for immunotherapy of AP. Methods From January to December 2020, 40 patients diagnosed with AP ( AP group) in The People’s Hospital of Xinjiang Uygur Autonomous Region and 40 healthy subjects who underwent physical examination (normal control group) during the same period in this hospital were selected as the research objects. Their peripheral bloods were collected and the proportion of Treg and Th17 cells was detected by flow cytometry. Plasma levels of interleukin-10 (IL-10) and interleukin-17 (IL-17) were detected. Results Compared with the normal control group, the proportions of Treg and Th17 cells increased before treatment in the AP group, the differences were statistically significant (t=5.78, P<0.001; t=5.82, P<0.001). The levels of IL-10 and IL-17 increased, the differences were statistically significant (t=7.14, P<0.001; t=35.22, P<0.001). After treatment, the AP group as compared with the normal control group, the proportions of Treg and Th17 cells increased but the differences were not statistically significant (t=1.87, P>0.05; t=0.29, P>0.05), the level of IL-10 increased and the difference was statistically significant (t=3.98, P<0.001), the level of IL-17 increased but the difference was not statistically significant (t=1.67, P>0.05). After treatment as compared with before treatment in the AP group, the proportions of Treg and Th17 cells decreased, the differences were statistically significant (t=3.07, P<0.01; t=4.99, P<0.001). The levels of IL-10 and IL-17 decreased, the differences were statistically significant (t=3.38, P<0.001; t=30.63, P<0.001). Conclusion In AP, Treg cells mediate immunosuppression and Th17 cells mediate inflammatory response, promoting the occurrence and development of inflammation in the disease. IL-10 and IL-17 may play an important role in regulating their differentiation and homeostasis.

Citation： ZHANG Tao, LI Zhiwei, XU Hui. Correlation between Treg/Th17 cell immune balance disorder and disease progression of acute pancreatitis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2022, 29(7): 892-896. doi: 10.7507/1007-9424.202110012 Copy

1.	Lee PJ, Papachristou GI. New insights into acute pancreatitis. Nat Rev Gastroenterol Hepatol, 2019, 16(8): 479-496.
2.	Paul J. Recent advances in diagnosis and severity assessment of acute pancreatitis. Prague Med Rep, 2020, 121(2): 65-86.
3.	Petrov MS, Yalav D. Global epidemiology and holistic prevenlion of pancreatitis. Nat Rey Gastenteral Hepatol, 2019, 16(3): 175-184.
4.	刘静. 多学科协作诊疗模式对老年重症急性胰腺炎合并肾衰竭患者预后的影响. 中国老年学杂志, 2021, 41(2): 311-315.
5.	张智鹏, 张伟辉. 非编码RNA在急性胰腺炎中的研究进展. 中国普外基础与临床杂志, 2021, 28(11): 1536-1540.
6.	Quero G, Covino M, Ojetti V, et al. Acute pancreatitis in oldest old: a 10-year retrospective analysis of patients referred to the emergency department of a large tertiary hospital. Eur J Gastroenterol Hepatol, 2020, 32(2): 159-165.
7.	中华医学会消化病学分会胰腺疾病学组, 《中华胰腺病杂志》编辑委员会, 《中华消化杂志》编辑委员会. 中国急性胰腺炎诊治指南(2019, 沈阳). 中华胰腺病杂志, 2019, 19(5): 321-331.
8.	Zhang Q, Qin M, Liang Z, et al. The relationship between serum triglyceride levels and acute pancreatitis in an animal model and a 14-year retrospective clinical study. Lipids Health Dis, 2019, 18(1): 183. doi: 10.1186/s12944-019-1126-0.
9.	Tsukamoto A, Ohgoda M, Haruki N, et al. The anti-inflammatory action of maropitant in a mouse model of acute pancreatitis. J Vet Med Sci 2018, 80(3): 492-498.
10.	刘广林, 张文成, 陈凯, 等. 慢性胰腺炎发病机制的研究进展. 中华胰腺病杂志, 2020, 20(4): 314-317.
11.	王立明, 冯辉, 牛泽群, 等. 血红素加氧酶-1对急性重症胰腺炎相关肺损伤TLR4/NF-κB通路的影响. 现代生物医学进展, 2020, 20(4): 661-664.
12.	伍洋, 刘英, 刘济滔, 等. 大黄素对重症急性胰腺炎小鼠Treg/Th17平衡的影响及机制研究. 重庆医科大学学报, 2019, 44(5): 617-621.
13.	徐劲, 蒋鑫, 严永峰, 等. 80岁以上老年急性胰腺炎患者的临床特征分析. 临床肝胆病杂志, 2021, 37(1): 142-146.
14.	陈英, 陈岳亮, 冯彬彬, 等. 耐碳青霉烯类肺炎克雷伯菌感染与急性胰腺炎严重程度的临床关系. 中华消化外科杂志, 2021, 20(11): 1201-1205.
15.	朱磊, 顾洪柱, 李珊珊, 等. 新辅助化疗前后系统免疫炎症指数的变化对进展期胰腺癌患者预后的临床价值. 中国普外基础与临床杂志, 2021, 28(1): 12-17.
16.	杨陈, 曹小瑶, 刘明宗, 等. miR-324-5p靶向调控CARD9对急性胰腺炎腺泡细胞增殖、凋亡的影响及机制. 中国老年学杂志, 2021, 41(2): 379-385.
17.	Zhang Z, Liu Q, Zang H, et al. Oxymatrine protects against l-arginine-induced acute pancreatitis and intestine injury involving Th1/Th17 cytokines and MAPK/NF-κB signaling. Pharm Biol, 2019, 57(1): 595-603.
18.	孙立新, 彭凡岭, 纪前. Toll样受体4通路在重症急性胰腺炎小鼠肺损伤中的作用及其机制. 中华实验外科杂志, 2019, 36(6): 1055-1057.
19.	徐鸥, 董金辉, 岳丽艳, 等. Treg细胞和TICAM-1分子对重度变应性鼻炎患者免疫调节机制研究. 中国煤炭工业医学杂志, 2020, 23(3): 303-306.
20.	唐义龙, 方晨光, 吴文伟, 等. 急性胆源性胰腺炎继发胰腺坏死高危因素及预测模型分析. 创伤与急危重病医学, 2020, 8(2): 104-106, 109.唐义龙, 方晨光, 吴文伟, 等. 急性胆源性胰腺炎继发胰腺坏死高危因素及预测模型分析. 创伤与急危重病医学, 2020, 8(2): 104-106, 109.
21.	解松龄, 蒋正, 赵涛, 等. 辅助性T细胞17及其细胞因子在急性胰腺炎患者诊治中的作用. 中华肝胆外科杂志, 2020, 26(2): 134-138.
22.	赵瑞臣, 次多, 何春娅, 等. 重症急性胰腺炎外周血miR-9、miR-155表达水平与淀粉酶、炎性反应及Th17/Treg平衡的关系. 疑难病杂志, 2021, 20(8): 795-800.
23.	姚超, 朱琦琦, 成向进. 中药联合生长抑素治疗急性胰腺炎临床疗效及对血清Th17/Treg细胞平衡变化的影响. 长春中医药大学学报, 2021, 37(6): 1313-1316.
24.	吕春婷, 付黎明, 岳磊. 杂合式血液净化在重症急性胰腺炎并发MODS患者中的应用. 实用医药杂志, 2021, 38(7): 602-604.
25.	马志兰, 孙雪婷, 梁艳琴. 血液净化对重症急性胰腺炎合并MODS患者 Th17/Treg细胞平衡的影响. 中华医院感染学杂志, 2020, 30(15): 2347-2351.

1. Lee PJ, Papachristou GI. New insights into acute pancreatitis. Nat Rev Gastroenterol Hepatol, 2019, 16(8): 479-496.
2. Paul J. Recent advances in diagnosis and severity assessment of acute pancreatitis. Prague Med Rep, 2020, 121(2): 65-86.
3. Petrov MS, Yalav D. Global epidemiology and holistic prevenlion of pancreatitis. Nat Rey Gastenteral Hepatol, 2019, 16(3): 175-184.
4. 刘静. 多学科协作诊疗模式对老年重症急性胰腺炎合并肾衰竭患者预后的影响. 中国老年学杂志, 2021, 41(2): 311-315.
5. 张智鹏, 张伟辉. 非编码RNA在急性胰腺炎中的研究进展. 中国普外基础与临床杂志, 2021, 28(11): 1536-1540.
6. Quero G, Covino M, Ojetti V, et al. Acute pancreatitis in oldest old: a 10-year retrospective analysis of patients referred to the emergency department of a large tertiary hospital. Eur J Gastroenterol Hepatol, 2020, 32(2): 159-165.
7. 中华医学会消化病学分会胰腺疾病学组, 《中华胰腺病杂志》编辑委员会, 《中华消化杂志》编辑委员会. 中国急性胰腺炎诊治指南(2019, 沈阳). 中华胰腺病杂志, 2019, 19(5): 321-331.
8. Zhang Q, Qin M, Liang Z, et al. The relationship between serum triglyceride levels and acute pancreatitis in an animal model and a 14-year retrospective clinical study. Lipids Health Dis, 2019, 18(1): 183. doi: 10.1186/s12944-019-1126-0.
9. Tsukamoto A, Ohgoda M, Haruki N, et al. The anti-inflammatory action of maropitant in a mouse model of acute pancreatitis. J Vet Med Sci 2018, 80(3): 492-498.
10. 刘广林, 张文成, 陈凯, 等. 慢性胰腺炎发病机制的研究进展. 中华胰腺病杂志, 2020, 20(4): 314-317.
11. 王立明, 冯辉, 牛泽群, 等. 血红素加氧酶-1对急性重症胰腺炎相关肺损伤TLR4/NF-κB通路的影响. 现代生物医学进展, 2020, 20(4): 661-664.
12. 伍洋, 刘英, 刘济滔, 等. 大黄素对重症急性胰腺炎小鼠Treg/Th17平衡的影响及机制研究. 重庆医科大学学报, 2019, 44(5): 617-621.
13. 徐劲, 蒋鑫, 严永峰, 等. 80岁以上老年急性胰腺炎患者的临床特征分析. 临床肝胆病杂志, 2021, 37(1): 142-146.
14. 陈英, 陈岳亮, 冯彬彬, 等. 耐碳青霉烯类肺炎克雷伯菌感染与急性胰腺炎严重程度的临床关系. 中华消化外科杂志, 2021, 20(11): 1201-1205.
15. 朱磊, 顾洪柱, 李珊珊, 等. 新辅助化疗前后系统免疫炎症指数的变化对进展期胰腺癌患者预后的临床价值. 中国普外基础与临床杂志, 2021, 28(1): 12-17.
16. 杨陈, 曹小瑶, 刘明宗, 等. miR-324-5p靶向调控CARD9对急性胰腺炎腺泡细胞增殖、凋亡的影响及机制. 中国老年学杂志, 2021, 41(2): 379-385.
17. Zhang Z, Liu Q, Zang H, et al. Oxymatrine protects against l-arginine-induced acute pancreatitis and intestine injury involving Th1/Th17 cytokines and MAPK/NF-κB signaling. Pharm Biol, 2019, 57(1): 595-603.
18. 孙立新, 彭凡岭, 纪前. Toll样受体4通路在重症急性胰腺炎小鼠肺损伤中的作用及其机制. 中华实验外科杂志, 2019, 36(6): 1055-1057.
19. 徐鸥, 董金辉, 岳丽艳, 等. Treg细胞和TICAM-1分子对重度变应性鼻炎患者免疫调节机制研究. 中国煤炭工业医学杂志, 2020, 23(3): 303-306.
20. 唐义龙, 方晨光, 吴文伟, 等. 急性胆源性胰腺炎继发胰腺坏死高危因素及预测模型分析. 创伤与急危重病医学, 2020, 8(2): 104-106, 109.唐义龙, 方晨光, 吴文伟, 等. 急性胆源性胰腺炎继发胰腺坏死高危因素及预测模型分析. 创伤与急危重病医学, 2020, 8(2): 104-106, 109.
21. 解松龄, 蒋正, 赵涛, 等. 辅助性T细胞17及其细胞因子在急性胰腺炎患者诊治中的作用. 中华肝胆外科杂志, 2020, 26(2): 134-138.
22. 赵瑞臣, 次多, 何春娅, 等. 重症急性胰腺炎外周血miR-9、miR-155表达水平与淀粉酶、炎性反应及Th17/Treg平衡的关系. 疑难病杂志, 2021, 20(8): 795-800.
23. 姚超, 朱琦琦, 成向进. 中药联合生长抑素治疗急性胰腺炎临床疗效及对血清Th17/Treg细胞平衡变化的影响. 长春中医药大学学报, 2021, 37(6): 1313-1316.
24. 吕春婷, 付黎明, 岳磊. 杂合式血液净化在重症急性胰腺炎并发MODS患者中的应用. 实用医药杂志, 2021, 38(7): 602-604.
25. 马志兰, 孙雪婷, 梁艳琴. 血液净化对重症急性胰腺炎合并MODS患者 Th17/Treg细胞平衡的影响. 中华医院感染学杂志, 2020, 30(15): 2347-2351.

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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Correlation between Treg/Th17 cell immune balance disorder and disease progression of acute pancreatitis

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