• 1. Department of Hepatobiliary Surgery, The Third Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, P. R. China;
  • 2. Zunyi Medical and Pharmaceutical College, Zunyi, Guizhou 563000, P. R. China;
FENG Chunlin, Email: 2084438832@qq.com
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Objective To summarize the application research progress of animal models of hepatocellular carcinoma at home and abroad in recent years. Method The relevant literature on animal models of hepatocellular carcinoma at home and abroad in recent years was reviewed. Results At present, the common animal models of hepatocellular carcinoma mainly included spontaneous animal model, induced animal model, gene modified animal model, transplanted animal model, and humanized animal model. The etiology, pathogenesis, and pathophysiological changes of various animal models were different. The selection of animal models of hepatocellular carcinoma depended on the type and purpose of research. Conclusions Various animal models of hepatocellular carcinoma have their own advantages and disadvantages. Researchers should choose different animal models according to their own research purposes to achieve the expected experimental purposes, so that more valuable research results of animal models of hepatocellular carcinoma can be applied to clinical practice, and finally these research results can be truly applied to diagnosis and treatment of hepatocellular carcinoma.

Citation: WANG Nana, FENG Chunlin. Research progress on animal model of hepatocellular carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2022, 29(10): 1376-1382. doi: 10.7507/1007-9424.202204007 Copy

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