Relation between marital status of patients with colorectal cancer and decision<b>-</b>making and treatment effect of neoadjuvant regimens: a real<b>-</b>world study based on DACCA_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LIU Jing ^1,2 , YI Hongxia ^1,2 , CEN Yueyan ³ , QI Yuhan ⁴ , WANG Xiaodong ¹ ,  LI Li ¹

1. Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;
2. West China School of Nursing, Sichuan University, Chengdu 610041, P. R. China;
3. West China School of Stomatology, Sichuan University, Chengdu 610041, P. R. China;
4. West China School of Medicine, Sichuan University, Chengdu 610041, P. R. China;

Corresponding author：

LI Li, Email: drlili116@126.com

Keywords：

marital status; colorectal cancer; neoadjuvant therapy; Database from Colorectal Cancer

DOI：

10.7507/1007-9424.202209043

Video：

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Objective To analyze the relation between the marital status of patients with colorectal cancer and neoadjuvant therapy (NAT) regimen decision-making and outcomes in the current version of the Database from Colorectal Cancer (DACCA). Methods The version of DACCA selected for this analysis was updated on June 29, 2022. The patients were enrolled according to the established screening criteria and then assigned to 5 groups: the unmarried, married, divorced, remarried and widowed groups. The differences in the NAT regimen decision-making and changes of symptom, imaging, and cancer markers in these 5 groups were analyzed. Results A total of 3 053 data that met the screened criteria were enrolled. The results of statistical analysis reflected that the difference in the constituent ratio of patients chosen NAT strategies among 5 groups was obviously statistically significant (χ²=27.944, P=0.004), showing that remarried patients were inclined to adopt combined target drug. No statistical differences were found in changes of symptom (H=5.717, P=0.221), image (H=8.551, P=0.073), and cancer markers (H=11.351, P=0.183) of the 5 groups after NAT. Conclusion Through analysis of DACCA data, it is found that in the selection of NAT strategy for colorectal cancer, more married and remarried patients tended to choose chemotherapy combined target drug regimen.

Citation： LIU Jing, YI Hongxia, CEN Yueyan, QI Yuhan, WANG Xiaodong, LI Li. Relation between marital status of patients with colorectal cancer and decision-making and treatment effect of neoadjuvant regimens: a real-world study based on DACCA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2022, 29(12): 1632-1637. doi: 10.7507/1007-9424.202209043 Copy

1.	张雷, 傅仲学. 结直肠癌新辅助治疗进展. 重庆医学, 2013, 42(5): 581-583.
2.	杜茜茜. 结直肠癌肠造口患者夫妻亲密关系、自我表露与适应水平的相关性研究. 河南大学, 2020.
3.	汪晓东, 由屹先, 余其澳, 等. 数据库建设第九部分: 结直肠癌新辅助治疗的标签与结构化. 中国普外基础与临床杂志, 2021, 28(6): 799-804.
4.	汪晓东, 李立. 数据库建设第一部分: 个人数据的标签与结构化. 中国普外基础与临床杂志, 2019, 26(3): 335-342.
5.	中国结直肠癌诊疗规范(2020年版). 中国实用外科杂志, 2020, 40(6): 601-625.
6.	李卫华, 于吉梅, 陆超君, 等. 基于积极心理学的心理干预对直肠癌患者心理状态、自我效能和生活质量的影响. 癌症进展, 2020, 18(21): 2265-2268.
7.	Dean LT, Gehlert S, Neuhouser ML, et al. Social factors matter in cancer risk and survivorship. Cancer Causes Control. 2018, 29(7): 611-618.
8.	Yang CC, Cheng LC, Lin YW, et al. The impact of marital status on survival in patients with surgically treated colon cancer. Medicine (Baltimore), 2019, 98(11): e14856. doi: 10.1097/MD.0000000000014856.
9.	Gomez SL, Hurley S, Canchola AJ, et al. Effects of marital status and economic resources on survival after cancer: A population-based study. Cancer, 2016, 122(10): 1618-1625.
10.	Lee S, Ma C, Zhang S, et al. Marital status, living arrangement, and cancer recurrence and survival in patients with stage Ⅲ colon cancer: Findings from CALGB 89803 (Alliance). Oncologist, 2022, 27(6): e494-e505. doi: 10.1093/oncolo/oyab070.
11.	Chen ZH, Yang KB, Zhang YZ, et al. Assessment of modifiable factors for the association of marital status with cancer-specific survival. JAMA Netw Open, 2021, 4(5): e2111813. doi: 10.1001/jamanetworkopen.
12.	Buja A, Lago L, Lago S, et al. Marital status and stage of cancer at diagnosis: A systematic review. Eur J Cancer Care (Engl), 2018, 27(1): 12755. doi: 10.1111/ecc.12755.
13.	马智伟, 朱苏雨. 高位直肠癌辅助性放疗的问题与争议探讨. 中国肿瘤临床, 2022, 49(7): 367-371.
14.	陈雨静, 黄铭霞, 李先越, 等. 结直肠癌术后患者支持性照顾需求现状及影响因素的研究. 护理与康复, 2021, 20(7): 17-22.
15.	宋张骏, 雷双燕, 谢娟. 重视癌症患者支持性照顾需求提高患者生存质量. 中国卫生质量管理, 2019, 26(1): 74-77.
16.	Miniotti M, Bassino S, Fanchini L, et al. Supportive care needs, quality of life and psychological morbidity of advanced colorectal cancer patients. Eur J Oncol Nurs, 2019, 43: 101668. doi: 10.1016/j.ejon.2019.09.009.
17.	麻亮. 结直肠癌术后患者社会支持现状及影响因素分析. 齐鲁护理杂志, 2018, 24(2): 25-28.
18.	Cho D, Chu Q, Lu Q. Associations among physical symptoms, fear of cancer recurrence, and emotional well-being among Chinese American breast cancer survivors: a path model. Support Care Cancer, 2018, 26(6): 1755-1761.
19.	林华琴. CEA对局部进展期直肠癌放疗价值的影响及获益人群筛选. 福建医科大学, 2021.
20.	骆亿. 第二原发结直肠癌临床特征分析及其肿瘤相关死亡预测模型的构建与临床应用研究. 扬州大学, 2020.

1. 张雷, 傅仲学. 结直肠癌新辅助治疗进展. 重庆医学, 2013, 42(5): 581-583.
2. 杜茜茜. 结直肠癌肠造口患者夫妻亲密关系、自我表露与适应水平的相关性研究. 河南大学, 2020.
3. 汪晓东, 由屹先, 余其澳, 等. 数据库建设第九部分: 结直肠癌新辅助治疗的标签与结构化. 中国普外基础与临床杂志, 2021, 28(6): 799-804.
4. 汪晓东, 李立. 数据库建设第一部分: 个人数据的标签与结构化. 中国普外基础与临床杂志, 2019, 26(3): 335-342.
5. 中国结直肠癌诊疗规范(2020年版). 中国实用外科杂志, 2020, 40(6): 601-625.
6. 李卫华, 于吉梅, 陆超君, 等. 基于积极心理学的心理干预对直肠癌患者心理状态、自我效能和生活质量的影响. 癌症进展, 2020, 18(21): 2265-2268.
7. Dean LT, Gehlert S, Neuhouser ML, et al. Social factors matter in cancer risk and survivorship. Cancer Causes Control. 2018, 29(7): 611-618.
8. Yang CC, Cheng LC, Lin YW, et al. The impact of marital status on survival in patients with surgically treated colon cancer. Medicine (Baltimore), 2019, 98(11): e14856. doi: 10.1097/MD.0000000000014856.
9. Gomez SL, Hurley S, Canchola AJ, et al. Effects of marital status and economic resources on survival after cancer: A population-based study. Cancer, 2016, 122(10): 1618-1625.
10. Lee S, Ma C, Zhang S, et al. Marital status, living arrangement, and cancer recurrence and survival in patients with stage Ⅲ colon cancer: Findings from CALGB 89803 (Alliance). Oncologist, 2022, 27(6): e494-e505. doi: 10.1093/oncolo/oyab070.
11. Chen ZH, Yang KB, Zhang YZ, et al. Assessment of modifiable factors for the association of marital status with cancer-specific survival. JAMA Netw Open, 2021, 4(5): e2111813. doi: 10.1001/jamanetworkopen.
12. Buja A, Lago L, Lago S, et al. Marital status and stage of cancer at diagnosis: A systematic review. Eur J Cancer Care (Engl), 2018, 27(1): 12755. doi: 10.1111/ecc.12755.
13. 马智伟, 朱苏雨. 高位直肠癌辅助性放疗的问题与争议探讨. 中国肿瘤临床, 2022, 49(7): 367-371.
14. 陈雨静, 黄铭霞, 李先越, 等. 结直肠癌术后患者支持性照顾需求现状及影响因素的研究. 护理与康复, 2021, 20(7): 17-22.
15. 宋张骏, 雷双燕, 谢娟. 重视癌症患者支持性照顾需求提高患者生存质量. 中国卫生质量管理, 2019, 26(1): 74-77.
16. Miniotti M, Bassino S, Fanchini L, et al. Supportive care needs, quality of life and psychological morbidity of advanced colorectal cancer patients. Eur J Oncol Nurs, 2019, 43: 101668. doi: 10.1016/j.ejon.2019.09.009.
17. 麻亮. 结直肠癌术后患者社会支持现状及影响因素分析. 齐鲁护理杂志, 2018, 24(2): 25-28.
18. Cho D, Chu Q, Lu Q. Associations among physical symptoms, fear of cancer recurrence, and emotional well-being among Chinese American breast cancer survivors: a path model. Support Care Cancer, 2018, 26(6): 1755-1761.
19. 林华琴. CEA对局部进展期直肠癌放疗价值的影响及获益人群筛选. 福建医科大学, 2021.
20. 骆亿. 第二原发结直肠癌临床特征分析及其肿瘤相关死亡预测模型的构建与临床应用研究. 扬州大学, 2020.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Relation between marital status of patients with colorectal cancer and decision-making and treatment effect of neoadjuvant regimens: a real-world study based on DACCA

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