Investigation and improvement of prevention and control strategies for gastric cancer: epidemiology, pathogens, and risk factors_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 CHEN Xinzu ^1,2,3 ,  HU Jiankun ¹ , SIGES Research Group ^1,2,3

1. Gastric Cancer Center & Gastric Cancer Laboratory, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;
2. Department of Gastrointestinal and Hernia Surgery, Second People’s Hospital of Yibin-West China Yibin Hospital, Sichuan University, Yibin, Sichuan 644000, P. R. China;
3. Cancer Prevention and Control Center of Yibin, Second People’s Hospital of Yibin-West China Yibin Hospital, Sichuan University, Yibin, Sichuan 644000, P. R. China;

Corresponding author：

CHEN Xinzu, Email: chenxinzu@scu.edu.cn; HU Jiankun, Email: hujkwch@126.com

Keywords：

gastric cancer; Helicobacter pylori; prevention; screening; epidemiology

DOI：

10.7507/1007-9424.202211028

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To summary the study results of the Sichuan Gastric Cancer Early Detection and Screening Research Program (SIGES). Methods In the past 10 years, SIGES program conducted a series of clinical and clinical epidemiological studies on the current situation and strategies of gastric cancer prevention and control in China, which provided evidence for supply-side structural reform to improve the gastric cancer prevention and control. We collected related studies and made a review. Results SIGES program systematically and specifically studied carcinogenic pathogens, risk factors, screening strategies, as well as critical technique and system construction of tertiary prevention for gastric cancer. The main results supported that Helicobacter pylori was highly correlated with precancerous atrophic gastritis and gastric cancer. Oncoviruses, such as Epstein-Barr virus, hepatitis B virus, human cytomegalovirus, human papillomavirus, John Cunningham virus were correlated with the risk of gastric cancer, and should be paid further attention in the prevention and screening strategy of gastric cancer. Ethnicity, domicile, and family history of gastric cancer were also correlated with gastric cancer and gastric cancer-related risk factors, so it was suggested to include in the personalized evaluation criteria system of high-risk groups for gastric cancer. Conclusions At present, the prevention and control of gastric cancer in China has achieved substantial achievements, but the burden of gastric cancer keeps heavy. It is still necessary to conduct further scientific research on critical technique or issues in designing prevention and control strategies.

Citation： CHEN Xinzu, HU Jiankun, SIGES Research Group. Investigation and improvement of prevention and control strategies for gastric cancer: epidemiology, pathogens, and risk factors. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2023, 30(1): 86-90. doi: 10.7507/1007-9424.202211028 Copy

1.	Wang R, Chen XZ. High mortality from hepatic, gastric and esophageal cancers in mainland China: 40 years of experience and development. Clin Res Hepatol Gastroenterol, 2014, 38(6): 751-756.
2.	Wang R, Zhang MG, Chen XZ, et al. Risk population of Helicobacter pylori infection among Han and Tibetan ethnicities in western China: a cross-sectional, longitudinal epidemiological study. Lancet, 2016, 388(Suppl 1): S17. doi: 10.1016/S0140-6736(16)31944-4.
3.	Chen XZ, Schöttker B, Castro FA, et al. Association of Helicobacter pylori infection and chronic atrophic gastritis with risk of colonic, pancreatic and gastric cancer: a ten-year follow-up of the ESTHER cohort study. Oncotarget, 2016, 7(13): 17182-17193.
4.	Xiang W, Wang R, Bai D, et al. Helicobacter pylori related gastric cancer screening and cost-effectiveness analysis: a Hospital-Based Cross-Sectional Study (SIGES). Nutr Cancer, 2022, 74(8): 2769-2778.
5.	Chen XZ, Chen H, Castro FA, et al. Epstein-Barr virus infection and gastric cancer: a systematic review. Medicine (Baltimore), 2015, 94(20): e792. doi:10.1097/MD.0000000000000792.
6.	Wang R, Chen XZ, Zhang MG, et al. Incidence and mortality of liver cancer in mainland China: changes in first decade of 21st century. Hepatogastroenterology, 2015, 62(137): 118-121.
7.	Wang R, Liu K, Chen XZ, et al. Associations between gastric cancer risk and virus infection other than Epstein-Barr virus: the protocol of a systematic review and meta-analysis based on epidemiological studies. Medicine (Baltimore), 2019, 98(32): e16708. doi:10.1097/MD.0000000000016708.
8.	Wang H, Chen XZ, Chen XL, et al. Associations between hepatitis B virus exposure and the risk of extrahepatic digestive system cancers: a hospital-based, case-control study (SIGES). Cancer Med, 2021, 10(11): 3741-3755.
9.	Wang H, Chen XL, Liu K, et al. Associations between gastric cancer risk and virus infection other than Epstein-Barr virus: asystematic review and meta-analysis based on epidemiological studies. Clin Transl Gastroenterol, 2020, 11(7): e00201. doi: 10.14309/ctg.0000000000000201.
10.	Chen XZ, Wang R, Hu JK. Hepatitis B virus infection and gastric cancer risk: pitfalls in the potential association. Br J Cancer, 2015, 112(11): 1844. doi: 10.1038/bjc.2015.161.
11.	Yang Y, Chen XZ. Comment on: “Hepatitis B virus infection and the risk of gastrointestinal cancers among Chinese population: a prospective cohort study”. Int J Cancer, 2022, 151(6): 967-968.
12.	Bai D, Wang AM, Liu K, et al. Prevalence difference of Helicobacter pylori infection between Tibetan and Han ethnics: the protocol of a meta-analysis on epidemiologic studies. Medicine (Baltimore), 2019, 98(52): e18566. doi: 10.1097/MD.0000000000018566.
13.	Bai D, Liu K, Wang R, et al. Prevalence difference of Helicobacter pylori infection between Tibetan and Han ethnics in China: a meta-analysis on Epidemiologic Studies (SIGES). Asia Pac J Public Health, 2022: 10105395221134651. doi: 10.1177/10105395221134651.
14.	Wang R, Bai D, Xiang W, et al. Tibetan ethnicity, birthplace, Helicobacter pylori infection, and gastric cancer risk. Am J Gastroenterol, 2022, 117(6): 1010. doi: 10.14309/ajg.0000000000001757.
15.	Yu TH, Wang R, Chen XZ, et al. Multifactorial co-exposure within family of gastric cancer: increased risk of familial gastric cancer and tailored prevention. Med Oncol, 2022, 40(1): 19. doi: 10.1007/s12032-022-01882-x.
16.	Zou JC, Yang Y, Chen XZ, et al. Active eradication of Helicobacter pylori within organized massive screening might improve survival of gastric cancer patients. Gastroenterology, 2022: S0016-5085(22)00498-X. doi: doi: 10.1053/j.gastro.2022.05.009.

1. Wang R, Chen XZ. High mortality from hepatic, gastric and esophageal cancers in mainland China: 40 years of experience and development. Clin Res Hepatol Gastroenterol, 2014, 38(6): 751-756.
2. Wang R, Zhang MG, Chen XZ, et al. Risk population of Helicobacter pylori infection among Han and Tibetan ethnicities in western China: a cross-sectional, longitudinal epidemiological study. Lancet, 2016, 388(Suppl 1): S17. doi: 10.1016/S0140-6736(16)31944-4.
3. Chen XZ, Schöttker B, Castro FA, et al. Association of Helicobacter pylori infection and chronic atrophic gastritis with risk of colonic, pancreatic and gastric cancer: a ten-year follow-up of the ESTHER cohort study. Oncotarget, 2016, 7(13): 17182-17193.
4. Xiang W, Wang R, Bai D, et al. Helicobacter pylori related gastric cancer screening and cost-effectiveness analysis: a Hospital-Based Cross-Sectional Study (SIGES). Nutr Cancer, 2022, 74(8): 2769-2778.
5. Chen XZ, Chen H, Castro FA, et al. Epstein-Barr virus infection and gastric cancer: a systematic review. Medicine (Baltimore), 2015, 94(20): e792. doi:10.1097/MD.0000000000000792.
6. Wang R, Chen XZ, Zhang MG, et al. Incidence and mortality of liver cancer in mainland China: changes in first decade of 21st century. Hepatogastroenterology, 2015, 62(137): 118-121.
7. Wang R, Liu K, Chen XZ, et al. Associations between gastric cancer risk and virus infection other than Epstein-Barr virus: the protocol of a systematic review and meta-analysis based on epidemiological studies. Medicine (Baltimore), 2019, 98(32): e16708. doi:10.1097/MD.0000000000016708.
8. Wang H, Chen XZ, Chen XL, et al. Associations between hepatitis B virus exposure and the risk of extrahepatic digestive system cancers: a hospital-based, case-control study (SIGES). Cancer Med, 2021, 10(11): 3741-3755.
9. Wang H, Chen XL, Liu K, et al. Associations between gastric cancer risk and virus infection other than Epstein-Barr virus: asystematic review and meta-analysis based on epidemiological studies. Clin Transl Gastroenterol, 2020, 11(7): e00201. doi: 10.14309/ctg.0000000000000201.
10. Chen XZ, Wang R, Hu JK. Hepatitis B virus infection and gastric cancer risk: pitfalls in the potential association. Br J Cancer, 2015, 112(11): 1844. doi: 10.1038/bjc.2015.161.
11. Yang Y, Chen XZ. Comment on: “Hepatitis B virus infection and the risk of gastrointestinal cancers among Chinese population: a prospective cohort study”. Int J Cancer, 2022, 151(6): 967-968.
12. Bai D, Wang AM, Liu K, et al. Prevalence difference of Helicobacter pylori infection between Tibetan and Han ethnics: the protocol of a meta-analysis on epidemiologic studies. Medicine (Baltimore), 2019, 98(52): e18566. doi: 10.1097/MD.0000000000018566.
13. Bai D, Liu K, Wang R, et al. Prevalence difference of Helicobacter pylori infection between Tibetan and Han ethnics in China: a meta-analysis on Epidemiologic Studies (SIGES). Asia Pac J Public Health, 2022: 10105395221134651. doi: 10.1177/10105395221134651.
14. Wang R, Bai D, Xiang W, et al. Tibetan ethnicity, birthplace, Helicobacter pylori infection, and gastric cancer risk. Am J Gastroenterol, 2022, 117(6): 1010. doi: 10.14309/ajg.0000000000001757.
15. Yu TH, Wang R, Chen XZ, et al. Multifactorial co-exposure within family of gastric cancer: increased risk of familial gastric cancer and tailored prevention. Med Oncol, 2022, 40(1): 19. doi: 10.1007/s12032-022-01882-x.
16. Zou JC, Yang Y, Chen XZ, et al. Active eradication of Helicobacter pylori within organized massive screening might improve survival of gastric cancer patients. Gastroenterology, 2022: S0016-5085(22)00498-X. doi: doi: 10.1053/j.gastro.2022.05.009.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Investigation and improvement of prevention and control strategies for gastric cancer: epidemiology, pathogens, and risk factors

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