Case study—intrahepatic splenosis with CT and MR findings mimicking hepatocellular carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WANG Ya , DENG Yujiao , WU Bing ,  LU Chunyan

Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;

Corresponding author：

LU Chunyan, Email: luchunyan@wchscu.cn

Keywords：

intrahepatic splenoisis; ectopic spleen; radiological finding

DOI：

10.7507/1007-9424.202302024

Video：

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This study reported a case of intrahepatic splenosis with CT and MR findings mimicking hepatocellular carcinoma. The patient had two risk factors for hepatocellular carcinoma, including elevated alpha-fetoprotein and a history of hepatitis B virus infection, and had previously splenectomy due to spleen trauma. This paper briefly described the etiology and pathogenesis of intrahepatic splenosis and reviewed the radiological findings of this disease reported in previous literature, in order to strengthen readers’ understanding of intrahepatic splenosis and reduce the misdiagnosis rate.

Citation： WANG Ya, DENG Yujiao, WU Bing, LU Chunyan. Case study—intrahepatic splenosis with CT and MR findings mimicking hepatocellular carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2023, 30(5): 539-542. doi: 10.7507/1007-9424.202302024 Copy

1.	Fremont RD, Rice TW. Splenosis: a review. South Med J, 2007, 100(6): 589-593.
2.	Toh WS, Chan KS, Ding CSL, et al. Intrahepatic splenosis: a world review. Clin Exp Hepatol, 2020, 6(3): 185-198.
3.	Guo S, Liu J, Zheng S. Intrahepatic splenosis mimicking hepatocellular carcinoma. Clin Gastroenterol Hepatol, 2022, 20(5): e915-e916.
4.	Varga I, Galfiova P, Adamkov M, et al. Congenital anomalies of the spleen from an embryological point of view. Med Sci Monit, 2009, 15(12): RA269-76.
5.	Kwok CM, Chen YT, Lin HT, et al. Portal vein entrance of splenic erythrocytic progenitor cells and local hypoxia of liver, two events cause intrahepatic splenosis. Med Hypotheses, 2006, 67(6): 1330-1332.
6.	Tsitouridis I, Michaelides M, Sotiriadis C, et al. CT and MRI of intraperitoneal splenosis. Diagn Interv Radiol, 2010, 16(2): 145-149.
7.	张烁琪, 曹红霞, 胡道予, 等. 肝包膜下脾组织植入的CT及MRI影像学特征. 中华放射学杂志, 2021, 55(5): 548-550.
8.	Varghese J, Bergson J, Yaipen O. Intrahepatic splenosis: incidental liver lesion after splenectomy. J Comput Assist Tomogr, 2018, 42(5): 730-731.
9.	Ota T, Tei M, Yoshioka A, et al. Intrapancreatic accessory spleen diagnosed by technetium-99m heat-damaged red blood cell SPECT. J Nucl Med, 1997, 38(3): 494-495.
10.	De Vuysere S, Van Steenbergen W, Aerts R, et al. Intrahepatic splenosis: imaging features. Abdom Imaging, 2000, 25(2): 187-189.
11.	Grandin C, Van Beers BE, Robert A, et al. Benign hepatocellular tumors: MRI after superparamagnetic iron oxide administration. J Comput Assist Tomogr, 1995, 19(3): 412-418.

1. Fremont RD, Rice TW. Splenosis: a review. South Med J, 2007, 100(6): 589-593.
2. Toh WS, Chan KS, Ding CSL, et al. Intrahepatic splenosis: a world review. Clin Exp Hepatol, 2020, 6(3): 185-198.
3. Guo S, Liu J, Zheng S. Intrahepatic splenosis mimicking hepatocellular carcinoma. Clin Gastroenterol Hepatol, 2022, 20(5): e915-e916.
4. Varga I, Galfiova P, Adamkov M, et al. Congenital anomalies of the spleen from an embryological point of view. Med Sci Monit, 2009, 15(12): RA269-76.
5. Kwok CM, Chen YT, Lin HT, et al. Portal vein entrance of splenic erythrocytic progenitor cells and local hypoxia of liver, two events cause intrahepatic splenosis. Med Hypotheses, 2006, 67(6): 1330-1332.
6. Tsitouridis I, Michaelides M, Sotiriadis C, et al. CT and MRI of intraperitoneal splenosis. Diagn Interv Radiol, 2010, 16(2): 145-149.
7. 张烁琪, 曹红霞, 胡道予, 等. 肝包膜下脾组织植入的CT及MRI影像学特征. 中华放射学杂志, 2021, 55(5): 548-550.
8. Varghese J, Bergson J, Yaipen O. Intrahepatic splenosis: incidental liver lesion after splenectomy. J Comput Assist Tomogr, 2018, 42(5): 730-731.
9. Ota T, Tei M, Yoshioka A, et al. Intrapancreatic accessory spleen diagnosed by technetium-99m heat-damaged red blood cell SPECT. J Nucl Med, 1997, 38(3): 494-495.
10. De Vuysere S, Van Steenbergen W, Aerts R, et al. Intrahepatic splenosis: imaging features. Abdom Imaging, 2000, 25(2): 187-189.
11. Grandin C, Van Beers BE, Robert A, et al. Benign hepatocellular tumors: MRI after superparamagnetic iron oxide administration. J Comput Assist Tomogr, 1995, 19(3): 412-418.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Case study—intrahepatic splenosis with CT and MR findings mimicking hepatocellular carcinoma

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