Recent research on ferroptosis in gallbladder cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LIU Fei ,  LI Fuyu

Division of Biliary Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;

Corresponding author：

LI Fuyu, Email: lfy_74@hotmail.com

Keywords：

gallbladder cancer; ferroptosis; targeted therapy

DOI：

10.7507/1007-9424.202308058

Video：

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The morbidity and mortality of gallbladder cancer were rising. At present, there was no effective chemotherapy regimen, so it was of great practical significance to explore new therapy target. Ferroptosis is a non-apoptotic form of cell death characterized by iron-dependent lipid peroxidation and metabolic constraints. In recent years, it had become a research hotspot. Many studies had been carried out on the relevant biological mechanisms such as liver cancer, breast cancer, pancreatic cancer, and other cancer. At present, there are still few studies on ferroptosis in gallbladder cancer, and its relevant mechanisms need further in-depth analysis, which opens up a new research direction for exploring the treatment of gallbladder cancer.

Citation： LIU Fei, LI Fuyu. Recent research on ferroptosis in gallbladder cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2023, 30(10): 1193-1194. doi: 10.7507/1007-9424.202308058 Copy

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6.	Yu H, Guo P, Xie X, et al. Ferroptosis, a new form of cell death, and its relationships with tumourous diseases. J Cell Mol Med, 2017, 21(4): 648-657.
7.	Huang HX, Yang G, Yang Y, et al. TFAP2A is a novel regulator that modulates ferroptosis in gallbladder carcinoma cells via the Nrf2 signalling axis. Eur Rev Med Pharmacol Sci, 2020, 24(9): 4745-4755.
8.	Liu L, Li Y, Cao D, et al. SIRT3 inhibits gallbladder cancer by induction of AKT-dependent ferroptosis and blockade of epithelial-mesenchymal transition. Cancer Lett, 2021, 510: 93-104.
9.	Cai C, Zhu Y, Mu J, et al. DNA methylation of RUNX3 promotes the progression of gallbladder cancer through repressing SLC7A11-mediated ferroptosis. Cell Signal, 2023, 108: 110710.
10.	Li W, Wang Z, Lin R, et al. Lithocholic acid inhibits gallbladder cancer proliferation through interfering glutaminase-mediated glutamine metabolism. Biochem Pharmacol, 2022, 205: 115253.
11.	Wang Z, Li W, Wang X, et al. Isoliquiritigenin induces HMOX1 and GPX4-mediated ferroptosis in gallbladder cancer cells. Chin Med J (Engl), 2023 Jul 24. doi: 10.1097/CM9.0000000000002675.

1. Song X, Hu Y, Li Y, et al. Overview of current targeted therapy in gallbladder cancer. Signal Transduct Target Ther, 2020, 5(1): 230.
2. Roa JC, García P, Kapoor VK, et al. Gallbladder cancer. Nat Rev Dis Primers, 2022, 8(1): 69.
3. Yifan T, Zheyong L, Miaoqin C, et al. A predictive model for survival of gallbladder adenocarcinoma. Surg Oncol, 2018, 27(3): 365-372.
4. Nath A, Li I, Roberts LR, et al. Elevated free fatty acid uptake via CD36 promotes epithelial-mesenchymal transition in hepatocellular carcinoma. Sci Rep, 2015, 5: 14752.
5. Dixon SJ, Lemberg KM, Lamprecht MR, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell, 2012, 149(5): 1060-1072.
6. Yu H, Guo P, Xie X, et al. Ferroptosis, a new form of cell death, and its relationships with tumourous diseases. J Cell Mol Med, 2017, 21(4): 648-657.
7. Huang HX, Yang G, Yang Y, et al. TFAP2A is a novel regulator that modulates ferroptosis in gallbladder carcinoma cells via the Nrf2 signalling axis. Eur Rev Med Pharmacol Sci, 2020, 24(9): 4745-4755.
8. Liu L, Li Y, Cao D, et al. SIRT3 inhibits gallbladder cancer by induction of AKT-dependent ferroptosis and blockade of epithelial-mesenchymal transition. Cancer Lett, 2021, 510: 93-104.
9. Cai C, Zhu Y, Mu J, et al. DNA methylation of RUNX3 promotes the progression of gallbladder cancer through repressing SLC7A11-mediated ferroptosis. Cell Signal, 2023, 108: 110710.
10. Li W, Wang Z, Lin R, et al. Lithocholic acid inhibits gallbladder cancer proliferation through interfering glutaminase-mediated glutamine metabolism. Biochem Pharmacol, 2022, 205: 115253.
11. Wang Z, Li W, Wang X, et al. Isoliquiritigenin induces HMOX1 and GPX4-mediated ferroptosis in gallbladder cancer cells. Chin Med J (Engl), 2023 Jul 24. doi: 10.1097/CM9.0000000000002675.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Recent research on ferroptosis in gallbladder cancer

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